IL42384A - N-benzhydryl-n'-p-hydroxybenzyl-piperazines and processes for their manufacture and pharmaceutical compositions containing them - Google Patents

N-benzhydryl-n'-p-hydroxybenzyl-piperazines and processes for their manufacture and pharmaceutical compositions containing them

Info

Publication number
IL42384A
IL42384A IL42384A IL4238473A IL42384A IL 42384 A IL42384 A IL 42384A IL 42384 A IL42384 A IL 42384A IL 4238473 A IL4238473 A IL 4238473A IL 42384 A IL42384 A IL 42384A
Authority
IL
Israel
Prior art keywords
hydrogen
benzhydryl
manufacture
compounds
general formula
Prior art date
Application number
IL42384A
Other languages
English (en)
Other versions
IL42384A0 (en
Original Assignee
Cassella Farbwerke Mainkur Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2226767A external-priority patent/DE2226767A1/de
Priority claimed from DE19732312212 external-priority patent/DE2312212A1/de
Application filed by Cassella Farbwerke Mainkur Ag filed Critical Cassella Farbwerke Mainkur Ag
Publication of IL42384A0 publication Critical patent/IL42384A0/xx
Publication of IL42384A publication Critical patent/IL42384A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Catalysts (AREA)
IL42384A 1972-06-02 1973-05-29 N-benzhydryl-n'-p-hydroxybenzyl-piperazines and processes for their manufacture and pharmaceutical compositions containing them IL42384A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2226767A DE2226767A1 (de) 1972-06-02 1972-06-02 N-benzhydryl-n'-p-hydroxybenzylpiperazin und verfahren zu seiner herstellung
DE19732312212 DE2312212A1 (de) 1973-03-12 1973-03-12 N-(p-chlorbenzhydryl)-n'-p-hydroxybenzyl-piperazin und verfahren zu seiner herstellung

Publications (2)

Publication Number Publication Date
IL42384A0 IL42384A0 (en) 1973-07-30
IL42384A true IL42384A (en) 1976-12-31

Family

ID=25763357

Family Applications (1)

Application Number Title Priority Date Filing Date
IL42384A IL42384A (en) 1972-06-02 1973-05-29 N-benzhydryl-n'-p-hydroxybenzyl-piperazines and processes for their manufacture and pharmaceutical compositions containing them

Country Status (26)

Country Link
US (1) US3868377A (sv)
JP (1) JPS4948687A (sv)
AR (5) AR201001A1 (sv)
AT (3) AT331252B (sv)
AU (1) AU470393B2 (sv)
BG (3) BG20371A3 (sv)
CA (1) CA980347A (sv)
CH (4) CH579064A5 (sv)
CS (4) CS178429B2 (sv)
DD (1) DD106644A5 (sv)
DK (1) DK139751C (sv)
EG (1) EG11434A (sv)
ES (3) ES415466A1 (sv)
FI (1) FI55656C (sv)
FR (1) FR2186265B1 (sv)
GB (1) GB1386916A (sv)
HU (1) HU165312B (sv)
IE (1) IE37717B1 (sv)
IL (1) IL42384A (sv)
NL (1) NL7306771A (sv)
NO (1) NO138026C (sv)
PH (1) PH9485A (sv)
PL (3) PL91050B1 (sv)
RO (3) RO68379A (sv)
SE (1) SE396385B (sv)
SU (4) SU507238A3 (sv)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59101475A (ja) * 1982-12-02 1984-06-12 Nippon Chemiphar Co Ltd 新規ピペラジン誘導体およびその製造法ならびにこれを含有する脳循環改善剤
HU186656B (en) * 1982-12-28 1985-09-30 Richter Gedeon Vegyeszet Process for producing new benzhydryl-piperazine derivatives, acid additionak salts and pharmaceutical compositions containing them
GB8320701D0 (en) * 1983-08-01 1983-09-01 Wellcome Found Chemotherapeutic agent
JPS60222472A (ja) * 1984-03-30 1985-11-07 Kanebo Ltd 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物
EP0354068B1 (en) * 1988-08-05 1994-06-15 Nippon Chemiphar Co., Ltd. Optically active piperazine derivative
FR2661176B1 (fr) * 1990-04-20 1992-06-12 Adir Nouveau procede de preparation de la 1-(2,3,4-trimethoxybenzyl) piperazine en amination reductive.
WO1995015958A1 (en) * 1993-12-08 1995-06-15 Alcon Laboratories, Inc. Compounds having both potent calcium antagonist and antioxidant activity and use thereof as cytoprotective agents
AU2009254959B2 (en) * 2008-06-02 2014-01-30 Cipla Limited Processes for the synthesis of levocetirizine and intermediates for use therein

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2709169A (en) * 1955-05-24 X c chs
US3051710A (en) * 1959-12-21 1962-08-28 Lakeside Lab Inc Glycolic acid amide derivatives of piperazine and use thereof

Also Published As

Publication number Publication date
JPS4948687A (sv) 1974-05-11
CS182234B2 (en) 1978-04-28
NL7306771A (sv) 1973-12-04
SE396385B (sv) 1977-09-19
FI55656C (fi) 1979-09-10
BG20596A3 (sv) 1975-12-05
CS178430B2 (sv) 1977-09-15
BG20595A3 (sv) 1975-12-05
RO68379A (ro) 1981-11-24
US3868377A (en) 1975-02-25
DD106644A5 (sv) 1974-06-20
IL42384A0 (en) 1973-07-30
NO138026C (no) 1978-06-14
IE37717B1 (en) 1977-09-28
DK139751B (da) 1979-04-09
AR200764A1 (es) 1974-12-13
FR2186265A1 (sv) 1974-01-11
BG20371A3 (sv) 1975-11-05
EG11434A (en) 1977-09-30
PL94759B1 (pl) 1977-08-31
PH9485A (en) 1976-01-08
SU577995A3 (ru) 1977-10-25
PL97129B1 (pl) 1978-02-28
AR204987A1 (es) 1976-03-31
ATA483073A (de) 1975-12-15
CS182248B2 (en) 1978-04-28
AU5634373A (en) 1974-12-05
CA980347A (en) 1975-12-23
ATA483173A (de) 1975-12-15
ES415465A1 (es) 1976-05-16
CS178429B2 (sv) 1977-09-15
FR2186265B1 (sv) 1976-03-05
ATA483273A (de) 1975-11-15
RO62900A (ro) 1982-10-26
AT331252B (de) 1976-08-10
SU507238A3 (ru) 1976-03-15
FI55656B (fi) 1979-05-31
SU508196A3 (ru) 1976-03-25
CH579064A5 (sv) 1976-08-31
CH593959A5 (sv) 1977-12-30
DK139751C (da) 1979-09-17
IE37717L (en) 1973-12-02
AR196936A1 (es) 1974-02-28
SU530644A3 (ru) 1976-09-30
PL91050B1 (sv) 1977-02-28
AU470393B2 (en) 1976-03-11
GB1386916A (en) 1975-03-12
NO138026B (no) 1978-03-06
ES415464A1 (es) 1976-05-01
AR194688A1 (es) 1973-07-31
CH574949A5 (sv) 1976-04-30
AT331802B (de) 1976-08-25
AT331801B (de) 1976-08-25
ES415466A1 (es) 1976-05-16
RO68378A (ro) 1982-02-01
CH594651A5 (sv) 1978-01-13
HU165312B (sv) 1974-08-28
AR201001A1 (es) 1975-02-06

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