SE417603B - Forfarande for framstellning av derivat av 8-aza-11-deoxiprostaglandin e?711 med terapeutiska egenskaper - Google Patents

Forfarande for framstellning av derivat av 8-aza-11-deoxiprostaglandin e?711 med terapeutiska egenskaper

Info

Publication number
SE417603B
SE417603B SE7703698A SE7703698A SE417603B SE 417603 B SE417603 B SE 417603B SE 7703698 A SE7703698 A SE 7703698A SE 7703698 A SE7703698 A SE 7703698A SE 417603 B SE417603 B SE 417603B
Authority
SE
Sweden
Prior art keywords
deoxiprostaglandin
aza
procedure
preparing derivatives
therapeutical properties
Prior art date
Application number
SE7703698A
Other languages
English (en)
Swedish (sv)
Other versions
SE7703698L (sv
Inventor
S Nanthavong
C Pigerol
P Eymard
J Simiand
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of SE7703698L publication Critical patent/SE7703698L/xx
Publication of SE417603B publication Critical patent/SE417603B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24Oxygen or sulfur atoms
    • C07D207/262-Pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/126Acids containing more than four carbon atoms
    • C07C53/128Acids containing more than four carbon atoms the carboxylic group being bound to a carbon atom bound to at least two other carbon atoms, e.g. neo-acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
SE7703698A 1976-03-31 1977-03-30 Forfarande for framstellning av derivat av 8-aza-11-deoxiprostaglandin e?711 med terapeutiska egenskaper SE417603B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL49325A IL49325A (en) 1976-03-31 1976-03-31 8-aza-11-deoxy-pge1 derivatives,their preparation and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
SE7703698L SE7703698L (sv) 1977-10-01
SE417603B true SE417603B (sv) 1981-03-30

Family

ID=11048789

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7703698A SE417603B (sv) 1976-03-31 1977-03-30 Forfarande for framstellning av derivat av 8-aza-11-deoxiprostaglandin e?711 med terapeutiska egenskaper

Country Status (18)

Country Link
US (1) US4115401A (xx)
JP (1) JPS52142060A (xx)
BE (1) BE852941A (xx)
CA (1) CA1074804A (xx)
CH (2) CH624101A5 (xx)
DD (1) DD130352A5 (xx)
DE (1) DE2714129A1 (xx)
ES (1) ES457385A1 (xx)
FR (1) FR2346332A1 (xx)
GB (1) GB1574246A (xx)
HU (1) HU178040B (xx)
IL (1) IL49325A (xx)
IT (1) IT1075373B (xx)
NL (1) NL7703503A (xx)
NO (1) NO149428C (xx)
PL (3) PL108289B1 (xx)
SE (1) SE417603B (xx)
SU (3) SU676162A3 (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5536475A (en) * 1978-07-11 1980-03-14 Glaxo Group Ltd Prostanoid compound
US4320136A (en) * 1980-08-11 1982-03-16 E. I. Du Pont De Nemours And Company 8-Aza-16,16-difluoroprostanoids
US4456613A (en) * 1982-12-27 1984-06-26 E. I. Du Pont De Nemours And Company 6-Keto- and 6-hydroxy-8-azaprostanoids and anti-ulcer use thereof
US4530933A (en) * 1982-12-27 1985-07-23 E. I. Du Pont De Nemours And Company 8-Aza-13-thiaprostanoids and a method of use thereof as anti-ulcer agents
OA12117A (en) 1999-12-22 2006-05-04 Pfizer Prod Inc EP4 receptor selective agonists in the treatment of osteoporosis.
PT1339678E (pt) * 2000-11-27 2007-11-30 Pfizer Prod Inc Agonistas selectivos do receptor ep4 no tratamento de osteoporose
AU2002328338C1 (en) * 2001-07-16 2009-01-08 Ono Pharmaceutical Co., Ltd 2 pyrrolidone derivatives as prostanoid agonists
BR0211201A (pt) 2001-07-16 2004-07-13 Hoffmann La Roche Composto, processo para a preparação desse composto, sua utilização, composição farmacêutica que compreende o mesmo e método para o tratamento de uma enfermidade em um mamìfero
TWI313608B (en) 2001-07-23 2009-08-21 Ono Pharmaceutical Co Lower bone mass treating agent containing er4 agonist as active ingredient
JP4547912B2 (ja) 2002-03-05 2010-09-22 小野薬品工業株式会社 8−アザプロスタグランジン誘導体化合物およびその化合物を有効成分として含有する薬剤
CA2479222A1 (en) * 2002-03-18 2003-09-25 Pfizer Products Inc. Use of selective ep4 receptor agonists for the treatment of liver failure, loss of patency of the ductus arteriosus, glaucoma or ocular hypertension
MXPA05007341A (es) * 2003-01-10 2005-09-30 Hoffmann La Roche Derivados de 2-piperidona como agonistas de prostaglandina.
US7179820B2 (en) 2003-06-06 2007-02-20 Allergan, Inc. Piperidinyl prostaglandin E analogs
US20080058375A1 (en) * 2004-01-08 2008-03-06 Elworthy Todd R 2-Piperidone derivatives as prostaglandin antagonists

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3975399A (en) * 1974-08-06 1976-08-17 E. I. Du Pont De Nemours And Company 1,5-Disubstituted-2-pyrrolidinones, -3-pyrrolin-2-ones, and -4-pyrrolin-2-ones

Also Published As

Publication number Publication date
JPS52142060A (en) 1977-11-26
SE7703698L (sv) 1977-10-01
SU676162A3 (ru) 1979-07-25
IT1075373B (it) 1985-04-22
CA1074804A (en) 1980-04-01
PL107643B1 (pl) 1980-02-29
DE2714129A1 (de) 1977-10-13
US4115401A (en) 1978-09-19
NO149428C (no) 1984-04-18
NL7703503A (nl) 1977-10-04
BE852941A (fr) 1977-09-28
CH628032A5 (fr) 1982-02-15
PL197005A1 (pl) 1978-10-09
NO771134L (no) 1977-10-03
FR2346332B1 (xx) 1980-05-09
PL108289B1 (pl) 1980-03-31
IL49325A (en) 1979-11-30
ES457385A1 (es) 1978-02-01
HU178040B (en) 1982-02-28
SU715019A3 (ru) 1980-02-05
PL107544B1 (pl) 1980-02-29
CH624101A5 (xx) 1981-07-15
FR2346332A1 (fr) 1977-10-28
IL49325A0 (en) 1976-05-31
DD130352A5 (de) 1978-03-22
GB1574246A (en) 1980-09-03
NO149428B (no) 1984-01-09
SU837321A3 (ru) 1981-06-07

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