IL60074A - Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide,their preparation and pharmaceutical compositions containing them - Google Patents

Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL60074A
IL60074A IL60074A IL6007480A IL60074A IL 60074 A IL60074 A IL 60074A IL 60074 A IL60074 A IL 60074A IL 6007480 A IL6007480 A IL 6007480A IL 60074 A IL60074 A IL 60074A
Authority
IL
Israel
Prior art keywords
methanediol
penicillins
bis
esters
dioxide
Prior art date
Application number
IL60074A
Other languages
English (en)
Other versions
IL60074A0 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL60074A0 publication Critical patent/IL60074A0/xx
Publication of IL60074A publication Critical patent/IL60074A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/28—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with modified 2-carboxyl group
    • C07D499/32—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IL60074A 1979-05-16 1980-05-14 Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide,their preparation and pharmaceutical compositions containing them IL60074A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/039,539 US4244951A (en) 1979-05-16 1979-05-16 Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide

Publications (2)

Publication Number Publication Date
IL60074A0 IL60074A0 (en) 1980-07-31
IL60074A true IL60074A (en) 1983-09-30

Family

ID=21906015

Family Applications (1)

Application Number Title Priority Date Filing Date
IL60074A IL60074A (en) 1979-05-16 1980-05-14 Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide,their preparation and pharmaceutical compositions containing them

Country Status (44)

Country Link
US (1) US4244951A (fi)
JP (1) JPS55157589A (fi)
KR (1) KR840000105B1 (fi)
AR (1) AR226062A1 (fi)
AT (2) AT369373B (fi)
AU (1) AU520066B2 (fi)
BE (1) BE883299A (fi)
BG (1) BG35467A3 (fi)
CA (1) CA1200545A (fi)
CH (1) CH646177A5 (fi)
CS (1) CS276964B6 (fi)
DD (1) DD150898A5 (fi)
DE (2) DE3018590A1 (fi)
DK (1) DK159786C (fi)
EC (1) ECSP941080A (fi)
EG (1) EG15129A (fi)
ES (1) ES491534A0 (fi)
FI (1) FI71742C (fi)
FR (2) FR2456745A1 (fi)
GB (2) GB2051057B (fi)
GR (1) GR68468B (fi)
GT (1) GT198063473A (fi)
HK (2) HK66787A (fi)
HU (1) HU184754B (fi)
IE (1) IE49892B1 (fi)
IL (1) IL60074A (fi)
IN (1) IN154371B (fi)
IT (1) IT1131187B (fi)
KE (2) KE3460A (fi)
LU (1) LU82452A1 (fi)
MX (1) MX6717E (fi)
MY (2) MY8500322A (fi)
NL (1) NL8002793A (fi)
NO (3) NO801415L (fi)
NZ (1) NZ193713A (fi)
PH (3) PH16554A (fi)
PL (2) PL127434B1 (fi)
PT (1) PT71248A (fi)
RO (2) RO84151B (fi)
SE (1) SE449749B (fi)
SG (1) SG56284G (fi)
SU (2) SU1122226A3 (fi)
YU (1) YU41925B (fi)
ZA (1) ZA801885B (fi)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE49881B1 (en) * 1979-02-13 1986-01-08 Leo Pharm Prod Ltd B-lactam intermediates
US4309347A (en) * 1979-05-16 1982-01-05 Pfizer Inc. Penicillanoyloxymethyl penicillanate 1,1,1',1'-tetraoxide
DE3051044C2 (fi) * 1979-06-19 1989-03-30 Leo Pharmaceutical Products Ltd. A/S (Loevens Kemiske Fabrik Produktionsaktieselskab), Ballerup, Dk
US4364957A (en) * 1979-09-26 1982-12-21 Pfizer Inc. Bis-esters of alkanediols as antibacterial agents
US4342768A (en) * 1979-10-22 1982-08-03 Pfizer Inc. Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicillanic acid 1,1-dioxide and beta-lactam antibiotics
IL61880A (en) * 1980-01-21 1984-11-30 Bristol Myers Co 2beta-chloromethyl-2alpha-methylpenam-3alpha-carboxylic acid sulfone derivatives,their preparation and pharmaceutical compositions containing them
US4488994A (en) * 1980-09-08 1984-12-18 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
IE51516B1 (en) * 1980-10-06 1987-01-07 Leo Pharm Prod Ltd 1,1-dioxapenicillanoyloxymethyl 6-(d-alpha-amino-alpha-phenylacetamido)penicillanate napsylate
IL64009A (en) * 1980-10-31 1984-09-30 Rech Applications Therap Crystalline 1,1-dioxopenicillanoyloxymethyl 6-(d-alpha-amino-alpha-phenylacetamido)penicillanate tosylate hydrates,their production and pharmaceutical compositions containing them
US4474698A (en) * 1980-12-11 1984-10-02 Pfizer Inc. Process for preparing esters of penicillanic acid sulfone
US4323499A (en) * 1981-01-05 1982-04-06 Pfizer Inc. 6-(2-Aryl-2-(1,1-dioxopenicillanoyloxy-methoxycarbonyl)acetamido penicillanic acids
US4478748A (en) * 1981-02-20 1984-10-23 Pfizer Inc. Bis-esters of alkanediols
IN157669B (fi) * 1981-03-23 1986-05-17 Pfizer
US4321196A (en) * 1981-03-23 1982-03-23 Pfizer Inc. Bis-esters of methanediol with acetonides of ampicillin or amoxicillin and penicillanic acid 1,1-dioxide
US4393001A (en) * 1981-03-23 1983-07-12 Pfizer Inc. Intermediates for production of 1,1-dioxopenicillanoyloxymethyl 6-(2-amino-2-phenylacetamido)penicillanates
US4376076A (en) * 1981-03-23 1983-03-08 Pfizer Inc. Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicillanic acid 1,1-dioxide
US4381263A (en) * 1981-03-23 1983-04-26 Pfizer Inc. Process for the preparation of penicillanic acid esters
US4582829A (en) * 1981-09-09 1986-04-15 Pfizer Inc. Antibacterial 6'-(2-amino-2-[4-acyloxyphenyl]acetamido)penicillanoyloxymethyl penicillanate 1,1-dioxide compounds
US4540687A (en) * 1981-09-09 1985-09-10 Pfizer Inc. Antibacterial 6'-(2-amino-2-[4-acyloxyphenyl]acetamido)penicillanoyloxymethyl penicillanate 1,1-dioxide compounds
ZA826687B (en) * 1981-09-14 1983-07-27 Pfizer Beta-lactamase inhibiting 2-beta-substituted-2-alpha-methyl 5(r)penam-3-alpha-carboxylic acid 1,1-dioxides and intermediates therefor
US4351840A (en) * 1981-09-18 1982-09-28 Pfizer Inc. Antibacterial esters of resorcinol with ampicillin and penicillanic acid 1,1-dioxide derivatives
US4359472A (en) * 1981-12-22 1982-11-16 Pfizer Inc. Bis-hydroxymethyl carbonate bridged antibacterial agents
US4457924A (en) * 1981-12-22 1984-07-03 Pfizer, Inc. 1,1-Alkanediol dicarboxylate linked antibacterial agents
US4452796A (en) * 1982-06-14 1984-06-05 Pfizer Inc. 6-Aminoalkylpenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
EP0084730A1 (en) * 1982-01-22 1983-08-03 Beecham Group Plc Esters of penicillin derivatives with beta-lactamase inhibitors, their preparation and their use
US4444686A (en) * 1982-01-25 1984-04-24 Pfizer Inc. Crystalline penicillin ester intermediate
US4432987A (en) * 1982-04-23 1984-02-21 Pfizer Inc. Crystalline benzenesulfonate salts of sultamicillin
US4377590A (en) * 1982-05-10 1983-03-22 Pfizer Inc. Derivatives of ampicillin and amoxicillin with beta-lactamase inhibitors
US4428935A (en) 1982-05-24 1984-01-31 Pfizer Inc. Penicillanic acid dioxide prodrug
US4375434A (en) * 1982-06-21 1983-03-01 Pfizer Inc. Process for 6'-amino-penicillanoyloxymethyl penicillanate 1,1-dioxide
US4530792A (en) * 1982-11-01 1985-07-23 Pfizer Inc. Process and intermediates for preparation of 1,1-dioxopenicillanoyloxymethyl 6-beta-aminopenicillanate
US4868297A (en) * 1982-12-06 1989-09-19 Pfizer Inc. Process for preparing sultamicillin and analogs
US4462934A (en) * 1983-03-31 1984-07-31 Pfizer Inc. Bis-esters of dicarboxylic acids with amoxicillin and certain hydroxymethylpenicillanate 1,1-dioxides
US4536393A (en) * 1983-06-06 1985-08-20 Pfizer Inc. 6-(Aminomethyl)penicillanic acid 1,1-dioxide esters and intermediates therefor
JPS60214792A (ja) * 1984-04-06 1985-10-28 Taiho Yakuhin Kogyo Kk ペナム酸エステル誘導体
JPH01139584A (ja) * 1987-11-25 1989-06-01 Yoshitomi Pharmaceut Ind Ltd ペニシラン酸化合物の製造法
GB8808001D0 (en) * 1988-04-06 1988-05-05 Scras Stereospecific preparative process for furol(3,4-c)pyridine derivatives
GB8808701D0 (en) * 1988-04-13 1988-05-18 Erba Carlo Spa Beta-lactam derivatives
GB2231049A (en) * 1989-04-14 1990-11-07 Yoshitomi Pharmaceutical Method for producing diester compounds
KR910009271B1 (ko) * 1989-06-20 1991-11-08 김영설 1,1-디옥소페닐실라노일 옥시메틸 D-6-[α-(메틸렌아미노)페닐-아세트아미도]-페니실라네이트와 그의 파라-톨루엔술폰산염
DE69103003T2 (de) * 1990-04-13 1994-11-03 Pfizer Inc., Groton, Conn. Verfahren für sultamicillinzwischenprodukt.
CN100384857C (zh) 2003-11-28 2008-04-30 浙江永宁制药厂 耐β-内酰胺酶的头孢菌素酯化合物及其盐
IT202000031070A1 (it) 2020-12-16 2022-06-16 Paolo Bonomi Procedimento di sintesi di derivati ammidici dell’acido 8-idrossi penicillanico
CN115385934A (zh) * 2022-10-26 2022-11-25 北京纳百生物科技有限公司 一种舒巴坦半抗原及其合成方法和应用

Family Cites Families (10)

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Publication number Priority date Publication date Assignee Title
IE34948B1 (en) * 1970-03-12 1975-10-01 Leo Pharm Prod Ltd New penicillin esters
GB1303491A (fi) * 1970-03-24 1973-01-17
GB1335718A (en) * 1971-05-05 1973-10-31 Leo Pharm Prod Ltd Penicillin esters salts thereof and methods for their preparation
US3838152A (en) * 1971-10-07 1974-09-24 American Home Prod Poly alpha-amino penicillins
DE2460477A1 (de) * 1973-12-26 1975-07-10 Yamanouchi Pharma Co Ltd Verbessertes verfahren zur herstellung von 6-alkoxy-substituierten penicillinen
GB1467604A (en) * 1974-06-27 1977-03-16 Toyama Chemical Co Ltd Bis-type penicillins and process for producing the same
GB1578128A (en) * 1976-03-30 1980-11-05 Leo Pharm Prod Ltd Amidinopenicillanoyloxyalkyl amoxycillinates
IN149747B (fi) * 1977-06-07 1982-04-03 Pfizer
KR830001903B1 (ko) * 1979-02-13 1983-09-19 레오 파마슈티칼 프로덕츠 리미티드 페니실란산유도체의 제조방법
IE49881B1 (en) 1979-02-13 1986-01-08 Leo Pharm Prod Ltd B-lactam intermediates

Also Published As

Publication number Publication date
GB2081269A (en) 1982-02-17
BG35467A3 (en) 1984-04-15
JPS6318595B2 (fi) 1988-04-19
RO84151B (ro) 1984-07-30
GT198063473A (es) 1981-11-07
HU184754B (en) 1984-10-29
FR2477154A1 (fr) 1981-09-04
DD150898A5 (de) 1981-09-23
FR2456745A1 (fr) 1980-12-12
HK66787A (en) 1987-09-25
FR2477154B1 (fi) 1983-08-19
YU41925B (en) 1988-02-29
IT8022097A0 (it) 1980-05-15
FI801546A (fi) 1980-11-17
ZA801885B (en) 1981-04-29
KE3460A (en) 1984-10-12
FR2456745B1 (fi) 1983-08-19
DE3018590A1 (de) 1980-11-20
KE3457A (en) 1984-10-12
NO831025L (no) 1980-11-17
IE49892B1 (en) 1986-01-08
JPS55157589A (en) 1980-12-08
DK159786B (da) 1990-12-03
NO801415L (no) 1980-11-17
HK66987A (en) 1987-09-25
PL224225A1 (fi) 1981-02-13
MY8500322A (en) 1985-12-31
ES8104300A1 (es) 1981-04-01
ECSP941080A (es) 1995-02-27
BE883299A (fr) 1980-11-14
SU1122226A3 (ru) 1984-10-30
FI71742B (fi) 1986-10-31
CS276964B6 (en) 1992-11-18
GB2051057B (en) 1983-02-09
MX6717E (es) 1985-11-07
ATA258880A (de) 1982-05-15
CA1200545A (en) 1986-02-11
AT369373B (de) 1982-12-27
SU1122228A3 (ru) 1984-10-30
DK159786C (da) 1991-04-22
PH15706A (en) 1983-03-14
AU5839680A (en) 1980-11-20
SG56284G (en) 1985-03-08
IL60074A0 (en) 1980-07-31
CH646177A5 (de) 1984-11-15
IN154371B (fi) 1984-10-20
AU520066B2 (en) 1982-01-14
SE449749B (sv) 1987-05-18
PL127283B1 (en) 1983-10-31
SE8003603L (sv) 1980-11-17
IT1131187B (it) 1986-06-18
DE3050440A1 (fi) 1982-07-29
KR840000105B1 (ko) 1984-02-11
KR830002772A (ko) 1983-05-30
NZ193713A (en) 1984-05-31
GB2081269B (en) 1983-01-19
IE801007L (en) 1980-11-16
US4244951A (en) 1981-01-13
FI71742C (fi) 1987-02-09
GB2051057A (en) 1981-01-14
MY8500324A (en) 1985-12-31
NO831026L (no) 1980-11-17
GR68468B (fi) 1982-01-04
AR226062A1 (es) 1982-05-31
PT71248A (en) 1980-06-01
EG15129A (en) 1985-12-31
RO84151A (ro) 1984-05-23
PL127434B1 (en) 1983-10-31
CS325280A3 (en) 1992-05-13
DK211880A (da) 1980-11-17
PH15539A (en) 1983-02-09
YU130380A (en) 1983-02-28
RO80220A (ro) 1982-10-26
AT377522B (de) 1985-03-25
PH16554A (en) 1983-11-16
ES491534A0 (es) 1981-04-01
ATA16082A (de) 1984-08-15
LU82452A1 (fr) 1980-12-16
NL8002793A (nl) 1980-11-18

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