IL49325A - 8-aza-11-deoxy-pge1 derivatives,their preparation and pharmaceutical compositions containing them - Google Patents

8-aza-11-deoxy-pge1 derivatives,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL49325A
IL49325A IL49325A IL4932576A IL49325A IL 49325 A IL49325 A IL 49325A IL 49325 A IL49325 A IL 49325A IL 4932576 A IL4932576 A IL 4932576A IL 49325 A IL49325 A IL 49325A
Authority
IL
Israel
Prior art keywords
aza
deoxy
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
IL49325A
Other languages
English (en)
Other versions
IL49325A0 (en
Original Assignee
Labaz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labaz filed Critical Labaz
Priority to IL49325A priority Critical patent/IL49325A/xx
Publication of IL49325A0 publication Critical patent/IL49325A0/xx
Priority to GB12991/77A priority patent/GB1574246A/en
Priority to BE176164A priority patent/BE852941A/xx
Priority to PL1977210101A priority patent/PL107544B1/pl
Priority to PL1977197005A priority patent/PL107643B1/pl
Priority to DD7700198124A priority patent/DD130352A5/xx
Priority to PL1977210102A priority patent/PL108289B1/pl
Priority to CA275,134A priority patent/CA1074804A/en
Priority to SE7703698A priority patent/SE417603B/xx
Priority to NO771134A priority patent/NO149428C/no
Priority to HU77LA913A priority patent/HU178040B/hu
Priority to CH400377A priority patent/CH624101A5/fr
Priority to DE19772714129 priority patent/DE2714129A1/de
Priority to SU772465855A priority patent/SU676162A3/ru
Priority to FR7709650A priority patent/FR2346332A1/fr
Priority to NL7703503A priority patent/NL7703503A/xx
Priority to IT21906/77A priority patent/IT1075373B/it
Priority to JP3742877A priority patent/JPS52142060A/ja
Priority to US05/783,284 priority patent/US4115401A/en
Priority to ES457385A priority patent/ES457385A1/es
Priority to SU782594353A priority patent/SU837321A3/ru
Priority to SU782595450A priority patent/SU715019A3/ru
Publication of IL49325A publication Critical patent/IL49325A/xx
Priority to CH697780A priority patent/CH628032A5/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/126—Acids containing more than four carbon atoms
    • C07C53/128—Acids containing more than four carbon atoms the carboxylic group being bound to a carbon atom bound to at least two other carbon atoms, e.g. neo-acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
IL49325A 1976-03-31 1976-03-31 8-aza-11-deoxy-pge1 derivatives,their preparation and pharmaceutical compositions containing them IL49325A (en)

Priority Applications (23)

Application Number Priority Date Filing Date Title
IL49325A IL49325A (en) 1976-03-31 1976-03-31 8-aza-11-deoxy-pge1 derivatives,their preparation and pharmaceutical compositions containing them
GB12991/77A GB1574246A (en) 1976-03-31 1977-03-28 Prostaglandin derivatives and process for preparing the same
BE176164A BE852941A (fr) 1976-03-31 1977-03-28 Nouveaux derives de prostaglandine
PL1977210101A PL107544B1 (pl) 1976-03-31 1977-03-29 Sposob wytwarzania nowych pochodnych prostaglandyn
PL1977197005A PL107643B1 (pl) 1976-03-31 1977-03-29 Sposob wytwarzania nowych pochodnych prostaglandyn
DD7700198124A DD130352A5 (de) 1976-03-31 1977-03-29 Verfahren zur herstellung von prostaglandin-derivaten
PL1977210102A PL108289B1 (pl) 1976-03-31 1977-03-29 Sposob wytwarzania nowych pochodnych prostaglandynmethod of producing new derivatives of prostaglandins
DE19772714129 DE2714129A1 (de) 1976-03-31 1977-03-30 Prostaglandinderivate, verfahren zu deren herstellung und deren verwendung
HU77LA913A HU178040B (en) 1976-03-31 1977-03-30 Process for preparing 8-aza-prostaglandin derivatives
SE7703698A SE417603B (sv) 1976-03-31 1977-03-30 Forfarande for framstellning av derivat av 8-aza-11-deoxiprostaglandin e?711 med terapeutiska egenskaper
NO771134A NO149428C (no) 1976-03-31 1977-03-30 Fremgangsmaate for fremstilling av fysiologisk aktive prostaglandinderivater.
CA275,134A CA1074804A (en) 1976-03-31 1977-03-30 Prostaglandin derivatives and process of preparing the same
CH400377A CH624101A5 (ru) 1976-03-31 1977-03-30
ES457385A ES457385A1 (es) 1976-03-31 1977-03-31 Procedimiento para preparar derivados de prostaglandinas.
IT21906/77A IT1075373B (it) 1976-03-31 1977-03-31 Derivati della prostaglandina e procedimento per la loro preparazione
FR7709650A FR2346332A1 (fr) 1976-03-31 1977-03-31 Nouveaux derives de prostaglandine, leur procede de preparation ainsi que les compositions therapeutiques les contenant
NL7703503A NL7703503A (nl) 1976-03-31 1977-03-31 Werkwijze voor de bereiding van nieuwe prostag- landine derivaten.
SU772465855A SU676162A3 (ru) 1976-03-31 1977-03-31 Способ получени производных простагландина
JP3742877A JPS52142060A (en) 1976-03-31 1977-03-31 Prostaglandin derivative its preparation and medicine containing same
US05/783,284 US4115401A (en) 1976-03-31 1977-03-31 Prostaglandin derivatives and process for preparing the same
SU782594353A SU837321A3 (ru) 1976-03-31 1978-03-30 Способ получени производныхпРОСТАглАНдиНА
SU782595450A SU715019A3 (ru) 1976-03-31 1978-03-30 Способ получени - -карбокси -1-гексил-5-/3 -ацетокси-1-октен (е)- ил/-2-пирролидинона
CH697780A CH628032A5 (fr) 1976-03-31 1980-09-17 Procede de preparation de derives de prostaglandine.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL49325A IL49325A (en) 1976-03-31 1976-03-31 8-aza-11-deoxy-pge1 derivatives,their preparation and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
IL49325A0 IL49325A0 (en) 1976-05-31
IL49325A true IL49325A (en) 1979-11-30

Family

ID=11048789

Family Applications (1)

Application Number Title Priority Date Filing Date
IL49325A IL49325A (en) 1976-03-31 1976-03-31 8-aza-11-deoxy-pge1 derivatives,their preparation and pharmaceutical compositions containing them

Country Status (18)

Country Link
US (1) US4115401A (ru)
JP (1) JPS52142060A (ru)
BE (1) BE852941A (ru)
CA (1) CA1074804A (ru)
CH (2) CH624101A5 (ru)
DD (1) DD130352A5 (ru)
DE (1) DE2714129A1 (ru)
ES (1) ES457385A1 (ru)
FR (1) FR2346332A1 (ru)
GB (1) GB1574246A (ru)
HU (1) HU178040B (ru)
IL (1) IL49325A (ru)
IT (1) IT1075373B (ru)
NL (1) NL7703503A (ru)
NO (1) NO149428C (ru)
PL (3) PL107544B1 (ru)
SE (1) SE417603B (ru)
SU (3) SU676162A3 (ru)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1117403B (it) * 1978-07-11 1986-02-17 Glaxo Group Ltd Composti prostanoidi e procedimento per produrli
US4320136A (en) * 1980-08-11 1982-03-16 E. I. Du Pont De Nemours And Company 8-Aza-16,16-difluoroprostanoids
US4530933A (en) * 1982-12-27 1985-07-23 E. I. Du Pont De Nemours And Company 8-Aza-13-thiaprostanoids and a method of use thereof as anti-ulcer agents
US4456613A (en) * 1982-12-27 1984-06-26 E. I. Du Pont De Nemours And Company 6-Keto- and 6-hydroxy-8-azaprostanoids and anti-ulcer use thereof
AP2002002555A0 (en) 1999-12-22 2002-06-30 Pfizer Prod Inc EP4 Receptor selective agonists in the treatment of osteoporosis.
CN1476429A (zh) * 2000-11-27 2004-02-18 �Ʒ� 治疗骨质疏松的ep4受体选择性激动剂
BR0211167A (pt) * 2001-07-16 2004-08-10 Hoffmann La Roche Derivados de 2-pirrolidona como agonistas de prostanóides
EP1409455B1 (en) 2001-07-16 2006-01-04 F. Hoffmann-La Roche Ag Prostaglandin analogues-as ep4 receptor agonists
WO2003009872A1 (en) * 2001-07-23 2003-02-06 Ono Pharmaceutical Co., Ltd. Remedies for diseases with bone mass loss having ep4 agonist as the active ingredient
WO2003074483A1 (fr) 2002-03-05 2003-09-12 Ono Pharmaceutical Co., Ltd. Composes derives de 8 azaprostaglandine et medicaments contenant ceux-ci comme principe actif
MXPA04009036A (es) * 2002-03-18 2005-01-25 Pfizer Prod Inc Uso de agonistas del receptor ep4 selectivos para el tratamiento de la insuficiencia hepatica, perdida de permeabilidad del ductus arterioso, glaucoma o hipertension ocular.
JP2006515015A (ja) * 2003-01-10 2006-05-18 エフ．ホフマン−ラ　ロシュ　アーゲー プロスタグランジンアゴニストとしての２−ピペリドン誘導体
US7179820B2 (en) 2003-06-06 2007-02-20 Allergan, Inc. Piperidinyl prostaglandin E analogs
US20080058375A1 (en) * 2004-01-08 2008-03-06 Elworthy Todd R 2-Piperidone derivatives as prostaglandin antagonists

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3975399A (en) * 1974-08-06 1976-08-17 E. I. Du Pont De Nemours And Company 1,5-Disubstituted-2-pyrrolidinones, -3-pyrrolin-2-ones, and -4-pyrrolin-2-ones

Also Published As

Publication number Publication date
GB1574246A (en) 1980-09-03
PL108289B1 (pl) 1980-03-31
NO149428B (no) 1984-01-09
PL107643B1 (pl) 1980-02-29
IL49325A0 (en) 1976-05-31
NO771134L (no) 1977-10-03
NL7703503A (nl) 1977-10-04
CA1074804A (en) 1980-04-01
FR2346332B1 (ru) 1980-05-09
FR2346332A1 (fr) 1977-10-28
SU715019A3 (ru) 1980-02-05
JPS52142060A (en) 1977-11-26
PL107544B1 (pl) 1980-02-29
CH628032A5 (fr) 1982-02-15
DD130352A5 (de) 1978-03-22
NO149428C (no) 1984-04-18
SE7703698L (sv) 1977-10-01
US4115401A (en) 1978-09-19
BE852941A (fr) 1977-09-28
ES457385A1 (es) 1978-02-01
IT1075373B (it) 1985-04-22
HU178040B (en) 1982-02-28
SU676162A3 (ru) 1979-07-25
SE417603B (sv) 1981-03-30
DE2714129A1 (de) 1977-10-13
CH624101A5 (ru) 1981-07-15
PL197005A1 (pl) 1978-10-09
SU837321A3 (ru) 1981-06-07

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