DE3277970D1 - (4-oxo-4h-(1)-benzopyran-8-yl)-alkanoic acids, salts and derivatives, preparation and medicines containing them - Google Patents

(4-oxo-4h-(1)-benzopyran-8-yl)-alkanoic acids, salts and derivatives, preparation and medicines containing them

Info

Publication number
DE3277970D1
DE3277970D1 DE8282402137T DE3277970T DE3277970D1 DE 3277970 D1 DE3277970 D1 DE 3277970D1 DE 8282402137 T DE8282402137 T DE 8282402137T DE 3277970 T DE3277970 T DE 3277970T DE 3277970 D1 DE3277970 D1 DE 3277970D1
Authority
DE
Germany
Prior art keywords
derivatives
benzopyran
oxo
salts
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8282402137T
Other languages
English (en)
Inventor
Philippe Briet
Jean-Jacques Berthelon
Francois Collonges
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sante SAS
Original Assignee
LIPHA SAS
LIPHA Liyonnaise Industrielle Pharmaceutique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LIPHA SAS, LIPHA Liyonnaise Industrielle Pharmaceutique filed Critical LIPHA SAS
Application granted granted Critical
Publication of DE3277970D1 publication Critical patent/DE3277970D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
    • C07D311/36—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only not hydrogenated in the hetero ring, e.g. isoflavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Control Of Motors That Do Not Use Commutators (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE8282402137T 1981-11-25 1982-11-24 (4-oxo-4h-(1)-benzopyran-8-yl)-alkanoic acids, salts and derivatives, preparation and medicines containing them Expired DE3277970D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8122020A FR2516922A1 (fr) 1981-11-25 1981-11-25 Acides (oxo-4-4h-(1)-benzopyran-8-yl) alcanoiques, sels et derives, preparation et medicament les contenant

Publications (1)

Publication Number Publication Date
DE3277970D1 true DE3277970D1 (en) 1988-02-18

Family

ID=9264332

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8282402137T Expired DE3277970D1 (en) 1981-11-25 1982-11-24 (4-oxo-4h-(1)-benzopyran-8-yl)-alkanoic acids, salts and derivatives, preparation and medicines containing them

Country Status (24)

Country Link
US (2) US4602034A (de)
EP (1) EP0080934B1 (de)
JP (1) JPS5896082A (de)
AT (1) ATE31927T1 (de)
AU (1) AU563190B2 (de)
CA (1) CA1213595A (de)
CS (1) CS248035B2 (de)
DD (1) DD204919A5 (de)
DE (1) DE3277970D1 (de)
DK (1) DK164163C (de)
ES (1) ES517637A0 (de)
FR (1) FR2516922A1 (de)
HU (1) HU192112B (de)
IE (1) IE54130B1 (de)
IL (1) IL67291A0 (de)
IN (1) IN158843B (de)
MA (1) MA19650A1 (de)
MX (1) MX173498B (de)
NO (1) NO159169C (de)
NZ (1) NZ202596A (de)
OA (1) OA07257A (de)
SU (1) SU1250171A3 (de)
YU (2) YU43726B (de)
ZA (1) ZA828436B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2536397A2 (en) * 1981-11-25 1984-05-25 Lipha [4-oxo-4H-1-Benzopyran-8-yl]alkanoic acids, their salts and derivatives, their preparation and medicinal products containing them
DE3311004A1 (de) * 1983-03-25 1984-09-27 Bayer Ag, 5090 Leverkusen Chromon- und thiochromon-8-aldehyde, sowie ein verfahren zu ihrer herstellung
JPS62215581A (ja) * 1986-03-18 1987-09-22 Koichi Shiyudo フラボンカルボン酸誘導体
IL85554A0 (en) * 1987-03-02 1988-08-31 Takeda Chemical Industries Ltd Chromone derivatives
US5116954A (en) * 1988-04-06 1992-05-26 Lipha, Lyonnaise Industrielle Pharmaceutique Pharmaceutically useful flavonoic compounds containing at least one substituent on the benzopyranone ring moiety
USH1427H (en) * 1988-04-06 1995-04-04 Briet; Phillipe Substituted flavonoid compounds, their salts, their manufacture and their use in combination with interleukin-2
MA21528A1 (fr) * 1988-04-06 1989-12-31 Lipha Composants substituants du flavonoide, leurs sels, leurs manufactures et produits contenant ces matieres .
US5126129A (en) * 1988-05-23 1992-06-30 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Cancer therapy using interleukin-2 and flavone compounds
US5238954A (en) * 1989-01-19 1993-08-24 The Upjohn Company Fluorinated flavone acetic acid
ES2062507T3 (es) * 1989-01-19 1994-12-16 Upjohn Co Acido flavonacetico fluorado.
US5703130A (en) * 1995-06-07 1997-12-30 Institute Of Materia Medica, An Institute Of The Chinese Academy Of Medical Sciences Chalcone retinoids and methods of use of same
US5716982A (en) * 1995-06-07 1998-02-10 Institute Of Materia Medica, An Institute Of The Chinese Academy Of Medical Sciences Retinoids and methods of use of same
US5968940A (en) * 1995-06-08 1999-10-19 Institute Of Materia Medica Retinoids and methods of use of same
DE60027719T2 (de) * 1999-06-14 2007-04-26 Cancer Research Technology Ltd. Krebstherapie
CA2389924A1 (en) 2000-01-24 2001-07-26 Jozef S. Mruk Use of flavone 8-acetic acid in vascular and cardiovascular interventions and acute coronary syndromes
WO2002009700A1 (en) * 2000-07-28 2002-02-07 Cancer Research Technology Limited Cancer treatment by combination therapy
GB0121285D0 (en) * 2001-09-03 2001-10-24 Cancer Res Ventures Ltd Anti-cancer combinations
GB2386836B (en) * 2002-03-22 2006-07-26 Cancer Res Ventures Ltd Anti-cancer combinations
GB2394658A (en) * 2002-11-01 2004-05-05 Cancer Rec Tech Ltd Oral anti-cancer composition
GB0321999D0 (en) * 2003-09-19 2003-10-22 Cancer Rec Tech Ltd Anti-cancer combinations
BRPI0614965A2 (pt) * 2005-08-26 2016-09-13 Antisoma Plc método para a modulação de crescimento neoplástico, usos de um composto ou, um sal, éster ou pró-droga farmaceuticamente aceitável do mesmo, de um aglutinante do fator de crescimento endotelial vascular, e de um taxano, formulação farmacêutica, e, kit
WO2011023287A1 (en) 2009-08-27 2011-03-03 Merck Patent Gmbh Use of faa and its derivatives in cosmetics and dermatology
CN105801550B (zh) 2009-11-05 2019-06-14 理森制药股份公司 新型苯并吡喃激酶调节剂
CN103304531A (zh) * 2013-06-25 2013-09-18 南方医科大学 一种3-芳基黄酮乙酸
EP3426242A4 (de) * 2016-03-11 2020-03-18 H. Lee Moffitt Cancer Center And Research Institute, Inc. Icariin- und icaritinderivate

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2921070A (en) * 1957-11-05 1960-01-12 Recordati Lab Farmacologico S Basic esters of 3-methylflavone-8-carboxylic acid
US3350411A (en) * 1963-10-10 1967-10-31 Pharma Seceph S A Soc D Expl C Process for preparing 3-methylflavone-8-carboxylic acid
BE757821A (fr) * 1970-08-01 1971-04-01 Recordati Chem Pharm Procede de preparation de l'acide 3-propionyl-salicylique et dederives de cet acide
US4148900A (en) * 1973-12-27 1979-04-10 Carlo Erba S.P.A. 5:6-Benzo-γ-pyrone derivatives and process for their preparation
GB1479518A (en) * 1973-12-27 1977-07-13 Erba Carlo Spa 5,6-benzo-ypsilon-pyrone derivatives
FR2281112A1 (fr) * 1974-08-05 1976-03-05 Lipha Nouveau medicament choleretique et anti-inflammatoire
GB1469823A (en) * 1974-08-13 1977-04-06 Farma Lepori Flavone derivatives
DE2549745A1 (de) * 1974-11-20 1976-05-26 Lipha Durch einen chromonylrest substituierte propionsaeuren sowie deren derivate und verwendungen

Also Published As

Publication number Publication date
IE822752L (en) 1983-05-25
ES8308323A1 (es) 1983-08-16
DK164163B (da) 1992-05-18
EP0080934A1 (de) 1983-06-08
IE54130B1 (en) 1989-06-21
SU1250171A3 (ru) 1986-08-07
FR2516922B1 (de) 1984-02-10
NO823940L (no) 1983-05-26
EP0080934B1 (de) 1988-01-13
IN158843B (de) 1987-01-31
CA1213595A (fr) 1986-11-04
ATE31927T1 (de) 1988-01-15
AU563190B2 (en) 1987-07-02
US4602034A (en) 1986-07-22
YU163084A (en) 1985-03-20
ZA828436B (en) 1983-09-28
OA07257A (fr) 1984-04-30
HU192112B (en) 1987-05-28
YU43726B (en) 1989-10-31
NZ202596A (en) 1986-02-21
IL67291A0 (en) 1983-03-31
JPS5896082A (ja) 1983-06-07
AU9073082A (en) 1983-06-02
YU43675B (en) 1989-10-31
ES517637A0 (es) 1983-08-16
DK164163C (da) 1992-10-19
JPH0214352B2 (de) 1990-04-06
NO159169C (no) 1988-12-07
YU264982A (en) 1984-12-31
MX173498B (es) 1994-03-10
CS248035B2 (en) 1987-01-15
FR2516922A1 (fr) 1983-05-27
MA19650A1 (fr) 1983-07-01
NO159169B (no) 1988-08-29
DK523082A (da) 1983-05-26
DD204919A5 (de) 1983-12-14
US4783533A (en) 1988-11-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee