DK2173868T3 - Rekombinant fremstilling af udvalgte bromelainfraktioner - Google Patents

Rekombinant fremstilling af udvalgte bromelainfraktioner

Info

Publication number
DK2173868T3
DK2173868T3 DK08785459.2T DK08785459T DK2173868T3 DK 2173868 T3 DK2173868 T3 DK 2173868T3 DK 08785459 T DK08785459 T DK 08785459T DK 2173868 T3 DK2173868 T3 DK 2173868T3
Authority
DK
Denmark
Prior art keywords
recombinant preparation
bromelain
fractions
bromelain fractions
recombinant
Prior art date
Application number
DK08785459.2T
Other languages
English (en)
Inventor
Rolf Mueller
Nora Luniak
Klaus Eschmann
Original Assignee
Ursapharm Arzneimittel Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ursapharm Arzneimittel Gmbh filed Critical Ursapharm Arzneimittel Gmbh
Application granted granted Critical
Publication of DK2173868T3 publication Critical patent/DK2173868T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/63—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Botany (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
DK08785459.2T 2007-09-14 2008-08-08 Rekombinant fremstilling af udvalgte bromelainfraktioner DK2173868T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07018125A EP2036978A1 (en) 2007-09-14 2007-09-14 Recombinant preparation of selected bromelain fractions
PCT/EP2008/006564 WO2009033536A1 (en) 2007-09-14 2008-08-08 Recombinant preparation of selected bromelain fractions

Publications (1)

Publication Number Publication Date
DK2173868T3 true DK2173868T3 (da) 2013-02-18

Family

ID=39144517

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08785459.2T DK2173868T3 (da) 2007-09-14 2008-08-08 Rekombinant fremstilling af udvalgte bromelainfraktioner

Country Status (11)

Country Link
US (1) US8409840B2 (da)
EP (2) EP2036978A1 (da)
JP (1) JP2010538622A (da)
CN (1) CN101889083A (da)
CA (1) CA2699429A1 (da)
DK (1) DK2173868T3 (da)
ES (1) ES2395591T3 (da)
MX (1) MX2010002769A (da)
PL (1) PL2173868T3 (da)
PT (1) PT2173868E (da)
WO (1) WO2009033536A1 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL165334A0 (en) * 2004-11-22 2006-01-15 Mediwound Ltd Debriding composition from bromelain and methods of producing same
MY190244A (en) * 2009-12-17 2022-04-08 International Islamic Univ Malaysia Method for producing recombinant stem bromelain
JP2015519879A (ja) 2012-03-26 2015-07-16 プロニュートリア・インコーポレイテッドＰｒｏｎｕｔｒｉａ， Ｉｎｃ． 荷電栄養タンパク質および方法
EP3715365A1 (en) 2012-03-26 2020-09-30 Axcella Health Inc. Nutritive fragments, proteins and methods
CA2868477A1 (en) 2012-03-26 2013-10-03 Pronutria, Inc. Nutritive proteins and methods
US9700071B2 (en) 2012-03-26 2017-07-11 Axcella Health Inc. Nutritive fragments, proteins and methods
AU2014324900A1 (en) 2013-09-25 2016-05-19 Axcella Health Inc. Compositions and formulations for prevention and reduction of tumorigenesis, cancer cell proliferation and invasion, and methods of production and use thereof in cancer treatment
ES2909565T3 (es) 2016-01-31 2022-05-09 Mediwound Ltd Composición desbridante para el tratamiento de heridas
JP6859158B2 (ja) * 2017-03-31 2021-04-14 第一工業製薬株式会社 ポリウレタン樹脂用ポリオール組成物、ポリウレタン樹脂形成性組成物、複合材料
CN110477100B (zh) * 2019-08-22 2023-11-07 内蒙古蒙牛乳业（集团）股份有限公司 一种两吃型酸奶固体饮料及其制备方法
WO2021255625A1 (en) * 2020-06-16 2021-12-23 Anatara Lifesciences Limited Protease composition

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3658651A (en) * 1970-04-28 1972-04-25 Castle & Cooke Ion exchange treatment of bromelain
US4286064A (en) * 1979-11-05 1981-08-25 Riker Laboratories, Inc. Process for isolating active debriding agent from bromelain
GB9313188D0 (en) * 1993-06-25 1993-08-11 Cortecs Ltd Medical use of enzymes
KR100201008B1 (ko) * 1996-10-09 1999-06-15 박종헌 글루텐 펩타이드를 외인성 고지혈증 및 고콜레스트레롤증 억제에 이용하는 방법
CN1091152C (zh) 1996-12-23 2002-09-18 茂名市茂辉公司化州分公司 菠萝蛋白酶的物理提取方法
JP2001513636A (ja) * 1997-02-25 2001-09-04 コルテクス（ユーケイ）リミティッド ブロメラインの成分
US6803038B1 (en) * 1998-07-15 2004-10-12 Ursapharm Arzneimittel Gmbh Use of bromelaine proteases for inhibiting blood coagulation
GB9819138D0 (en) * 1998-09-02 1998-10-28 Cortecs Uk Ltd Nucleic acids and proteins from pineapple stem
JP2002003362A (ja) * 2000-06-22 2002-01-09 Kyoei Kagaku Kogyo Kk 皮膚外用剤
JP4969741B2 (ja) * 2001-07-26 2012-07-04 株式会社ノエビア 皮膚外用剤
JP4411192B2 (ja) * 2003-12-05 2010-02-10 エフ．ホフマン−ラ ロシュ アーゲー 組換えで発現されるカルボキシペプチダーゼｂおよびその精製
JP2007527726A (ja) * 2004-03-08 2007-10-04 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト 自己プロセシング植物および植物部分
EP2540831A3 (en) * 2006-08-17 2013-04-10 Monsanto Technology, LLC Transgenic plants with enhanced agronomic traits

Also Published As

Publication number Publication date
MX2010002769A (es) 2010-09-07
US20100272659A1 (en) 2010-10-28
PT2173868E (pt) 2013-01-08
JP2010538622A (ja) 2010-12-16
EP2173868B1 (en) 2012-10-17
WO2009033536A1 (en) 2009-03-19
PL2173868T3 (pl) 2013-03-29
EP2036978A1 (en) 2009-03-18
CA2699429A1 (en) 2009-03-19
ES2395591T3 (es) 2013-02-13
CN101889083A (zh) 2010-11-17
EP2173868A1 (en) 2010-04-14
US8409840B2 (en) 2013-04-02

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