DK1733039T3 - Forbedret bakteriel værtscelle til direkte ekspression af peptider - Google Patents

Forbedret bakteriel værtscelle til direkte ekspression af peptider

Info

Publication number
DK1733039T3
DK1733039T3 DK05734021.8T DK05734021T DK1733039T3 DK 1733039 T3 DK1733039 T3 DK 1733039T3 DK 05734021 T DK05734021 T DK 05734021T DK 1733039 T3 DK1733039 T3 DK 1733039T3
Authority
DK
Denmark
Prior art keywords
peptides
host cell
bacterial host
direct expression
improved bacterial
Prior art date
Application number
DK05734021.8T
Other languages
English (en)
Inventor
Nozer M Mehta
Angelo P Consalvo
Martha V L Ray
Christopher P Meenan
Original Assignee
Enteris Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enteris Biopharma Inc filed Critical Enteris Biopharma Inc
Application granted granted Critical
Publication of DK1733039T3 publication Critical patent/DK1733039T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK05734021.8T 2004-03-12 2005-03-10 Forbedret bakteriel værtscelle til direkte ekspression af peptider DK1733039T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55282404P 2004-03-12 2004-03-12
US11/076,260 US8227241B2 (en) 2004-03-12 2005-03-09 Bacterial host cell for the direct expression of peptides
PCT/US2005/007873 WO2005089182A2 (en) 2004-03-12 2005-03-10 Improved bacterial host cell for the direct expression of peptides

Publications (1)

Publication Number Publication Date
DK1733039T3 true DK1733039T3 (da) 2014-01-06

Family

ID=34994183

Family Applications (2)

Application Number Title Priority Date Filing Date
DK05734021.8T DK1733039T3 (da) 2004-03-12 2005-03-10 Forbedret bakteriel værtscelle til direkte ekspression af peptider
DK09156191.0T DK2067854T3 (da) 2004-03-12 2005-03-10 Kloningsvektorer

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK09156191.0T DK2067854T3 (da) 2004-03-12 2005-03-10 Kloningsvektorer

Country Status (9)

Country Link
US (6) US8227241B2 (da)
EP (2) EP1733039B1 (da)
JP (2) JP5591447B2 (da)
CN (3) CN101389750B (da)
AU (2) AU2005222860A1 (da)
CA (2) CA2557295C (da)
DK (2) DK1733039T3 (da)
ES (2) ES2440658T3 (da)
WO (1) WO2005089182A2 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8227241B2 (en) * 2004-03-12 2012-07-24 Unigene Laboratories, Inc. Bacterial host cell for the direct expression of peptides
US7445911B2 (en) * 2004-11-24 2008-11-04 Unigene Laboratories Inc. Enzymatic reactions in the presence of keto acids
JP4856177B2 (ja) 2005-06-24 2012-01-18 ユニジーン・ラボラトリーズ・インコーポレーテッド アミド化生成物の調製に有用な酵素を発現させるための細胞株
MX2009000813A (es) 2006-07-27 2009-02-03 Wyeth Corp Proceso de fermentacion alimentada de alta densidad celular para producir proteinas recombinantes.
US8377863B2 (en) 2007-05-29 2013-02-19 Unigene Laboratories Inc. Peptide pharmaceutical for oral delivery
WO2013052168A2 (en) * 2011-05-26 2013-04-11 Georgetown University Detection aib1-delta 4 protein
US20150353940A1 (en) * 2013-08-05 2015-12-10 Absci, Llc Vectors for use in an inducible coexpression system
EP2964193B1 (en) 2013-03-05 2019-12-11 Enteris BioPharma, Inc. Pharmaceuticals for oral delivery
BR112016002622B1 (pt) 2013-08-20 2023-04-11 Lek Pharmaceuticals D.D Meio de cultura celular e uso de selênio
CN103911390B (zh) * 2014-04-24 2017-02-15 江南大学 一种通过调节OmpA表达提高大肠杆菌黄酮类物质耐受性的方法
KR102294577B1 (ko) 2015-01-12 2021-08-26 엔터리스 바이오파마, 인크. 고체 경구 제형
CA3010598A1 (en) 2016-01-06 2017-07-13 Oncobiologics, Inc. Modulation of afucosylated species in a monoclonal antibody composition
EP3411401A1 (en) 2016-02-03 2018-12-12 Oncobiologics, Inc. Buffer formulations for enhanced antibody stability
CN107365779A (zh) * 2017-08-22 2017-11-21 中国科学院天津工业生物技术研究所 利用谷氨酸棒状杆菌生产紫色杆菌素的方法
JP2022525775A (ja) 2019-03-18 2022-05-19 バイオ－ラッド エービーディー セロテック ゲーエムベーハー ＳｐｙＴａｇ含有ペリプラズム融合タンパク質のプロテアーゼＴＳＰ及びＯＭＰＴ分解からの保護
CN114875063A (zh) * 2022-02-28 2022-08-09 华侨大学 一种提高植物基础抗逆的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4595658A (en) 1982-09-13 1986-06-17 The Rockefeller University Method for facilitating externalization of proteins synthesized in bacteria
ATE78515T1 (de) 1984-10-05 1992-08-15 Genentech Inc Dna, zellkulturen und verfahren zur sekretion von heterologen proteinen und periplasmische proteinrueckgewinnung.
US5223407A (en) 1988-08-31 1993-06-29 Allelix Inc. Excretion of heterologous proteins from e. coli
US5264365A (en) * 1990-11-09 1993-11-23 Board Of Regents, The University Of Texas System Protease-deficient bacterial strains for production of proteolytically sensitive polypeptides
US6201925B1 (en) * 1996-11-15 2001-03-13 Futuretel, Inc. Method and apparatus for editing video files
ATE522598T1 (de) 1997-04-16 2011-09-15 Unigene Lab Inc Direkte expression von peptiden in nährmedien
ATE318890T1 (de) 2000-12-14 2006-03-15 Genentech Inc Bakterielle wirtstämme
EP1279739A1 (en) * 2001-07-26 2003-01-29 Vrije Universiteit Brussel Recombinant vectors derived from adeno-associated virus expressing TAM67 for gene therapy
US8227241B2 (en) * 2004-03-12 2012-07-24 Unigene Laboratories, Inc. Bacterial host cell for the direct expression of peptides

Also Published As

Publication number Publication date
US8227241B2 (en) 2012-07-24
US8835161B2 (en) 2014-09-16
CN101389750B (zh) 2012-07-11
CA2557295A1 (en) 2005-09-29
US20080057566A1 (en) 2008-03-06
DK2067854T3 (da) 2015-01-26
US7553655B2 (en) 2009-06-30
ES2528754T3 (es) 2015-02-12
JP2007535313A (ja) 2007-12-06
JP2010162051A (ja) 2010-07-29
CA2795418A1 (en) 2005-09-29
ES2440658T3 (es) 2014-01-29
EP1733039A4 (en) 2008-09-24
US8216822B2 (en) 2012-07-10
EP2067854A1 (en) 2009-06-10
CN102337241A (zh) 2012-02-01
WO2005089182A3 (en) 2007-12-13
CN101389750A (zh) 2009-03-18
US20080102510A1 (en) 2008-05-01
EP2067854B1 (en) 2014-11-05
CN102337241B (zh) 2014-12-03
US7541174B2 (en) 2009-06-02
JP5591447B2 (ja) 2014-09-17
US20080102509A1 (en) 2008-05-01
US20130034897A1 (en) 2013-02-07
US20080102491A1 (en) 2008-05-01
EP1733039A2 (en) 2006-12-20
AU2009200466A1 (en) 2009-02-26
EP1733039B1 (en) 2013-09-25
AU2005222860A1 (en) 2005-09-29
US8252580B2 (en) 2012-08-28
AU2009200466A2 (en) 2009-03-12
CA2795418C (en) 2015-02-24
CN102337286A (zh) 2012-02-01
CA2557295C (en) 2013-01-29
WO2005089182A2 (en) 2005-09-29
AU2009200466B2 (en) 2012-03-15
US20050221442A1 (en) 2005-10-06

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