ATE318890T1 - Bakterielle wirtstämme - Google Patents

Bakterielle wirtstämme

Info

Publication number
ATE318890T1
ATE318890T1 AT01987349T AT01987349T ATE318890T1 AT E318890 T1 ATE318890 T1 AT E318890T1 AT 01987349 T AT01987349 T AT 01987349T AT 01987349 T AT01987349 T AT 01987349T AT E318890 T1 ATE318890 T1 AT E318890T1
Authority
AT
Austria
Prior art keywords
prc
strain
bacterial host
host strains
degp
Prior art date
Application number
AT01987349T
Other languages
English (en)
Inventor
Christina Yu-Ching Chen
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE318890T1 publication Critical patent/ATE318890T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia
    • C12R2001/19—Escherichia coli

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
AT01987349T 2000-12-14 2001-12-07 Bakterielle wirtstämme ATE318890T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25616200P 2000-12-14 2000-12-14

Publications (1)

Publication Number Publication Date
ATE318890T1 true ATE318890T1 (de) 2006-03-15

Family

ID=22971286

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01987349T ATE318890T1 (de) 2000-12-14 2001-12-07 Bakterielle wirtstämme

Country Status (23)

Country Link
US (1) US6828121B2 (de)
EP (1) EP1341899B9 (de)
JP (1) JP4056880B2 (de)
KR (1) KR100841486B1 (de)
CN (1) CN1233820C (de)
AT (1) ATE318890T1 (de)
AU (2) AU3957602A (de)
BR (1) BR0116680A (de)
CA (1) CA2430249A1 (de)
CZ (1) CZ304484B6 (de)
DE (1) DE60117601T2 (de)
DK (1) DK1341899T3 (de)
ES (1) ES2259338T3 (de)
HK (1) HK1058686A1 (de)
HU (1) HU230065B1 (de)
IL (2) IL156111A0 (de)
MX (1) MXPA03005271A (de)
NO (1) NO328987B1 (de)
NZ (1) NZ526134A (de)
PL (1) PL205897B1 (de)
RU (1) RU2287574C2 (de)
WO (1) WO2002048376A2 (de)
ZA (1) ZA200304101B (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6979556B2 (en) * 2000-12-14 2005-12-27 Genentech, Inc. Separate-cistron contructs for secretion of aglycosylated antibodies from prokaryotes
WO2003018771A2 (en) 2001-08-27 2003-03-06 Genentech, Inc. A system for antibody expression and assembly
JP4050559B2 (ja) * 2002-06-28 2008-02-20 富士通株式会社 コンテンツ検索処理プログラム、コンテンツ検索処理プログラムを記録した記録媒体およびオペレータ問合せ処理システム
US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
NZ568403A (en) * 2003-05-09 2009-10-30 Univ Duke CD20-specific antibodies and methods of employing same
ES2383300T3 (es) 2003-11-13 2012-06-20 Hanmi Holdings Co., Ltd Fragmento Fc de IgG para un vehículo de fármacos y procedimiento para su preparación
US8110665B2 (en) 2003-11-13 2012-02-07 Hanmi Holdings Co., Ltd. Pharmaceutical composition comprising an immunoglobulin FC region as a carrier
US8227241B2 (en) 2004-03-12 2012-07-24 Unigene Laboratories, Inc. Bacterial host cell for the direct expression of peptides
US8603824B2 (en) 2004-07-26 2013-12-10 Pfenex, Inc. Process for improved protein expression by strain engineering
DE602006017690D1 (de) 2005-05-26 2010-12-02 Genentech Inc Humanisierte antikörper gegen cd40 und verfahren zu ihrer anwendung
EP2142651B1 (de) 2007-04-27 2013-05-22 Pfenex Inc. Schnellscreeningverfahren für bakterienwirte zur identifizierung bestimmter stämme mit verbessertem ertrag und/oder verbesserter qualität bei der expression heterologer proteine
US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
EP2176291A1 (de) * 2007-08-10 2010-04-21 Wacker Chemie AG Expression von igg vollständiger länge und sekretion in das kulturmedium prokaryontischer zellen
BRPI1012321A8 (pt) * 2009-06-17 2016-09-27 Abbott Biotherapeutics Corp Anticorpos anti-vegf e seus usos
WO2011036455A1 (en) * 2009-09-24 2011-03-31 Ucb Pharma S.A. Bacterial strain for recombinant protein expression, having protease deficient degp retaining chaperone activity, and knocked out tsp and ptr genes
HUE040306T2 (hu) * 2009-09-24 2019-03-28 Ucb Biopharma Sprl Baktériumtörzs rekombináns fehérje expresszálására, amely tartalmaz proteázhiányos, de chaperonaktivitását megtartott DEGP-t és génkiütött TSP és PTR gént
ES2636971T3 (es) * 2009-11-05 2017-10-10 F. Hoffmann-La Roche Ag Procedimientos y composición para la secreción de polipéptidos heterógenos
GB201000587D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial hoist strain
GB201000591D0 (en) * 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial hoist strain
GB201000590D0 (en) * 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial host strain
GB201012599D0 (en) 2010-07-27 2010-09-08 Ucb Pharma Sa Process for purifying proteins
JP6431370B2 (ja) 2011-07-13 2018-11-28 ユセベ ファルマ ソシエテ アノニム 組換えＤｓｂＣを発現する細菌宿主系統
GB201208367D0 (en) 2012-05-14 2012-06-27 Ucb Pharma Sa Biological product
US9370321B2 (en) * 2012-06-25 2016-06-21 Empire Technology Development Llc Ultrasound based antigen binding detection
CA2880469A1 (en) 2012-09-17 2014-03-20 Christian Schantz Method for the production of polypeptides in the periplasm of prokaryotic cells
US20140154255A1 (en) 2012-11-30 2014-06-05 Abbvie Biotherapeutics Inc. Anti-vegf antibodies and their uses
ES2897765T3 (es) 2014-03-14 2022-03-02 Hoffmann La Roche Procedimientos y composiciones para la secreción de polipéptidos heterólogos
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
WO2018155587A1 (ja) * 2017-02-22 2018-08-30 国立大学法人 長崎大学 生体由来材料の透明化用試薬
CN106967658B (zh) * 2017-02-23 2020-09-15 郑州大学 一种提高Fab抗体表达量的方法
CN108587992B (zh) * 2018-04-10 2022-03-15 安徽大学 一种高效分泌表达抗VEGF-Fab抗体片段的高产菌株及其构建方法
US11471497B1 (en) 2019-03-13 2022-10-18 David Gordon Bermudes Copper chelation therapeutics
JP2022525775A (ja) 2019-03-18 2022-05-19 バイオ－ラッド エービーディー セロテック ゲーエムベーハー ＳｐｙＴａｇ含有ペリプラズム融合タンパク質のプロテアーゼＴＳＰ及びＯＭＰＴ分解からの保護
CN114829578A (zh) * 2019-08-05 2022-07-29 瓦克化学股份公司 用于在发酵方法中释放重组蛋白的细菌菌株
WO2021193566A1 (ja) * 2020-03-23 2021-09-30 国立大学法人京都工芸繊維大学 新規抗体及びその用途
US10973908B1 (en) 2020-05-14 2021-04-13 David Gordon Bermudes Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine
EP4405473A1 (de) 2021-09-24 2024-07-31 Xbrane Biopharma AB Dna-konstrukte und wirtszellen zur expression von rekombinantem protein
SE545694C2 (en) * 2021-09-24 2023-12-05 Xbrane Biopharma Ab Dna construct comprising nucleotide sequences encoding amino acid sequences of certolizumab and pelb signal peptides
SE545715C2 (en) * 2021-09-24 2023-12-19 Xbrane Biopharma Ab Dna contructs comprising tirs for producing recombinant proteins
SE545714C2 (en) * 2021-09-24 2023-12-19 Xbrane Biopharma Ab Dna contructs for producing a pelb signal peptide

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4439523A (en) * 1981-07-07 1984-03-27 Phillips Petroleum Company Production of single cell protein material
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
WO1988005821A1 (en) 1987-01-30 1988-08-11 President And Fellows Of Harvard College Periplasmic protease mutants of escherichia coli
CA1341235C (en) 1987-07-24 2001-05-22 Randy R. Robinson Modular assembly of antibody genes, antibodies prepared thereby and use
US5508192A (en) * 1990-11-09 1996-04-16 Board Of Regents, The University Of Texas System Bacterial host strains for producing proteolytically sensitive polypeptides
US20020037558A1 (en) 1991-10-23 2002-03-28 Kin-Ming Lo E.coli produced immunoglobulin constructs
US6251395B1 (en) * 1993-12-23 2001-06-26 W. Michael Gallatin Methods of inhibiting inflammation at the site of a central nervous system injury with alphaD-specific antibodies
FR2787810B1 (fr) * 1998-12-24 2002-10-31 Inst Nat De La Rech Agronomique Inra Bacteries a gram positif depourvues d'activite proteasique htra, et leurs utilisations

Also Published As

Publication number Publication date
PL205897B1 (pl) 2010-06-30
DK1341899T3 (da) 2006-04-10
MXPA03005271A (es) 2003-09-25
CN1526010A (zh) 2004-09-01
CZ20031523A3 (cs) 2003-10-15
RU2287574C2 (ru) 2006-11-20
WO2002048376A3 (en) 2003-06-19
US20020142388A1 (en) 2002-10-03
IL156111A0 (en) 2003-12-23
ES2259338T3 (es) 2006-10-01
PL366194A1 (en) 2005-01-24
BR0116680A (pt) 2005-04-05
HK1058686A1 (en) 2004-05-28
CZ304484B6 (cs) 2014-05-21
WO2002048376A2 (en) 2002-06-20
HU230065B1 (hu) 2015-06-29
NZ526134A (en) 2005-07-29
NO328987B1 (no) 2010-07-12
CA2430249A1 (en) 2002-06-20
NO20032694L (no) 2003-08-14
RU2003121232A (ru) 2005-01-20
DE60117601D1 (de) 2006-04-27
AU2002239576B2 (en) 2007-03-29
US6828121B2 (en) 2004-12-07
KR20030057579A (ko) 2003-07-04
DE60117601T2 (de) 2006-11-16
HUP0303892A3 (en) 2011-03-28
EP1341899B1 (de) 2006-03-01
HUP0303892A2 (hu) 2004-03-01
NO20032694D0 (no) 2003-06-13
IL156111A (en) 2010-05-31
EP1341899B9 (de) 2007-03-21
CN1233820C (zh) 2005-12-28
KR100841486B1 (ko) 2008-06-25
JP2004537262A (ja) 2004-12-16
AU3957602A (en) 2002-06-24
ZA200304101B (en) 2005-07-27
EP1341899A2 (de) 2003-09-10
JP4056880B2 (ja) 2008-03-05

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