IL264316B2 - Stable liquid formulations comprising an antibody to il-1beta, syringes and autoinjectors comprising the same - Google Patents

Stable liquid formulations comprising an antibody to il-1beta, syringes and autoinjectors comprising the same

Info

Publication number
IL264316B2
IL264316B2 IL264316A IL26431619A IL264316B2 IL 264316 B2 IL264316 B2 IL 264316B2 IL 264316 A IL264316 A IL 264316A IL 26431619 A IL26431619 A IL 26431619A IL 264316 B2 IL264316 B2 IL 264316B2
Authority
IL
Israel
Prior art keywords
formulation
antibody
formulation according
formulations
concentration
Prior art date
Application number
IL264316A
Other languages
English (en)
Hebrew (he)
Other versions
IL264316B1 (en
IL264316A (en
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40637230&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL264316(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IL264316A publication Critical patent/IL264316A/en
Publication of IL264316B1 publication Critical patent/IL264316B1/en
Publication of IL264316B2 publication Critical patent/IL264316B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/245—IL-1

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
IL264316A 2008-12-10 2009-12-09 Stable liquid formulations comprising an antibody to il-1beta, syringes and autoinjectors comprising the same IL264316B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08170884A EP2196476A1 (en) 2008-12-10 2008-12-10 Antibody formulation
PCT/EP2009/066675 WO2010066762A1 (en) 2008-12-10 2009-12-09 Antibody formulation

Publications (3)

Publication Number Publication Date
IL264316A IL264316A (en) 2019-02-28
IL264316B1 IL264316B1 (en) 2023-09-01
IL264316B2 true IL264316B2 (en) 2024-01-01

Family

ID=40637230

Family Applications (3)

Application Number Title Priority Date Filing Date
IL264316A IL264316B2 (en) 2008-12-10 2009-12-09 Stable liquid formulations comprising an antibody to il-1beta, syringes and autoinjectors comprising the same
IL212922A IL212922B (en) 2008-12-10 2011-05-16 Stable liquid formulations comprising an antibody to il-1beta and syringes and autoinjectors comprising the same
IL276622A IL276622A (en) 2008-12-10 2020-08-10 Antibody formulation

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL212922A IL212922B (en) 2008-12-10 2011-05-16 Stable liquid formulations comprising an antibody to il-1beta and syringes and autoinjectors comprising the same
IL276622A IL276622A (en) 2008-12-10 2020-08-10 Antibody formulation

Country Status (31)

Country Link
US (3) US20110236398A1 (enExample)
EP (4) EP2196476A1 (enExample)
JP (6) JP6143416B2 (enExample)
KR (2) KR101762966B1 (enExample)
CN (3) CN104399076B (enExample)
AU (1) AU2009324371B2 (enExample)
BR (1) BRPI0922730A2 (enExample)
CA (1) CA2745938C (enExample)
CL (1) CL2011001406A1 (enExample)
CO (1) CO6361952A2 (enExample)
CY (2) CY1117735T1 (enExample)
DK (2) DK2376533T3 (enExample)
EC (1) ECSP11011192A (enExample)
ES (2) ES2579835T3 (enExample)
HR (2) HRP20160754T1 (enExample)
HU (2) HUE028408T2 (enExample)
IL (3) IL264316B2 (enExample)
LT (1) LT3072906T (enExample)
MA (1) MA33023B1 (enExample)
MX (1) MX2011006242A (enExample)
MY (2) MY157772A (enExample)
NZ (1) NZ592918A (enExample)
PE (1) PE20120342A1 (enExample)
PL (2) PL3072906T3 (enExample)
PT (2) PT3072906T (enExample)
RU (2) RU2745601C2 (enExample)
SI (2) SI3072906T1 (enExample)
SM (1) SMT201600222B (enExample)
TN (1) TN2011000229A1 (enExample)
WO (1) WO2010066762A1 (enExample)
ZA (1) ZA201103362B (enExample)

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Also Published As

Publication number Publication date
JP2026021446A (ja) 2026-02-10
KR20170044211A (ko) 2017-04-24
PT2376533T (pt) 2016-07-13
CA2745938C (en) 2018-04-24
IL212922B (en) 2019-02-28
JP2023109938A (ja) 2023-08-08
JP6143416B2 (ja) 2017-06-07
JP2020203889A (ja) 2020-12-24
KR101762966B1 (ko) 2017-07-31
RU2011127913A (ru) 2013-01-20
DK3072906T3 (da) 2021-12-13
WO2010066762A1 (en) 2010-06-17
SMT201600222B (it) 2016-08-31
JP2018168158A (ja) 2018-11-01
IL264316B1 (en) 2023-09-01
CN102245639B (zh) 2014-12-24
HUE056626T2 (hu) 2022-02-28
US20110236398A1 (en) 2011-09-29
SI3072906T1 (sl) 2022-01-31
HRP20160754T1 (hr) 2016-08-12
MY157772A (en) 2016-07-29
NZ592918A (en) 2012-12-21
ZA201103362B (en) 2012-01-25
CY1124844T1 (el) 2022-11-25
AU2009324371A1 (en) 2011-06-23
BRPI0922730A2 (en) 2018-11-06
CN104399076B (zh) 2021-09-14
RU2563179C2 (ru) 2015-09-20
JP2015231997A (ja) 2015-12-24
ES2900624T3 (es) 2022-03-17
RU2015132431A3 (enExample) 2018-12-24
PE20120342A1 (es) 2012-04-24
RU2015132431A (ru) 2018-12-24
LT3072906T (lt) 2021-12-27
CA2745938A1 (en) 2010-06-17
CN102245639A (zh) 2011-11-16
EP3792282A1 (en) 2021-03-17
IL264316A (en) 2019-02-28
IL276622A (en) 2020-09-30
US8623367B2 (en) 2014-01-07
US20200384108A1 (en) 2020-12-10
EP2376533B1 (en) 2016-03-30
AU2009324371B2 (en) 2013-10-10
HUE028408T2 (en) 2016-12-28
TN2011000229A1 (en) 2012-12-17
HK1159130A1 (zh) 2012-07-27
CN104399076A (zh) 2015-03-11
ES2579835T3 (es) 2016-08-17
MY166050A (en) 2018-05-22
JP7286595B2 (ja) 2023-06-05
SI2376533T1 (sl) 2016-07-29
HRP20211899T1 (hr) 2022-03-04
CO6361952A2 (es) 2012-01-20
ECSP11011192A (es) 2011-08-31
KR20120009421A (ko) 2012-01-31
PL2376533T3 (pl) 2016-09-30
PT3072906T (pt) 2021-12-14
EP3072906A1 (en) 2016-09-28
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CL2011001406A1 (es) 2012-03-30

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