IL66243A - 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-quinoline-3-carboxylic acids,their preparation and antibacterial agents containing them - Google Patents

1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-quinoline-3-carboxylic acids,their preparation and antibacterial agents containing them

Info

Publication number
IL66243A
IL66243A IL66243A IL6624382A IL66243A IL 66243 A IL66243 A IL 66243A IL 66243 A IL66243 A IL 66243A IL 6624382 A IL6624382 A IL 6624382A IL 66243 A IL66243 A IL 66243A
Authority
IL
Israel
Prior art keywords
quinoline
cyclopropyl
dihydro
oxo
fluoro
Prior art date
Application number
IL66243A
Other languages
English (en)
Other versions
IL66243A0 (en
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6145081&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL66243(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ag filed Critical Bayer Ag
Priority to IL7699882A priority Critical patent/IL76998A/xx
Priority to IL7699982A priority patent/IL76999A/xx
Priority to IL7700082A priority patent/IL77000A/xx
Priority to IL8051482A priority patent/IL80514A/xx
Publication of IL66243A0 publication Critical patent/IL66243A0/xx
Priority to IL76998A priority patent/IL76998A0/xx
Priority to IL77000A priority patent/IL77000A0/xx
Priority to IL76999A priority patent/IL76999A0/xx
Priority to IL80514A priority patent/IL80514A0/xx
Publication of IL66243A publication Critical patent/IL66243A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Fodder In General (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL66243A 1981-10-29 1982-07-06 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-quinoline-3-carboxylic acids,their preparation and antibacterial agents containing them IL66243A (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IL7699882A IL76998A (en) 1981-10-29 1982-07-06 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-chloro-quinoline-3-carboxylic acid
IL7699982A IL76999A (en) 1981-10-29 1982-07-06 Ethyl 2,4-dichloro-5-fluorobenzoyl-acetate
IL7700082A IL77000A (en) 1981-10-29 1982-07-06 Ethyl 2-(2,4-dichloro-5-fluorobenzoyl)-3-ethoxyacrylate
IL8051482A IL80514A (en) 1981-10-29 1982-07-06 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4beta-hydroxyethyl piperazino)-quinoline-3-carboxylic acid,its preparation and antibacterial agents containing it
IL76998A IL76998A0 (en) 1981-10-29 1985-11-11 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-chloro-quinoline-3-carboxylic acid
IL77000A IL77000A0 (en) 1981-10-29 1985-11-11 Ethyl 2,4-dichloro-5-fluorobenzoyl-acetate
IL76999A IL76999A0 (en) 1981-10-29 1985-11-11 Ethyl 2,4-dichloro-5-fluorobenzoyl-acetate
IL80514A IL80514A0 (en) 1981-10-29 1986-11-05 1-cyclopropyl-6-fluoro-1,-4-dihydro-4-oxo-7-(4beta-hydroxyethyl piperazino)-quinoline-3-carboxylic acid,its preparation and antibacterial agents containing it

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813142854 DE3142854A1 (de) 1981-10-29 1981-10-29 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel

Publications (2)

Publication Number Publication Date
IL66243A0 IL66243A0 (en) 1982-11-30
IL66243A true IL66243A (en) 1987-10-20

Family

ID=6145081

Family Applications (1)

Application Number Title Priority Date Filing Date
IL66243A IL66243A (en) 1981-10-29 1982-07-06 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-quinoline-3-carboxylic acids,their preparation and antibacterial agents containing them

Country Status (20)

Country Link
EP (1) EP0078362B1 (sv)
JP (5) JPS5874667A (sv)
KR (1) KR870000895B1 (sv)
AT (1) ATE23040T1 (sv)
AU (3) AU561103B2 (sv)
CA (1) CA1218067A (sv)
DD (1) DD202560A5 (sv)
DE (2) DE3142854A1 (sv)
DK (2) DK160491C (sv)
ES (1) ES516921A0 (sv)
FI (1) FI78689C (sv)
GR (1) GR77707B (sv)
HU (1) HU187580B (sv)
IE (1) IE53709B1 (sv)
IL (1) IL66243A (sv)
LU (1) LU88325I2 (sv)
NO (2) NO158018C (sv)
NZ (1) NZ202278A (sv)
PH (1) PH18803A (sv)
ZA (1) ZA824829B (sv)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3248505A1 (de) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(4- (oxoalkyl)-1-piperazinyl/-3-chinolincarbonsaeuren und ihre derivate, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3248506A1 (de) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(alkyl-1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3306771A1 (de) * 1983-02-25 1984-08-30 Bayer Ag, 5090 Leverkusen Chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3306772A1 (de) * 1983-02-25 1984-08-30 Bayer Ag, 5090 Leverkusen Chinolonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3318145A1 (de) * 1983-05-18 1984-11-22 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4730000A (en) * 1984-04-09 1988-03-08 Abbott Laboratories Quinoline antibacterial compounds
US4551456A (en) * 1983-11-14 1985-11-05 Merck & Co., Inc. Ophthalmic use of norfloxacin and related antibiotics
EP0160578B1 (en) * 1984-02-17 1989-11-23 Daiichi Seiyaku Co., Ltd. 1,8-naphthyridine derivatives
US4542133A (en) * 1984-04-26 1985-09-17 Abbott Laboratories Methylenedioxy quino-benoxazine derivatives and antibacterial use
US4607032A (en) * 1984-04-26 1986-08-19 Abbott Laboratories Quino-benoxazine antibacterial compounds
US4528285A (en) * 1984-04-26 1985-07-09 Abbott Laboratories Methylenedioxy quino-benzothiazine derivatives
US4533663A (en) * 1984-04-26 1985-08-06 Abbott Laboratories Quino-benzothiazine antibacterial compounds
US4529725A (en) * 1984-04-26 1985-07-16 Abbott Laboratories 1-Pyridine substituted quino-benzothiazine
US4540694A (en) * 1984-04-26 1985-09-10 Abbott Laboratories 1-Pyridine substituted quino-benoxazines and antibacterial use
GB8412094D0 (en) * 1984-05-11 1984-06-20 Scras Quinoline derivatives
DE3420798A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-(3-aryl-l-piperazinyl)- sowie 7-(3-cyclohexyl-l-piperazinyl)-3-chinoloncarbonsaeuren
DE3426482A1 (de) * 1984-07-18 1986-01-30 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von halogenierten aroylessigestern
IE58742B1 (en) * 1984-07-20 1993-11-05 Warner Lambert Co Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds
DE3502935A1 (de) * 1984-09-29 1986-04-10 Bayer Ag, 5090 Leverkusen 3-amino-2-benzoyl-acrylsaeurederivate und ein verfahren zu ihrer herstellung
FR2574404B1 (fr) * 1984-12-12 1987-04-24 Provesan Sa Derives 1-substitues de l'acide 6-fluoro-7-(pyrrol-1-yl)-1,4-dihydro-4-oxoquinoleine-3-carboxylique, leur preparation et leur application en tant que medicaments
EP0191185B1 (en) * 1984-12-14 1990-03-07 Daiichi Seiyaku Co., Ltd. Quinoline-carboxylic acid derivatives
DE3517709A1 (de) * 1985-01-05 1986-07-10 Bayer Ag Basische zubereitungen von chinoloncarbonsaeuren
JPS61180771A (ja) * 1985-01-05 1986-08-13 バイエル・アクチエンゲゼルシヤフト 安定な抗バクテリア剤水溶液
DE3508816A1 (de) * 1985-01-10 1986-07-10 Bayer Ag, 5090 Leverkusen 6,7-disubstituierte 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphtyridin-3-carbonsaeuren
DE3501247A1 (de) * 1985-01-16 1986-07-17 Bayer Ag, 5090 Leverkusen Aminoacrylsaeure-derivate
AT392789B (de) * 1985-01-23 1991-06-10 Toyama Chemical Co Ltd Verfahren zur herstellung von 1-substituierten aryl-1,4-dihydro-4-oxonaphthyridinderivaten
US4851535A (en) * 1985-01-23 1989-07-25 Toyama Chemical Co., Ltd. Nicotinic acid derivatives
AT392791B (de) * 1985-01-23 1991-06-10 Toyama Chemical Co Ltd Verfahren zur herstellung von 1-substituierten aryl-1,4-dihydro-4-oxonaphthyridinderivaten
DE3509546A1 (de) * 1985-03-16 1986-09-25 Bayer Ag, 5090 Leverkusen 7-amino-1-(subst.cyclopropyl)-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3608745A1 (de) * 1985-07-24 1987-01-29 Bayer Ag Bakterizide zubereitungen zur anwendung auf dem gebiet der veterinaermedizin
EP0224121A3 (en) * 1985-11-19 1987-11-11 ROTTAPHARM S.p.A. 7-[4-amino-piperazinyl]- or 7-[4-chloro-piperazinyl]quinolinone derivatives, a process for the preparation thereof and pharmaceutical compositions containing them
DE3542002A1 (de) * 1985-11-28 1987-06-04 Bayer Ag 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
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US4687770A (en) * 1985-12-23 1987-08-18 Abbott Laboratories Isoxazolo-pyrido-benzoxazine and isothiazolo-pyrido-benzoxazine derivatives
US4689325A (en) * 1985-12-23 1987-08-25 Abbott Laboratories Isoxazolo-pyrido-phenoxazine and isothiazolo-pyrido-phenoxazine derivatives
US4772706A (en) * 1986-01-13 1988-09-20 Warner-Lambert Company Process for quinoline-3-carboxylic acid antibacterial agents
JPS62246541A (ja) * 1986-01-20 1987-10-27 Kyorin Pharmaceut Co Ltd ベンゾイル酢酸エステル誘導体とその製造方法
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
JPS62215572A (ja) * 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
JPS63198664A (ja) * 1986-03-31 1988-08-17 Sankyo Co Ltd キノロンカルボン酸誘導体
DE3641312A1 (de) * 1986-12-03 1988-06-09 Bayer Ag Verfahren zur herstellung von chinolincarbonsaeuren
HU198709B (en) * 1987-04-08 1989-11-28 Chinoin Gyogyszer Es Vegyeszet Process for producing quinoline-carboxylic acid derivatives
US5563138A (en) * 1987-04-16 1996-10-08 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
DE3713672A1 (de) * 1987-04-24 1988-11-17 Bayer Ag Verfahren zur herstellung von parenteral verabreichbaren chinoloncarbonsaeuren
JP2556330B2 (ja) * 1987-07-09 1996-11-20 杏林製薬株式会社 アニソ−ル誘導体並びにその製造方法
DE3724466A1 (de) * 1987-07-24 1989-02-02 Bayer Ag Verfahren zur herstellung von chinoloncarbonsaeuren
IL88003A (en) * 1987-10-16 1992-11-15 Dainippon Pharmaceutical Co Quinoline derivatives,their preparation and pharmaceutical compositions containing them
US5164392A (en) * 1987-10-16 1992-11-17 Dainippon Pharmaceutical Co., Ltd. Quinoline derivatives and antibacterial agent containing them
EP0342849A3 (en) * 1988-05-19 1990-03-14 Pfizer Inc. Intermediates for preparing 1,4-dihydro-4-oxo-quinoline-3-carboxylic acid esters
KR910003630B1 (ko) * 1988-06-17 1991-06-07 한국과학기술원 벤조일 아세틱 에스테르 유도체 및 그 제조방법
GR1000201B (el) * 1988-06-23 1992-03-20 Tsetis Kleon Mέ?οδος για την παρασκευή του 1-κυκλοπροπυλο-6-φ?ορο-1,4-διϋδρο-4-οξο-7κινολίνο-3-καρβοξυλικού οξέος δομικού λί?ου παρασκευής των 1-κυκλοπρόπυλο-6-φ?όρο-1,4-διϋδρο-4οξο-7-πιπεράζινο-κινολινο 3καρβοξυλικών οξέων.
FI95130C (sv) * 1988-07-20 1995-12-27 Sankyo Co Förfarande för framställning av som läkemedel användbara derivat av 4-oxokinolin-3-karboxylsyra
US5262417A (en) * 1988-12-06 1993-11-16 The Upjohn Company Antibacterial quinolone compounds
US5219781A (en) * 1988-12-08 1993-06-15 Mitsubishi Denki Kabushiki Kaisha Method for manufacturing semiconductor memory device having a stacked type capacitor
FR2655545B1 (fr) 1989-12-11 1994-06-10 Rhone Poulenc Sante Nouvelle application therapeutique des derives des fluoroquinolones.
EP0449445A3 (en) * 1990-03-27 1993-08-25 Pfizer Inc. Preparation of beta-ketoesters useful in preparing quinolone antibiotics
ES2039301B1 (es) * 1991-11-20 1994-05-16 Genesis Para La Investigacion Procedimiento de obtencion de nuevos intermedios de sintesis utiles para la preparacion de fluoroquinolonas.
ES2050594B1 (es) * 1991-12-31 1994-12-16 Ind Quimica Agropecuaria S A Procedimiento para la obtencion de acidos 6-fluoro-1,4-dihidro-4-oxo-7-piperazino-quinolin-3-carboxilicos sustituidos en 1-n.
ES2050613B1 (es) * 1992-10-16 1996-03-16 Iteve S A Nuevo procedimiento para la preparacion de derivados del acido 1-ciclopropil-3-quinolincarboxilico.
US5532239A (en) * 1993-08-02 1996-07-02 Assistance Publique - Hopitaux De Paris Therapeutic application of fluoroquinolone derivatives
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JP2944759B2 (ja) * 1995-05-24 1999-09-06 アルコン ラボラトリーズ，インコーポレイテッド 抗菌性組成物
DE19547635A1 (de) 1995-12-20 1997-06-26 Bayer Ag Verfahren zur Herstellung von Cyclopropancarbonsäureamiden
US6326391B1 (en) 1998-12-04 2001-12-04 Influx, Inc. Inhibitors of multidrug transporters
JP3477466B2 (ja) 1999-09-02 2003-12-10 湧永製薬株式会社 キノリンカルボン酸誘導体又はその塩
SE9904108D0 (sv) 1999-11-15 1999-11-15 New Pharma Research Ab Nya föreningar
DE10031043A1 (de) 2000-06-26 2002-02-14 Bayer Ag Retardzubereitungen von Chinolonantibiotika und Verfahren zu ihrer Herstellung
ES2256331T3 (es) 2000-12-21 2006-07-16 PHARMACIA & UPJOHN COMPANY LLC Derivados de quinolina antimicrobianos y uso de los mismos para tratar infecciones bacterianas.
US20070197548A1 (en) 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone compositions
US7973022B2 (en) 2006-02-17 2011-07-05 Idexx Laboratories, Inc. Fluoroquinolone carboxylic acid salt compositions
DE102007004732A1 (de) * 2007-01-31 2008-08-07 Bayer Healthcare Ag Enrofloxacin-Hexahydrat
US7902227B2 (en) * 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
WO2013157018A1 (en) 2012-04-18 2013-10-24 Indian Institute Of Technology Madras A process for the preparation of the core structure in quinolone and napthyridone class of antibiotics
CN113912539B (zh) * 2021-12-13 2022-03-11 山东国邦药业有限公司 一种环丙羧酸的合成方法

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JPS5188973A (ja) * 1975-01-29 1976-08-04 Shinkinakinoronkarubonsanjudotainoseiho
JPS53141286A (en) * 1977-05-16 1978-12-08 Kyorin Seiyaku Kk Novel substituted quinolinecarboxylic acid
JPS5466686A (en) * 1977-09-20 1979-05-29 Dainippon Pharmaceut Co Ltd Quinoline-3-carboxylic acid derivative, its preparation, and pharmaceutical composition containig the same
CA1175836A (en) * 1977-09-20 1984-10-09 Marcel Pesson Production of 1,4-dihydroquinoline-3-carboxylic acid derivatives
DE2808070A1 (de) * 1978-02-24 1979-08-30 Bayer Ag Verfahren zur herstellung von 4-pyridon-3-carbonsaeuren und/oder deren derivaten
DE3033157A1 (de) * 1980-09-03 1982-04-01 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
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US4788320A (en) * 1986-01-20 1988-11-29 Kyorin Pharmaceutical Co., Ltd. Benzoylacetic acid ester derivatives and process for their preparations
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Also Published As

Publication number Publication date
DD202560A5 (de) 1983-09-21
DE3142854A1 (de) 1983-05-11
IE821606L (en) 1983-04-29
NO1994030I1 (no) 1994-12-30
FI822442L (fi) 1983-04-30
AU7140687A (en) 1987-07-30
DK160491B (da) 1991-03-18
GR77707B (sv) 1984-09-25
DK190890A (da) 1990-08-10
AU573126B2 (en) 1988-05-26
HU187580B (en) 1986-01-28
JPH0244827B2 (sv) 1990-10-05
JPS6362510B2 (sv) 1988-12-02
EP0078362A2 (de) 1983-05-11
LU88325I2 (fr) 1994-05-04
ZA824829B (en) 1983-05-25
FI78689C (sv) 1989-09-11
DK306082A (da) 1983-04-30
JPH04253963A (ja) 1992-09-09
ES8307787A1 (es) 1983-07-16
FI822442A0 (fi) 1982-07-08
AU7140587A (en) 1987-08-06
PH18803A (en) 1985-09-27
AU573125B2 (en) 1988-05-26
JPH0463067B2 (sv) 1992-10-08
DK190890D0 (da) 1990-08-10
AU8576882A (en) 1983-05-05
CA1218067A (en) 1987-02-17
JPS6322075A (ja) 1988-01-29
JPH0457674B2 (sv) 1992-09-14
EP0078362B1 (de) 1986-10-22
JPS5874667A (ja) 1983-05-06
DK160491C (da) 1991-08-26
JPS6322076A (ja) 1988-01-29
IE53709B1 (en) 1989-01-18
ATE23040T1 (de) 1986-11-15
NO158018C (no) 1988-06-29
DK162637B (da) 1991-11-25
ES516921A0 (es) 1983-07-16
JPS6322057A (ja) 1988-01-29
NO822346L (no) 1983-05-02
NZ202278A (en) 1985-02-28
DK162637C (da) 1992-04-13
JPH0824536B2 (ja) 1996-03-13
EP0078362A3 (en) 1984-08-22
KR870000895B1 (ko) 1987-05-02
NO158018B (no) 1988-03-21
FI78689B (fi) 1989-05-31
IL66243A0 (en) 1982-11-30
AU561103B2 (en) 1987-04-30
KR840000525A (ko) 1984-02-25
DE3273892D1 (en) 1986-11-27

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