CA980347A - N-benzhydryl-n'-p-hydroxybenzyl-piperazine and processes for its manufacture - Google Patents

N-benzhydryl-n'-p-hydroxybenzyl-piperazine and processes for its manufacture

Info

Publication number
CA980347A
CA980347A CA172,824A CA172824A CA980347A CA 980347 A CA980347 A CA 980347A CA 172824 A CA172824 A CA 172824A CA 980347 A CA980347 A CA 980347A
Authority
CA
Canada
Prior art keywords
benzhydryl
hydroxybenzyl
piperazine
manufacture
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA172,824A
Other languages
English (en)
Other versions
CA172824S (en
Inventor
Rolf-Eberhard Nitz
Thomas Raabe
Josef Scholtholt
Eckhard Schraven
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cassella Farbwerke Mainkur AG
Original Assignee
Cassella Farbwerke Mainkur AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2226767A external-priority patent/DE2226767A1/de
Priority claimed from DE19732312212 external-priority patent/DE2312212A1/de
Application filed by Cassella Farbwerke Mainkur AG filed Critical Cassella Farbwerke Mainkur AG
Application granted granted Critical
Publication of CA980347A publication Critical patent/CA980347A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
CA172,824A 1972-06-02 1973-05-31 N-benzhydryl-n'-p-hydroxybenzyl-piperazine and processes for its manufacture Expired CA980347A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2226767A DE2226767A1 (de) 1972-06-02 1972-06-02 N-benzhydryl-n'-p-hydroxybenzylpiperazin und verfahren zu seiner herstellung
DE19732312212 DE2312212A1 (de) 1973-03-12 1973-03-12 N-(p-chlorbenzhydryl)-n'-p-hydroxybenzyl-piperazin und verfahren zu seiner herstellung

Publications (1)

Publication Number Publication Date
CA980347A true CA980347A (en) 1975-12-23

Family

ID=25763357

Family Applications (1)

Application Number Title Priority Date Filing Date
CA172,824A Expired CA980347A (en) 1972-06-02 1973-05-31 N-benzhydryl-n'-p-hydroxybenzyl-piperazine and processes for its manufacture

Country Status (26)

Country Link
US (1) US3868377A (sv)
JP (1) JPS4948687A (sv)
AR (5) AR194688A1 (sv)
AT (3) AT331802B (sv)
AU (1) AU470393B2 (sv)
BG (3) BG20371A3 (sv)
CA (1) CA980347A (sv)
CH (4) CH593959A5 (sv)
CS (4) CS178430B2 (sv)
DD (1) DD106644A5 (sv)
DK (1) DK139751C (sv)
EG (1) EG11434A (sv)
ES (3) ES415464A1 (sv)
FI (1) FI55656C (sv)
FR (1) FR2186265B1 (sv)
GB (1) GB1386916A (sv)
HU (1) HU165312B (sv)
IE (1) IE37717B1 (sv)
IL (1) IL42384A (sv)
NL (1) NL7306771A (sv)
NO (1) NO138026C (sv)
PH (1) PH9485A (sv)
PL (3) PL91050B1 (sv)
RO (3) RO68379A (sv)
SE (1) SE396385B (sv)
SU (4) SU508196A3 (sv)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59101475A (ja) * 1982-12-02 1984-06-12 Nippon Chemiphar Co Ltd 新規ピペラジン誘導体およびその製造法ならびにこれを含有する脳循環改善剤
HU186656B (en) * 1982-12-28 1985-09-30 Richter Gedeon Vegyeszet Process for producing new benzhydryl-piperazine derivatives, acid additionak salts and pharmaceutical compositions containing them
GB8320701D0 (en) * 1983-08-01 1983-09-01 Wellcome Found Chemotherapeutic agent
JPS60222472A (ja) * 1984-03-30 1985-11-07 Kanebo Ltd 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物
US4978666A (en) * 1988-08-05 1990-12-18 Nippon Chemiphar Co., Ltd. Optically active piperazine derivative
FR2661176B1 (fr) * 1990-04-20 1992-06-12 Adir Nouveau procede de preparation de la 1-(2,3,4-trimethoxybenzyl) piperazine en amination reductive.
ES2156934T3 (es) * 1993-12-08 2001-08-01 Alcon Lab Inc Compuestos que presentan una potente actividad de antagonistas del calcio y de antioxidantes y su utilizacion como agentes citoprotectores.
CA2724887A1 (en) * 2008-06-02 2009-12-10 Cipla Limited Processes for the synthesis of levocetirizine and intermediates for use therein

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2709169A (en) * 1955-05-24 X c chs
US3051710A (en) * 1959-12-21 1962-08-28 Lakeside Lab Inc Glycolic acid amide derivatives of piperazine and use thereof

Also Published As

Publication number Publication date
AT331801B (de) 1976-08-25
AR200764A1 (es) 1974-12-13
FR2186265A1 (sv) 1974-01-11
SE396385B (sv) 1977-09-19
IL42384A0 (en) 1973-07-30
IL42384A (en) 1976-12-31
CS178429B2 (sv) 1977-09-15
ATA483273A (de) 1975-11-15
FR2186265B1 (sv) 1976-03-05
RO62900A (ro) 1982-10-26
ES415465A1 (es) 1976-05-16
GB1386916A (en) 1975-03-12
AR201001A1 (es) 1975-02-06
SU507238A3 (ru) 1976-03-15
AT331252B (de) 1976-08-10
AU5634373A (en) 1974-12-05
CS182234B2 (en) 1978-04-28
PL94759B1 (pl) 1977-08-31
BG20595A3 (bg) 1975-12-05
FI55656B (fi) 1979-05-31
CH579064A5 (sv) 1976-08-31
RO68379A (ro) 1981-11-24
BG20596A3 (bg) 1975-12-05
ATA483073A (de) 1975-12-15
ES415464A1 (es) 1976-05-01
CS178430B2 (sv) 1977-09-15
AR196936A1 (es) 1974-02-28
AR204987A1 (es) 1976-03-31
DD106644A5 (sv) 1974-06-20
PL91050B1 (sv) 1977-02-28
HU165312B (sv) 1974-08-28
IE37717L (en) 1973-12-02
DK139751B (da) 1979-04-09
SU508196A3 (ru) 1976-03-25
SU577995A3 (ru) 1977-10-25
NO138026B (no) 1978-03-06
US3868377A (en) 1975-02-25
AU470393B2 (en) 1976-03-11
CH594651A5 (sv) 1978-01-13
CS182248B2 (en) 1978-04-28
NL7306771A (sv) 1973-12-04
PL97129B1 (pl) 1978-02-28
NO138026C (no) 1978-06-14
IE37717B1 (en) 1977-09-28
ES415466A1 (es) 1976-05-16
PH9485A (en) 1976-01-08
DK139751C (da) 1979-09-17
FI55656C (fi) 1979-09-10
AT331802B (de) 1976-08-25
CH593959A5 (sv) 1977-12-30
CH574949A5 (sv) 1976-04-30
ATA483173A (de) 1975-12-15
AR194688A1 (es) 1973-07-31
EG11434A (en) 1977-09-30
SU530644A3 (ru) 1976-09-30
RO68378A (ro) 1982-02-01
BG20371A3 (bg) 1975-11-05
JPS4948687A (sv) 1974-05-11

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