BRPI0915387B8 - agente para a regeneração da membrana timpânica ou canal auditivo externo e uso de uma esponja de gelatina que carrega o fator de crescimento fibroblástico básico e uma cola de fibrina - Google Patents
agente para a regeneração da membrana timpânica ou canal auditivo externo e uso de uma esponja de gelatina que carrega o fator de crescimento fibroblástico básico e uma cola de fibrinaInfo
- Publication number
- BRPI0915387B8 BRPI0915387B8 BRPI0915387A BRPI0915387A BRPI0915387B8 BR PI0915387 B8 BRPI0915387 B8 BR PI0915387B8 BR PI0915387 A BRPI0915387 A BR PI0915387A BR PI0915387 A BRPI0915387 A BR PI0915387A BR PI0915387 B8 BRPI0915387 B8 BR PI0915387B8
- Authority
- BR
- Brazil
- Prior art keywords
- regeneration
- ear canal
- tympanic membrane
- agent
- gelatin sponge
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0046—Ear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/222—Gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/225—Fibrin; Fibrinogen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F11/00—Methods or devices for treatment of the ears or hearing sense; Non-electric hearing aids; Methods or devices for enabling ear patients to achieve auditory perception through physiological senses other than hearing sense; Protective devices for the ears, carried on the body or in the hand
- A61F11/20—Ear surgery
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/14—Materials or treatment for tissue regeneration for ear reconstruction or ear implants, e.g. implantable hearing aids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polymers & Plastics (AREA)
- Prostheses (AREA)
Abstract
agente para a regeneração da membrana timpânica ou canal auditivo externo. a presente invenção refere-se a um agente de regeneração da membrana timpânica ou canal auditivo que compreende uma combinação de uma esponja de gelatina que carrega o fator de crescimento fibroblástico básico (bfgf) e um material de cobertura. o material de cobertura é utilizado não apenas para fixar a esponja de gelatina na parte afetada, mas também para o propósito de prevenir a secagem e infecções para proporcionar um ambiente de cultura que é favorável à regeneração do tecido isolado a partir da parte externa. para promover a regeneração do tecido, a margem do defeito da membrana timpânica ou canal auditivo é preferivelmente renovada antecipadamente.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008167744 | 2008-06-26 | ||
JP2008-167744 | 2008-06-26 | ||
PCT/JP2009/061767 WO2009157558A1 (ja) | 2008-06-26 | 2009-06-26 | 鼓膜または外耳道再生剤 |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0915387A2 BRPI0915387A2 (pt) | 2016-10-11 |
BRPI0915387B1 BRPI0915387B1 (pt) | 2019-09-24 |
BRPI0915387B8 true BRPI0915387B8 (pt) | 2021-05-25 |
Family
ID=41444618
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0915387A BRPI0915387B8 (pt) | 2008-06-26 | 2009-06-26 | agente para a regeneração da membrana timpânica ou canal auditivo externo e uso de uma esponja de gelatina que carrega o fator de crescimento fibroblástico básico e uma cola de fibrina |
Country Status (12)
Country | Link |
---|---|
US (3) | US9161904B2 (pt) |
EP (1) | EP2353547B1 (pt) |
JP (1) | JP5398712B2 (pt) |
KR (1) | KR101604150B1 (pt) |
CN (2) | CN102131478A (pt) |
AU (1) | AU2009263249B2 (pt) |
BR (1) | BRPI0915387B8 (pt) |
CA (1) | CA2729093C (pt) |
ES (1) | ES2671068T3 (pt) |
MX (1) | MX2010014077A (pt) |
RU (1) | RU2544367C2 (pt) |
WO (1) | WO2009157558A1 (pt) |
Families Citing this family (13)
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EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
EP2731549B1 (en) * | 2011-07-11 | 2021-09-15 | Ear Science Institute Australia | Device for ear drum repair |
MX2014015668A (es) * | 2012-06-28 | 2015-07-14 | Univ Tulane | Composiciones polimerizables selectivamente y metodos de uso in vivo. |
SI2996709T1 (sl) * | 2013-05-15 | 2020-09-30 | The Board Of Trustees Of The Leland Stanford Junior University | Modulacija aktivnosti heparin vezavnega epidermalnega rastnega faktorja za celjenje bobniča |
CN111921076B (zh) | 2015-10-01 | 2023-05-23 | 耐贝医药株式会社 | 鼓膜修复剂制造夹具及鼓膜修复剂制造容器 |
CN106693064B (zh) * | 2016-12-07 | 2020-07-28 | 同济大学 | 一种用于上颌窦底提升的复合材料以及制备方法 |
CN107349471A (zh) * | 2017-06-16 | 2017-11-17 | 卓阮医疗科技(苏州)有限公司 | 一种载药缓释的复合组织修复材料及其制备方法 |
JP2022043368A (ja) * | 2018-12-26 | 2022-03-16 | 国立大学法人京都大学 | 感音難聴治療用組成物 |
WO2020243478A1 (en) * | 2019-05-29 | 2020-12-03 | Massachusetts Eye And Ear Infirmary | Fibroblast growth factor 2 (fgf2) for treatment of human sensorineural hearing loss |
CN110302425A (zh) * | 2019-06-20 | 2019-10-08 | 温州医科大学附属第一医院 | 混合水凝胶生物材料的制备方法及其应用 |
JPWO2021112254A1 (pt) * | 2019-12-06 | 2021-06-10 | ||
RU2763980C1 (ru) * | 2021-06-04 | 2022-01-12 | федеральное государственное автономное образовательное учреждение высшего образования Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет) (ФГАОУ ВО Первый МГМУ им. И.М. Сеченова Минздрава России (Се | Способ закрытия стойких перфораций барабанной перепонки |
EP4384203A1 (en) * | 2021-08-09 | 2024-06-19 | Rajan, Gunesh | Compositions and methods for wound healing |
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2009
- 2009-06-26 CA CA2729093A patent/CA2729093C/en active Active
- 2009-06-26 KR KR1020107029638A patent/KR101604150B1/ko active IP Right Grant
- 2009-06-26 RU RU2011102755/14A patent/RU2544367C2/ru active
- 2009-06-26 MX MX2010014077A patent/MX2010014077A/es active IP Right Grant
- 2009-06-26 WO PCT/JP2009/061767 patent/WO2009157558A1/ja active Application Filing
- 2009-06-26 CN CN2009801333108A patent/CN102131478A/zh active Pending
- 2009-06-26 JP JP2010518080A patent/JP5398712B2/ja active Active
- 2009-06-26 ES ES09770268.2T patent/ES2671068T3/es active Active
- 2009-06-26 BR BRPI0915387A patent/BRPI0915387B8/pt active Search and Examination
- 2009-06-26 AU AU2009263249A patent/AU2009263249B2/en active Active
- 2009-06-26 US US13/001,318 patent/US9161904B2/en active Active
- 2009-06-26 CN CN201510678619.2A patent/CN105381506A/zh active Pending
- 2009-06-26 EP EP09770268.2A patent/EP2353547B1/en active Active
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2015
- 2015-09-09 US US14/849,001 patent/US10117969B2/en active Active
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2018
- 2018-10-12 US US16/159,238 patent/US10357595B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
RU2544367C2 (ru) | 2015-03-20 |
RU2011102755A (ru) | 2012-08-10 |
EP2353547B1 (en) | 2018-01-17 |
JPWO2009157558A1 (ja) | 2011-12-15 |
BRPI0915387A2 (pt) | 2016-10-11 |
US10117969B2 (en) | 2018-11-06 |
BRPI0915387B1 (pt) | 2019-09-24 |
CN102131478A (zh) | 2011-07-20 |
KR101604150B1 (ko) | 2016-03-16 |
KR20110021994A (ko) | 2011-03-04 |
CN105381506A (zh) | 2016-03-09 |
AU2009263249A1 (en) | 2009-12-30 |
EP2353547A4 (en) | 2013-11-06 |
JP5398712B2 (ja) | 2014-01-29 |
EP2353547A1 (en) | 2011-08-10 |
AU2009263249B2 (en) | 2015-03-19 |
WO2009157558A1 (ja) | 2009-12-30 |
MX2010014077A (es) | 2011-04-05 |
US9161904B2 (en) | 2015-10-20 |
ES2671068T3 (es) | 2018-06-04 |
US20110110987A1 (en) | 2011-05-12 |
US10357595B2 (en) | 2019-07-23 |
CA2729093C (en) | 2018-04-10 |
CA2729093A1 (en) | 2009-12-30 |
US20190038811A1 (en) | 2019-02-07 |
US20160067383A1 (en) | 2016-03-10 |
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