IL245187B - Pyrazolopyrimidine compounds - Google Patents
Pyrazolopyrimidine compoundsInfo
- Publication number
- IL245187B IL245187B IL245187A IL24518716A IL245187B IL 245187 B IL245187 B IL 245187B IL 245187 A IL245187 A IL 245187A IL 24518716 A IL24518716 A IL 24518716A IL 245187 B IL245187 B IL 245187B
- Authority
- IL
- Israel
- Prior art keywords
- pyrazolopyrimidine compounds
- pyrazolopyrimidine
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261727581P | 2012-11-16 | 2012-11-16 | |
| US201361808152P | 2013-04-03 | 2013-04-03 | |
| PCT/CA2013/000957 WO2014075168A1 (en) | 2012-11-16 | 2013-11-15 | Pyrazolopyrimidine compounds |
| PCT/CA2014/051091 WO2015070349A1 (en) | 2012-11-16 | 2014-11-14 | Pyrazolopyrimidine compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL245187A0 IL245187A0 (en) | 2016-06-30 |
| IL245187B true IL245187B (en) | 2019-12-31 |
Family
ID=50730425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL245187A IL245187B (en) | 2012-11-16 | 2016-04-18 | Pyrazolopyrimidine compounds |
Country Status (24)
| Country | Link |
|---|---|
| US (9) | US9573954B2 (enExample) |
| EP (2) | EP2920181B1 (enExample) |
| JP (1) | JP6377068B2 (enExample) |
| CN (1) | CN105793261B (enExample) |
| AU (1) | AU2013344716B2 (enExample) |
| BR (1) | BR112016010080B1 (enExample) |
| CA (1) | CA2889919C (enExample) |
| CY (1) | CY1120480T1 (enExample) |
| DK (1) | DK3068786T3 (enExample) |
| ES (1) | ES2686097T3 (enExample) |
| HR (1) | HRP20181041T1 (enExample) |
| HU (1) | HUE039351T2 (enExample) |
| IL (1) | IL245187B (enExample) |
| LT (1) | LT3068786T (enExample) |
| ME (1) | ME03093B (enExample) |
| MX (1) | MX373713B (enExample) |
| NZ (1) | NZ707432A (enExample) |
| PL (1) | PL3068786T3 (enExample) |
| PT (1) | PT3068786T (enExample) |
| RS (1) | RS57481B1 (enExample) |
| SG (1) | SG11201603102TA (enExample) |
| SI (1) | SI3068786T1 (enExample) |
| TW (1) | TWI679201B (enExample) |
| WO (2) | WO2014075168A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2920181B1 (en) | 2012-11-16 | 2019-01-09 | University Health Network | Pyrazolopyrimidine compounds |
| JP6095857B2 (ja) * | 2013-11-15 | 2017-03-15 | ユニバーシティ・ヘルス・ネットワーク | ピラゾロピリミジン化合物 |
| CA2958771A1 (en) * | 2014-09-08 | 2016-03-17 | Dana-Farber Cancer Institute, Inc. | Methods of treating cancer |
| CA2966581A1 (en) | 2014-11-06 | 2016-05-12 | Lysosomal Therapeutics Inc. | Substituted pyrrolo[1,2-a]pyrimidines and their use in the treatment of medical disorders |
| PT3215511T (pt) | 2014-11-06 | 2024-05-22 | Bial R&D Invest S A | Pirazolo(1,5-a)pirimidinas substituídas e a sua utilização no tratamento de distúrbios médicos |
| US20170333435A1 (en) | 2014-11-06 | 2017-11-23 | Lysosomal Therapeutics Inc. | Substituted imidazo[1,5-a]pyrimidines and their use in the treatment of medical disorders |
| RU2712196C2 (ru) * | 2015-06-24 | 2020-01-24 | Куровир Аб | Производные пиразоло[1,5-a]триазин-4-амина, применимые в терапии |
| EP3440081A4 (en) | 2016-04-06 | 2019-09-18 | Lysosomal Therapeutics Inc. | PYRROLO [1,2-A] PYRIMIDINYL-CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDER |
| CA3020305A1 (en) | 2016-04-06 | 2017-10-12 | Lysosomal Therapeutics Inc. | Imidazo [1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
| BR112018070586A8 (pt) | 2016-04-06 | 2023-03-14 | Lysosomal Therapeutics Inc | Compostos de pirazol[1,5-a]pirimidinil carboxamida e seu uso no tratamento de distúrbios médicos |
| KR102530515B1 (ko) | 2016-05-05 | 2023-05-09 | 비알 - 알&디 인베스트먼츠, 에스.에이. | 치환된 이미다조[1,2-b]피리다진, 치환된 이미다조[1,5-b]피리다진, 관련 화합물, 및 의학적 장애의 치료에서의 그의 용도 |
| EP3452455A4 (en) | 2016-05-05 | 2019-11-13 | Lysosomal Therapeutics Inc. | SUBSTITUTED IMDAZO [1,2-] PYRIDINES, SUBSTITUTED IMIDAZO [1,2-] PYRAZINES, RELATED COMPOUNDS AND THEIR USE IN THE TREATMENT OF ILLNESSES |
| SG10202103332UA (en) * | 2016-07-18 | 2021-05-28 | Univ Health Network | Solid forms of ttk inhibitor |
| ES2994013T3 (en) | 2017-07-28 | 2025-01-15 | Takeda Pharmaceuticals Co | Tyk2 inhibitors and uses thereof |
| WO2019023786A1 (en) * | 2017-08-01 | 2019-02-07 | University Health Network | COMBINED THERAPIES FOR THE INHIBITION OF TTK PROTEIN KINASE |
| EP3796914A4 (en) * | 2018-05-23 | 2022-03-02 | University Health Network | METHODS FOR THE TREATMENT OF CANCERS CHARACTERIZED BY HIGH RATE EXPRESSION OF THE SPINDLE AND KINETOCHORE-ASSOCIATED COMPLEX (SKA3) SUBUNIT 3 GENE |
| CN112996790B (zh) | 2018-10-30 | 2023-11-03 | 克洛诺斯生物公司 | 用于调节cdk9活性的化合物、组合物和方法 |
| CN111377925B (zh) * | 2018-12-28 | 2024-03-12 | 四川科伦博泰生物医药股份有限公司 | 嘌呤类衍生物、其制备方法及其在医药上的应用 |
| CN112142744A (zh) * | 2019-06-28 | 2020-12-29 | 上海瑛派药业有限公司 | 取代的稠合杂芳双环化合物作为激酶抑制剂及其应用 |
| TW202146416A (zh) * | 2019-12-11 | 2021-12-16 | 德商拜耳廠股份有限公司 | 吡唑并三𠯤 |
| CN113773324B (zh) * | 2021-09-07 | 2022-07-26 | 武汉九州钰民医药科技有限公司 | 抗肿瘤药cfi-402257的合成制备工艺 |
| CN116396298A (zh) * | 2023-06-06 | 2023-07-07 | 四川维亚本苑生物科技有限公司 | CDK Ligand-1的中间体XII及CDK Ligand-1的制备方法 |
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| JPH04156452A (ja) | 1990-10-19 | 1992-05-28 | Konica Corp | 新規な写真用カプラー |
| JPH04156453A (ja) | 1990-10-19 | 1992-05-28 | Konica Corp | 新規な写真用カプラー |
| US6313124B1 (en) | 1997-07-23 | 2001-11-06 | Dupont Pharmaceuticals Company | Tetrazine bicyclic compounds |
| US6060478A (en) | 1996-07-24 | 2000-05-09 | Dupont Pharmaceuticals | Azolo triazines and pyrimidines |
| US6191131B1 (en) | 1997-07-23 | 2001-02-20 | Dupont Pharmaceuticals Company | Azolo triazines and pyrimidines |
| US6124289A (en) | 1996-07-24 | 2000-09-26 | Dupont Pharmaceuticals Co. | Azolo triazines and pyrimidines |
| AU4331500A (en) | 1999-04-06 | 2000-10-23 | Du Pont Pharmaceuticals Company | Pyrazolotriazines as crf antagonists |
| CN1377355A (zh) | 1999-09-30 | 2002-10-30 | 纽罗杰有限公司 | 氨基取代的吡唑并[1,5－a]－1,5－嘧啶和吡唑并[1,5－a]－1,3,5－三嗪 |
| KR20020047198A (ko) | 1999-09-30 | 2002-06-21 | 해피 페너 ; 해리 에이치. 페너 2세 | 특정 알킬렌 디아민-치환된피라졸로[1,5-ａ]-1,5-피리미딘 및피라졸로[1,5-ａ]-1,3,5-트리아진 |
| US7067520B2 (en) | 2000-11-17 | 2006-06-27 | Ishihara Sangyo Kaisha, Ltd. | Preventive or therapeutic medicines for diabetes containing fused-heterocyclic compounds or their salts |
| ES2245772T3 (es) | 2002-03-07 | 2006-01-16 | Smithkline Beecham Corporation | Derivados de pirazolopirimidina y pirazolotriazina y composiciones farmaceuticas que los contienen. |
| US7662826B2 (en) | 2002-04-23 | 2010-02-16 | Shionogi & Co., Ltd. | Pyrazolo [1,5-a] pyrimidine derivative and nad (p) h oxidase inhibitor containing the same |
| FR2842809A1 (fr) | 2002-07-26 | 2004-01-30 | Greenpharma Sas | NOUVELLES PYRAZOLO[1,5-a]-1,3,5-TRIAZINES SUBSTITUEES ET LEURS ANALOGUES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION |
| KR101050700B1 (ko) | 2002-08-26 | 2011-07-20 | 다케다 야쿠힌 고교 가부시키가이샤 | 칼슘 수용체 조절 화합물 및 이의 용도 |
| US7605155B2 (en) | 2002-09-04 | 2009-10-20 | Schering Corporation | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
| US7119200B2 (en) | 2002-09-04 | 2006-10-10 | Schering Corporation | Pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| TW200413377A (en) | 2002-09-04 | 2004-08-01 | Schering Corp | Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| ATE469903T1 (de) | 2002-09-04 | 2010-06-15 | Schering Corp | Zur behandlung von krebserkrankungen geeignete pyrazolopyrimidine |
| WO2004052315A2 (en) * | 2002-12-11 | 2004-06-24 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| CA2518318A1 (en) | 2003-03-17 | 2004-09-30 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| WO2004087707A1 (en) * | 2003-03-31 | 2004-10-14 | Vernalis (Cambridge) Limited | Pyrazolopyrimidine compounds and their use in medicine |
| US7285550B2 (en) | 2003-04-09 | 2007-10-23 | Biogen Idec Ma Inc. | Triazolotriazines and pyrazolotriazines and methods of making and using the same |
| EP1633756B1 (en) | 2003-04-09 | 2008-12-24 | Biogen Idec MA Inc. | A2a adenosine receptor antagonists |
| BRPI0418112A (pt) | 2003-12-23 | 2007-04-17 | Novartis Ag | inibidores de p-38 quinase bicìclico heterocìclicos |
| TW200536536A (en) | 2004-02-25 | 2005-11-16 | Schering Corp | Pyrazolotriazines as kinase inhibitors |
| US7306631B2 (en) | 2004-03-30 | 2007-12-11 | The Procter & Gamble Company | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof |
| US20100216798A1 (en) | 2005-07-29 | 2010-08-26 | Astellas Pharma Inc | Fused heterocycles as lck inhibitors |
| US20070078136A1 (en) | 2005-09-22 | 2007-04-05 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
| US7723336B2 (en) | 2005-09-22 | 2010-05-25 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
| BRPI0616985B1 (pt) | 2005-10-06 | 2021-10-26 | Merck Sharp & Dohme Corp. | Composto de pirazolo[1,5-a]pirimidina, e, uso de um composto |
| EP1873157A1 (en) * | 2006-06-21 | 2008-01-02 | Bayer Schering Pharma Aktiengesellschaft | Pyrazolopyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same |
| EP1900739A1 (en) | 2006-08-30 | 2008-03-19 | Cellzome Ag | Diazolodiazine derivatives as kinase inhibitors |
| NZ576234A (en) | 2006-11-06 | 2011-06-30 | Supergen Inc | Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors |
| WO2008056176A1 (en) | 2006-11-10 | 2008-05-15 | Scottish Biomedical Limited | Pyrazolopyrimidines as phosphodiesterase inhibitors |
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| US20100029657A1 (en) | 2008-02-29 | 2010-02-04 | Wyeth | Bridged, Bicyclic Heterocyclic or Spiro Bicyclic Heterocyclic Derivatives of Pyrazolo[1, 5-A]Pyrimidines, Methods for Preparation and Uses Thereof |
| EP2346508B1 (en) | 2008-09-26 | 2016-08-24 | Intellikine, LLC | Heterocyclic kinase inhibitors |
| WO2010086040A1 (en) | 2009-01-29 | 2010-08-05 | Biomarin Iga, Ltd. | Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy |
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| JP5824040B2 (ja) | 2010-06-01 | 2015-11-25 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 置換イミダゾピラジン |
| US20120083498A1 (en) | 2010-06-17 | 2012-04-05 | Fatah Kashanchi | Modulators of Viral Transcription, and Methods and Compositions Therewith |
| US20120149708A1 (en) | 2010-06-17 | 2012-06-14 | George Mason University | Modulators of viral transcription, and methods and compositions therewith |
| RS54761B1 (sr) | 2010-06-24 | 2016-10-31 | Gilead Sciences | Pirazolo[1,5-a]pirimidini i-triazini kao antiviralni agensi |
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| US20120077814A1 (en) | 2010-09-10 | 2012-03-29 | Zhong Wang | Sulfonamide, sulfamate, and sulfamothioate derivatives |
| TWI541243B (zh) | 2010-09-10 | 2016-07-11 | 拜耳知識產權公司 | 經取代咪唑并嗒 |
| JP2014503521A (ja) | 2010-12-17 | 2014-02-13 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 過増殖性障害の処置におけるｍｐｓ−１およびｔｋｋ阻害剤としての使用のための、イミダゾピラジン類 |
| JP2013545779A (ja) * | 2010-12-17 | 2013-12-26 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 過剰増殖性障害の治療におけるｍｐｓ−１およびｔｋｋ阻害剤として使用するための６置換イミダゾピラジン |
| US20140187548A1 (en) * | 2010-12-17 | 2014-07-03 | Bayer Intellectual Property Gmbh | 6 substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders |
| EP2665726A4 (en) | 2011-01-21 | 2014-09-03 | Gen Hospital Corp | COMPOSITIONS AND METHODS OF TREATING CARDIOVASCULAR DISEASES |
| WO2012136531A1 (en) | 2011-04-06 | 2012-10-11 | Bayer Pharma Aktiengesellschaft | Substituted imidazopyridines and intermediates thereof |
| EP3409278B8 (en) | 2011-07-21 | 2020-11-04 | Sumitomo Dainippon Pharma Oncology, Inc. | Heterocyclic protein kinase inhibitors |
| KR20140077964A (ko) | 2011-10-20 | 2014-06-24 | 글락소스미스클라인 엘엘씨 | 시르투인 조절제로서의 치환된 비시클릭 아자-헤테로사이클 및 유사체 |
| EP2920181B1 (en) | 2012-11-16 | 2019-01-09 | University Health Network | Pyrazolopyrimidine compounds |
-
2013
- 2013-11-15 EP EP13855919.0A patent/EP2920181B1/en active Active
- 2013-11-15 AU AU2013344716A patent/AU2013344716B2/en active Active
- 2013-11-15 JP JP2015542121A patent/JP6377068B2/ja active Active
- 2013-11-15 WO PCT/CA2013/000957 patent/WO2014075168A1/en not_active Ceased
- 2013-11-15 NZ NZ707432A patent/NZ707432A/en unknown
- 2013-11-15 CA CA2889919A patent/CA2889919C/en active Active
- 2013-11-15 US US14/443,072 patent/US9573954B2/en active Active
-
2014
- 2014-11-14 ES ES14861448.0T patent/ES2686097T3/es active Active
- 2014-11-14 CN CN201480062623.XA patent/CN105793261B/zh active Active
- 2014-11-14 PT PT148614480T patent/PT3068786T/pt unknown
- 2014-11-14 HR HRP20181041TT patent/HRP20181041T1/hr unknown
- 2014-11-14 PL PL14861448T patent/PL3068786T3/pl unknown
- 2014-11-14 SI SI201430815T patent/SI3068786T1/sl unknown
- 2014-11-14 TW TW103139540A patent/TWI679201B/zh active
- 2014-11-14 SG SG11201603102TA patent/SG11201603102TA/en unknown
- 2014-11-14 BR BR112016010080-8A patent/BR112016010080B1/pt active IP Right Grant
- 2014-11-14 HU HUE14861448A patent/HUE039351T2/hu unknown
- 2014-11-14 EP EP14861448.0A patent/EP3068786B1/en active Active
- 2014-11-14 RS RS20180775A patent/RS57481B1/sr unknown
- 2014-11-14 DK DK14861448.0T patent/DK3068786T3/en active
- 2014-11-14 WO PCT/CA2014/051091 patent/WO2015070349A1/en not_active Ceased
- 2014-11-14 ME MEP-2018-171A patent/ME03093B/me unknown
- 2014-11-14 MX MX2016006336A patent/MX373713B/es active IP Right Grant
- 2014-11-14 LT LTEP14861448.0T patent/LT3068786T/lt unknown
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2015
- 2015-10-29 US US14/926,977 patent/US9657025B2/en active Active
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2016
- 2016-04-18 IL IL245187A patent/IL245187B/en active IP Right Grant
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2017
- 2017-02-16 US US15/434,275 patent/US10106545B2/en active Active
- 2017-05-18 US US15/598,402 patent/US10167289B2/en active Active
-
2018
- 2018-07-30 CY CY20181100786T patent/CY1120480T1/el unknown
- 2018-10-09 US US16/155,846 patent/US10570143B2/en active Active
- 2018-12-19 US US16/225,970 patent/US20190322669A1/en not_active Abandoned
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2020
- 2020-05-21 US US16/880,192 patent/US20210009595A1/en not_active Abandoned
-
2021
- 2021-11-08 US US17/521,255 patent/US20220204511A1/en not_active Abandoned
-
2023
- 2023-12-20 US US18/391,047 patent/US20240287077A1/en not_active Abandoned
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| GB201218018D0 (en) | Compounds |
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