HK1113498A1 - Recombinant co-expression of vitamin k epoxide reductase subunit 1 to improve vitamin k dependent protein expression - Google Patents

Recombinant co-expression of vitamin k epoxide reductase subunit 1 to improve vitamin k dependent protein expression

Info

Publication number
HK1113498A1
HK1113498A1 HK08103591.9A HK08103591A HK1113498A1 HK 1113498 A1 HK1113498 A1 HK 1113498A1 HK 08103591 A HK08103591 A HK 08103591A HK 1113498 A1 HK1113498 A1 HK 1113498A1
Authority
HK
Hong Kong
Prior art keywords
vitamin
expression
recombinant
dependent protein
improve
Prior art date
Application number
HK08103591.9A
Other languages
English (en)
Inventor
Friedrich Scheiflinger
Ernst Boehm
Original Assignee
Baxter Int
Baxter Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36130202&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1113498(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Baxter Int, Baxter Healthcare Sa filed Critical Baxter Int
Publication of HK1113498A1 publication Critical patent/HK1113498A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0093—Oxidoreductases (1.) acting on CH or CH2 groups (1.17)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/644—Coagulation factor IXa (3.4.21.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y117/00—Oxidoreductases acting on CH or CH2 groups (1.17)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21022—Coagulation factor IXa (3.4.21.22)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
HK08103591.9A 2005-02-28 2008-04-01 Recombinant co-expression of vitamin k epoxide reductase subunit 1 to improve vitamin k dependent protein expression HK1113498A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65704105P 2005-02-28 2005-02-28
PCT/EP2006/000734 WO2006089613A1 (en) 2005-02-28 2006-01-27 Recombinant co-expression of vitamin k epoxide reductase subunit 1 to improve vitamin k dependent protein expression

Publications (1)

Publication Number Publication Date
HK1113498A1 true HK1113498A1 (en) 2008-10-03

Family

ID=36130202

Family Applications (1)

Application Number Title Priority Date Filing Date
HK08103591.9A HK1113498A1 (en) 2005-02-28 2008-04-01 Recombinant co-expression of vitamin k epoxide reductase subunit 1 to improve vitamin k dependent protein expression

Country Status (18)

Country Link
US (2) US9617523B2 (xx)
EP (2) EP2295547B1 (xx)
JP (3) JP2008531026A (xx)
KR (2) KR20130025952A (xx)
CN (2) CN103396998A (xx)
AU (1) AU2006218216B2 (xx)
BR (1) BRPI0607751A8 (xx)
CA (1) CA2599284A1 (xx)
DK (1) DK1853700T3 (xx)
ES (1) ES2397530T3 (xx)
HK (1) HK1113498A1 (xx)
HR (1) HRP20130028T1 (xx)
IL (1) IL184696A (xx)
MX (2) MX349285B (xx)
PL (1) PL1853700T3 (xx)
PT (1) PT1853700E (xx)
SI (1) SI1853700T1 (xx)
WO (1) WO2006089613A1 (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004025157D1 (de) * 2003-09-23 2010-03-04 Univ North Carolina Zellen, die Vitamin-K-Reduktase und Vitamin-K-abhängiges Protein coexprimieren und deren Anwendung zur Verbesserung der Produktivität von diesem Vitamin-K-abhängigen Protein
ES2344413T3 (es) 2003-10-14 2010-08-26 Baxter International Inc. Polipeptido vkorc1 de reciclaje de la vitamina k-epoxido, una diana terapeutica de la cumarina y sus derivados.
EP2295547B1 (en) 2005-02-28 2017-09-20 Baxalta GmbH Recombinant co-expression of vitamin K epoxide reductase subunit 1 to improve vitamin K dependant protein expression
US20090325226A1 (en) 2005-03-15 2009-12-31 Stafford Darrel W Methods and Compositions for Producing Active Vitamin K-Dependent Proteins
ATE486128T1 (de) * 2005-12-02 2010-11-15 Univ Wake Forest Health Sciences Zusammensetzungen und verfahren zur erhöhung der produktion rekombinanter gamma-carboxylierter proteine
WO2007075976A2 (en) * 2005-12-21 2007-07-05 Inspiration Biopharmaceuticals, Inc. Method of producing biologically active vitamin k dependent proteins by recombinant methods
UA101497C2 (ru) 2008-04-24 2013-04-10 Селтик Фарма Пег Лтд. Конъюгаты фактора ix с увеличенным временем полужизни
WO2011003153A1 (en) * 2009-07-10 2011-01-13 Csl Limited Method of increasing the expression yield of vitamin k-dependent proteins
EP2655607A4 (en) * 2010-12-21 2014-05-14 Univ North Carolina METHOD AND COMPOSITIONS FOR PRODUCING ACTIVE VITAMIN K-DEPENDENT PROTEINS
JP2012139232A (ja) * 2012-03-15 2012-07-26 Univ Of North Carolina At Chapel Hill 活性ビタミンｋ依存性タンパク質を生産するための方法及び組成物
RU2535871C1 (ru) * 2013-07-10 2014-12-20 Общество с ограниченной ответственностью "Лаборатория медицинской биотехнологии" (ООО "ЛМБТ") Плазмида для экспрессии в клетке китайского хомячка, клетка китайского хомячка - продуцент белка с Gla-доменом и способ получения белка с Gla-доменом
JP2014221048A (ja) * 2014-06-16 2014-11-27 ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル 活性ビタミンｋ依存性タンパク質を生産するための方法及び組成物
CN104293737B (zh) * 2014-09-16 2017-06-13 太原博奥特生物技术有限公司 一种包含表达功能性重组人凝血因子ⅶ载体的宿主细胞及其高水平表达方法
AU2016363789B2 (en) 2015-12-02 2022-06-02 CSL Behring Lengnau AG Improved media for the expression of recombinant vitamin K-dependent proteins

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8822584D0 (en) 1988-09-27 1988-11-02 Abco Technology Ltd Steam boiler system
WO1991001372A1 (en) 1989-07-17 1991-02-07 New England Medical Center Hospitals, Inc. VITAMIN K-DEPENDENT η-CARBOXYLASE
JPH05508551A (ja) 1990-07-23 1993-12-02 ザイモジェネティクス，インコーポレイティド ガンマーカルボキシラーゼおよび使用の方法
US5268275A (en) 1991-05-08 1993-12-07 The University Of North Carolina At Chapel Hill Vitamin K-dependent carboxylase
WO2002102994A2 (en) 2001-03-21 2002-12-27 Human Genome Sciences, Inc. Human secreted proteins
WO2000003015A2 (en) 1998-07-10 2000-01-20 Incyte Pharmaceuticals, Inc. Human transport protein homologs
KR100880624B1 (ko) 2000-10-02 2009-01-30 노보 노르디스크 헬스 케어 악티엔게젤샤프트 비타민 ｋ-의존 단백질의 생산 방법
DE602004025157D1 (de) 2003-09-23 2010-03-04 Univ North Carolina Zellen, die Vitamin-K-Reduktase und Vitamin-K-abhängiges Protein coexprimieren und deren Anwendung zur Verbesserung der Produktivität von diesem Vitamin-K-abhängigen Protein
ES2344413T3 (es) * 2003-10-14 2010-08-26 Baxter International Inc. Polipeptido vkorc1 de reciclaje de la vitamina k-epoxido, una diana terapeutica de la cumarina y sus derivados.
WO2006067116A1 (en) 2004-12-21 2006-06-29 Novo Nordisk Health Care Ag Expression of gamma-carboxylated polypeptides in gamma-carboxylation deficient host systems
EP2295547B1 (en) 2005-02-28 2017-09-20 Baxalta GmbH Recombinant co-expression of vitamin K epoxide reductase subunit 1 to improve vitamin K dependant protein expression
US20090325226A1 (en) 2005-03-15 2009-12-31 Stafford Darrel W Methods and Compositions for Producing Active Vitamin K-Dependent Proteins

Also Published As

Publication number Publication date
JP2013063089A (ja) 2013-04-11
EP2295547A1 (en) 2011-03-16
KR20070110106A (ko) 2007-11-15
CN101124320A (zh) 2008-02-13
HRP20130028T1 (hr) 2013-02-28
EP1853700A1 (en) 2007-11-14
EP2295547B1 (en) 2017-09-20
IL184696A (en) 2013-09-30
EP1853700B1 (en) 2012-10-24
KR101310532B1 (ko) 2013-09-23
MX349285B (es) 2017-07-20
US9617523B2 (en) 2017-04-11
WO2006089613A1 (en) 2006-08-31
PL1853700T3 (pl) 2013-05-31
BRPI0607751A8 (pt) 2015-10-27
MX2007010489A (es) 2007-11-08
BRPI0607751A2 (pt) 2010-03-16
JP2008531026A (ja) 2008-08-14
JP2011142923A (ja) 2011-07-28
AU2006218216A1 (en) 2006-08-31
CA2599284A1 (en) 2006-08-31
US20060194284A1 (en) 2006-08-31
SI1853700T1 (sl) 2013-02-28
US20170226487A1 (en) 2017-08-10
ES2397530T3 (es) 2013-03-07
AU2006218216B2 (en) 2011-01-20
DK1853700T3 (da) 2013-01-07
IL184696A0 (en) 2007-12-03
PT1853700E (pt) 2013-01-14
CN103396998A (zh) 2013-11-20
KR20130025952A (ko) 2013-03-12
JP5339391B2 (ja) 2013-11-13

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20200125