IL56468A - 9-deoxy-9a-methylene isosteres of pgi2,process for their preparation and pharmaceutical and veterinary compositions containing them - Google Patents

9-deoxy-9a-methylene isosteres of pgi2,process for their preparation and pharmaceutical and veterinary compositions containing them

Info

Publication number
IL56468A
IL56468A IL56468A IL5646879A IL56468A IL 56468 A IL56468 A IL 56468A IL 56468 A IL56468 A IL 56468A IL 5646879 A IL5646879 A IL 5646879A IL 56468 A IL56468 A IL 56468A
Authority
IL
Israel
Prior art keywords
pgi2
isosteres
deoxy
methylene
pharmaceutical
Prior art date
Application number
IL56468A
Other languages
English (en)
Other versions
IL56468A0 (en
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT7819616A external-priority patent/IT7819616A0/it
Priority claimed from IT3107378A external-priority patent/IT1160370B/it
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of IL56468A0 publication Critical patent/IL56468A0/xx
Publication of IL56468A publication Critical patent/IL56468A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cephalosporin Compounds (AREA)
  • External Artificial Organs (AREA)
IL56468A 1978-01-26 1979-01-19 9-deoxy-9a-methylene isosteres of pgi2,process for their preparation and pharmaceutical and veterinary compositions containing them IL56468A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT7819616A IT7819616A0 (it) 1978-01-26 1978-01-26 9-deossi-9a-metilene-isosteri della pgi 2.
IT3107378A IT1160370B (it) 1978-12-21 1978-12-21 9-deossi-9a-metilene-isosteri della pgi2

Publications (2)

Publication Number Publication Date
IL56468A0 IL56468A0 (en) 1979-03-12
IL56468A true IL56468A (en) 1986-08-31

Family

ID=26327236

Family Applications (1)

Application Number Title Priority Date Filing Date
IL56468A IL56468A (en) 1978-01-26 1979-01-19 9-deoxy-9a-methylene isosteres of pgi2,process for their preparation and pharmaceutical and veterinary compositions containing them

Country Status (26)

Country Link
US (1) US4307112A (fi)
JP (1) JPS54119444A (fi)
AT (1) AT374165B (fi)
AU (1) AU530571B2 (fi)
CA (1) CA1209133A (fi)
CH (1) CH647222A5 (fi)
DE (1) DE2902442A1 (fi)
DK (1) DK35779A (fi)
ES (1) ES477172A1 (fi)
FI (1) FI72509C (fi)
FR (3) FR2422634A1 (fi)
GB (3) GB2013661B (fi)
GR (1) GR73109B (fi)
HK (1) HK18483A (fi)
IE (1) IE48311B1 (fi)
IL (1) IL56468A (fi)
KE (1) KE3262A (fi)
MY (1) MY8400104A (fi)
NL (1) NL7900369A (fi)
NO (1) NO153926C (fi)
NZ (1) NZ189461A (fi)
PT (1) PT69129A (fi)
SE (2) SE453291B (fi)
SG (1) SG4083G (fi)
SU (1) SU1053745A3 (fi)
YU (2) YU15579A (fi)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4732914A (en) * 1978-02-13 1988-03-22 The Upjohn Company Prostacyclin analogs
DE2845770A1 (de) * 1978-10-19 1980-04-30 Schering Ag Neue prostacyclin-derivate und verfahren zu ihrer herstellung
JPS55105638A (en) * 1979-02-09 1980-08-13 Sumitomo Chem Co Ltd Aldol derivative and its preparation
US4525586A (en) * 1980-02-28 1985-06-25 The Upjohn Company Composition and process
JPS56145239A (en) * 1980-04-11 1981-11-11 Sumitomo Chem Co Ltd Novel bicyclooctane derivative and its preparation
DE3025325A1 (de) * 1980-07-04 1982-02-04 Merck Patent Gmbh, 6100 Darmstadt Neue 13-thiaprostaglandin-zwischenprodukte, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von 13-thiaprostaglandin-derivaten
DE3048906A1 (de) * 1980-12-19 1982-07-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
EP0063538B1 (de) * 1981-04-13 1986-08-06 Schering Aktiengesellschaft Neue Prostaglandine und Prostacycline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE3121155A1 (de) * 1981-05-22 1982-12-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
IL67332A (en) * 1981-12-01 1985-12-31 Chinoin Gyogyszer Es Vegyeszet Inter-m-phenylene-prostacyclin analogues,process for the preparation thereof and pharmaceutical compositions containing them
JPS58121243A (ja) * 1982-01-12 1983-07-19 Sumitomo Chem Co Ltd 新規ビシクロオクタン誘導体及びその製造法
US4588823A (en) * 1982-02-16 1986-05-13 The Upjohn Company 9-substituted carbacyclin analogs
US4533749A (en) * 1982-02-16 1985-08-06 The Upjohn Company 9-Substituted carbacyclin analogs
US4590297A (en) * 1982-02-16 1986-05-20 The Upjohn Company Novel 9-substituted carbacyclin analogs
US4487961A (en) * 1982-02-16 1984-12-11 The Upjohn Company 9-Substituted carbacyclin analogs
DE3306125A1 (de) * 1983-02-18 1984-08-23 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4486598A (en) * 1982-02-22 1984-12-04 The Upjohn Company Carbacyclin analogs
GR77976B (fi) * 1982-03-12 1984-09-25 Schering Ag
US4490555A (en) * 1982-03-19 1984-12-25 The Upjohn Company 9-Substituted carbacyclin analogs
US4585886A (en) * 1982-03-19 1986-04-29 The Upjohn Company 9-Substituted carbacyclin analogs
US4487960A (en) * 1982-04-19 1984-12-11 The Upjohn Company 9-Substituted carbacyclin analogs
US4689345A (en) * 1982-05-06 1987-08-25 Cbd Corporation Oxygenated alkyl substituted bicyclo alkanes
DE3378265D1 (en) * 1982-05-06 1988-11-24 Cbd Corp Cycloaliphatic pharmaceutical compounds
US4689349A (en) * 1982-05-06 1987-08-25 Cbd Corporation Anti-tumor halo bicyclo alkanones
DE3225287A1 (de) * 1982-07-02 1984-01-05 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacyclinamide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3226550A1 (de) * 1982-07-13 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4423068A (en) * 1982-07-14 1983-12-27 Syntex (U.S.A.) Inc. (3.2.0) Bicycloheptanone oxime ethers with therapeutic properties
HU191110B (en) * 1982-10-01 1987-01-28 Farmitala Carlo Erba Spa,It Process for the production of the 15-cycloaliphatic derivatives 13,14-didehydro-carbaprostacyclines
EP0108451A3 (en) * 1982-11-05 1985-04-10 The Procter & Gamble Company Novel prostaglandin analogues
GB2135881A (en) * 1983-03-02 1984-09-12 Erba Farmitalia Method and pharmaceutical compositions for inhibiting or reducing gastrointestinal side effects of non-steroidal anti-inflammatory drugs
US4561604A (en) * 1983-07-18 1985-12-31 Shimano Industrial Company Limited Spinning reel
JPS60181041A (ja) * 1984-02-29 1985-09-14 Sankyo Co Ltd カルバサイクリン誘導体
JPS60172941A (ja) * 1984-02-16 1985-09-06 Sankyo Co Ltd カルバサイクリン類
JPS6092255A (ja) * 1983-10-26 1985-05-23 Sumitomo Chem Co Ltd 新規ビシクロオクタン誘導体及び製造法
DE3405181A1 (de) * 1984-02-10 1985-08-22 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4683330A (en) * 1984-03-08 1987-07-28 The Upjohn Company Interphenylene carbacyclin derivatives
US4668814A (en) * 1984-03-08 1987-05-26 The Upjohn Company Interphenylene carbacyclin derivatives
GB2156342B (en) * 1984-03-26 1987-12-23 Erba Farmitalia 13,14,19,20-tetradehydro derivatives of carboprostacyclins and process for their preparation
GB2156340A (en) * 1984-03-26 1985-10-09 Erba Farmitalia 1-Nor-2-hydroxymethyl-derivatives of carboprostacyclins and process for their preparation
DE3428266A1 (de) * 1984-07-27 1986-01-30 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4757087A (en) * 1985-03-19 1988-07-12 Sankyo Company Limited Carbacyclin derivatives
JPS61280294A (ja) * 1985-06-04 1986-12-10 Nisshin Flour Milling Co Ltd 光学活性カルバサイクリン中間体の製造方法
JPS62153259A (ja) * 1985-12-26 1987-07-08 Sagami Chem Res Center （２−クロロ−３−オキソ−１−アルケニル）−ビシクロ〔３．３．０〕オクテン誘導体及びその製法
GB2225573A (en) * 1988-09-16 1990-06-06 Ueno Seiyaku Oyo Kenkyujo Kk 13,14-dihydro-15-keto-PGFs
JP3250936B2 (ja) * 1995-03-10 2002-01-28 科学技術振興事業団 イソカルバサイクリン誘導体
JP6207065B2 (ja) * 2012-10-01 2017-10-04 住友化学株式会社 塩、レジスト組成物及びレジストパターンの製造方法
CN111689994B (zh) * 2020-06-05 2023-06-13 安徽师范大学 以联芴Aza-BODIPY为基本骨架的有机共轭分子材料及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5495552A (en) * 1978-01-06 1979-07-28 Sankyo Co Ltd Prostacyline derivative and its preparation
US4705806A (en) * 1978-02-13 1987-11-10 Morton Jr Douglas R Prostacyclin analogs
JPS54119441A (en) * 1978-03-09 1979-09-17 Sumitomo Chem Co Ltd Novel bicyclooctane derivative
GB2017699B (en) * 1978-03-31 1983-01-12 Ono Pharmaceutical Co 6,9-methano-pgi2 analogues
DE2845770A1 (de) * 1978-10-19 1980-04-30 Schering Ag Neue prostacyclin-derivate und verfahren zu ihrer herstellung
JPS55105638A (en) * 1979-02-09 1980-08-13 Sumitomo Chem Co Ltd Aldol derivative and its preparation
US4225507A (en) * 1979-07-05 1980-09-30 The Upjohn Company 19-Hydroxy-19-methyl-PGI2 compounds

Also Published As

Publication number Publication date
SE453291B (sv) 1988-01-25
IE48311B1 (en) 1984-12-12
FI790178A (fi) 1979-07-27
FR2422634B1 (fi) 1982-08-20
ES477172A1 (es) 1980-03-01
YU21783A (en) 1983-09-30
GB2013661A (en) 1979-08-15
JPS54119444A (en) 1979-09-17
SU1053745A3 (ru) 1983-11-07
ATA45279A (de) 1983-08-15
IL56468A0 (en) 1979-03-12
IE790145L (en) 1979-07-26
NZ189461A (en) 1982-03-23
AU530571B2 (en) 1983-07-21
MY8400104A (en) 1984-12-31
SG4083G (en) 1984-07-20
CA1209133A (en) 1986-08-05
FI72509B (fi) 1987-02-27
SE8303479D0 (sv) 1983-06-17
FR2466445A1 (fr) 1981-04-10
GB2013661B (en) 1982-11-10
SE453289B (sv) 1988-01-25
YU15579A (en) 1983-09-30
AT374165B (de) 1984-03-26
PT69129A (en) 1979-02-01
NO153926C (no) 1986-06-18
FR2466446A1 (fr) 1981-04-10
NL7900369A (nl) 1979-07-30
FI72509C (fi) 1987-06-08
NO790257L (no) 1979-07-27
DE2902442A1 (de) 1979-08-30
DK35779A (da) 1979-09-06
GB2038333B (en) 1982-10-06
FR2466446B1 (fi) 1983-02-11
GR73109B (fi) 1984-02-02
GB2040928B (en) 1982-12-08
KE3262A (en) 1983-03-25
GB2040928A (en) 1980-09-03
CH647222A5 (de) 1985-01-15
AU4343879A (en) 1979-08-02
US4307112A (en) 1981-12-22
SE7900685L (sv) 1979-07-27
FR2466445B1 (fi) 1983-04-22
FR2422634A1 (fr) 1979-11-09
GB2038333A (en) 1980-07-23
NO153926B (no) 1986-03-10
HK18483A (en) 1983-06-10
SE8303479L (sv) 1983-06-17
YU42835B (en) 1988-12-31

Similar Documents

Publication Publication Date Title
IL56468A (en) 9-deoxy-9a-methylene isosteres of pgi2,process for their preparation and pharmaceutical and veterinary compositions containing them
PH15877A (en) Novel n-heterocyclyl-4-piperidiamines,pharmaceutical composition containing same and method of use
DE3064173D1 (en) Novel 20-0-acylmaytansinoids, process for their preparation and pharmaceutical compositions containing them
IL56411A0 (en) New derivatives of 4-amino-5-alkylsulphonyl-ortho-anisamides, their preparation and pharmaceutical compositions containing them
IL56734A0 (en) Phemoxyalkylcarboxylic acid derivatives,process for their preparation and pharmaceutical compositions containing thesame
IL59915A (en) Amides of acyl-carnitines,process for their preparation and pharmaceutical compositions containing them
PH18091A (en) Novel spiro-oxazolidindiones,pharmaceutical compositions containing same and method of use thereof
IL56115A (en) 14-deoxy-14-glycoside-mutilin derivatives,process for their preparation and pharmaceutical and veterinary compositions containing them
IL57662A (en) Acyl-esters of carnitine,process for their preparation and pharmaceutical compositions comprising them
DE2960954D1 (en) 1-aryloxy-3-nitratoalkylamino-2-propanols, process for their preparation and pharmaceutical compositions
DE2964209D1 (en) Spiro-furanohydantoin derivatives, process for their preparation and pharmaceutical compositions containing them
ZA791276B (en) N-oxacyclic-alkylpiperidyl-diazacompounds,process for their manufacture and pharmaceutical compositions containing them
DE2962112D1 (en) Alkanolamine derivatives, process for their preparation and pharmaceutical compositions containing them
EP0003144A3 (en) 4-pyridone-3-carboxylic acid derivatives, pharmaceutical compositions containing them, processes for their preparation, their application and intermediates in their preparation
PH13924A (en) Glavulanic acid derivatives,pharmaceutical compositions containing same and method of preparation thereof
GB2038802B (en) Aryltrifluoroethanols process for their preparation and pharmaceutical compositions containing them
ZA793682B (en) New piperidylbenzimidazolinone derivatives,processes for their preparation and pharmaceutical compositions containing them
IL57533A (en) 17alpha-acetylene derivatives of androst-4-ene,process for preparing them and pharmaceutical compositions containing them
DE2966444D1 (en) Benzopyranotriazoles, preparation of these compounds and pharmaceutical composition containing them
DE2961285D1 (en) Frenolicin b, process for preparation thereof and pharmaceutical compositions containing it
DE2960503D1 (en) Novel androstadienes, processes for their preparation and pharmaceutical compositions containing them
IL61099A (en) 9-deoxy-6,9alpha-imino-delta6,8-pgi analogues,process for their preparation and pharmaceutical compositions containing them
DE2860212D1 (en) 4-phenyl-8-amino-tetrahydroisoquinolines, pharmaceutical compositions containing them and process for preparation of these compositions
EP0008421A3 (en) Benzodiazepine derivatives, their application, process and intermediates for their preparation and pharmaceutical compositions containing them
IL56613A0 (en) Carboxylates of 3-oxo-androst adienes,their preparation and pharmaceutical compositions containing same