AT331252B - Verfahren zur herstellung von neuen n-benzhydryl-n'-p-hydroxybenzyl-piperazinen und ihren salzen - Google Patents

Verfahren zur herstellung von neuen n-benzhydryl-n'-p-hydroxybenzyl-piperazinen und ihren salzen

Info

Publication number
AT331252B
AT331252B AT483273A AT483273A AT331252B AT 331252 B AT331252 B AT 331252B AT 483273 A AT483273 A AT 483273A AT 483273 A AT483273 A AT 483273A AT 331252 B AT331252 B AT 331252B
Authority
AT
Austria
Prior art keywords
piperazines
benzhydryl
hydroxybenzyl
salts
preparation
Prior art date
Application number
AT483273A
Other languages
English (en)
Other versions
ATA483273A (de
Original Assignee
Cassella Farbwerke Mainkur Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2226767A external-priority patent/DE2226767A1/de
Priority claimed from DE19732312212 external-priority patent/DE2312212A1/de
Application filed by Cassella Farbwerke Mainkur Ag filed Critical Cassella Farbwerke Mainkur Ag
Publication of ATA483273A publication Critical patent/ATA483273A/de
Application granted granted Critical
Publication of AT331252B publication Critical patent/AT331252B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
AT483273A 1972-06-02 1973-06-01 Verfahren zur herstellung von neuen n-benzhydryl-n'-p-hydroxybenzyl-piperazinen und ihren salzen AT331252B (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2226767A DE2226767A1 (de) 1972-06-02 1972-06-02 N-benzhydryl-n'-p-hydroxybenzylpiperazin und verfahren zu seiner herstellung
DE19732312212 DE2312212A1 (de) 1973-03-12 1973-03-12 N-(p-chlorbenzhydryl)-n'-p-hydroxybenzyl-piperazin und verfahren zu seiner herstellung

Publications (2)

Publication Number Publication Date
ATA483273A ATA483273A (de) 1975-11-15
AT331252B true AT331252B (de) 1976-08-10

Family

ID=25763357

Family Applications (3)

Application Number Title Priority Date Filing Date
AT483173A AT331802B (de) 1972-06-02 1973-06-01 Verfahren zur herstellung von neuen n-benzhydryl-n'-p-hydroxybenzyl-piperazinen und ihren saureadditionssalzen
AT483073A AT331801B (de) 1972-06-02 1973-06-01 Verfahren zur herstellung von neuen n-benzhydryl-n'-p-hydroxybenzyl-piperazinen und ihren saureadditionssalzen
AT483273A AT331252B (de) 1972-06-02 1973-06-01 Verfahren zur herstellung von neuen n-benzhydryl-n'-p-hydroxybenzyl-piperazinen und ihren salzen

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AT483173A AT331802B (de) 1972-06-02 1973-06-01 Verfahren zur herstellung von neuen n-benzhydryl-n'-p-hydroxybenzyl-piperazinen und ihren saureadditionssalzen
AT483073A AT331801B (de) 1972-06-02 1973-06-01 Verfahren zur herstellung von neuen n-benzhydryl-n'-p-hydroxybenzyl-piperazinen und ihren saureadditionssalzen

Country Status (26)

Country Link
US (1) US3868377A (de)
JP (1) JPS4948687A (de)
AR (5) AR201001A1 (de)
AT (3) AT331802B (de)
AU (1) AU470393B2 (de)
BG (3) BG20596A3 (de)
CA (1) CA980347A (de)
CH (4) CH593959A5 (de)
CS (4) CS182234B2 (de)
DD (1) DD106644A5 (de)
DK (1) DK139751C (de)
EG (1) EG11434A (de)
ES (3) ES415466A1 (de)
FI (1) FI55656C (de)
FR (1) FR2186265B1 (de)
GB (1) GB1386916A (de)
HU (1) HU165312B (de)
IE (1) IE37717B1 (de)
IL (1) IL42384A (de)
NL (1) NL7306771A (de)
NO (1) NO138026C (de)
PH (1) PH9485A (de)
PL (3) PL91050B1 (de)
RO (3) RO68379A (de)
SE (1) SE396385B (de)
SU (4) SU508196A3 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59101475A (ja) * 1982-12-02 1984-06-12 Nippon Chemiphar Co Ltd 新規ピペラジン誘導体およびその製造法ならびにこれを含有する脳循環改善剤
HU186656B (en) * 1982-12-28 1985-09-30 Richter Gedeon Vegyeszet Process for producing new benzhydryl-piperazine derivatives, acid additionak salts and pharmaceutical compositions containing them
GB8320701D0 (en) * 1983-08-01 1983-09-01 Wellcome Found Chemotherapeutic agent
JPS60222472A (ja) * 1984-03-30 1985-11-07 Kanebo Ltd 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物
AU617631B2 (en) * 1988-08-05 1991-11-28 Nippon Chemiphar Co. Ltd. Optically active piperazine derivative
FR2661176B1 (fr) * 1990-04-20 1992-06-12 Adir Nouveau procede de preparation de la 1-(2,3,4-trimethoxybenzyl) piperazine en amination reductive.
JP3150155B2 (ja) * 1993-12-08 2001-03-26 アルコン ラボラトリーズ，インコーポレイテッド 有力なカルシウム拮抗活性および酸化防止活性の両方を有する化合物および細胞保護剤としてのその使用
WO2009147389A2 (en) * 2008-06-02 2009-12-10 Cipla Limited Processes for the synthesis of levocetirizine and intermediates for use therein

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2709169A (en) * 1955-05-24 X c chs
US3051710A (en) * 1959-12-21 1962-08-28 Lakeside Lab Inc Glycolic acid amide derivatives of piperazine and use thereof

Also Published As

Publication number Publication date
CH574949A5 (de) 1976-04-30
AT331801B (de) 1976-08-25
AU5634373A (en) 1974-12-05
AR194688A1 (es) 1973-07-31
BG20371A3 (de) 1975-11-05
RO68378A (ro) 1982-02-01
GB1386916A (en) 1975-03-12
ATA483073A (de) 1975-12-15
DK139751B (da) 1979-04-09
CS182234B2 (en) 1978-04-28
BG20595A3 (de) 1975-12-05
NO138026B (no) 1978-03-06
AR200764A1 (es) 1974-12-13
ES415466A1 (es) 1976-05-16
IL42384A0 (en) 1973-07-30
US3868377A (en) 1975-02-25
CS178429B2 (de) 1977-09-15
ES415465A1 (es) 1976-05-16
DD106644A5 (de) 1974-06-20
AU470393B2 (en) 1976-03-11
JPS4948687A (de) 1974-05-11
SU508196A3 (ru) 1976-03-25
CH594651A5 (de) 1978-01-13
CS178430B2 (de) 1977-09-15
ATA483173A (de) 1975-12-15
BG20596A3 (de) 1975-12-05
CH579064A5 (de) 1976-08-31
RO62900A (ro) 1982-10-26
EG11434A (en) 1977-09-30
PH9485A (en) 1976-01-08
NO138026C (no) 1978-06-14
FI55656B (fi) 1979-05-31
HU165312B (de) 1974-08-28
PL97129B1 (pl) 1978-02-28
SE396385B (sv) 1977-09-19
SU530644A3 (ru) 1976-09-30
IE37717B1 (en) 1977-09-28
ATA483273A (de) 1975-11-15
SU507238A3 (ru) 1976-03-15
ES415464A1 (es) 1976-05-01
DK139751C (da) 1979-09-17
CS182248B2 (en) 1978-04-28
AT331802B (de) 1976-08-25
PL94759B1 (pl) 1977-08-31
CA980347A (en) 1975-12-23
FI55656C (fi) 1979-09-10
FR2186265B1 (de) 1976-03-05
RO68379A (ro) 1981-11-24
NL7306771A (de) 1973-12-04
AR204987A1 (es) 1976-03-31
FR2186265A1 (de) 1974-01-11
PL91050B1 (de) 1977-02-28
AR196936A1 (es) 1974-02-28
CH593959A5 (de) 1977-12-30
SU577995A3 (ru) 1977-10-25
AR201001A1 (es) 1975-02-06
IE37717L (en) 1973-12-02
IL42384A (en) 1976-12-31

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Legal Events

Date Code Title Description
EFA Change in the company name
ELJ Ceased due to non-payment of the annual fee