IL67291A0 - (4-oxo-4h-(1)-benzopyran-8-yl)alkanoic acids and salts and derivatives thereof,their manufacture and pharmaceutical compositions containing them - Google Patents
(4-oxo-4h-(1)-benzopyran-8-yl)alkanoic acids and salts and derivatives thereof,their manufacture and pharmaceutical compositions containing themInfo
- Publication number
- IL67291A0 IL67291A0 IL67291A IL6729182A IL67291A0 IL 67291 A0 IL67291 A0 IL 67291A0 IL 67291 A IL67291 A IL 67291A IL 6729182 A IL6729182 A IL 6729182A IL 67291 A0 IL67291 A0 IL 67291A0
- Authority
- IL
- Israel
- Prior art keywords
- derivatives
- benzopyran
- oxo
- salts
- manufacture
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- -1 4-oxo-4h-(1)-benzopyran-8-yl Chemical group 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
- C07D311/36—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only not hydrogenated in the hetero ring, e.g. isoflavones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
- Control Of Motors That Do Not Use Commutators (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8122020A FR2516922A1 (fr) | 1981-11-25 | 1981-11-25 | Acides (oxo-4-4h-(1)-benzopyran-8-yl) alcanoiques, sels et derives, preparation et medicament les contenant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL67291A0 true IL67291A0 (en) | 1983-03-31 |
Family
ID=9264332
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL67291A IL67291A0 (en) | 1981-11-25 | 1982-11-17 | (4-oxo-4h-(1)-benzopyran-8-yl)alkanoic acids and salts and derivatives thereof,their manufacture and pharmaceutical compositions containing them |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US4602034A (enEXAMPLES) |
| EP (1) | EP0080934B1 (enEXAMPLES) |
| JP (1) | JPS5896082A (enEXAMPLES) |
| AT (1) | ATE31927T1 (enEXAMPLES) |
| AU (1) | AU563190B2 (enEXAMPLES) |
| CA (1) | CA1213595A (enEXAMPLES) |
| CS (1) | CS248035B2 (enEXAMPLES) |
| DD (1) | DD204919A5 (enEXAMPLES) |
| DE (1) | DE3277970D1 (enEXAMPLES) |
| DK (1) | DK164163C (enEXAMPLES) |
| ES (1) | ES517637A0 (enEXAMPLES) |
| FR (1) | FR2516922A1 (enEXAMPLES) |
| HU (1) | HU192112B (enEXAMPLES) |
| IE (1) | IE54130B1 (enEXAMPLES) |
| IL (1) | IL67291A0 (enEXAMPLES) |
| IN (1) | IN158843B (enEXAMPLES) |
| MA (1) | MA19650A1 (enEXAMPLES) |
| MX (1) | MX173498B (enEXAMPLES) |
| NO (1) | NO159169C (enEXAMPLES) |
| NZ (1) | NZ202596A (enEXAMPLES) |
| OA (1) | OA07257A (enEXAMPLES) |
| SU (1) | SU1250171A3 (enEXAMPLES) |
| YU (2) | YU43726B (enEXAMPLES) |
| ZA (1) | ZA828436B (enEXAMPLES) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2536397A2 (en) * | 1981-11-25 | 1984-05-25 | Lipha | [4-oxo-4H-1-Benzopyran-8-yl]alkanoic acids, their salts and derivatives, their preparation and medicinal products containing them |
| DE3311004A1 (de) * | 1983-03-25 | 1984-09-27 | Bayer Ag, 5090 Leverkusen | Chromon- und thiochromon-8-aldehyde, sowie ein verfahren zu ihrer herstellung |
| JPS62215581A (ja) * | 1986-03-18 | 1987-09-22 | Koichi Shiyudo | フラボンカルボン酸誘導体 |
| IL85554A0 (en) * | 1987-03-02 | 1988-08-31 | Takeda Chemical Industries Ltd | Chromone derivatives |
| USH1427H (en) * | 1988-04-06 | 1995-04-04 | Briet; Phillipe | Substituted flavonoid compounds, their salts, their manufacture and their use in combination with interleukin-2 |
| IL89840A (en) * | 1988-04-06 | 1996-10-31 | Lipha | Substituted flavonoid compounds and salts thereof their preparation and pharmaceutical composition containing them |
| US5116954A (en) * | 1988-04-06 | 1992-05-26 | Lipha, Lyonnaise Industrielle Pharmaceutique | Pharmaceutically useful flavonoic compounds containing at least one substituent on the benzopyranone ring moiety |
| US5126129A (en) * | 1988-05-23 | 1992-06-30 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services | Cancer therapy using interleukin-2 and flavone compounds |
| AU4847390A (en) * | 1989-01-19 | 1990-08-13 | Upjohn Company, The | Fluorinated flavone acetic acid |
| US5238954A (en) * | 1989-01-19 | 1993-08-24 | The Upjohn Company | Fluorinated flavone acetic acid |
| DK0625138T3 (da) * | 1992-02-05 | 1999-11-15 | Boehringer Ingelheim Int | Nye amidinderivater, deres fremstilling og anvendelse som medikament med LTB-4 antagonistvirkning |
| US5703130A (en) * | 1995-06-07 | 1997-12-30 | Institute Of Materia Medica, An Institute Of The Chinese Academy Of Medical Sciences | Chalcone retinoids and methods of use of same |
| US5716982A (en) * | 1995-06-07 | 1998-02-10 | Institute Of Materia Medica, An Institute Of The Chinese Academy Of Medical Sciences | Retinoids and methods of use of same |
| US5968940A (en) * | 1995-06-08 | 1999-10-19 | Institute Of Materia Medica | Retinoids and methods of use of same |
| JP4638098B2 (ja) * | 1999-06-14 | 2011-02-23 | キャンサー・リサーチ・テクノロジー・リミテッド | 癌治療 |
| WO2001052839A1 (en) | 2000-01-24 | 2001-07-26 | Mruk Jozef S | Use of flavone 8-acetic acid in vascular and cardiovascular interventions and acute coronary syndromes |
| WO2002009700A1 (en) * | 2000-07-28 | 2002-02-07 | Cancer Research Technology Limited | Cancer treatment by combination therapy |
| GB0121285D0 (en) * | 2001-09-03 | 2001-10-24 | Cancer Res Ventures Ltd | Anti-cancer combinations |
| GB2386836B (en) * | 2002-03-22 | 2006-07-26 | Cancer Res Ventures Ltd | Anti-cancer combinations |
| GB2394658A (en) * | 2002-11-01 | 2004-05-05 | Cancer Rec Tech Ltd | Oral anti-cancer composition |
| GB0321999D0 (en) * | 2003-09-19 | 2003-10-22 | Cancer Rec Tech Ltd | Anti-cancer combinations |
| RU2404764C2 (ru) * | 2005-08-26 | 2010-11-27 | Антисома Рисерч Лимитед | Комбинации (составы), включающие dmxaa, для лечения рака |
| WO2011023287A1 (en) | 2009-08-27 | 2011-03-03 | Merck Patent Gmbh | Use of faa and its derivatives in cosmetics and dermatology |
| EP2496567B1 (en) | 2009-11-05 | 2017-07-12 | Rhizen Pharmaceuticals S.A. | Novel benzopyran kinase modulators |
| CN103304531A (zh) * | 2013-06-25 | 2013-09-18 | 南方医科大学 | 一种3-芳基黄酮乙酸 |
| AU2017230119A1 (en) * | 2016-03-11 | 2018-09-27 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Icariin and icaritin derivatives |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2921070A (en) * | 1957-11-05 | 1960-01-12 | Recordati Lab Farmacologico S | Basic esters of 3-methylflavone-8-carboxylic acid |
| US3350411A (en) * | 1963-10-10 | 1967-10-31 | Pharma Seceph S A Soc D Expl C | Process for preparing 3-methylflavone-8-carboxylic acid |
| BE757821A (fr) * | 1970-08-01 | 1971-04-01 | Recordati Chem Pharm | Procede de preparation de l'acide 3-propionyl-salicylique et dederives de cet acide |
| US4148900A (en) * | 1973-12-27 | 1979-04-10 | Carlo Erba S.P.A. | 5:6-Benzo-γ-pyrone derivatives and process for their preparation |
| GB1479518A (en) * | 1973-12-27 | 1977-07-13 | Erba Carlo Spa | 5,6-benzo-ypsilon-pyrone derivatives |
| FR2281112A1 (fr) * | 1974-08-05 | 1976-03-05 | Lipha | Nouveau medicament choleretique et anti-inflammatoire |
| GB1469823A (en) * | 1974-08-13 | 1977-04-06 | Farma Lepori | Flavone derivatives |
| DE2549745A1 (de) * | 1974-11-20 | 1976-05-26 | Lipha | Durch einen chromonylrest substituierte propionsaeuren sowie deren derivate und verwendungen |
-
1981
- 1981-11-25 FR FR8122020A patent/FR2516922A1/fr active Granted
-
1982
- 1982-11-16 ZA ZA828436A patent/ZA828436B/xx unknown
- 1982-11-17 IL IL67291A patent/IL67291A0/xx not_active IP Right Cessation
- 1982-11-18 IE IE2752/82A patent/IE54130B1/en not_active IP Right Cessation
- 1982-11-18 IN IN848/DEL/82A patent/IN158843B/en unknown
- 1982-11-19 AU AU90730/82A patent/AU563190B2/en not_active Ceased
- 1982-11-23 HU HU823764A patent/HU192112B/hu not_active IP Right Cessation
- 1982-11-24 NO NO823940A patent/NO159169C/no unknown
- 1982-11-24 EP EP82402137A patent/EP0080934B1/fr not_active Expired
- 1982-11-24 ES ES517637A patent/ES517637A0/es active Granted
- 1982-11-24 AT AT82402137T patent/ATE31927T1/de not_active IP Right Cessation
- 1982-11-24 MA MA19863A patent/MA19650A1/fr unknown
- 1982-11-24 MX MX010425A patent/MX173498B/es unknown
- 1982-11-24 DK DK523082A patent/DK164163C/da not_active IP Right Cessation
- 1982-11-24 SU SU823516803A patent/SU1250171A3/ru active
- 1982-11-24 NZ NZ202596A patent/NZ202596A/en unknown
- 1982-11-24 CS CS828426A patent/CS248035B2/cs unknown
- 1982-11-24 DE DE8282402137T patent/DE3277970D1/de not_active Expired
- 1982-11-25 CA CA000416354A patent/CA1213595A/fr not_active Expired
- 1982-11-25 JP JP57205582A patent/JPS5896082A/ja active Granted
- 1982-11-25 YU YU2649/82A patent/YU43726B/xx unknown
- 1982-11-25 OA OA57850A patent/OA07257A/xx unknown
- 1982-11-25 DD DD82245217A patent/DD204919A5/de unknown
-
1984
- 1984-09-21 YU YU1630/84A patent/YU43675B/xx unknown
- 1984-11-06 US US06/669,037 patent/US4602034A/en not_active Expired - Fee Related
-
1986
- 1986-05-29 US US06/872,381 patent/US4783533A/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL67291A0 (en) | (4-oxo-4h-(1)-benzopyran-8-yl)alkanoic acids and salts and derivatives thereof,their manufacture and pharmaceutical compositions containing them | |
| DE3268321D1 (en) | Carboxylic-acid derivatives, process for their preparation and medicines containing them | |
| JPS5520751A (en) | Pyrrolidine derivative | |
| NZ218786A (en) | 1,4 disubstituted piperidine derivatives and pharmaceutical compositions | |
| ZA817696B (en) | N-substituted omega-(2-oxo-4-imidazolin-1-yl)alcanoic acids,salts and esters thereof,process for producing the same and these active agents containing pharmaceutical compounds | |
| ZW14482A1 (en) | Pyrrolidine derivates | |
| JPS54154760A (en) | Lactammnnacetic acid or its amide and said manufacture | |
| IL75116A0 (en) | Beta-carboline-3-carboxylic acid derivatives,process for the preparation thereof and pharmaceutical compositions containing the same | |
| ZA817698B (en) | N-benzoyl-omega-anilino alkane carboxylic acids,salts and esters thereof,process for producing the same and pharmaceutical preparations containing the same | |
| EP0395528A3 (fr) | Dérivés du 4-phénylméthyl 1H-indole, procédé et intermédiaires de préparation, application à titre de médicaments et compositions les renfermant. | |
| SE8405275D0 (sv) | 1,2-dithiolan derivatives, processes for their production, pharmaceutical compositions containing them and their use | |
| IL91212A0 (en) | 6-fluoro-3,5-dihydroxy carboxylic acids and derivatives thereof,a process for the preparation thereof and pharmaceutical compositions containing them | |
| DE59004292D1 (de) | Renin-hemmende Aminooligohydroxy-Derivate. | |
| ATE118773T1 (de) | Verfahren zur herstellung von 2-(3-pyridyl)- tetrahydrothiopyran-2-carbonsäurethioamid-1- (1r,2r)oxyden, die so erhaltenen 2-(3-pyridyl)- tetrahydrothiopyran-2-carbothioamid-1- (1r,2r)oxyde und diese enthaltende pharmazeutische zusammenstellungen. | |
| ES8104179A1 (es) | Procedimiento para la preparacion de esteres de 2-(6-metoxi-2-naftil)propilo | |
| TNSN89051A1 (fr) | Composants substituants du flavonoide leurs sels leur manufacture et les medicaments contenant ces matieres | |
| SU1009049A1 (ru) | 2-дихлорметил-2-тиазолин-4-карбоновая кислота в качестве стабилизатора центров скрытого изображения галогенсеребряных фотографических материалов и способ ее получения | |
| DE58909563D1 (de) | 3-Anilino-2-hydroxycarbonyl-4-thiophenessigsäuren | |
| DE58909745D1 (de) | Tetrahydro-4-phenylimino-3-thiophenessigsäuren |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RH | Patent void |