CS182234B2 - Method of producing n-benzhydryl-n-p-hydroxy-benzylpiperazine - Google Patents

Method of producing n-benzhydryl-n-p-hydroxy-benzylpiperazine

Info

Publication number
CS182234B2
CS182234B2 CS7300003883A CS388373A CS182234B2 CS 182234 B2 CS182234 B2 CS 182234B2 CS 7300003883 A CS7300003883 A CS 7300003883A CS 388373 A CS388373 A CS 388373A CS 182234 B2 CS182234 B2 CS 182234B2
Authority
CS
Czechoslovakia
Prior art keywords
benzylpiperazine
benzhydryl
hydroxy
producing
Prior art date
Application number
CS7300003883A
Other languages
English (en)
Inventor
Thomas Raabe
Josef Scholtholt
Eckhard Schraven
Rolf-Eberhard Nitz
Original Assignee
Cassella Farbwerke Mainkur Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2226767A external-priority patent/DE2226767A1/de
Priority claimed from DE19732312212 external-priority patent/DE2312212A1/de
Application filed by Cassella Farbwerke Mainkur Ag filed Critical Cassella Farbwerke Mainkur Ag
Publication of CS182234B2 publication Critical patent/CS182234B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
CS7300003883A 1972-06-02 1973-05-29 Method of producing n-benzhydryl-n-p-hydroxy-benzylpiperazine CS182234B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2226767A DE2226767A1 (de) 1972-06-02 1972-06-02 N-benzhydryl-n'-p-hydroxybenzylpiperazin und verfahren zu seiner herstellung
DE19732312212 DE2312212A1 (de) 1973-03-12 1973-03-12 N-(p-chlorbenzhydryl)-n'-p-hydroxybenzyl-piperazin und verfahren zu seiner herstellung

Publications (1)

Publication Number Publication Date
CS182234B2 true CS182234B2 (en) 1978-04-28

Family

ID=25763357

Family Applications (4)

Application Number Title Priority Date Filing Date
CS7300003883A CS182234B2 (en) 1972-06-02 1973-05-29 Method of producing n-benzhydryl-n-p-hydroxy-benzylpiperazine
CS7600004284A CS182248B2 (en) 1972-06-02 1973-05-29 Method of producing n-benzhydryl-n-p-hydroxy-benzylpiperazine
CS3878A CS178430B2 (cs) 1972-06-02 1973-05-29
CS3877A CS178429B2 (cs) 1972-06-02 1973-05-29

Family Applications After (3)

Application Number Title Priority Date Filing Date
CS7600004284A CS182248B2 (en) 1972-06-02 1973-05-29 Method of producing n-benzhydryl-n-p-hydroxy-benzylpiperazine
CS3878A CS178430B2 (cs) 1972-06-02 1973-05-29
CS3877A CS178429B2 (cs) 1972-06-02 1973-05-29

Country Status (26)

Country Link
US (1) US3868377A (cs)
JP (1) JPS4948687A (cs)
AR (5) AR201001A1 (cs)
AT (3) AT331802B (cs)
AU (1) AU470393B2 (cs)
BG (3) BG20596A3 (cs)
CA (1) CA980347A (cs)
CH (4) CH593959A5 (cs)
CS (4) CS182234B2 (cs)
DD (1) DD106644A5 (cs)
DK (1) DK139751C (cs)
EG (1) EG11434A (cs)
ES (3) ES415466A1 (cs)
FI (1) FI55656C (cs)
FR (1) FR2186265B1 (cs)
GB (1) GB1386916A (cs)
HU (1) HU165312B (cs)
IE (1) IE37717B1 (cs)
IL (1) IL42384A (cs)
NL (1) NL7306771A (cs)
NO (1) NO138026C (cs)
PH (1) PH9485A (cs)
PL (3) PL91050B1 (cs)
RO (3) RO68379A (cs)
SE (1) SE396385B (cs)
SU (4) SU508196A3 (cs)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59101475A (ja) * 1982-12-02 1984-06-12 Nippon Chemiphar Co Ltd 新規ピペラジン誘導体およびその製造法ならびにこれを含有する脳循環改善剤
HU186656B (en) * 1982-12-28 1985-09-30 Richter Gedeon Vegyeszet Process for producing new benzhydryl-piperazine derivatives, acid additionak salts and pharmaceutical compositions containing them
GB8320701D0 (en) * 1983-08-01 1983-09-01 Wellcome Found Chemotherapeutic agent
JPS60222472A (ja) * 1984-03-30 1985-11-07 Kanebo Ltd 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物
AU617631B2 (en) * 1988-08-05 1991-11-28 Nippon Chemiphar Co. Ltd. Optically active piperazine derivative
FR2661176B1 (fr) * 1990-04-20 1992-06-12 Adir Nouveau procede de preparation de la 1-(2,3,4-trimethoxybenzyl) piperazine en amination reductive.
JP3150155B2 (ja) * 1993-12-08 2001-03-26 アルコン ラボラトリーズ，インコーポレイテッド 有力なカルシウム拮抗活性および酸化防止活性の両方を有する化合物および細胞保護剤としてのその使用
WO2009147389A2 (en) * 2008-06-02 2009-12-10 Cipla Limited Processes for the synthesis of levocetirizine and intermediates for use therein

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2709169A (en) * 1955-05-24 X c chs
US3051710A (en) * 1959-12-21 1962-08-28 Lakeside Lab Inc Glycolic acid amide derivatives of piperazine and use thereof

Also Published As

Publication number Publication date
CH574949A5 (cs) 1976-04-30
AT331801B (de) 1976-08-25
AU5634373A (en) 1974-12-05
AR194688A1 (es) 1973-07-31
BG20371A3 (cs) 1975-11-05
RO68378A (ro) 1982-02-01
GB1386916A (en) 1975-03-12
ATA483073A (de) 1975-12-15
DK139751B (da) 1979-04-09
BG20595A3 (cs) 1975-12-05
NO138026B (no) 1978-03-06
AR200764A1 (es) 1974-12-13
ES415466A1 (es) 1976-05-16
IL42384A0 (en) 1973-07-30
US3868377A (en) 1975-02-25
CS178429B2 (cs) 1977-09-15
ES415465A1 (es) 1976-05-16
DD106644A5 (cs) 1974-06-20
AU470393B2 (en) 1976-03-11
JPS4948687A (cs) 1974-05-11
SU508196A3 (ru) 1976-03-25
CH594651A5 (cs) 1978-01-13
CS178430B2 (cs) 1977-09-15
ATA483173A (de) 1975-12-15
BG20596A3 (cs) 1975-12-05
CH579064A5 (cs) 1976-08-31
RO62900A (ro) 1982-10-26
EG11434A (en) 1977-09-30
PH9485A (en) 1976-01-08
NO138026C (no) 1978-06-14
FI55656B (fi) 1979-05-31
HU165312B (cs) 1974-08-28
PL97129B1 (pl) 1978-02-28
SE396385B (sv) 1977-09-19
SU530644A3 (ru) 1976-09-30
IE37717B1 (en) 1977-09-28
ATA483273A (de) 1975-11-15
SU507238A3 (ru) 1976-03-15
ES415464A1 (es) 1976-05-01
DK139751C (da) 1979-09-17
CS182248B2 (en) 1978-04-28
AT331802B (de) 1976-08-25
PL94759B1 (pl) 1977-08-31
CA980347A (en) 1975-12-23
AT331252B (de) 1976-08-10
FI55656C (fi) 1979-09-10
FR2186265B1 (cs) 1976-03-05
RO68379A (ro) 1981-11-24
NL7306771A (cs) 1973-12-04
AR204987A1 (es) 1976-03-31
FR2186265A1 (cs) 1974-01-11
PL91050B1 (cs) 1977-02-28
AR196936A1 (es) 1974-02-28
CH593959A5 (cs) 1977-12-30
SU577995A3 (ru) 1977-10-25
AR201001A1 (es) 1975-02-06
IE37717L (en) 1973-12-02
IL42384A (en) 1976-12-31

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