ES2001967A6 - Un metoo para producir una proteina a partir de un cultivo de celulas. - Google Patents

Un metoo para producir una proteina a partir de un cultivo de celulas.

Info

Publication number
ES2001967A6
ES2001967A6 ES8601884A ES8601884A ES2001967A6 ES 2001967 A6 ES2001967 A6 ES 2001967A6 ES 8601884 A ES8601884 A ES 8601884A ES 8601884 A ES8601884 A ES 8601884A ES 2001967 A6 ES2001967 A6 ES 2001967A6
Authority
ES
Spain
Prior art keywords
fibroblast growth
growth factors
recombinant fibroblast
recombinant
fgf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8601884A
Other languages
English (en)
Inventor
John C Fiddes
Judith A Abraham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biotechnology Research Partners Ltd
Original Assignee
Biotechnology Research Partners Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27419719&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2001967(A6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/809,163 external-priority patent/US5439818A/en
Application filed by Biotechnology Research Partners Ltd filed Critical Biotechnology Research Partners Ltd
Publication of ES2001967A6 publication Critical patent/ES2001967A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Dermatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

UN METODO PARA PRODUCIR UNA PROTEINA A PARTIR DE UN CULTIVO DE CELULAS, EN EL QUE SE CULTIVAN CELULAS PROCARIOTICAS O EUCARIOTICAS CAPACES DE PRODUCIR DICHA PROTEINA EN CONDICIONES DE CULTIVO UTILIZADAS NORMALMENTE PARA LAS CELULAS PROCARIOTICAS O EUCARIOTICAS PARTICULARES EMPLEADAS Y QUE FAVORECEN LA PRODUCCION DE DICHA PROTEINA, Y SE RECUPERA LA PROTEINA PRODUCIDA DEL CULTIVO DE CELULAS, HABIENDOSE TRANSFORMADO LAS CELULAS CON UNA SECUENCIA DE ADN AISLADA, CLONADA, RECOMBINANTE O SINTETICA QUE CODIFICA FACTORES DE CRECIMIENTO DE FIBROPLASTOS (FGF) ACIDOS O BASICOS DE MAMIFEROS. LAS PROTEINAS OBTENIDAS QUE ABARCAN FGF BOVINO ACIDO, FGF HUMANO ACIDO, FGF BOVINO BASICO Y FGF HUMANO BASICO, SON ESPECIALMENTE UTILES EN LA REPARACION DE TEJIDOS, INCLUIDA LA CURACION DE HERIDAS.
ES8601884A 1985-09-12 1986-09-12 Un metoo para producir una proteina a partir de un cultivo de celulas. Expired ES2001967A6 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77552185A 1985-09-12 1985-09-12
US06/809,163 US5439818A (en) 1985-09-12 1985-12-16 DNA encoding human recombinant basic fibroblast growth factor
US86938286A 1986-05-30 1986-05-30

Publications (1)

Publication Number Publication Date
ES2001967A6 true ES2001967A6 (es) 1988-07-01

Family

ID=27419719

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8601884A Expired ES2001967A6 (es) 1985-09-12 1986-09-12 Un metoo para producir una proteina a partir de un cultivo de celulas.

Country Status (11)

Country Link
EP (2) EP0248819B2 (es)
JP (3) JPH0789936B2 (es)
AT (2) ATE222602T1 (es)
AU (1) AU590006B2 (es)
CA (1) CA1341640C (es)
DE (2) DE3650774T2 (es)
DK (2) DK175795B1 (es)
ES (1) ES2001967A6 (es)
IE (1) IE66689B1 (es)
IL (1) IL80022A (es)
WO (1) WO1987001728A1 (es)

Families Citing this family (63)

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US5235042A (en) * 1984-02-29 1993-08-10 The Children's Medical Center Corporation Endothelial cell growth factor
US4956455A (en) * 1984-03-05 1990-09-11 The Salk Institute For Biological Studies Bovine fibroblast growth factor
US4889919A (en) * 1986-08-13 1989-12-26 Zymogenetics, Inc. Biologically active PDGF derived A-chain homodimers
US5165938A (en) * 1984-11-29 1992-11-24 Regents Of The University Of Minnesota Wound healing agents derived from platelets
US5401832A (en) * 1984-12-24 1995-03-28 Merck & Co., Inc. Brain derived and recombinant acidic fibroblast growth factor
US4994559A (en) * 1985-12-17 1991-02-19 Synergen, Inc. Human basic fibroblast growth factor
US5026839A (en) * 1985-12-17 1991-06-25 Synergen, Inc DNA encoding a basic fibroblast growth factor
ES2056787T3 (es) * 1985-12-17 1994-10-16 Synergen Inc Factor angiogenico de placenta humana capaz de estimular la sintesis capilar de proteasa de celulas endoteliales, la sintesis de adn y la migracion.
US5827826A (en) * 1986-03-03 1998-10-27 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compositions of human endothelial cell growth factor
US5552528A (en) 1986-03-03 1996-09-03 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bovine b-endothelial cell growth factor
US4868113A (en) * 1986-03-03 1989-09-19 Rorer Biotechnology, Inc. Recombinant DNA vector encoding human endothelial cell growth factor
EP0246753B1 (en) * 1986-04-22 1994-07-13 The Salk Institute For Biological Studies Fibroblast growth factor antagonists
NZ220917A (en) * 1986-07-11 1991-05-28 Merck & Co Inc Human and bovine acidic fibroblast growth factor vectors, hosts and compositions
US5474982A (en) * 1986-08-13 1995-12-12 Zymogenetics, Inc. PDGF analogs and methods of use
CA1323317C (en) * 1987-01-16 1993-10-19 Allen R. Banks Production of fibroblast growth factor
US5852177A (en) * 1987-02-24 1998-12-22 Takeda Chemical Industries, Ltd. Basic fibroblast growth factor (bFGF) muteins
JP2526965B2 (ja) * 1987-02-24 1996-08-21 武田薬品工業株式会社 ムテイン，ｄｎａおよびその用途
DE3852561T2 (de) * 1987-03-03 1995-07-13 Takeda Chemical Industries Ltd Monoklonaler Antikörper, Hybridomen, ihre Herstellung und ihre Verwendung.
EP0364481A4 (en) * 1987-06-18 1992-01-22 Monash University Growth factors
AU611614B2 (en) * 1987-06-18 1991-06-13 Monash University Growth factors
DE3721081A1 (de) * 1987-06-26 1989-01-19 Progen Biotechnik Gmbh Dna-sequenz, die codiert fuer ein zellteilungsfoerderndes polypeptid, sowie ein plasmid, ein wirtsorganismus und ein verfahren zur gewinnung dieses polypeptids
US5312911A (en) * 1987-10-22 1994-05-17 Merck & Co., Inc. Cysteine-modified acidic fibroblast growth factor
NZ226543A (en) * 1987-10-22 1992-02-25 Merck & Co Inc Recombinant mutant acidic fibroblast growth factor
AU638402B2 (en) * 1987-11-24 1993-07-01 Amgen, Inc. Analogs of fibroblast growth factor
EP0326907A1 (en) * 1988-01-26 1989-08-09 Takeda Chemical Industries, Ltd. Polypeptide, DNA and its use
WO1989007944A1 (en) * 1988-02-24 1989-09-08 American National Red Cross Device for site directed neovascularization and method for same
GB2223495B (en) * 1988-08-08 1992-05-20 British Bio Technology Synthetic gene encoding basic fibroblast growth factor
GB2223496B (en) * 1988-08-08 1992-05-27 British Bio Technology Synthetic gene encoding mature human acid fibroblast growth factor
GB2223497B (en) * 1988-08-08 1992-04-01 British Bio Technology Synthetic gene encoding human beta endothelial cell growth factor
US5175147A (en) * 1988-08-19 1992-12-29 Takeda Chemical Industries, Ltd Acid-resistant fgf composition and method of treating ulcerating diseases of the gastrointestinal tract
CA2002210C (en) * 1988-11-04 2001-04-24 Philip J. Barr Expression and processing of authentic fgf's in yeast
US5656458A (en) * 1988-11-04 1997-08-12 Chiron Corporation Expression and processing of amino terminus acetylated FGF's in yeast
US5464943A (en) * 1989-04-26 1995-11-07 Takeda Chemical Industries, Ltd. DNA encoding glycosylated FGF and production thereof
EP0406738A3 (en) * 1989-07-03 1991-08-14 Takeda Chemical Industries, Ltd. Production of acidic fgf protein
US5126323A (en) * 1989-11-16 1992-06-30 Genetics Institute, Inc. Homogeneous purified k-fgf and compositions containing the same
IT1237795B (it) * 1989-12-22 1993-06-17 Erba Carlo Spa Fattori di crescita fibroblastici per l'uso nella prevenzione e nel trattamento di infezioni virali.
US5143829A (en) * 1990-03-29 1992-09-01 California Biotechnology Inc. High level expression of basic fibroblast growth factor having a homogeneous n-terminus
JPH047617A (ja) * 1990-04-26 1992-01-13 Canon Inc 電子機器
US6833354B1 (en) 1990-12-19 2004-12-21 Kaken Pharmaceutical Co., Ltd. Agent for the treatment of bone diseases
JP3135138B2 (ja) * 1990-12-19 2001-02-13 科研製薬株式会社 骨疾患治療剤
GR1002610B (el) * 1991-01-02 1997-02-20 Johnson & Johnson Consumer Products Inc. Θεραπευτικες συνθεσεις πληγων που περιεχουν παραγοντα αναπτυξης ινοβλαστων και ασκορβικον οξυ.
WO1992013958A1 (en) * 1991-02-06 1992-08-20 Georgetown University Receptor blocking peptides of fibroblast growth factor receptor
EP0499242B1 (en) * 1991-02-15 1996-06-26 Takeda Chemical Industries, Ltd. Stimulation of endosteal bone formation with a cell growth factor
US5492894A (en) * 1991-03-21 1996-02-20 The Procter & Gamble Company Compositions for treating wrinkles comprising a peptide
DE4132005A1 (de) * 1991-09-26 1993-04-01 Merck Patent Gmbh Kombination enthaltend wachstumsfaktoren und polyelektrolyte
JP3747416B2 (ja) * 1991-11-25 2006-02-22 インスティテュート オブ モレキュラー バイオロジー インコーポレイテッド 哺乳類の神経の増殖を促進する薬物
EP0580874A4 (en) * 1992-02-14 1997-02-26 Kaken Pharma Co Ltd Remedy for airway diseases
GB9203533D0 (en) * 1992-02-19 1992-04-08 Erba Carlo Spa Use of the conjugate between a fibroblast growth factor and a saporin in treating ocular pathologies
US5348941A (en) * 1992-04-01 1994-09-20 Merck & Co., Inc. Stabilizers for fibroblast growth factors
EP0830368A1 (en) 1995-06-07 1998-03-25 Genta Incorporated Novel carbamate-based cationic lipids
AU2763099A (en) 1998-06-22 2000-01-10 Charles E. Worden Enriched platelet wound healant
EP2123292B1 (en) * 1998-09-03 2016-05-04 Novartis Vaccines and Diagnostics, Inc. Angiogenically effective unit dose of FGF-2 and method of use
US20030166550A1 (en) 1999-08-27 2003-09-04 Chiron Corporation Angiogenically effective unit dose of FGF-2 and method of use
US6649072B2 (en) 2001-11-16 2003-11-18 Robert Brandt Method for producing autologous platelet-rich plasma
US7820438B2 (en) 2002-06-18 2010-10-26 Eisai R&D Management Co., Ltd. Primary cultured adipocytes for gene therapy
WO2005087257A1 (ja) * 2004-03-16 2005-09-22 Kaken Pharmaceutical Co., Ltd. 架橋ゼラチンゲルを担体とする軟骨組織修復治療剤
ES2318915B1 (es) * 2004-12-29 2010-02-16 Universidad De Salamanca Uso de fgf-2 en celulas precursoras de oligodendrocitos.
CN101300097B (zh) 2005-12-22 2010-09-15 Hoya株式会社 眼镜透镜的透镜面切削加工装置、透镜面切削加工方法及眼镜透镜
EP2353547B1 (en) 2008-06-26 2018-01-17 Nobelpharma Co., Ltd. Agent for regenerating tympanic membrane or external auditory canal
WO2010091122A1 (en) 2009-02-03 2010-08-12 Amunix, Inc. Extended recombinant polypeptides and compositions comprising same
CN104946656B (zh) * 2015-06-08 2018-08-17 吉林省农业科学院 一种人源碱性成纤维细胞生长因子、烟草叶绿体表达载体及生产方法
CN110151977B (zh) * 2019-05-29 2022-11-29 新乡医学院 一种保护aFGF蛋白药物稳定性和活性的方法
IL292863A (en) 2019-11-13 2022-07-01 Amunix Pharmaceuticals Inc Barcoded xanthan polypeptides and their compositions, and methods for their preparation and use

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US4296100A (en) * 1980-06-30 1981-10-20 Franco Wayne P Method of treating the heart for myocardial infarction
DK161152C (da) * 1983-03-03 1991-11-11 Genentech Inc Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat
US4444760A (en) * 1983-06-17 1984-04-24 Merck & Co., Inc. Purification and characterization of a protein fibroblast growth factor
US4956455A (en) * 1984-03-05 1990-09-11 The Salk Institute For Biological Studies Bovine fibroblast growth factor
JP2770926B2 (ja) * 1985-12-17 1998-07-02 サイナーゲン インコーポレーテッド 毛管内皮細胞プロテアーゼ合成、ｄｎａ合成および遊走を促進することの出来るヒト胎盤血管形成誘導因子
US4868113A (en) * 1986-03-03 1989-09-19 Rorer Biotechnology, Inc. Recombinant DNA vector encoding human endothelial cell growth factor
DK122687A (da) * 1986-03-14 1987-09-15 Takeda Chemical Industries Ltd Polypeptid, dna og anvendelse deraf
NZ220917A (en) * 1986-07-11 1991-05-28 Merck & Co Inc Human and bovine acidic fibroblast growth factor vectors, hosts and compositions

Also Published As

Publication number Publication date
IE66689B1 (en) 1996-01-24
EP0593065B1 (en) 2002-08-21
DK176067B1 (da) 2006-03-06
JPS63500843A (ja) 1988-03-31
DE3650774T2 (de) 2003-05-28
WO1987001728A1 (en) 1987-03-26
JP2761513B2 (ja) 1998-06-04
IE862432L (en) 1987-03-12
EP0248819B2 (en) 2000-08-30
DK241887D0 (da) 1987-05-12
DE3689845T2 (de) 1994-09-01
DE3650774D1 (de) 2002-09-26
IE950301L (en) 1987-03-12
JP2619208B2 (ja) 1997-06-11
AU6375586A (en) 1987-04-07
JPH0767659A (ja) 1995-03-14
IL80022A (en) 1993-06-10
ATE222602T1 (de) 2002-09-15
DK241887A (da) 1987-05-12
EP0593065A1 (en) 1994-04-20
EP0248819B1 (en) 1994-05-18
DE3689845D1 (de) 1994-06-23
EP0248819A4 (en) 1989-02-23
DK200401589A (da) 2004-10-18
EP0248819A1 (en) 1987-12-16
JPH09118695A (ja) 1997-05-06
DE3689845T3 (de) 2001-11-15
AU590006B2 (en) 1989-10-26
CA1341640C (en) 2014-09-16
DK175795B1 (da) 2005-02-21
IL80022A0 (en) 1986-12-31
JPH0789936B2 (ja) 1995-10-04
ATE105868T1 (de) 1994-06-15

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2006-09-12

FD1A Patent lapsed

Effective date: 20060913