IL280004A - Antibody molecules that bind pd-l1 and cd137 - Google Patents
Antibody molecules that bind pd-l1 and cd137Info
- Publication number
- IL280004A IL280004A IL280004A IL28000421A IL280004A IL 280004 A IL280004 A IL 280004A IL 280004 A IL280004 A IL 280004A IL 28000421 A IL28000421 A IL 28000421A IL 280004 A IL280004 A IL 280004A
- Authority
- IL
- Israel
- Prior art keywords
- bind
- antibody molecules
- antibody
- molecules
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1811405.8A GB201811405D0 (en) | 2018-07-12 | 2018-07-12 | Antibody molecules that bind PD-L1 and CD137 |
| GBGB1818283.2A GB201818283D0 (en) | 2018-11-09 | 2018-11-09 | Antibody molecules that bind PD-L1 and CD137 |
| GBGB1902594.9A GB201902594D0 (en) | 2019-02-26 | 2019-02-26 | Antibody molecules that bind pd-l1 and cd137 |
| PCT/EP2019/068793 WO2020011964A1 (en) | 2018-07-12 | 2019-07-12 | Antibody molecules that bind pd-l1 and cd137 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL280004A true IL280004A (en) | 2021-03-01 |
Family
ID=67303457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL280004A IL280004A (en) | 2018-07-12 | 2021-01-07 | Antibody molecules that bind pd-l1 and cd137 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US12344672B2 (https=) |
| EP (2) | EP4512417A3 (https=) |
| JP (2) | JP7360440B2 (https=) |
| KR (1) | KR102926972B1 (https=) |
| CN (1) | CN112423845B (https=) |
| AU (1) | AU2019301204B2 (https=) |
| BR (1) | BR112021000394A2 (https=) |
| CA (1) | CA3106046A1 (https=) |
| DK (1) | DK3820569T3 (https=) |
| ES (1) | ES3006183T3 (https=) |
| IL (1) | IL280004A (https=) |
| MX (1) | MX2021000398A (https=) |
| PL (1) | PL3820569T3 (https=) |
| PT (1) | PT3820569T (https=) |
| SG (1) | SG11202100170RA (https=) |
| TW (1) | TWI861005B (https=) |
| WO (1) | WO2020011964A1 (https=) |
| ZA (1) | ZA202100717B (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190022632A (ko) | 2016-06-20 | 2019-03-06 | 에프-스타 베타 리미티드 | Lag-3 결합 구성원 |
| GB201612520D0 (en) | 2016-07-19 | 2016-08-31 | F-Star Beta Ltd | Binding molecules |
| SG11202000198QA (en) | 2017-08-04 | 2020-02-27 | Genmab As | Binding agents binding to pd-l1 and cd137 and use thereof |
| WO2019121906A1 (en) | 2017-12-19 | 2019-06-27 | F-Star Beta Limited | Specific pd-l1 binding sequences inserted in a ch3 domain |
| JP7332627B2 (ja) | 2018-04-25 | 2023-08-23 | プロメテウス バイオサイエンシーズ，インク． | 最適化された抗ｔｌ１ａ抗体 |
| GB201811410D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | OX40 Binding molecules |
| GB201811403D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | Antibody molecules |
| GB201811408D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | CD137 Binding Molecules |
| BR112021000282A2 (pt) | 2018-07-12 | 2021-04-06 | F-Star Beta Limited | Moléculas de anticorpo que se ligam a cd137 e ox40 |
| GB201811415D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | Anti-Mesothelin Anti bodies |
| GB201811450D0 (en) | 2018-07-12 | 2018-08-29 | F Star Delta Ltd | Mesothelin and CD137 binding molecules |
| GB201811404D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | Anti-CD137 Antibodies |
| EP3835321A4 (en) | 2018-08-10 | 2022-11-02 | Chugai Seiyaku Kabushiki Kaisha | ANTI-CD137 ANTIGEN-BINDING MOLECULE AND USE THEREOF |
| KR20220103721A (ko) | 2019-10-24 | 2022-07-22 | 프로메테우스 바이오사이언시즈, 인크. | Tnf 유사 리간드 1a(tl1a)에 대한 인간화 항체 및 그의 용도 |
| IL294967A (en) * | 2020-02-04 | 2022-09-01 | Genmab As | Antibodies for use in therapy |
| TWI895351B (zh) * | 2020-02-12 | 2025-09-01 | 日商中外製藥股份有限公司 | 用於癌症之治療的抗cd137抗原結合分子 |
| US12473349B2 (en) * | 2020-05-06 | 2025-11-18 | Korea University Research And Business Foundation | PD-1 variants having increased PD-L1 affinity |
| EP4126965A4 (en) * | 2020-05-14 | 2024-10-02 | Elixiron Immunotherapeutics (Hong Kong) Limited | ANTI-PD-L1 ANTIBODIES AND ANTI-PD-L1/IL10 FUSION PROTEINS |
| CA3203718A1 (en) * | 2021-01-08 | 2022-07-14 | Jiawang Liu | Anti-pd-l1/anti-4-1bb natural antibody structure-like heterodimeric form bispecific antibody and preparation thereof |
| JP2024536716A (ja) * | 2021-09-03 | 2024-10-08 | ノヴァロック バイオセラピューティクス， リミテッド | ＰＤ－Ｌ１、ＣＤ１３７及び／又はＴＧＦβへの二重特異性及び三重特異性結合タンパク質ならびにそれらの使用 |
| CN114702569B (zh) * | 2022-05-25 | 2023-01-10 | 深圳吉诺因生物科技有限公司 | Pd-l1相关疫苗及其应用 |
| WO2024040194A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
| US12311033B2 (en) | 2023-05-31 | 2025-05-27 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| AU2024287529A1 (en) * | 2023-07-10 | 2026-02-05 | Regeneron Pharmaceuticals, Inc. | Bispecific pd-l1x4-1bb antibodies and methods of use thereof |
| WO2025076113A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Ionizable cationic lipids with conserved spacing and lipid nanoparticles |
| WO2025076127A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Constrained ionizable cationic lipids and lipid nanoparticles |
| WO2025179294A2 (en) | 2024-02-22 | 2025-08-28 | Capstan Therapeutics, Inc. | Immune engineering amplification |
| WO2025217452A1 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Constrained ionizable cationic lipids and lipid nanoparticles |
| WO2025242843A1 (en) | 2024-05-22 | 2025-11-27 | Invox Pharma Limited | Dosage regimes for the administration of an anti-cd137/pd-l1 antigen-binding protein |
| WO2025242842A1 (en) | 2024-05-22 | 2025-11-27 | Invox Pharma Limited | Dosage regimes for the administration of an anti-cd137/pd-l1 antigen-binding protein |
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-
2019
- 2019-07-12 PL PL19740347.0T patent/PL3820569T3/pl unknown
- 2019-07-12 CA CA3106046A patent/CA3106046A1/en active Pending
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- 2019-07-12 KR KR1020217003611A patent/KR102926972B1/ko active Active
- 2019-07-12 EP EP24213991.3A patent/EP4512417A3/en active Pending
- 2019-07-12 JP JP2021500385A patent/JP7360440B2/ja active Active
- 2019-07-12 PT PT197403470T patent/PT3820569T/pt unknown
- 2019-07-12 EP EP19740347.0A patent/EP3820569B1/en active Active
- 2019-07-12 SG SG11202100170RA patent/SG11202100170RA/en unknown
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| EP4512417A3 (en) | 2025-09-17 |
| EP4512417A2 (en) | 2025-02-26 |
| BR112021000394A2 (pt) | 2021-04-06 |
| JP2023181176A (ja) | 2023-12-21 |
| US20250346679A1 (en) | 2025-11-13 |
| AU2019301204A1 (en) | 2021-02-25 |
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| JP2021524268A (ja) | 2021-09-13 |
| CA3106046A1 (en) | 2020-01-16 |
| JP7587656B2 (ja) | 2024-11-20 |
| TW202005984A (zh) | 2020-02-01 |
| DK3820569T3 (da) | 2025-01-02 |
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| US20220049007A1 (en) | 2022-02-17 |
| PL3820569T3 (pl) | 2025-07-14 |
| KR102926972B1 (ko) | 2026-02-20 |
| MX2021000398A (es) | 2021-05-27 |
| ES3006183T3 (en) | 2025-03-17 |
| US12344672B2 (en) | 2025-07-01 |
| CN112423845A (zh) | 2021-02-26 |
| ZA202100717B (en) | 2025-09-25 |
| TWI861005B (zh) | 2024-11-11 |
| EP3820569A1 (en) | 2021-05-19 |
| PT3820569T (pt) | 2025-01-14 |
| JP7360440B2 (ja) | 2023-10-12 |
| CN112423845B (zh) | 2024-07-30 |
| EP3820569B1 (en) | 2024-11-20 |
| AU2019301204B2 (en) | 2025-10-23 |
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