IL62494A - 2-alkyl-3-(4'-aroyl-and 4'-(indol-3"-yl)-piperidin-1'-alkyl)-4h-pyrido(1,2-a)pyrimidin-4-one derivatives,their preparation and pharmaceutical compositions containing them - Google Patents
2-alkyl-3-(4'-aroyl-and 4'-(indol-3"-yl)-piperidin-1'-alkyl)-4h-pyrido(1,2-a)pyrimidin-4-one derivatives,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL62494A IL62494A IL62494A IL6249481A IL62494A IL 62494 A IL62494 A IL 62494A IL 62494 A IL62494 A IL 62494A IL 6249481 A IL6249481 A IL 6249481A IL 62494 A IL62494 A IL 62494A
- Authority
- IL
- Israel
- Prior art keywords
- alkyl
- aroyl
- pyrido
- indol
- pyrimidin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13484580A | 1980-03-28 | 1980-03-28 | |
| US06/191,632 US4342870A (en) | 1980-03-28 | 1980-09-29 | Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL62494A0 IL62494A0 (en) | 1981-05-20 |
| IL62494A true IL62494A (en) | 1984-08-31 |
Family
ID=26832744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL62494A IL62494A (en) | 1980-03-28 | 1981-03-26 | 2-alkyl-3-(4'-aroyl-and 4'-(indol-3"-yl)-piperidin-1'-alkyl)-4h-pyrido(1,2-a)pyrimidin-4-one derivatives,their preparation and pharmaceutical compositions containing them |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4342870A (de) |
| EP (1) | EP0037265B1 (de) |
| AU (1) | AU537700B2 (de) |
| BG (1) | BG36199A3 (de) |
| CA (1) | CA1163994A (de) |
| CS (1) | CS256366B2 (de) |
| DE (1) | DE3168433D1 (de) |
| DK (1) | DK159390C (de) |
| ES (1) | ES500814A0 (de) |
| FI (1) | FI71737C (de) |
| GR (1) | GR72488B (de) |
| HU (1) | HU187329B (de) |
| IE (1) | IE51319B1 (de) |
| IL (1) | IL62494A (de) |
| MA (1) | MA19107A1 (de) |
| NO (1) | NO156752C (de) |
| NZ (1) | NZ196522A (de) |
| PH (1) | PH16530A (de) |
| PT (1) | PT72740B (de) |
| RO (1) | RO82508A (de) |
| SU (1) | SU1068037A3 (de) |
| YU (1) | YU43010B (de) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4443451A (en) * | 1981-07-15 | 1984-04-17 | Janssen Pharmaceutica N.V. | Bicyclic pyrimidin-5-one derivatives |
| US4548938A (en) * | 1981-07-15 | 1985-10-22 | Janssen Pharmaceutica N.V. | 5-H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one compounds |
| US4355037A (en) * | 1981-11-12 | 1982-10-19 | Hoechst-Roussel Pharmaceuticals | 3-(4-Piperidyl)-1,2-benzisoxales |
| US4485107A (en) * | 1982-11-01 | 1984-11-27 | Janssen Pharmaceutica N.V. | [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones |
| US4581171A (en) * | 1983-07-27 | 1986-04-08 | Janssen Pharmaceutica, N.V. | [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders |
| US4695569A (en) * | 1983-11-30 | 1987-09-22 | Janssen Pharmaceutica N.V. | Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines |
| US4888426A (en) * | 1983-11-30 | 1989-12-19 | Janssen Pharmaceutica N.V. | 1-(5-methyl-furan-2-ylmethyl)-N-(4-piperidinyl)imidazo [4,5-6]pyridine-2-amine |
| PH23995A (en) * | 1984-01-09 | 1990-02-09 | Janssen Pharmaceutica Nv | 4((bicycle heterocyclyl)-methyl and hetero)piperidines |
| US4548939A (en) * | 1984-10-01 | 1985-10-22 | Janssen Pharmaceutica N. V. | 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones |
| US4804663A (en) * | 1985-03-27 | 1989-02-14 | Janssen Pharmaceutica N.V. | 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles |
| ES2094718T3 (es) * | 1986-09-22 | 1997-02-01 | Janssen Pharmaceutica Nv | Antagonistas de la serotonine para el tratamiento de heridas. |
| IL90879A0 (en) * | 1988-09-02 | 1990-02-09 | Janssen Pharmaceutica Nv | 3-piperidinyl-indazole derivatives,their preparation and antihypertensive compositions containing them |
| CA2000786C (en) * | 1988-11-07 | 1999-01-26 | Cornelus G. M. Janssen | 3-piperidinyl-1,2-benzisoxazoles |
| WO1990006303A1 (en) * | 1988-12-02 | 1990-06-14 | Pfizer Inc. | Arylpiperidine derivatives |
| JPH04504263A (ja) * | 1989-03-23 | 1992-07-30 | マリンクロッド・インコーポレイテッド | 放射性沃素又は臭素標識ピペリジン化合物、並びに上記化合物の及び上記化合物を含む組成物の製法 |
| DE4138756A1 (de) * | 1991-11-26 | 1993-05-27 | Troponwerke Gmbh & Co Kg | Kombination mit neuroprotektiver wirkung |
| US5266571A (en) * | 1992-01-09 | 1993-11-30 | Amer Moh Samir | Treatment of hemorrhoids with 5-HT2 antagonists |
| PT626968E (pt) * | 1992-02-13 | 2002-03-28 | Merrell Pharma Inc | Derivados de piperidinilo tiaciclicos |
| AU669196B2 (en) | 1992-07-13 | 1996-05-30 | Janssen Pharmaceutica N.V. | Novel 4-(3-benzofuranyl)piperidinyl and 4-(3-benzothienyl)piperidinyl derivatives and pharmaceutical compositions containing them |
| SK282231B6 (sk) | 1993-11-19 | 2001-12-03 | Janssen Pharmaceutica N. V. | Farmaceutický prostriedok na liečenie psychotických porúch |
| ES2085234B1 (es) * | 1994-02-24 | 1997-01-16 | Vita Invest Sa | Agente activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen. |
| TW421649B (en) * | 1995-01-31 | 2001-02-11 | Janssen Pharmaceutica Nv | 4-(1H-indol-1yl)-1-piperidinyl derivatives |
| US5753664A (en) * | 1995-03-16 | 1998-05-19 | Takeda Chemical Industries, Ltd. | Heterocyclic compounds, their production and use |
| CN100390146C (zh) * | 2002-11-13 | 2008-05-28 | 斯索恩有限公司 | 制备利培酮的方法和用于该方法的中间体 |
| EP1615924A1 (de) * | 2003-04-22 | 2006-01-18 | Synthon B.V. | Wasserlöslich salze von risperidon |
| CN101970427A (zh) | 2008-02-29 | 2011-02-09 | Vm生物医药公司 | 治疗疼痛症状及其它失调的方法 |
| EP3406252B1 (de) | 2012-02-10 | 2020-05-13 | PTC Therapeutics, Inc. | Verbindungen zur behandlung von spinaler muskelatrophie |
| EA029155B1 (ru) | 2012-03-01 | 2018-02-28 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Соединения для лечения спинальной мышечной атрофии |
| CN104470909B (zh) | 2012-03-23 | 2018-04-24 | Ptc医疗公司 | 用于治疗脊髓性肌萎缩的化合物 |
| CN105143197A (zh) * | 2013-03-15 | 2015-12-09 | Vm医药有限责任公司 | 新的晶体形式 |
| EP3082820B1 (de) | 2013-12-19 | 2022-07-20 | PTC Therapeutics, Inc. | Verfahren zur modulation der menge von rna-transkripten |
| EP4249472A3 (de) | 2015-05-30 | 2023-12-13 | PTC Therapeutics, Inc. | Verfahren zur modulation von rna-spleissen |
| MX2021001091A (es) | 2015-12-10 | 2022-04-26 | Ptc Therapeutics Inc | Compuestos para usarse en el tratamiento o mejoramiento de la enfermedad de huntington. |
| EA201991309A1 (ru) | 2016-11-28 | 2019-11-29 | Способы модуляции сплайсинга рнк | |
| EP3634953B1 (de) | 2017-06-05 | 2024-01-03 | PTC Therapeutics, Inc. | Verbindungen zur behandlung von morbus huntington |
| JP2020523365A (ja) | 2017-06-14 | 2020-08-06 | ピーティーシー セラピューティクス，インコーポレーテッド | Ｒｎａスプライシングを改変する方法 |
| MX2019015580A (es) | 2017-06-28 | 2020-07-28 | Ptc Therapeutics Inc | Metodos para tratar la enfermedad de huntington. |
| BR112019027717A2 (pt) | 2017-06-28 | 2020-07-28 | Ptc Therapeutics, Inc. | métodos para tratar a doença de huntington |
| CA3094703A1 (en) | 2018-03-27 | 2019-10-03 | Ptc Therapeutics, Inc. | Compounds for treating huntington's disease |
| EP3814360A1 (de) | 2018-06-27 | 2021-05-05 | PTC Therapeutics, Inc. | Heteroarylverbindungen zur behandlung von morbus huntington |
| EP3814357B1 (de) | 2018-06-27 | 2024-05-01 | PTC Therapeutics, Inc. | Heterocyclische und heteroaryl verbindungen zur behandlung von morbus huntington |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3412094A (en) * | 1967-06-21 | 1968-11-19 | Searle & Co | 5-alkyl-2-amino-4-azido-6-phenylpyrimidines and congeners |
| US3960863A (en) * | 1974-06-25 | 1976-06-01 | Sankyo Company Limited | Pyrido[1,2-a]pyrimidinone derivatives |
| JPS5146497A (en) * | 1974-10-19 | 1976-04-20 | Masato Aiura | Hobuban |
| JPS525795A (en) * | 1975-06-28 | 1977-01-17 | Sankyo Co Ltd | Preparation of tetrahydro pyridopyrimidinone derivatives |
| HU173438B (hu) * | 1975-11-27 | 1979-05-28 | Chinoin Gyogyszer Es Vegyeszet | Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom |
-
1980
- 1980-09-29 US US06/191,632 patent/US4342870A/en not_active Expired - Lifetime
-
1981
- 1981-03-03 GR GR64291A patent/GR72488B/el unknown
- 1981-03-04 CA CA000372258A patent/CA1163994A/en not_active Expired
- 1981-03-17 AU AU68429/81A patent/AU537700B2/en not_active Ceased
- 1981-03-17 NZ NZ196522A patent/NZ196522A/en unknown
- 1981-03-21 MA MA19313A patent/MA19107A1/fr unknown
- 1981-03-24 SU SU813261927A patent/SU1068037A3/ru active
- 1981-03-24 CS CS812134A patent/CS256366B2/cs unknown
- 1981-03-26 PH PH25429A patent/PH16530A/en unknown
- 1981-03-26 PT PT72740A patent/PT72740B/pt not_active IP Right Cessation
- 1981-03-26 IL IL62494A patent/IL62494A/xx unknown
- 1981-03-26 DK DK138281A patent/DK159390C/da not_active IP Right Cessation
- 1981-03-27 IE IE706/81A patent/IE51319B1/en not_active IP Right Cessation
- 1981-03-27 EP EP81301335A patent/EP0037265B1/de not_active Expired
- 1981-03-27 NO NO811058A patent/NO156752C/no unknown
- 1981-03-27 HU HU81783A patent/HU187329B/hu not_active IP Right Cessation
- 1981-03-27 DE DE8181301335T patent/DE3168433D1/de not_active Expired
- 1981-03-27 ES ES500814A patent/ES500814A0/es active Granted
- 1981-03-27 FI FI810956A patent/FI71737C/fi not_active IP Right Cessation
- 1981-03-27 YU YU810/81A patent/YU43010B/xx unknown
- 1981-03-27 BG BG8151433A patent/BG36199A3/xx unknown
- 1981-03-28 RO RO81103848A patent/RO82508A/ro unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES8300763A1 (es) | 1982-11-01 |
| IE51319B1 (en) | 1986-12-10 |
| IL62494A0 (en) | 1981-05-20 |
| RO82508B (ro) | 1983-08-30 |
| CS256366B2 (en) | 1988-04-15 |
| NZ196522A (en) | 1985-10-11 |
| AU537700B2 (en) | 1984-07-05 |
| US4342870A (en) | 1982-08-03 |
| GR72488B (de) | 1983-11-14 |
| DK159390B (da) | 1990-10-08 |
| FI71737C (fi) | 1987-02-09 |
| PT72740A (en) | 1981-04-01 |
| BG36199A3 (en) | 1984-09-14 |
| YU43010B (en) | 1989-02-28 |
| IE810706L (en) | 1981-09-28 |
| PT72740B (en) | 1982-11-16 |
| FI810956L (fi) | 1981-09-29 |
| DK159390C (da) | 1991-03-04 |
| AU6842981A (en) | 1981-10-01 |
| DE3168433D1 (de) | 1985-03-07 |
| SU1068037A3 (ru) | 1984-01-15 |
| FI71737B (fi) | 1986-10-31 |
| MA19107A1 (fr) | 1981-10-01 |
| RO82508A (ro) | 1983-09-26 |
| NO811058L (no) | 1981-09-29 |
| YU81081A (en) | 1983-12-31 |
| ES500814A0 (es) | 1982-11-01 |
| NO156752C (no) | 1987-11-18 |
| CA1163994A (en) | 1984-03-20 |
| PH16530A (en) | 1983-11-10 |
| DK138281A (da) | 1981-09-29 |
| HU187329B (en) | 1985-12-28 |
| EP0037265A1 (de) | 1981-10-07 |
| EP0037265B1 (de) | 1985-01-23 |
| NO156752B (no) | 1987-08-10 |
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