IL295118B2 - Solution-based plasmon specific-binding partner assays and metallic nanostructures - Google Patents

Solution-based plasmon specific-binding partner assays and metallic nanostructures

Info

Publication number
IL295118B2
IL295118B2 IL295118A IL29511822A IL295118B2 IL 295118 B2 IL295118 B2 IL 295118B2 IL 295118 A IL295118 A IL 295118A IL 29511822 A IL29511822 A IL 29511822A IL 295118 B2 IL295118 B2 IL 295118B2
Authority
IL
Israel
Prior art keywords
nanostructures
assay complex
conjugates
detection
antigen
Prior art date
Application number
IL295118A
Other languages
English (en)
Hebrew (he)
Other versions
IL295118B1 (en
IL295118A (en
Inventor
Vincent Chiang
Sarah Ann Unser
Rajesh K Mehra
Kenneth P Aron
Original Assignee
Zoetis Services Llc
Vincent Chiang
Sarah Ann Unser
Rajesh K Mehra
Kenneth P Aron
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zoetis Services Llc, Vincent Chiang, Sarah Ann Unser, Rajesh K Mehra, Kenneth P Aron filed Critical Zoetis Services Llc
Publication of IL295118A publication Critical patent/IL295118A/en
Publication of IL295118B1 publication Critical patent/IL295118B1/en
Publication of IL295118B2 publication Critical patent/IL295118B2/en

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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55Specular reflectivity
    • G01N21/552Attenuated total reflection
    • G01N21/553Attenuated total reflection and using surface plasmons
    • G01N21/554Attenuated total reflection and using surface plasmons detecting the surface plasmon resonance of nanostructured metals, e.g. localised surface plasmon resonance
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346Nanoparticles
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553Metal or metal coated
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00Immunoassays for the detection of microorganisms
    • G01N2469/10Detection of antigens from microorganism in sample from host
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00Immunoassays for the detection of microorganisms
    • G01N2469/20Detection of antibodies in sample from host which are directed against antigens from microorganisms

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Nanotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
IL295118A 2017-01-30 2018-01-30 Solution-based plasmon specific-binding partner assays and metallic nanostructures IL295118B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762451932P 2017-01-30 2017-01-30
PCT/US2018/015981 WO2018140953A1 (en) 2017-01-30 2018-01-30 Solution-based plasmon specific-binding partner assays and metallic nanostructures

Publications (3)

Publication Number Publication Date
IL295118A IL295118A (en) 2022-09-01
IL295118B1 IL295118B1 (en) 2025-02-01
IL295118B2 true IL295118B2 (en) 2025-06-01

Family

ID=62978809

Family Applications (2)

Application Number Title Priority Date Filing Date
IL295118A IL295118B2 (en) 2017-01-30 2018-01-30 Solution-based plasmon specific-binding partner assays and metallic nanostructures
IL268238A IL268238B (en) 2017-01-30 2018-01-30 Tests for a specific plasmon-based solution for co-linking and metallic nanostructures

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL268238A IL268238B (en) 2017-01-30 2018-01-30 Tests for a specific plasmon-based solution for co-linking and metallic nanostructures

Country Status (10)

Country Link
US (2) US11977072B2 (enExample)
EP (1) EP3574308A4 (enExample)
JP (2) JP7308148B2 (enExample)
KR (3) KR102897521B1 (enExample)
CN (3) CN120446063A (enExample)
AU (2) AU2018212009B2 (enExample)
CA (1) CA3051465A1 (enExample)
IL (2) IL295118B2 (enExample)
MX (3) MX2019008970A (enExample)
WO (1) WO2018140953A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2783216B1 (en) 2011-11-21 2018-09-26 Abaxis, Inc. Signal amplification immunoassays
TWI691716B (zh) 2014-08-13 2020-04-21 美商艾巴希斯公司 電漿特異性結合搭配物檢定中之信號放大
CA3227799A1 (en) 2015-08-04 2017-02-09 Zoetis Services Llc Signal amplification in solution-based plasmonic specific-binding partner assays
US9617587B1 (en) 2016-04-04 2017-04-11 Nat Diagnostics, Inc. Isothermal amplification components and processes
US11299777B2 (en) 2016-04-04 2022-04-12 Nat Diagnostics, Inc. Isothermal amplification components and processes
US11977072B2 (en) 2017-01-30 2024-05-07 Zoetis Services Llc Solution-based plasmonic specific-binding partner assays using metallic nanostructures
JP7292741B2 (ja) * 2018-11-01 2023-06-19 エヌビー ポステク 非共有結合的に付着された有機ナノ構造分子を含むニトロセルロース膜
GB2590485B (en) * 2019-12-19 2022-04-13 Vidya Holdings Ltd Nanoparticle conjugation
US11609229B2 (en) 2020-04-30 2023-03-21 Mytech Co. Ltd. Fluorescence counting system for quantifying viruses or antibodies on an immobilized metal substrate by using an antigen-antibody reaction
JP7589532B2 (ja) * 2020-12-14 2024-11-26 日油株式会社 イムノクロマト測定法用増感剤及び測定法
WO2022221946A1 (en) * 2021-04-21 2022-10-27 Nicoya Lifesciences, Inc. System and method for simulating a localized surface plasmon resonance (lspr) spectrometer
CN114480591B (zh) * 2022-03-09 2022-11-08 武汉爱博泰克生物科技有限公司 一种用于一步法qpcr试剂的冻干保护剂及其应用
JPWO2023224100A1 (enExample) * 2022-05-18 2023-11-23
JPWO2024075847A1 (enExample) * 2022-10-06 2024-04-11
CN116183901B (zh) * 2023-01-04 2025-04-18 烟台大学 一种基于环糊精-金刚烷化铱络合物主客体组装标记的蛋白标记物荧光检测方法
CN120741863A (zh) * 2025-06-06 2025-10-03 上海太阳生物技术有限公司 蛋白c检测试剂

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110275061A1 (en) * 2007-03-20 2011-11-10 Kristin Weidemaier Assays using surface-enhanced raman spectroscopy (sers)-active particles

Family Cites Families (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4704366A (en) 1984-06-22 1987-11-03 Bio-Rad Laboratories, Inc. Process for binding IgG to protein A
US5061381A (en) 1990-06-04 1991-10-29 Abaxis, Inc. Apparatus and method for separating cells from biological fluids
US5122284A (en) 1990-06-04 1992-06-16 Abaxis, Inc. Apparatus and method for optically analyzing biological fluids
US5186844A (en) 1991-04-01 1993-02-16 Abaxis, Inc. Apparatus and method for continuous centrifugal blood cell separation
US5413732A (en) 1991-08-19 1995-05-09 Abaxis, Inc. Reagent compositions for analytical testing
US5304348A (en) 1992-02-11 1994-04-19 Abaxis, Inc. Reagent container for analytical rotor
AU4047493A (en) 1992-04-02 1993-11-08 Abaxis, Inc. Analytical rotor with dye mixing chamber
JP3706214B2 (ja) 1996-10-28 2005-10-12 株式会社三菱化学ヤトロン 免疫学的分析方法
US5939021A (en) 1997-01-23 1999-08-17 Hansen; W. Peter Homogeneous binding assay
JP4209471B2 (ja) 1997-02-20 2009-01-14 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア プラズモン共鳴粒子、方法、および装置
US7144627B2 (en) 1997-03-12 2006-12-05 William Marsh Rice University Multi-layer nanoshells comprising a metallic or conducting shell
US6344272B1 (en) 1997-03-12 2002-02-05 Wm. Marsh Rice University Metal nanoshells
JPH10282100A (ja) * 1997-04-11 1998-10-23 Sekisui Chem Co Ltd 測定方法及び測定キット
EP1021723B1 (en) * 1997-09-22 2008-12-10 Novartis Vaccines and Diagnostics, Inc. Buffers for stabilizing hcv antigens
US6699724B1 (en) 1998-03-11 2004-03-02 Wm. Marsh Rice University Metal nanoshells for biosensing applications
JP2000028612A (ja) 1998-07-07 2000-01-28 Nitto Denko Corp 免疫学的検査方法および免疫学的検査キット
JP3841559B2 (ja) 1998-07-07 2006-11-01 日東電工株式会社 免疫学的検査方法および免疫学的検査キット
JP3298836B2 (ja) 1998-11-12 2002-07-08 アークレイ株式会社 検体分析用具
US6579726B1 (en) 1999-07-30 2003-06-17 Surromed, Inc. Instruments, methods and reagents for surface plasmon resonance
JP2001074742A (ja) * 1999-09-06 2001-03-23 Jsr Corp ラテックス免疫比濁法および測定キット
EP1236034A4 (en) 1999-11-12 2006-05-03 Surromed Inc PLASMON RESONANCE SURFACE BIODETECTION
US6660381B2 (en) 2000-11-03 2003-12-09 William Marsh Rice University Partial coverage metal nanoshells and method of making same
US6861263B2 (en) 2001-01-26 2005-03-01 Surromed, Inc. Surface-enhanced spectroscopy-active sandwich nanoparticles
US20030170618A1 (en) 2001-02-02 2003-09-11 Chien David Y. Buffers for stabilizing antigens
AU2002239726A1 (en) 2001-05-25 2002-12-09 Northwestern University Non-alloying core shell nanoparticles
EP1428028A2 (de) 2001-09-14 2004-06-16 Reinhard Zeidler Identifizierung von antigenen durch xenogene, allogene oder autologe antikörper-vermittelte präzipitation
US7135054B2 (en) 2001-09-26 2006-11-14 Northwestern University Nanoprisms and method of making them
CN1417586A (zh) 2001-11-05 2003-05-14 福州市迈新生物技术开发公司 一种免疫检测信号放大系统和它的制备方法及其应用
JP3851807B2 (ja) 2001-11-07 2006-11-29 アルフレッサファーマ株式会社 免疫反応におけるプロゾーン現象抑制方法及び免疫反応測定用試薬
US6970239B2 (en) 2002-06-12 2005-11-29 Intel Corporation Metal coated nanocrystalline silicon as an active surface enhanced Raman spectroscopy (SERS) substrate
US7212692B2 (en) 2002-11-08 2007-05-01 Ming Yan Multiple array surface plasmon resonance biosensor
KR20050083623A (ko) * 2002-12-10 2005-08-26 마쯔시다덴기산교 가부시키가이샤 면역반응 측정방법
JP4787938B2 (ja) 2003-03-28 2011-10-05 ザ・プロウボウスト・フェロウズ・ファウンデーション・スカラーズ・アンド・ザ・アザー・メンバーズ・オブ・ボード・オブ・ザ・カレッジ・オブ・ザ・ホリー・アンド・アンデバイデッド・トリニティ・オブ・クイーン 銀ナノ粒子を用いた検体検出用センサ
KR100531760B1 (ko) 2003-04-28 2005-11-29 대한민국(관리부서 : 농림부 국립수의과학검역원) 구제역 바이러스의 감염여부를 진단하는 방법 및 이를구현하기 위한 진단키트
US20060240573A1 (en) 2003-07-29 2006-10-26 Lamdagen, Llc Optical system including nanostructures for biological or chemical sensing
GB0321937D0 (en) 2003-09-19 2003-10-22 Univ Liverpool Nanoparticle conjugates and method of production thereof
BRPI0416270A (pt) 2003-11-07 2007-01-09 Hepgenics Pty Ltd método para detectar um analito em uma amostra, e, método e kit para detectar um anticorpo especìfico de uma amostra
JP4109205B2 (ja) 2004-01-07 2008-07-02 富士フイルム株式会社 被検体検出方法
US20080227219A1 (en) 2004-11-17 2008-09-18 Frank Gamez Electrochemiluminescent assay
CN1296492C (zh) * 2004-11-18 2007-01-24 博奥生物有限公司 一种基于生物芯片检测能结合特异序列的核酸结合蛋白的方法
US7405054B1 (en) 2004-12-13 2008-07-29 University Of Washington Uw Tech Transfer - Invention Licensing Signal amplification method for surface plasmon resonance-based chemical detection
CN101133328A (zh) 2004-12-31 2008-02-27 健泰科生物技术公司 检测非人血清中的人抗体
US8628727B2 (en) 2005-04-08 2014-01-14 Northwestern University Compositions, devices and methods for SERS and LSPR
US20060246513A1 (en) 2005-05-02 2006-11-02 Bohannon Robert C Method and device to detect the presence of analytes in a sample
EP1915610A4 (en) 2005-06-15 2010-05-19 Univ Maryland Biotech Inst BIOASSAYS WITH PLASMONIC SPREADING OF PRECIOUS METAL NANOSTRUCTURES
US20070092978A1 (en) 2005-10-20 2007-04-26 Ronald Mink Target ligand detection
JP5442179B2 (ja) 2005-10-21 2014-03-12 アルフレッサファーマ株式会社 反応性物質が結合した微小粒子の沈降抑制方法および該微小粒子含有試薬
AU2006347951B2 (en) 2005-10-25 2011-12-22 Louisiana Tech University Research Foundation Multilayer films, coatings and microcapsules comprising polypeptides
CN101360997B (zh) 2005-11-18 2013-05-01 美国政府健康及人类服务部,疾病控制和预防中心 改性心磷脂及其应用
WO2007103802A2 (en) 2006-03-03 2007-09-13 William Marsh Rice University Nanorice particles: hybrid plasmonic nanostructures
JP4810304B2 (ja) 2006-05-12 2011-11-09 キヤノン株式会社 化学センサ素子及びその製造方法
WO2007141581A1 (en) 2006-06-06 2007-12-13 Vivacta Ltd A method for sensing a chemical
JP2008157652A (ja) 2006-12-21 2008-07-10 Yokogawa Electric Corp 電源装置
US8426152B2 (en) 2007-01-03 2013-04-23 Lamdagen Corporation Enzymatic assay for LSPR
JP2009150708A (ja) 2007-12-19 2009-07-09 Canon Inc 標的物質の検出方法及び検査キット
WO2009081386A2 (en) 2007-12-21 2009-07-02 The Provost Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin A process for preparing nanoparticles
US8846169B2 (en) * 2007-12-28 2014-09-30 3M Innovative Properties Company Flexible encapsulating film systems
US8137920B2 (en) 2008-03-20 2012-03-20 Abaxis, Inc. Multi-wavelength analyses of sol-particle specific binding assays
WO2010006201A2 (en) 2008-07-10 2010-01-14 Abaxis, Inc. Methods of reducing non-specific interaction in metal nanoparticle assays
CA2742678C (en) 2008-12-03 2020-03-31 Abaxis, Inc. Lateral flow strip assay with immobilized conjugate
US8313915B2 (en) 2009-01-21 2012-11-20 Gundersen Lutheran Medical Foundation, Inc. Early detection of canine lyme disease by specific peptides and antibodies
WO2010091293A1 (en) 2009-02-06 2010-08-12 The Regents Of The University Of California Plasmonic system for detecting binding of biological molecules
US9029092B2 (en) * 2009-02-27 2015-05-12 Beckman Coulter, Inc. Solution phase homogeneous assays
US20120101007A1 (en) 2009-04-08 2012-04-26 Provost Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizebeth Nea Silver nanoplates
JP5563789B2 (ja) 2009-06-11 2014-07-30 富士フイルム株式会社 検出方法
CN102687015A (zh) 2009-10-30 2012-09-19 协和梅迪克斯株式会社 用于分析样本中的待分析成分的方法和分析试剂盒
CN102791727A (zh) 2009-11-17 2012-11-21 爱贝斯股份有限公司 用于检测莱姆病抗体的肽和方法
JP6161291B2 (ja) 2009-11-20 2017-07-12 アバクシス, インコーポレイテッド エールリッヒア抗体の検出のためのペプチド、装置、および方法
KR101256628B1 (ko) 2009-11-24 2013-04-19 한국생명공학연구원 나노입자를 이용한 미생물의 고속 검출방법
US9308582B2 (en) 2009-12-24 2016-04-12 Yi Sun Solution stable and chemically reactive metallic nanoparticles
EP2354792A1 (en) 2010-02-08 2011-08-10 Biomonitor A/S Method for detecting anti-drug antibodies
WO2011139792A2 (en) 2010-04-27 2011-11-10 Ventana Medical Systems, Inc. Antibody-nanoparticle conjugates and methods for making and using such conjugates
JP5728006B2 (ja) 2010-05-28 2015-06-03 国立大学法人東京工業大学 金属微粒子複合体及びその製造方法
CN102023151B (zh) 2010-09-17 2013-01-02 江南大学 用拉曼光谱在金纳米棒端面自组装介导下检测微囊藻毒素的方法
JP5822239B2 (ja) 2010-12-08 2015-11-24 公立大学法人大阪府立大学 金属ナノ粒子集積構造体を利用した被検出物質の検出装置および方法
JP5614278B2 (ja) 2010-12-24 2014-10-29 セイコーエプソン株式会社 センサーチップ、センサーチップの製造方法、検出装置
CN102103145B (zh) 2011-02-24 2013-01-16 南京基蛋生物科技有限公司 一种双放大系统的胶体金试纸条及其制备方法
US8697129B2 (en) 2011-03-02 2014-04-15 Imra America, Inc. Stable colloidal gold nanoparticles with controllable surface modification and functionalization
WO2012125693A2 (en) 2011-03-15 2012-09-20 Northwestern University Multifunctional metal nanoparticles having a polydopamine-based surface and methods of making and using the same
JP5703098B2 (ja) 2011-03-31 2015-04-15 富士フイルム株式会社 生体分子検出装置および生体分子検出方法
CN102323422B (zh) 2011-05-30 2014-03-12 中国科学院上海微系统与信息技术研究所 半定量同时检测cTnI和Myo的免疫层析试纸条及其制备
US20130230717A1 (en) 2011-09-02 2013-09-05 Washington University In St. Louis Copper nanostructures and methods for their preparation
US8758772B2 (en) 2011-11-04 2014-06-24 Abaxis, Inc. Peptides and methods for the detection of lyme disease antibodies
CH705758B1 (fr) 2011-11-15 2016-03-31 Metalor Technologies Int Nanoparticules cœur-coquille métal-silice, procédé de fabrication et dispositif de test par immunochromatographie comprenant de telles nanoparticules.
EP2783216B1 (en) 2011-11-21 2018-09-26 Abaxis, Inc. Signal amplification immunoassays
US9823246B2 (en) 2011-12-28 2017-11-21 The Board Of Trustees Of The Leland Stanford Junior University Fluorescence enhancing plasmonic nanoscopic gold films and assays based thereon
DE112013000636T5 (de) 2012-01-20 2014-10-09 Imra America, Inc. Stabile Kolloidale Suspensionen aus Goldnanokonjugaten und das Verfahren zur Zubereitung derselben
WO2013116513A2 (en) 2012-01-31 2013-08-08 American University Of Cairo (Auc) Direct detection of disease biomarkers in clinical specimens using cationic nanoparticle-based assays & versatile and green methods forsynthesis of anisotropic silver nanostructures
EP2625966A1 (en) 2012-02-13 2013-08-14 Bionanoplus, S.L. Nanoparticles comprising a vegetable hydrophobic protein and a water miscible non-volatile organic solvent and uses thereof
TWI435843B (zh) 2012-04-27 2014-05-01 Univ Nat Taiwan 奈米顆粒的製造方法
TW201408690A (zh) 2012-05-05 2014-03-01 Academia Sinica 二氨基苯甲酸或鄰苯二胺共軛的胜肽作為功能性的醣類標幟劑
WO2014020293A1 (en) * 2012-07-31 2014-02-06 Imperial Innovations Limited Assay
DK2906286T3 (en) 2012-10-11 2017-07-17 Nanocomposix Inc SILVER CHARACTER COMPOSITIONS AND PROCEDURES
ES2668863T3 (es) 2012-10-11 2018-05-22 Abaxis, Inc. Péptidos, dispositivos y métodos para la detección de anticuerpos de Ehrlichia
US9441301B2 (en) 2012-12-06 2016-09-13 Nanyang Technological University Method for forming a bimetallic core-shell nanostructure
EP2963419A4 (en) 2013-03-01 2016-11-02 Fujirebio Kk METHOD FOR PREVENTING THE DECOMPOSITION OF AN UNSENSIBILIZED LATEX REAGENT
CN105209616A (zh) * 2013-03-14 2015-12-30 雅培制药有限公司 用于改进的抗体检测的hcv ns3重组抗原及其突变体
US9194873B2 (en) * 2013-03-14 2015-11-24 Abbott Laboratories HCV antigen-antibody combination assay and methods and compositions for use therein
FR3003353B1 (fr) 2013-03-14 2015-03-06 Horiba Abx Sas Nouvelle methode de dosage en flux d'un objet d'interet
JP2014228385A (ja) 2013-05-22 2014-12-08 キヤノン株式会社 免疫試験方法および免疫試験キット
EP3003190A4 (en) 2013-06-05 2016-04-13 Purdue Research Foundation PLASMONIC TITANIUM RIDNANOPARTICLES FOR CLINICAL THERAPEUTIC APPLICATIONS
CN103335984B (zh) 2013-06-09 2015-10-28 清华大学 一种基于lspr的无实体壁微阵列芯片及其应用
WO2015017285A2 (en) 2013-07-30 2015-02-05 Bio-Rad Laboratories, Inc. Multiplex blocker beads for immunoassays
EP3111214B1 (en) 2014-02-26 2020-09-30 Lamdagen Corporation Digital lspr for enhanced assay sensitivity
US10024800B2 (en) * 2014-04-15 2018-07-17 Rutgers, The State University Of New Jersey Gold nanostar substrates for SERS sensing in the femtomolar regime
US10518331B2 (en) 2014-07-11 2019-12-31 Northwestern University Synthesis of uniform anisotropic nanoparticles
JP5867890B1 (ja) * 2014-08-01 2016-02-24 株式会社ビークル 免疫学的測定法に用いられるウイルス様粒子、それに用いられるブロッキング剤、及びこれらを含むキット
TWI691716B (zh) 2014-08-13 2020-04-21 美商艾巴希斯公司 電漿特異性結合搭配物檢定中之信號放大
AU2016219897C1 (en) * 2015-02-19 2022-04-21 Ionica Sciences Reagents and methods for detecting infectious diseases
WO2016170183A1 (en) * 2015-04-24 2016-10-27 Pharmadiagnostics Nv Improved method of measuring an interaction between molecules
CA3227799A1 (en) 2015-08-04 2017-02-09 Zoetis Services Llc Signal amplification in solution-based plasmonic specific-binding partner assays
CN106290893B (zh) 2016-07-18 2018-09-25 南昌大学 一种基于纳米铂探针检测牛乳β-乳球蛋白及其致敏性残基的方法
US11977072B2 (en) 2017-01-30 2024-05-07 Zoetis Services Llc Solution-based plasmonic specific-binding partner assays using metallic nanostructures

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110275061A1 (en) * 2007-03-20 2011-11-10 Kristin Weidemaier Assays using surface-enhanced raman spectroscopy (sers)-active particles

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DEBRINA JANA ET AL, CAPPING AGENT-FREE GOLD NANOSTARS SHOW GREATLY INCREASED VERSATILITY AND SENSITIVITY FOR BIOSENSING, 27 February 2015 (2015-02-27) *
H.D. DHRUV, CONTROLLING NONSPECIFIC ADSORPTION OF PROTEINS AT BIO-INTERFACES FOR BIOSENSOR AND BIOMEDICAL APPLICATIONS, 31 December 2009 (2009-12-31) *

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