IL80022A - Cloned human basic fibroblast growth factor, methods for its preparation, compositions containing it, dna sequences encoding therefor and vectors and host cells containing said dna - Google Patents

Cloned human basic fibroblast growth factor, methods for its preparation, compositions containing it, dna sequences encoding therefor and vectors and host cells containing said dna

Info

Publication number
IL80022A
IL80022A IL80022A IL8002286A IL80022A IL 80022 A IL80022 A IL 80022A IL 80022 A IL80022 A IL 80022A IL 8002286 A IL8002286 A IL 8002286A IL 80022 A IL80022 A IL 80022A
Authority
IL
Israel
Prior art keywords
dna
fgf
dna sequence
host cells
fibroblast growth
Prior art date
Application number
IL80022A
Other languages
English (en)
Other versions
IL80022A0 (en
Original Assignee
California Biotechnology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27419719&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL80022(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/809,163 external-priority patent/US5439818A/en
Application filed by California Biotechnology Inc filed Critical California Biotechnology Inc
Publication of IL80022A0 publication Critical patent/IL80022A0/xx
Publication of IL80022A publication Critical patent/IL80022A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Physics & Mathematics (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
IL80022A 1985-09-12 1986-09-12 Cloned human basic fibroblast growth factor, methods for its preparation, compositions containing it, dna sequences encoding therefor and vectors and host cells containing said dna IL80022A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77552185A 1985-09-12 1985-09-12
US06/809,163 US5439818A (en) 1985-09-12 1985-12-16 DNA encoding human recombinant basic fibroblast growth factor
US86938286A 1986-05-30 1986-05-30

Publications (2)

Publication Number Publication Date
IL80022A0 IL80022A0 (en) 1986-12-31
IL80022A true IL80022A (en) 1993-06-10

Family

ID=27419719

Family Applications (1)

Application Number Title Priority Date Filing Date
IL80022A IL80022A (en) 1985-09-12 1986-09-12 Cloned human basic fibroblast growth factor, methods for its preparation, compositions containing it, dna sequences encoding therefor and vectors and host cells containing said dna

Country Status (11)

Country Link
EP (2) EP0593065B1 (de)
JP (3) JPH0789936B2 (de)
AT (2) ATE105868T1 (de)
AU (1) AU590006B2 (de)
CA (1) CA1341640C (de)
DE (2) DE3650774T2 (de)
DK (2) DK175795B1 (de)
ES (1) ES2001967A6 (de)
IE (1) IE66689B1 (de)
IL (1) IL80022A (de)
WO (1) WO1987001728A1 (de)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5235042A (en) * 1984-02-29 1993-08-10 The Children's Medical Center Corporation Endothelial cell growth factor
US4956455A (en) * 1984-03-05 1990-09-11 The Salk Institute For Biological Studies Bovine fibroblast growth factor
US4889919A (en) * 1986-08-13 1989-12-26 Zymogenetics, Inc. Biologically active PDGF derived A-chain homodimers
US5165938A (en) * 1984-11-29 1992-11-24 Regents Of The University Of Minnesota Wound healing agents derived from platelets
US5401832A (en) * 1984-12-24 1995-03-28 Merck & Co., Inc. Brain derived and recombinant acidic fibroblast growth factor
US5026839A (en) * 1985-12-17 1991-06-25 Synergen, Inc DNA encoding a basic fibroblast growth factor
ES2056787T3 (es) * 1985-12-17 1994-10-16 Synergen Inc Factor angiogenico de placenta humana capaz de estimular la sintesis capilar de proteasa de celulas endoteliales, la sintesis de adn y la migracion.
US4994559A (en) * 1985-12-17 1991-02-19 Synergen, Inc. Human basic fibroblast growth factor
US5827826A (en) 1986-03-03 1998-10-27 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compositions of human endothelial cell growth factor
US5552528A (en) * 1986-03-03 1996-09-03 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bovine b-endothelial cell growth factor
US4868113A (en) * 1986-03-03 1989-09-19 Rorer Biotechnology, Inc. Recombinant DNA vector encoding human endothelial cell growth factor
DE3750197D1 (de) * 1986-04-22 1994-08-18 Salk Inst For Biological Studi Antagonisten des Fibroblasten-Wachstumsfaktors.
NZ220917A (en) * 1986-07-11 1991-05-28 Merck & Co Inc Human and bovine acidic fibroblast growth factor vectors, hosts and compositions
US5474982A (en) * 1986-08-13 1995-12-12 Zymogenetics, Inc. PDGF analogs and methods of use
AU1185488A (en) * 1987-01-16 1988-08-10 Amgen, Inc. Production of fibroblast growth factor
JP2526965B2 (ja) * 1987-02-24 1996-08-21 武田薬品工業株式会社 ムテイン，ｄｎａおよびその用途
US5852177A (en) * 1987-02-24 1998-12-22 Takeda Chemical Industries, Ltd. Basic fibroblast growth factor (bFGF) muteins
EP0288687B1 (de) * 1987-03-03 1994-12-28 Takeda Chemical Industries, Ltd. Monoklonaler Antikörper, Hybridomen, ihre Herstellung und ihre Verwendung
AU611614B2 (en) * 1987-06-18 1991-06-13 Monash University Growth factors
EP0364481A4 (en) * 1987-06-18 1992-01-22 Monash University Growth factors
DE3721081A1 (de) * 1987-06-26 1989-01-19 Progen Biotechnik Gmbh Dna-sequenz, die codiert fuer ein zellteilungsfoerderndes polypeptid, sowie ein plasmid, ein wirtsorganismus und ein verfahren zur gewinnung dieses polypeptids
US5312911A (en) * 1987-10-22 1994-05-17 Merck & Co., Inc. Cysteine-modified acidic fibroblast growth factor
NZ226543A (en) * 1987-10-22 1992-02-25 Merck & Co Inc Recombinant mutant acidic fibroblast growth factor
JPH02504468A (ja) * 1987-11-24 1990-12-20 アムジエン・インコーポレーテツド 繊維芽細胞成長因子のアナログ
EP0326907A1 (de) * 1988-01-26 1989-08-09 Takeda Chemical Industries, Ltd. Polypeptide, DNA und ihre Verwendung
JPH03503167A (ja) * 1988-02-24 1991-07-18 アメリカン ナショナル レッド クロス 部位指定血管形成素子とその使用法
GB2223496B (en) * 1988-08-08 1992-05-27 British Bio Technology Synthetic gene encoding mature human acid fibroblast growth factor
GB2223495B (en) * 1988-08-08 1992-05-20 British Bio Technology Synthetic gene encoding basic fibroblast growth factor
GB2223497B (en) * 1988-08-08 1992-04-01 British Bio Technology Synthetic gene encoding human beta endothelial cell growth factor
US5175147A (en) * 1988-08-19 1992-12-29 Takeda Chemical Industries, Ltd Acid-resistant fgf composition and method of treating ulcerating diseases of the gastrointestinal tract
ATE141643T1 (de) * 1988-11-04 1996-09-15 Chiron Corp Expression und prozessierung von acetylierten fgfs in hefen
US5656458A (en) * 1988-11-04 1997-08-12 Chiron Corporation Expression and processing of amino terminus acetylated FGF's in yeast
US5464943A (en) * 1989-04-26 1995-11-07 Takeda Chemical Industries, Ltd. DNA encoding glycosylated FGF and production thereof
EP0406738A3 (en) * 1989-07-03 1991-08-14 Takeda Chemical Industries, Ltd. Production of acidic fgf protein
US5126323A (en) * 1989-11-16 1992-06-30 Genetics Institute, Inc. Homogeneous purified k-fgf and compositions containing the same
IT1237795B (it) * 1989-12-22 1993-06-17 Erba Carlo Spa Fattori di crescita fibroblastici per l'uso nella prevenzione e nel trattamento di infezioni virali.
US5143829A (en) * 1990-03-29 1992-09-01 California Biotechnology Inc. High level expression of basic fibroblast growth factor having a homogeneous n-terminus
JPH047617A (ja) * 1990-04-26 1992-01-13 Canon Inc 電子機器
JP3135138B2 (ja) * 1990-12-19 2001-02-13 科研製薬株式会社 骨疾患治療剤
US6833354B1 (en) 1990-12-19 2004-12-21 Kaken Pharmaceutical Co., Ltd. Agent for the treatment of bone diseases
GR1002610B (el) * 1991-01-02 1997-02-20 Johnson & Johnson Consumer Products Inc. Θεραπευτικες συνθεσεις πληγων που περιεχουν παραγοντα αναπτυξης ινοβλαστων και ασκορβικον οξυ.
AU1194092A (en) * 1991-02-06 1992-09-07 Georgetown University Receptor blocking peptides of fibroblast growth factor receptor
DE69211723T2 (de) * 1991-02-15 1996-10-31 Takeda Chemical Industries Ltd Mit einem Zellwachstumsfaktor bewirkte Anregung von Wachstum im Knocheninneren
US5492894A (en) * 1991-03-21 1996-02-20 The Procter & Gamble Company Compositions for treating wrinkles comprising a peptide
DE4132005A1 (de) * 1991-09-26 1993-04-01 Merck Patent Gmbh Kombination enthaltend wachstumsfaktoren und polyelektrolyte
CH684573A5 (de) * 1991-11-25 1994-10-31 Inst Molecular Biology Inc Verwendung von Wachstumsfaktoren zur Herstellung eines Arzneimittels für die Wachstumsförderung von Säugetiernerven.
WO1993015753A1 (en) * 1992-02-14 1993-08-19 Kaken Pharmaceutical Co., Ltd. Remedy for airway diseases
GB9203533D0 (en) * 1992-02-19 1992-04-08 Erba Carlo Spa Use of the conjugate between a fibroblast growth factor and a saporin in treating ocular pathologies
US5348941A (en) * 1992-04-01 1994-09-20 Merck & Co., Inc. Stabilizers for fibroblast growth factors
JPH11507352A (ja) 1995-06-07 1999-06-29 ジンタ・インコーポレイテッド 新規カルバメート基本カチオン性脂質
WO1999066797A1 (en) 1998-06-22 1999-12-29 Worden Charles E Enriched platelet wound healant
AU6022399A (en) * 1998-09-03 2000-03-27 Chiron Corporation Angiogenically effective unit dose of fgf-2 and method of use
US20030166550A1 (en) 1999-08-27 2003-09-04 Chiron Corporation Angiogenically effective unit dose of FGF-2 and method of use
US6649072B2 (en) 2001-11-16 2003-11-18 Robert Brandt Method for producing autologous platelet-rich plasma
PT2213730E (pt) 2002-06-18 2016-02-26 Eisai R&D Man Co Ltd Adipócitos de cultura primária para terapia génica
WO2005087257A1 (ja) * 2004-03-16 2005-09-22 Kaken Pharmaceutical Co., Ltd. 架橋ゼラチンゲルを担体とする軟骨組織修復治療剤
ES2318915B1 (es) * 2004-12-29 2010-02-16 Universidad De Salamanca Uso de fgf-2 en celulas precursoras de oligodendrocitos.
US7861626B2 (en) 2005-12-22 2011-01-04 Hoya Corporation Lens surface cutting apparatus and lens surface cutting method for spectacle lens, and spectacle lens
KR101604150B1 (ko) 2008-06-26 2016-03-16 노벨파마 컴퍼니 리미티드 고막 또는 외이도 재생제
BR122021021381B1 (pt) 2009-02-03 2023-05-16 Amunix Pharmaceuticals, Inc Método de aprimoramento de uma propriedade de uma proteína biologicamente ativa
CN104946656B (zh) * 2015-06-08 2018-08-17 吉林省农业科学院 一种人源碱性成纤维细胞生长因子、烟草叶绿体表达载体及生产方法
CN110151977B (zh) * 2019-05-29 2022-11-29 新乡医学院 一种保护aFGF蛋白药物稳定性和活性的方法
AU2020382621A1 (en) 2019-11-13 2022-06-02 Amunix Pharmaceuticals, Inc. Barcoded XTEN polypeptides and compositions thereof, and methods for making and using the same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4296100A (en) * 1980-06-30 1981-10-20 Franco Wayne P Method of treating the heart for myocardial infarction
DK161152C (da) * 1983-03-03 1991-11-11 Genentech Inc Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat
US4444760A (en) * 1983-06-17 1984-04-24 Merck & Co., Inc. Purification and characterization of a protein fibroblast growth factor
US4956455A (en) * 1984-03-05 1990-09-11 The Salk Institute For Biological Studies Bovine fibroblast growth factor
JP2770926B2 (ja) * 1985-12-17 1998-07-02 サイナーゲン インコーポレーテッド 毛管内皮細胞プロテアーゼ合成、ｄｎａ合成および遊走を促進することの出来るヒト胎盤血管形成誘導因子
US4868113A (en) * 1986-03-03 1989-09-19 Rorer Biotechnology, Inc. Recombinant DNA vector encoding human endothelial cell growth factor
IL81839A0 (en) * 1986-03-14 1987-10-20 Takeda Chemical Industries Ltd Polypeptide,dna and its use
NZ220917A (en) * 1986-07-11 1991-05-28 Merck & Co Inc Human and bovine acidic fibroblast growth factor vectors, hosts and compositions

Also Published As

Publication number Publication date
DK176067B1 (da) 2006-03-06
EP0593065B1 (de) 2002-08-21
JPH0767659A (ja) 1995-03-14
IE950301L (en) 1987-03-12
JPH0789936B2 (ja) 1995-10-04
DK241887D0 (da) 1987-05-12
IE862432L (en) 1987-03-12
IL80022A0 (en) 1986-12-31
IE66689B1 (en) 1996-01-24
DK200401589A (da) 2004-10-18
JP2761513B2 (ja) 1998-06-04
EP0248819A1 (de) 1987-12-16
ATE222602T1 (de) 2002-09-15
JP2619208B2 (ja) 1997-06-11
CA1341640C (en) 2014-09-16
DK175795B1 (da) 2005-02-21
JPS63500843A (ja) 1988-03-31
DE3689845T2 (de) 1994-09-01
EP0248819A4 (de) 1989-02-23
DK241887A (da) 1987-05-12
EP0248819B1 (de) 1994-05-18
EP0248819B2 (de) 2000-08-30
WO1987001728A1 (en) 1987-03-26
JPH09118695A (ja) 1997-05-06
ATE105868T1 (de) 1994-06-15
DE3650774T2 (de) 2003-05-28
EP0593065A1 (de) 1994-04-20
ES2001967A6 (es) 1988-07-01
DE3650774D1 (de) 2002-09-26
AU590006B2 (en) 1989-10-26
DE3689845D1 (de) 1994-06-23
DE3689845T3 (de) 2001-11-15
AU6375586A (en) 1987-04-07

Similar Documents

Publication Publication Date Title
IL80022A (en) Cloned human basic fibroblast growth factor, methods for its preparation, compositions containing it, dna sequences encoding therefor and vectors and host cells containing said dna
EP0048970A3 (de) Polypeptide, Verfahren zu ihrer mikrobischen Herstellung, Zwischenprodukte dafür und diese enthaltende Zusammensetzungen
YU177386A (en) Process for obtaining and excreting of heterologic protein by using culture of y bacteria
DE69534822D1 (de) Verfahren zur bakteriellen herstellung von heterologen polypeptiden mit disulfidbrücke
GB2007676A (en) Method and means for microbial polypeptide expression
WO1988003173A3 (en) New forms of colony stimulating factor-1
EP0147178A3 (en) Expression plasmids for improved production of heterologous protein in bacteria
GB2171703B (en) Expression-secretion vector for gene expression and protein secretion, recombinant dna including the vector, and method of producing proteins by use of the re
DE3889562D1 (de) Rekombinante Plasmide, die zur Expression von heterologen Proteinen in Bacillus verwendet werden können.
AU2979192A (en) Po438 - a new calcium-regulated promoter