IL77415A - Diamino-tetrahydrobenzthiazoles,their preparation and pharmaceutical compositions containing them - Google Patents

Diamino-tetrahydrobenzthiazoles,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL77415A
IL77415A IL77415A IL7741585A IL77415A IL 77415 A IL77415 A IL 77415A IL 77415 A IL77415 A IL 77415A IL 7741585 A IL7741585 A IL 7741585A IL 77415 A IL77415 A IL 77415A
Authority
IL
Israel
Prior art keywords
group
phenyl
alkyl
hydrogen atom
alkenyl
Prior art date
Application number
IL77415A
Other languages
English (en)
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25827684&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL77415(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE19843447075 external-priority patent/DE3447075A1/de
Priority claimed from DE19853508947 external-priority patent/DE3508947A1/de
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of IL77415A publication Critical patent/IL77415A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62Benzothiazoles
    • C07D277/68Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cereal-Derived Products (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
  • Professional, Industrial, Or Sporting Protective Garments (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL77415A 1984-12-22 1985-12-20 Diamino-tetrahydrobenzthiazoles,their preparation and pharmaceutical compositions containing them IL77415A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19843447075 DE3447075A1 (de) 1984-12-22 1984-12-22 Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arzneimittel
DE19853508947 DE3508947A1 (de) 1985-03-13 1985-03-13 Mittel zur behandlung des parkinsonismus bzw. der parkinsonschen-erkrankung

Publications (1)

Publication Number Publication Date
IL77415A true IL77415A (en) 1990-03-19

Family

ID=25827684

Family Applications (1)

Application Number Title Priority Date Filing Date
IL77415A IL77415A (en) 1984-12-22 1985-12-20 Diamino-tetrahydrobenzthiazoles,their preparation and pharmaceutical compositions containing them

Country Status (25)

Country Link
US (3) US4731374A (fr)
EP (1) EP0186087B1 (fr)
KR (1) KR930009791B1 (fr)
AT (1) ATE45735T1 (fr)
AU (1) AU583874B2 (fr)
BG (1) BG62023B2 (fr)
CA (1) CA1263653A (fr)
CS (1) CS409991A3 (fr)
DE (1) DE3572485D1 (fr)
DK (1) DK168862B1 (fr)
ES (5) ES8702787A1 (fr)
FI (1) FI81787C (fr)
GR (1) GR853126B (fr)
HK (1) HK78692A (fr)
HU (1) HU193618B (fr)
IE (1) IE58863B1 (fr)
IL (1) IL77415A (fr)
LU (1) LU90208I2 (fr)
MX (1) MX9202792A (fr)
NL (1) NL980002I2 (fr)
NO (1) NO165070C (fr)
NZ (1) NZ214661A (fr)
PH (1) PH24533A (fr)
PT (1) PT81735B (fr)
SG (1) SG82492G (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7868029B2 (en) 2002-09-17 2011-01-11 Generics [Uk] Limited Process for the preparation of 2-amino-4,5,6,7-tetrahydro-6-aminobenzothiazoles from cyclohexanes and cyclohexanones as intermediates

Families Citing this family (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3620813A1 (de) * 1986-06-21 1987-12-23 Boehringer Ingelheim Kg Neue tetrahydro-benzothiazole, ihre herstellung und verwendung
US4826860A (en) * 1987-03-16 1989-05-02 Warner-Lambert Company Substituted 2-aminobenzothiazoles and derivatives useful as cerebrovascular agents
US4988699A (en) * 1989-03-14 1991-01-29 Warner-Lambert Company Substituted tetrahydrobenzothiazoles as dopaminergic agents
DE3923689A1 (de) * 1989-07-18 1991-01-24 Boehringer Ingelheim Kg Neue verwendung von tetrahydrobenzthiazolderivaten als arzneistoffe
DE3930282A1 (de) * 1989-09-11 1991-03-21 Boehringer Ingelheim Kg Verwendung von dopamin-autorezeptor-agonisten bei der behandlung von drogenabhaengigkeit
DE3937271A1 (de) * 1989-11-09 1991-05-16 Boehringer Ingelheim Kg Transdermale applikation von 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzothiazol
FR2674853B1 (fr) * 1991-04-03 1995-01-20 Synthelabo Derives de piperidinylguanidine, leur preparation et leur application en therapeutique.
DE4241013A1 (de) 1992-12-05 1994-06-09 Boehringer Ingelheim Kg Verwendung von 2-Amino-6-n-propyl-amino-4,5,6,7-tetrahydrobenzothiazol als Arzneimittel mit antidepressiver Wirkung
US6156777A (en) * 1994-12-15 2000-12-05 Pharmacia & Upjohn Company Use of pramipexole as a neuroprotective agent
US5650420A (en) * 1994-12-15 1997-07-22 Pharmacia & Upjohn Company Pramipexole as a neuroprotective agent
DE19507752A1 (de) * 1995-03-06 1996-09-12 Bayer Ag Verfahren zur Herstellung von substituierten Cyclohexanonen
DE19536916A1 (de) * 1995-10-04 1997-04-10 Boehringer Ingelheim Kg Inhalative Applikation von 2-Amino-6n-propyl-amino-4,5,6,7-tetrahydrobenzothiazol, insbesondere seines (-)-Enantiomeren, sowie deren pharmakologisch verträgliche Säureadditionssalze
CZ370198A3 (cs) * 1996-05-31 1999-05-12 Pharmacia & Upjohn Company Aryl substituované cyklické aminy jako selektivní dopaminové D3 ligandy
US6001861A (en) 1998-01-16 1999-12-14 Pharmacia & Upjohn Company Use of pramipexole in the treatment of restless legs syndrome
DE19701619B4 (de) * 1997-01-17 2007-10-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von Pramipexol zur Behandlung des restless legs syndroms
AU760439B2 (en) * 1998-05-15 2003-05-15 Pharmacia & Upjohn Company Cabergoline and pramipexole: new uses and combinations
SE9802360D0 (sv) 1998-07-01 1998-07-01 Wikstroem Hakan Vilhelm New 2-aminothiazol-fused 2-aminoindans and 2-aminotetralins ((basic)-N-substituted and (basic)-N,N-disubstituted derivatives of 2,6-diamino-thiazolo(4,5-f)indan and 2,7-di-amino-thiazolo(4,5-g)tetralin
DE19830201A1 (de) * 1998-07-07 2000-01-13 Boehringer Ingelheim Pharma Mittel mit antidepressiver Wirkung
US6232326B1 (en) 1998-07-14 2001-05-15 Jodi A. Nelson Treatment for schizophrenia and other dopamine system dysfunctions
PE20011074A1 (es) 2000-02-23 2001-10-04 Upjohn Co Uso de pramipexol en el tratamiento de trastornos de adiccion
CA2415815A1 (fr) * 2000-07-06 2002-01-17 Nigel H. Greig Agents neuroprotecteurs a base d'analogues de tetrahydrobenzothiazole
US6277875B1 (en) 2000-07-17 2001-08-21 Andrew J. Holman Use of dopamine D2/D3 receptor agonists to treat fibromyalgia
US20030114410A1 (en) 2000-08-08 2003-06-19 Technion Research And Development Foundation Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis
DE10041478A1 (de) * 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh Neue pharmazeutische Zusammensetzung
ES2187249B1 (es) 2000-09-18 2004-09-16 Synthon Bv Procedimiento para la preparacion de 2-amino-6-(alquil)amino-4,5,6,7-tetrahidrobenzotiazoles.
US20020165246A1 (en) * 2001-03-05 2002-11-07 Andrew Holman Administration of sleep restorative agents
DE10137453A1 (de) * 2001-08-02 2003-02-20 Boehringer Ingelheim Pharma Pramlpexol als Antikonvulsivum
DE10138275A1 (de) * 2001-08-10 2003-02-27 Boehringer Ingelheim Pharma Verbindungen zur Beseitigung der Anhedonie
US20060281797A1 (en) * 2001-12-11 2006-12-14 University Of Virginia Patent Foundation Neurorestoration with R(+) Pramipexole
EP2305253A1 (fr) 2001-12-11 2011-04-06 University Of Virginia Patent Foundation Utilisation de pramipexole pour traiter la sclérose latérale amyotrophique
US20030166696A1 (en) * 2002-01-24 2003-09-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pramipexole for the treatment of HIV dementia
EP2266590A3 (fr) 2002-02-22 2011-04-20 Shire LLC Système d'administration de substances actives et méthodes de protection et d'administration de substances actives
MY142204A (en) * 2002-07-25 2010-10-29 Pharmacia Corp Pramipexole once-daily dosage form
MY136318A (en) * 2002-07-25 2008-09-30 Pharmacia Corp Sustained-release tablet composition
US20050226926A1 (en) * 2002-07-25 2005-10-13 Pfizer Inc Sustained-release tablet composition of pramipexole
GB2394951A (en) * 2002-11-04 2004-05-12 Cipla Ltd One pot synthesis of 2,6-diamino-4,5,6,7-tetrahydro-benzothiazole
US7365086B2 (en) * 2003-07-25 2008-04-29 Synthon Ip Inc. Pramipexole acid addition salts
DE102004006808A1 (de) 2004-02-11 2005-09-01 Grünenthal GmbH Substituierte 4,5,6,7-Tetrahydro-benzothiazol-2-ylamin-Verbindungen
CA2560128A1 (fr) 2004-03-19 2005-10-06 Dipharma S.P.A. Intermediaires pour la preparation de pramipexole
ES2245604B1 (es) 2004-06-25 2006-12-01 Ragactives, S. L. Procedimiento para la obtencion de 2-amino-6-alquil-amino-4,5,6,7-tetrahidrobenzotiazoles.
WO2006012276A1 (fr) * 2004-06-30 2006-02-02 Amr Technology, Inc. Processus pour préparer des 2-amino-6-(alkyl)amino-4,5,6,7-tétrahydrobenzothiazoles chiralement purs par résolution chromatographique en phase liquide
CA2553311A1 (fr) * 2004-07-01 2006-01-12 Alembic Limited Procede ameliore de preparation d'un derive de tetrahydrobenzothiazole biologiquement actif
WO2006003471A2 (fr) * 2004-07-03 2006-01-12 Generics [Uk] Limited Nouveau procede
EP2431026A1 (fr) * 2004-08-13 2012-03-21 Boehringer Ingelheim International GmbH Formulation de pastille à libération prolongée contenant du pramipexole ou l'un de ses sels pharmaceutiquement acceptable, son procédé de fabrication et utilisation associée
BRPI0513846A (pt) 2004-08-13 2008-05-20 Boehringer Ingelheim Int formulação de comprimido de liberação prolongada contendo pramipexol ou um sal farmaceuticamente aceitável do mesmo, método para a fabricação do mesmo e o uso do mesmo
CA2579279C (fr) * 2004-10-07 2013-10-01 Boehringer Ingelheim International Gmbh Derives de thiazole tricyclique en tant que pi3-kinases
ES2310146B1 (es) * 2004-12-30 2009-11-11 Chemagis Ltd. Nuevo procedimiento para preparar pramipexol y su mezcla isomerica optica mediante reduccion con triacetoxiborohidruro de sodio.
CN1834092B (zh) * 2005-03-15 2010-04-28 姜能桥 盐酸普拉克索的制备方法
US20090062549A1 (en) * 2005-05-03 2009-03-05 Seema Kanwar Process for the preparation of pramipexole and new anhydrous forms of its dihydrochloride
ES2264378B1 (es) * 2005-05-09 2007-11-01 Ragactives, S.L. Procedimiento para la resolucion de 2-amino-6propilamino-4,5,6,7-tetrahidrobenzotiazol y compuestos intermedios.
EP1731514A1 (fr) 2005-06-02 2006-12-13 Sandoz AG Méthode de préparation du pramipexole
CA2619217A1 (fr) * 2005-08-15 2007-02-22 University Of Virginia Patent Foundation Neurorestauration avec du pramipexole r(+)
US7994220B2 (en) 2005-09-28 2011-08-09 Cypress Bioscience, Inc. Milnacipran for the long-term treatment of fibromyalgia syndrome
US20080262053A1 (en) * 2005-10-18 2008-10-23 Juergen Reess Use of Pramipexole for Treating Moderate to Severe Restless Legs Syndrome (Rls)
US20070129329A1 (en) * 2005-12-02 2007-06-07 Alembic Limited Stabilized pharmaceutical composition of pramipexole and method of preparation thereof
PL378587A1 (pl) * 2005-12-29 2007-07-09 Instytut Farmaceutyczny Sposób wytwarzania (S)-(-)-2-amino-6-n-propyloamino-4,5,6,7-tetrahydrobenzotiazolu i/lub jego soli
ITMI20060044A1 (it) * 2006-01-13 2007-07-14 Dipharma Spa Sintesi di intermedi pr la preparazione di pramipexolo
US20090098202A1 (en) * 2006-02-10 2009-04-16 Boehringer Ingelheim International Gmbh Extended Release Formulation
WO2007090881A2 (fr) * 2006-02-10 2007-08-16 Boehringer Ingelheim International Gmbh Formulation a liberation modifiee
US8017598B2 (en) 2006-05-16 2011-09-13 Knopp Neurosciences, Inc. Compositions of R(+) and S(−) pramipexole and methods of using the same
US8518926B2 (en) 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
US20070259930A1 (en) * 2006-04-10 2007-11-08 Knopp Neurosciences, Inc. Compositions and methods of using r(+) pramipexole
EP2497473A1 (fr) 2006-05-16 2012-09-12 Knopp Neurosciences, Inc. Quantités thérapeutiquement efficaces de R(+) et S(-) pramipexole pour une utilisation dans le traitement de la maladie de Parkinson et compositions pharmaceutiques correspondantes
EP2026766A1 (fr) 2006-05-17 2009-02-25 Synthon B.V. Composition en comprimé pour la libération prolongée de la tamsulosine
WO2008001200A2 (fr) * 2006-06-29 2008-01-03 Antares Pharma Ipl Ag Composition transdermique à stabilité de couleur améliorée
US20080254118A1 (en) * 2007-04-11 2008-10-16 Hans-Werner Wernersbach Process for preparing pramipexole dihydrochloride tablets
WO2008041240A1 (fr) * 2006-10-03 2008-04-10 Cadila Healthcare Limited Procédé de préparation de (s)-pramipexole et de ses intermédiaires
US8524695B2 (en) 2006-12-14 2013-09-03 Knopp Neurosciences, Inc. Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
WO2008086353A1 (fr) * 2007-01-08 2008-07-17 Zurawski Vincent R Jr Dérivés contenant du propargyle de tétrahydro-benzthiazoles et procédés de fabrication et d'utilisation de ceux-ci
SI22446A (sl) * 2007-02-07 2008-08-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek za sintezo pramipeksola in njegovih farmacevtsko sprejemljivih soli
US8519148B2 (en) 2007-03-14 2013-08-27 Knopp Neurosciences, Inc. Synthesis of chirally purified substituted benzothiazole diamines
US20080254117A1 (en) * 2007-04-10 2008-10-16 Noel Cotton Process for preparing pramipexole dihydrochloride tablets
CN105330743B (zh) 2007-08-02 2019-05-28 吉利德生物制剂公司 Lox和loxl2抑制剂及其应用
GB0721333D0 (en) * 2007-10-31 2007-12-12 Motac Neuroscience Ltd Medicaments
US20090247537A1 (en) * 2008-03-25 2009-10-01 William Dale Overfield Methods for preventing or treating bruxism using dopaminergic agents
CN102186350A (zh) * 2008-08-19 2011-09-14 诺普神经科学股份有限公司 使用(r)-普拉克索的组合物与方法
WO2010080769A2 (fr) 2009-01-06 2010-07-15 Arresto Biosciences, Inc. Procédés et compositions chimiothérapeutiques
BRPI1010084A2 (pt) * 2009-06-19 2015-08-25 Knopp Neurosciences Inc Método para tratar esclerose lateral amiotrófica em um paciente
AU2010284039A1 (en) * 2009-08-21 2012-03-22 Gilead Biologics, Inc. In vivo screening assays
US20110044907A1 (en) * 2009-08-21 2011-02-24 Derek Marshall In vivo screening assays
AU2010284000A1 (en) * 2009-08-21 2012-03-22 Gilead Biologics, Inc. In vitro screening assays
BR112012008084A2 (pt) * 2009-08-21 2019-09-24 Gilead Biologics Inc método terapêuticos e composições.
JP2013502226A (ja) 2009-08-21 2013-01-24 ギリアド バイオロジクス,インク. リシル酸化酵素及びloxl2由来の触媒ドメイン
TR200906997A1 (tr) 2009-09-11 2011-03-21 Sanovel �La� San. Ve T�C. A. �. Pramipeksol farmasötik bileşimleri.
TR200907554A1 (tr) 2009-10-06 2011-04-21 Sanovel İlaç San.Ve Ti̇c.A.Ş. Oral yolla dağılan pramıpexole bileşimleri.
EP2525786A2 (fr) 2010-01-18 2012-11-28 Synthon BV Comprimés à libération prolongée de pramipexole
CN105622757A (zh) 2010-02-04 2016-06-01 吉联亚生物科技有限公司 结合赖氨酰氧化酶样2(loxl2)的抗体和其使用方法
US20130079526A1 (en) 2010-03-03 2013-03-28 Knopp Neurosciences Inc. Synthesis of Chirally Purified Substituted Benzothiazole Diamines
TR201001862A1 (tr) * 2010-03-11 2011-10-21 Sanovel �La� San.Ve T�C.A.�. Kontrollü salım gerçekleştiren pramipeksol formülasyonları.
AU2011256928A1 (en) 2010-05-24 2012-12-20 Lupin Limited Extended release formulation of pramipexole
EP2462925A1 (fr) 2010-11-12 2012-06-13 Neuraxpharm Arzneimittel GmbH Granulé de dihydrochlorure de pramipexole
TWI537274B (zh) 2011-03-14 2016-06-11 橘生藥品工業股份有限公司 新穎之八氫噻吩并喹啉衍生物、含有其之醫藥組成物及該等之用途
WO2012140604A1 (fr) 2011-04-15 2012-10-18 Sandoz Ag Formulations stables de chlorhydrate de pramipexole
ITMI20110666A1 (it) * 2011-04-19 2012-10-20 Dipharma Francis Srl Procedimento per la preparazione di (r) ed (s) pramipexolo e suoi intermedi
WO2013096816A1 (fr) 2011-12-22 2013-06-27 Biogen Idec Ma Inc. Synthèse améliorée de composés substitués par amine de 4,5,6,7-tétrahydrobenzothiazole
EP2732812A1 (fr) 2012-11-15 2014-05-21 Aristo Pharma GmbH Comprimé de pramipexol à libération prolongée
WO2014092006A1 (fr) 2012-12-10 2014-06-19 キッセイ薬品工業株式会社 Nouveau dérivé d'octahydropyridoquinazoline, composition pharmaceutique le contenant, et utilisations pour ledit dérivé et ladite composition
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
BR112016000627B1 (pt) 2013-07-12 2022-02-08 Knopp Biosciences Llc Uso de dexpramipexol ou um sal farmaceuticamente aceitável do mesmo
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
ES2813674T3 (es) 2013-08-13 2021-03-24 Knopp Biosciences Llc Composiciones y métodos para el tratamiento de trastornos de células plasmáticas y trastornos prolinfocíticos de células b
HUE055850T2 (hu) 2013-08-13 2022-01-28 Knopp Biosciences Llc Készítmények és módszerek a krónikus urticaria (csalánkiütés) kezelésére
EP2870965A1 (fr) 2013-11-06 2015-05-13 Sanovel Ilac Sanayi ve Ticaret A.S. Formulations pharmaceutiques liquides orales de pramipexole
EP2870961B1 (fr) 2013-11-06 2018-07-18 Sanovel Ilac Sanayi ve Ticaret A.S. Formulations effervescentes de pramipexole
CN103626718A (zh) * 2013-12-13 2014-03-12 山东新华制药股份有限公司 盐酸普拉克索的工业化制备方法
CN103664820B (zh) * 2013-12-30 2016-01-27 四川科伦药业股份有限公司 普拉克索类似物及其制备方法
CN109922796B (zh) 2016-06-23 2023-04-07 考里安有限责任公司 具有亲水和疏水域的粘合剂基质和治疗剂
KR102555208B1 (ko) 2016-07-27 2023-07-17 코리움, 엘엘씨 아민 약물의 나트륨 바이카보네이트 제자리 전환 구동된 경피성 전달
MX2019001104A (es) 2016-07-27 2019-10-02 Corium Int Inc Sistemas de suministro transdermico de memantina.
JP7469879B2 (ja) 2016-07-27 2024-04-17 コリウム, エルエルシー 経口送達と生物学的に同等である薬物動態を有する経皮送達システム
CA3059418A1 (fr) 2017-04-10 2018-10-18 Chase Therapeutics Corporation Association comprenant un antagoniste de nk1 et methode de traitement de synucleinopathies
CA3104811C (fr) 2017-06-30 2024-05-28 Chase Therapeutics Corporation Composition comprenant du pramipexole et des antagonistes nk1 pour traiter la depression
WO2019126531A1 (fr) 2017-12-20 2019-06-27 Corium, Inc. Composition adhésive transdermique comprenant un agent thérapeutique liquide volatil à bas point de fusion
CN110734413A (zh) * 2019-12-02 2020-01-31 山东铂源药业有限公司 一种普拉克索中间体2,6-二氨基-4,5,6,7-四氢苯并噻唑的制备方法
CN111333593B (zh) * 2020-04-22 2022-04-29 湖北可赛化工有限公司 一种合成4-甲基-2肼基苯并噻唑的方法
EP4249476A1 (fr) * 2020-11-19 2023-09-27 Sichuan Kelun Pharmaceutical Research Institute Co., Ltd. Sel de composé benzothiazole, forme cristalline et son utilisation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB812512A (en) * 1956-04-12 1959-04-29 Bayer Ag Compositions for combating nematodes
DE2136233A1 (de) * 1971-07-20 1973-02-01 Riedel De Haen Ag Tetrahydrobenzthiazolderivate enthaltende pharmazeutische praeparate
FR2406635A1 (fr) * 1977-10-24 1979-05-18 Logeais Labor Jacques Nouveaux derives du benzo(d)thiazole, leur procede de preparation et leurs applications en therapeutique
FR2459239A1 (fr) * 1979-06-20 1981-01-09 Logeais Labor Jacques Nouveaux derives amines du benzothiazole, leur procede de preparation et leur application en therapeutique
DE3027528A1 (de) * 1980-07-19 1982-02-18 Basf Ag, 6700 Ludwigshafen Ueberbrueckte thiazolyloxamidsaeure-derivate, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel
EP0207696A1 (fr) * 1985-06-24 1987-01-07 Eli Lilly And Company Dialkylaminotétrahydrobenzothiazoles et -oxazoles

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7868029B2 (en) 2002-09-17 2011-01-11 Generics [Uk] Limited Process for the preparation of 2-amino-4,5,6,7-tetrahydro-6-aminobenzothiazoles from cyclohexanes and cyclohexanones as intermediates

Also Published As

Publication number Publication date
AU583874B2 (en) 1989-05-11
FI855102A0 (fi) 1985-12-20
MX9202792A (es) 1992-06-30
EP0186087A1 (fr) 1986-07-02
NL980002I2 (nl) 1998-05-06
ES8707513A1 (es) 1987-08-01
NO165070B (no) 1990-09-10
PT81735A (de) 1986-01-01
GR853126B (fr) 1986-04-22
LU90208I2 (fr) 1998-04-06
HK78692A (en) 1992-10-23
NZ214661A (en) 1990-04-26
DK590285A (da) 1986-06-23
ES556873A0 (es) 1987-08-01
SG82492G (en) 1992-12-04
NL980002I1 (nl) 1998-03-02
FI855102A (fi) 1986-06-23
DE3572485D1 (en) 1989-09-28
BG62023B2 (bg) 1998-12-30
IE853270L (en) 1986-06-22
HUT39736A (en) 1986-10-29
IE58863B1 (en) 1993-11-17
FI81787C (fi) 1990-12-10
NO855195L (no) 1986-06-23
ATE45735T1 (de) 1989-09-15
ES550235A0 (es) 1987-01-16
NO165070C (no) 1990-12-19
EP0186087B1 (fr) 1989-08-23
ES8702787A1 (es) 1987-01-16
PH24533A (en) 1990-08-03
FI81787B (fi) 1990-08-31
US4731374A (en) 1988-03-15
KR860004862A (ko) 1986-07-14
ES8707514B9 (es) 2011-04-14
ES556874A0 (es) 1987-08-01
HU193618B (en) 1987-11-30
KR930009791B1 (ko) 1993-10-11
DK168862B1 (da) 1994-06-27
CA1263653A (fr) 1989-12-05
ES8707515A1 (es) 1987-08-01
ES556875A0 (es) 1987-08-01
US4886812A (en) 1989-12-12
AU5154485A (en) 1986-07-17
DK590285D0 (da) 1985-12-18
CS409991A3 (en) 1992-09-16
ES8707514A1 (es) 1987-08-01
PT81735B (pt) 1988-04-21
US4843086A (en) 1989-06-27

Similar Documents

Publication Publication Date Title
IL77415A (en) Diamino-tetrahydrobenzthiazoles,their preparation and pharmaceutical compositions containing them
IL66650A (en) Dibenzoxepines and dibenzooxazepines,their preparation and pharmaceutical compositions containing them
DK623586A (da) Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne
IE901314L (en) 2- substituted-n,n'-di(trimethoxybenzoyl)piperazines
ES8801637A1 (es) Un procedimiento para la preparacion de benzimidazoles.
HUT39445A (en) Herbicides containing as reagent derivatives of benzodisultam and process for production of the reagents
ATE53839T1 (de) 2,3-dihydro-3-phenyl-benzofuran-2-onacetamidderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
ES8300752A1 (es) "un procedimiento para la preparacion de derivados de n-ftalidil-5-fluorouracilo".

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
EXTP Application for extension order is pending
PEL Intention of commissioner to extend period of protection
EXTN Extension order renewed
EXP Patent expired