ES2194010T3 - Mejoras en el diagnostico y profilaxis de la borrelia burgdorferi. - Google Patents
Mejoras en el diagnostico y profilaxis de la borrelia burgdorferi.Info
- Publication number
- ES2194010T3 ES2194010T3 ES92922907T ES92922907T ES2194010T3 ES 2194010 T3 ES2194010 T3 ES 2194010T3 ES 92922907 T ES92922907 T ES 92922907T ES 92922907 T ES92922907 T ES 92922907T ES 2194010 T3 ES2194010 T3 ES 2194010T3
- Authority
- ES
- Spain
- Prior art keywords
- burgdorferi
- dna
- ospb
- sample
- polypeptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000589969 Borreliella burgdorferi Species 0.000 title abstract 6
- 238000003745 diagnosis Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 101001086191 Borrelia burgdorferi Outer surface protein A Proteins 0.000 abstract 2
- 108020004414 DNA Proteins 0.000 abstract 2
- 208000016604 Lyme disease Diseases 0.000 abstract 2
- 108010076504 Protein Sorting Signals Proteins 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 241000589968 Borrelia Species 0.000 abstract 1
- 102000034342 Calnexin Human genes 0.000 abstract 1
- 108010056891 Calnexin Proteins 0.000 abstract 1
- 235000012601 Euterpe oleracea Nutrition 0.000 abstract 1
- 244000207620 Euterpe oleracea Species 0.000 abstract 1
- 102000004895 Lipoproteins Human genes 0.000 abstract 1
- 108090001030 Lipoproteins Proteins 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 235000003650 acai Nutrition 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 238000002649 immunization Methods 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/20—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
METODOS PARA DIAGNOSTICAR LA BORRELIOSIS, ENFERMEDAD DE LYME, DETECTANDO LA PRESENCIA DE UN ORGANISMO BORRELIA BURGDORFERI EN UNA MUESTRA DE UN ANIMAL, INCLUYENDO EL HOMBRE, POR EL USO DE ANALISIS PCR-DNA, EN EL QUE LOS ORIGINALES SON SUBSECUENCIAS DE LAS SECUENCIAS OSPA Y OSPB DNA DE CUALQUIERA DE TRES ESPECIES B. BURGDORFERI I, II Y III, TAL COMO SECUENCIAS OSPA Y OSPB DNA DE UNA DE LAS SIGUIENTES CEPAS B. BURGDORFERI: B31, IP90 (O IPER90) Y ACAI, RESPECTIVAMENTE. EL METODO PUEDE SER USADO PARA DETECTAR LA PRESENCIA DE B. BURGDORFERI EN UNA MUESTRA CUALQUIERA DE LAS ESPECIES Y CEPAS DEL ORGANISMO B. BURGDORFERI PROPUESTO QUE ESTA EN LA MUESTRA, PERO TAMBIEN PUEDE SER USADO PARA DETECTAR CEPAS ESPECIFICAS, DEPENDIENDO DE LOS ORIGINALES ESCOGIDOS. VACUNAS QUE COMPRENDEN POLIPEPTIDOS CAPACES DE PROVOCAR UNA RESPUESTA INMUNE CONTRA OSPA O OSPB DE ORGANISMOS B. BURGDORFERI PARA ACTIVAR LA INMUNIZACION, ESTANDO LOS POLIPEPTIDOS PREFERIBLEMENTE LIPIDADOS. SECUENCIAS DNA QUE CODIFICAN LOS POLIPEPTIDOS, CON PREFERENCIA TAMBIEN CODIFICAN UN PEPTIDO DE SEÑAL LIPOPROTEINA, POR EJEMPLO, UN PEPTIDO DE SEÑAL QUE COMPRENDE L-X-Y-C EN LA REGION TERMINAL C Y UN METODO PARA PRODUCIR EL POLIPEPTIDO
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77918591A | 1991-10-22 | 1991-10-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2194010T3 true ES2194010T3 (es) | 2003-11-16 |
Family
ID=25115605
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92922907T Expired - Lifetime ES2194010T3 (es) | 1991-10-22 | 1992-10-22 | Mejoras en el diagnostico y profilaxis de la borrelia burgdorferi. |
Country Status (7)
Country | Link |
---|---|
EP (2) | EP0540457A1 (es) |
AT (1) | ATE234365T1 (es) |
AU (1) | AU2903892A (es) |
DE (1) | DE69232956T2 (es) |
DK (1) | DK0650527T3 (es) |
ES (1) | ES2194010T3 (es) |
WO (1) | WO1993008306A1 (es) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6054296A (en) * | 1988-10-24 | 2000-04-25 | Symbicom Ab | 66 kDa antigen from Borrelia |
DE69229476T2 (de) * | 1991-08-15 | 2000-03-16 | Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts | Ospa proteine von borrelia burgdorferi untergruppen, dafür kodierende gene sowie impfstoffe |
US6676942B1 (en) | 1991-08-15 | 2004-01-13 | Smithkline Beecham Biologicals (S.A.) | Osp a proteins of Borrelia burgdorferi subgroups, encoding genes and vaccines |
BE1006728A3 (fr) * | 1993-02-19 | 1994-11-29 | Wallone Region | Sondes d'acides nucleiques specifiques au spirochete borrelia burgdorferi. |
CA2157004A1 (en) * | 1993-02-26 | 1994-09-01 | Richard T. Coughlin | Methods of inducing immunity to lyme disease and a colorimetric assay for borreliacidal activity of antisera |
US5656451A (en) * | 1993-07-30 | 1997-08-12 | Yale University | OspE, OspF, and S1 polypeptides in borrelia burgdorferi |
US6716591B1 (en) | 1993-07-30 | 2004-04-06 | Yale University | B. burgdorferi polypeptides |
US6248562B1 (en) | 1993-11-01 | 2001-06-19 | Research Foundation State University Of New York | Chimeric proteins comprising borrelia polypeptides and uses therefor |
US7008625B2 (en) | 1993-11-01 | 2006-03-07 | Research Foundation Of The State University Of New York | Recombinant constructs of Borrelia burgdorferi |
DE69433690T2 (de) * | 1993-11-01 | 2005-03-10 | Brookhaven Science Associates | Chimere proteine, welche borrelia polypeptide beinhalten, verwendungen dafür |
ES2265643T3 (es) * | 1994-04-11 | 2007-02-16 | Wyeth Holdings Corporation | Bacteria de borrelia burgdorferi. |
US6087097A (en) * | 1994-05-12 | 2000-07-11 | Mayo Foundation For Medical Education And Research | PCR detection of Borrelia burgdorferi |
US6251405B1 (en) * | 1995-06-07 | 2001-06-26 | Connaught Laboratories, Inc. | Immunological combination compositions and methods |
AU721954B2 (en) * | 1995-06-07 | 2000-07-20 | Connaught Laboratories Inc. | Expression of lipoproteins |
ZA964896B (en) | 1995-06-07 | 1997-01-08 | Connaught Lab | Expression of lipoproteins |
DE19605475C1 (de) * | 1996-02-14 | 1997-11-20 | Deutsches Krebsforsch | Verfahren zur Erkennung des Erkrankungsrisikos nach Arthropodenstich |
US6045804A (en) * | 1996-03-07 | 2000-04-04 | Mayo Foundation For Medical Educational Research | Method for detecting B. burgdorferi infection |
DE19632862B4 (de) * | 1996-08-14 | 2006-08-03 | Mikrogen Molekularbiologische Entwicklungs-Gmbh | Immunologisch aktive Proteine von Borrelia burgdorferi, dafür kodierende Nukleinsäuren sowie deren Verwendung in Testkits und als Impfstoffe |
EP1012269A2 (en) * | 1997-09-10 | 2000-06-28 | Symbicom Ab | P13 antigens from borrelia |
US6224882B1 (en) | 1997-11-07 | 2001-05-01 | Protein Science Corp. | Insect cells or fractions as adjuvant for antigens |
EP1311540B1 (en) | 2000-08-18 | 2007-12-19 | Research Foundation Of State University Of New York | Altered ospa of borrelia burgdorferi |
EA013219B1 (ru) | 2006-01-19 | 2010-04-30 | Мэри Кэй, Инк. | Композиция местного применения по уходу за кожей, продукт на ее основе и способ лечения |
BRPI0719360B1 (pt) | 2006-11-03 | 2016-09-06 | Intervet Int Bv | vacina da doença de lyme canina, e, uso de organismos de uma genoespécie de borrelia |
EP2361930A3 (en) | 2007-03-26 | 2011-10-26 | Dako Denmark A/S | Multimers of MHC-peptide complexes and uses thereof in Borrelia infectious diseases |
EP3023436A1 (en) | 2007-07-03 | 2016-05-25 | Dako Denmark A/S | Improved methods for generation, labeling and use of mhc multimers |
WO2009039854A2 (en) | 2007-09-27 | 2009-04-02 | Dako Denmark A/S | Mhc multimers in tuberculosis diagnostics, vaccine and therapeutics |
DK2254592T3 (da) | 2008-02-28 | 2019-09-09 | Dako Denmark As | MHC-multimerer til Borrelia-diagnostik og sygdom |
EP2711021B1 (en) | 2008-05-02 | 2016-03-09 | BliNK Therapeutics Limited | Products and methods for stimulating an immune response |
US10722562B2 (en) | 2008-07-23 | 2020-07-28 | Immudex Aps | Combinatorial analysis and repair |
GB0817244D0 (en) | 2008-09-20 | 2008-10-29 | Univ Cardiff | Use of a protein kinase inhibitor to detect immune cells, such as T cells |
WO2010037402A1 (en) | 2008-10-02 | 2010-04-08 | Dako Denmark A/S | Molecular vaccines for infectious disease |
US11992518B2 (en) | 2008-10-02 | 2024-05-28 | Agilent Technologies, Inc. | Molecular vaccines for infectious disease |
CA2772626C (en) | 2009-08-28 | 2013-12-10 | Mary Kay Inc. | Skin care formulations |
EA025280B1 (ru) | 2010-03-09 | 2016-12-30 | Амир Максютов | Полиэпитопные конструкции и способы их получения и применения |
US9109007B2 (en) | 2010-08-18 | 2015-08-18 | Purdue Pharma L.P. | MHC-I restricted epitopes containing non-natural amino acid residues |
US9383360B2 (en) | 2012-01-20 | 2016-07-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Compositions and methods relating to lyme disease |
WO2023240109A1 (en) | 2022-06-07 | 2023-12-14 | Regeneron Pharmaceuticals, Inc. | Multispecific molecules for modulating t-cell activity, and uses thereof |
WO2023240124A1 (en) | 2022-06-07 | 2023-12-14 | Regeneron Pharmaceuticals, Inc. | Pseudotyped viral particles for targeting tcr-expressing cells |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK590288D0 (da) * | 1988-10-24 | 1988-10-24 | Symbicom Ab | Kemiske forbindelser |
DE4015911A1 (de) * | 1989-09-19 | 1991-03-28 | Max Planck Gesellschaft | Impfstoff gegen die lyme-krankheit |
SG47447A1 (en) * | 1990-06-15 | 1998-04-17 | Univ Yale | Compositions and methods for the prevention and diagnosis of lyme disease |
-
1992
- 1992-10-22 AT AT92922907T patent/ATE234365T1/de active
- 1992-10-22 DE DE69232956T patent/DE69232956T2/de not_active Expired - Lifetime
- 1992-10-22 EP EP92610073A patent/EP0540457A1/en not_active Withdrawn
- 1992-10-22 EP EP92922907A patent/EP0650527B1/en not_active Expired - Lifetime
- 1992-10-22 AU AU29038/92A patent/AU2903892A/en not_active Abandoned
- 1992-10-22 DK DK92922907T patent/DK0650527T3/da active
- 1992-10-22 ES ES92922907T patent/ES2194010T3/es not_active Expired - Lifetime
- 1992-10-22 WO PCT/US1992/008972 patent/WO1993008306A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
DE69232956T2 (de) | 2003-10-02 |
EP0650527A1 (en) | 1995-05-03 |
EP0650527B1 (en) | 2003-03-12 |
DK0650527T3 (da) | 2003-07-14 |
ATE234365T1 (de) | 2003-03-15 |
WO1993008306A1 (en) | 1993-04-29 |
AU2903892A (en) | 1993-05-21 |
DE69232956D1 (de) | 2003-04-17 |
EP0540457A1 (en) | 1993-05-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2194010T3 (es) | Mejoras en el diagnostico y profilaxis de la borrelia burgdorferi. | |
Skuballa et al. | European hedgehogs as hosts for Borrelia spp., Germany | |
ES2135411T3 (es) | Proteinas osp a de subgrupos de borrelia burgdorferi, genes codificantes y vacunas. | |
ES2147178T3 (es) | Dominio de union a cd2 del antigeno 3 asociado con la funcion linfocitica. | |
ES2149772T3 (es) | Receptores humanos pf4a y su utilizacion. | |
PT726955E (pt) | Proteinas quimericas compreendendo polipeptidos borrelia: suas utilizacoes | |
MX6339E (es) | Metodo para elaborar dentro de un huesped bacteriano y excretar a traves de la membrana de la celula huesped,una proteina o un polipeptido seleccionados | |
DK0510079T3 (da) | Proteiner, der er produceret af humane lymfocytter, DNA-sekvenser, der koder for disse proteiner, og farmaceutiske og biolo | |
DK0548200T3 (da) | Kloning og sekventering af allergener fra dermatophagoides (husstøvmide) | |
ATE444360T1 (de) | T-zell epitopen von den wichtigsten allergene von dermatophagoides (hausmilbe) | |
ES2046462T3 (es) | Marcadores de activacion de celulas "t". | |
WO1995014781A3 (en) | Methods for diagnosing early lyme disease | |
FI895050A0 (fi) | Diagnostiska preparat och vaccin foer mykobakterier i folkhaelso-, medicinsk och veterinaermedicinsk praxis. | |
BR9710433A (pt) | Proteínas associada a escherichia coli patogênica | |
ES2174835T3 (es) | Carboxilasa dependiente de la vitamina k. | |
Daly et al. | Serological heterogeneity of recent isolates of Yersinia ruckeri from Ontario and British Columbia. | |
ATE162550T1 (de) | Ospc-antigen-impfstoffe immunogene zusammensetzung zur vorbeugung und behandlung von lyme-krankheit und rekombinante verfahren zur herstellung von derartige antigene | |
MX9203138A (es) | Dominio de enlace cd2-de antigeno 3 (lfa-3) asociado con funcion linfositos. | |
Blevins et al. | The luxS gene is not required for Borrelia burgdorferi tick colonization, transmission to a mammalian host, or induction of disease | |
NO983238L (no) | Exodus kjemokin materialer og fremgangsmÕter | |
Von Lackum et al. | Regulated synthesis of the Borrelia burgdorferi inner-membrane lipoprotein IpLA7 (P22, P22-A) during the Lyme disease spirochaete's mammal–tick infectious cycle | |
Wang et al. | Two distinct ospA genes among Borrelia valaisiana strains | |
UA27771C2 (uk) | Електролітична комірка (варіанти) та спосіб мічення протеїнів, пептидів і інших органічних молекул | |
DK0616642T3 (da) | Hidtil ukendte thrombininhibitoriske proteiner fra landblodigler | |
Gross et al. | Molecular mimicry and Lyme arthritis |