IL75721A - Substituted benzoate ester derivatives of 3-hydroxy-morphinans,their preparation and pharmaceutical compositions containing them for oral administration - Google Patents

Substituted benzoate ester derivatives of 3-hydroxy-morphinans,their preparation and pharmaceutical compositions containing them for oral administration

Info

Publication number
IL75721A
IL75721A IL75721A IL7572185A IL75721A IL 75721 A IL75721 A IL 75721A IL 75721 A IL75721 A IL 75721A IL 7572185 A IL7572185 A IL 7572185A IL 75721 A IL75721 A IL 75721A
Authority
IL
Israel
Prior art keywords
morphinans
hydroxy
preparation
pharmaceutical compositions
oral administration
Prior art date
Application number
IL75721A
Other languages
English (en)
Other versions
IL75721A0 (en
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of IL75721A0 publication Critical patent/IL75721A0/xx
Publication of IL75721A publication Critical patent/IL75721A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL75721A 1984-07-05 1985-07-04 Substituted benzoate ester derivatives of 3-hydroxy-morphinans,their preparation and pharmaceutical compositions containing them for oral administration IL75721A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62792384A 1984-07-05 1984-07-05
US06/733,464 US4668685A (en) 1984-07-05 1985-05-14 Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists

Publications (2)

Publication Number Publication Date
IL75721A0 IL75721A0 (en) 1985-11-29
IL75721A true IL75721A (en) 1990-04-29

Family

ID=27090564

Family Applications (1)

Application Number Title Priority Date Filing Date
IL75721A IL75721A (en) 1984-07-05 1985-07-04 Substituted benzoate ester derivatives of 3-hydroxy-morphinans,their preparation and pharmaceutical compositions containing them for oral administration

Country Status (18)

Country Link
US (1) US4668685A (forum.php)
EP (1) EP0170090B1 (forum.php)
AU (1) AU578391B2 (forum.php)
CA (1) CA1301150C (forum.php)
DE (1) DE3573251D1 (forum.php)
DK (1) DK160501C (forum.php)
ES (1) ES8704443A1 (forum.php)
FI (1) FI83215C (forum.php)
GR (1) GR851653B (forum.php)
HK (1) HK39790A (forum.php)
HU (1) HU193995B (forum.php)
IE (1) IE58136B1 (forum.php)
IL (1) IL75721A (forum.php)
MX (1) MX160445A (forum.php)
NO (1) NO171209C (forum.php)
NZ (1) NZ212641A (forum.php)
PT (1) PT80773B (forum.php)
SU (2) SU1450742A3 (forum.php)

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US6225321B1 (en) * 1997-06-05 2001-05-01 Oliver Yoa-Pu Hu Long analgesic acting nalbuphine polyester derivative and method of use
US6375957B1 (en) 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
ES2264226T3 (es) 1997-12-22 2006-12-16 Euro-Celtique S.A. Forma farmaceutica de dosificacion oral que comprende una combinacion de un agonista opioide y naltrexona.
ES2188481T3 (es) * 2000-04-27 2003-07-01 Oliver Yoa-Pu Hu Derivados de polinalbufina.
US6569449B1 (en) 2000-11-13 2003-05-27 University Of Kentucky Research Foundation Transdermal delivery of opioid antagonist prodrugs
ES2361148T3 (es) 2001-05-11 2011-06-14 Endo Pharmaceuticals Inc. Forma de dosificación de opioides de liberación controlada resistente al abuso.
AU2002331163B2 (en) * 2001-08-23 2008-02-21 Merck Sharp & Dohme B.V. Process for the Preparation of a 14-hydroxynormorphinone Compound
US20040033253A1 (en) * 2002-02-19 2004-02-19 Ihor Shevchuk Acyl opioid antagonists
EP2311438A1 (en) 2002-04-05 2011-04-20 Euro-Celtique S.A. Matrix for sustained, invariant and independent release of active compounds
US20040202717A1 (en) 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
US20080020028A1 (en) * 2003-08-20 2008-01-24 Euro-Celtique S.A. Transdermal dosage form comprising an active agent and a salt and a free-base form of an adverse agent
EP1604666A1 (en) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
EP1604667A1 (en) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the restless leg syndrome
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
CA2580694A1 (en) * 2004-09-23 2006-03-30 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
KR20090029856A (ko) * 2005-01-28 2009-03-23 유로-셀띠끄 소시에떼 아노님 알코올 저항성 제형
EP1695700A1 (en) * 2005-02-28 2006-08-30 Euro-Celtique S.A. Dosage form containing oxycodone and naloxone
EP1702558A1 (en) * 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
WO2006126529A1 (ja) * 2005-05-25 2006-11-30 Shionogi & Co., Ltd. ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体
WO2007022535A2 (en) 2005-08-19 2007-02-22 Pharmacofore, Inc. Prodrugs of active agents
GB0606124D0 (en) * 2006-03-28 2006-05-03 Reckitt Benckiser Healthcare Buprenorphine derivatives and uses thereof
EP2137156B1 (en) * 2007-03-09 2013-08-28 Green Cross Corporation Orally bioavailable prodrugs of (+)-3-hydroxymorphinan for parkinson's disease prevention or treatment
PE20110422A1 (es) * 2008-07-07 2011-07-01 Euro Celtique Sa Composicion farmaceutica que comprende antagonistas opioides
UY32487A (es) 2009-03-10 2010-06-30 Euro Celtique Sa Composiciones farmacéuticas de liberación inmediata comprendiendo oxicodona y naloxona
UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
US10849981B2 (en) 2009-07-02 2020-12-01 KemPham, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
WO2011008636A1 (en) * 2009-07-15 2011-01-20 Mallinckrodt Inc. 3-oxy-hydromorphone derivatives
TWI545124B (zh) * 2010-11-12 2016-08-11 鹽野義製藥股份有限公司 ６，７－不飽合－７－胺甲醯基嗎啡喃衍生物之結晶及其製造方法
JP5769889B2 (ja) 2011-10-26 2015-08-26 ケムファーム・インコーポレーテッド ヒドロモルホンの安息香酸、安息香酸誘導体及びヘテロアリールカルボン酸結合体、そのプロドラッグ、製造法及び使用
WO2015011189A1 (en) 2013-07-23 2015-01-29 Euro-Celtique S.A. A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation
WO2016086113A1 (en) 2014-11-25 2016-06-02 Kempharm, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone
HK1244209A1 (zh) 2014-12-02 2018-08-03 Kempharm, Inc. 羟吗啡酮的苯甲酸缀合物、苯甲酸衍生物缀合物和杂芳基羧酸缀合物、其前药、制备和使用方法
US10155771B2 (en) * 2015-11-04 2018-12-18 Noramco, Inc. Selective reduction of morphinan alkaloids
WO2020012245A1 (en) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Thienothiophene-naltrexone prodrugs for long-acting injectable compositions
US10799496B2 (en) 2018-07-13 2020-10-13 Alkermes Pharma Ireland Limited Naphthylenyl compounds for long-acting injectable compositions and related methods
US11186585B2 (en) 2018-08-17 2021-11-30 Kappa-Pharma LLC Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates
US10975099B2 (en) 2018-11-05 2021-04-13 Alkermes Pharma Ireland Limited Thiophene compounds for long-acting injectable compositions and related methods
CN114828961B (zh) 2019-08-11 2024-03-29 卡帕制药有限责任公司 通过阿片类己二烯酸酯和任选取代的己二烯酸酯增强阿片受体结合的组合物及方法

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DE224197C (forum.php) *
US3254088A (en) * 1961-03-14 1966-05-31 Lewenstein Morphine derivative
FR1602610A (en) * 1962-10-10 1971-01-04 10.10.62.-17.4.63. 38445-15209 thebaine derivs
US3332950A (en) * 1963-03-23 1967-07-25 Endo Lab 14-hydroxydihydronormorphinone derivatives
IL26896A (en) * 1966-01-19 1970-11-30 Endo Lab 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
GB1097167A (en) * 1966-05-31 1967-12-29 Shionogi & Co 3-hydroxy-6-oxo-n-phenethylmorphinan compounds and their production
CH560194A5 (forum.php) * 1967-08-25 1975-03-27 Hoffmann La Roche
US3654280A (en) * 1968-03-21 1972-04-04 Shionogi & Co L-n allylic-3-hydroxy-6-oxomorphinans
DE2323192A1 (de) * 1972-05-10 1973-12-13 Endo Lab Injizierbare, langwirkende antagonistpraeparate gegen narkotika und rauschgifte
US4161597A (en) * 1976-12-20 1979-07-17 Research Corporation N-alkyl-14-hydroxymorphinans and derivatives
JPS59184182A (ja) * 1983-04-02 1984-10-19 Res Inst For Prod Dev ３−ベンゾイルチオ−４、５α−エポキシ−７α−〔１（Ｒ）−ヒドロキシ−１−メチルベンチル〕−６−メトキシ−１７−メチル−６、１４−エンド−エタノモルヒナン
JPS59184183A (ja) * 1983-04-02 1984-10-19 Res Inst For Prod Dev ３−ベンゾイルチオ−４、５α−エポキシ−７α−〔１（Ｒ）−ヒドロキシ−１−メチルブチル〕−６−メトキシ−１７−メチル−６、１４−エンド−エテノモルヒナン
JPS59184163A (ja) * 1983-04-02 1984-10-19 Res Inst For Prod Dev ３−ベンゾイルチオ−１７−メチルモルヒナン
JPS59186987A (ja) * 1983-04-06 1984-10-23 Res Inst For Prod Dev ３−ベンゾイルチオ−４、５α−エポキシ−７α−〔１（Ｒ）−ヒドロキシ−１−メチルブチル〕−６−メトキシ−１７−メチル−６、１４−エンド−エテノモルヒナン

Also Published As

Publication number Publication date
AU578391B2 (en) 1988-10-20
HUT40132A (en) 1986-11-28
DK160501C (da) 1991-08-26
IE58136B1 (en) 1993-07-14
PT80773A (en) 1985-08-01
FI83215B (fi) 1991-02-28
SU1508960A3 (ru) 1989-09-15
GR851653B (forum.php) 1985-11-26
DK306885A (da) 1986-01-06
ES8704443A1 (es) 1987-04-01
FI83215C (fi) 1991-06-10
SU1450742A3 (ru) 1989-01-07
FI852659A0 (fi) 1985-07-04
IE851683L (en) 1986-01-05
MX160445A (es) 1990-03-02
AU4451685A (en) 1986-01-09
EP0170090A1 (en) 1986-02-05
NO171209C (no) 1993-02-10
EP0170090B1 (en) 1989-09-27
PT80773B (pt) 1987-10-20
HK39790A (en) 1990-06-01
NZ212641A (en) 1988-10-28
ES544852A0 (es) 1987-04-01
HU193995B (en) 1987-12-28
IL75721A0 (en) 1985-11-29
NO171209B (no) 1992-11-02
FI852659L (fi) 1986-01-06
US4668685A (en) 1987-05-26
CA1301150C (en) 1992-05-19
DK160501B (da) 1991-03-18
DE3573251D1 (en) 1989-11-02
NO852699L (no) 1986-01-06
DK306885D0 (da) 1985-07-04

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