ME03093B - Pirazolopirimidinska jedinjenja - Google Patents
Pirazolopirimidinska jedinjenjaInfo
- Publication number
- ME03093B ME03093B MEP-2018-171A MEP2018171A ME03093B ME 03093 B ME03093 B ME 03093B ME P2018171 A MEP2018171 A ME P2018171A ME 03093 B ME03093 B ME 03093B
- Authority
- ME
- Montenegro
- Prior art keywords
- pyrazolopyrimidine
- units
- pyrazolopyrimidine units
- Prior art date
Links
- OGEBRHQLRGFBNV-RZDIXWSQSA-N chembl2036808 Chemical group C12=NC(NCCCC)=NC=C2C(C=2C=CC(F)=CC=2)=NN1C[C@H]1CC[C@H](N)CC1 OGEBRHQLRGFBNV-RZDIXWSQSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261727581P | 2012-11-16 | 2012-11-16 | |
| US201361808152P | 2013-04-03 | 2013-04-03 | |
| PCT/CA2013/000957 WO2014075168A1 (en) | 2012-11-16 | 2013-11-15 | Pyrazolopyrimidine compounds |
| PCT/CA2014/051091 WO2015070349A1 (en) | 2012-11-16 | 2014-11-14 | Pyrazolopyrimidine compounds |
| EP14861448.0A EP3068786B1 (en) | 2012-11-16 | 2014-11-14 | Pyrazolopyrimidine compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME03093B true ME03093B (me) | 2019-01-20 |
Family
ID=50730425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2018-171A ME03093B (me) | 2012-11-16 | 2014-11-14 | Pirazolopirimidinska jedinjenja |
Country Status (24)
| Country | Link |
|---|---|
| US (9) | US9573954B2 (me) |
| EP (2) | EP2920181B1 (me) |
| JP (1) | JP6377068B2 (me) |
| CN (1) | CN105793261B (me) |
| AU (1) | AU2013344716B2 (me) |
| BR (1) | BR112016010080B1 (me) |
| CA (1) | CA2889919C (me) |
| CY (1) | CY1120480T1 (me) |
| DK (1) | DK3068786T3 (me) |
| ES (1) | ES2686097T3 (me) |
| HR (1) | HRP20181041T1 (me) |
| HU (1) | HUE039351T2 (me) |
| IL (1) | IL245187B (me) |
| LT (1) | LT3068786T (me) |
| ME (1) | ME03093B (me) |
| MX (1) | MX373713B (me) |
| NZ (1) | NZ707432A (me) |
| PL (1) | PL3068786T3 (me) |
| PT (1) | PT3068786T (me) |
| RS (1) | RS57481B1 (me) |
| SG (1) | SG11201603102TA (me) |
| SI (1) | SI3068786T1 (me) |
| TW (1) | TWI679201B (me) |
| WO (2) | WO2014075168A1 (me) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013344716B2 (en) | 2012-11-16 | 2018-03-01 | University Health Network | Pyrazolopyrimidine compounds |
| JP6095857B2 (ja) * | 2013-11-15 | 2017-03-15 | ユニバーシティ・ヘルス・ネットワーク | ピラゾロピリミジン化合物 |
| CA2958771A1 (en) * | 2014-09-08 | 2016-03-17 | Dana-Farber Cancer Institute, Inc. | Methods of treating cancer |
| EP3215509B1 (en) | 2014-11-06 | 2020-02-26 | Lysosomal Therapeutics Inc. | Substituted pyrrolo[1,2-a]pyrimidines and their use in the treatment of medical disorders |
| ES2958391T3 (es) | 2014-11-06 | 2024-02-08 | Bial R&D Invest S A | Imidazo[1,5-a]pirimidinas sustituidas y su uso en el tratamiento de trastornos médicos |
| SMT202400187T1 (it) | 2014-11-06 | 2024-07-09 | Bial R&D Investments S A | Pirazolo(1,5-a)pirimidine sostituite e loro utilizzo nel trattamento di disturbi medici |
| RU2712196C2 (ru) * | 2015-06-24 | 2020-01-24 | Куровир Аб | Производные пиразоло[1,5-a]триазин-4-амина, применимые в терапии |
| WO2017176962A1 (en) | 2016-04-06 | 2017-10-12 | Lysosomal Therapeutics, Inc. | Pyrrolo[1,2-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
| US10787454B2 (en) | 2016-04-06 | 2020-09-29 | BIAL—BioTech Investments, Inc. | Imidazo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
| AU2017246455B2 (en) | 2016-04-06 | 2021-09-30 | Bial - R&D Investments, S.A. | Pyrazolo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
| US11345698B2 (en) | 2016-05-05 | 2022-05-31 | Bial—R&D Investments, S.A. | Substituted imidazo[1,2-a]pyridines, substituted imidazo[1,2-a]pyrazines, related compounds, and their use in the treatment of medical disorders |
| BR112018072552A8 (pt) | 2016-05-05 | 2023-03-14 | Lysosomal Therapeutics Inc | Compostos de imidazo [1,2-b]piridazinas e imidazo [1,5-b] piridazinas substituídas, composição farmacêutica que os compreende e seu uso no tratamento de distúrbios médicos |
| KR102700233B1 (ko) | 2016-07-18 | 2024-08-28 | 유니버시티 헬스 네트워크 | 고체 형태의 ttk 억제제 |
| WO2019023468A1 (en) | 2017-07-28 | 2019-01-31 | Nimbus Lakshmi, Inc. | TYK2 INHIBITORS AND USES THEREOF |
| WO2019023786A1 (en) * | 2017-08-01 | 2019-02-07 | University Health Network | COMBINED THERAPIES FOR THE INHIBITION OF TTK PROTEIN KINASE |
| CA3101035A1 (en) * | 2018-05-23 | 2019-11-28 | University Health Network | Methods of treating cancers characterized by a high expression level of spindle and kinetochore associated complex subunit 3 (ska3) gene |
| PE20212196A1 (es) | 2018-10-30 | 2021-11-16 | Kronos Bio Inc | Compuestos, composiciones, y metodos para modular la actividad cdk9 |
| CN111377925B (zh) * | 2018-12-28 | 2024-03-12 | 四川科伦博泰生物医药股份有限公司 | 嘌呤类衍生物、其制备方法及其在医药上的应用 |
| CN112142744A (zh) * | 2019-06-28 | 2020-12-29 | 上海瑛派药业有限公司 | 取代的稠合杂芳双环化合物作为激酶抑制剂及其应用 |
| TW202146416A (zh) * | 2019-12-11 | 2021-12-16 | 德商拜耳廠股份有限公司 | 吡唑并三𠯤 |
| CN113773324B (zh) * | 2021-09-07 | 2022-07-26 | 武汉九州钰民医药科技有限公司 | 抗肿瘤药cfi-402257的合成制备工艺 |
| CN116396298A (zh) * | 2023-06-06 | 2023-07-07 | 四川维亚本苑生物科技有限公司 | CDK Ligand-1的中间体XII及CDK Ligand-1的制备方法 |
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| JPH04156452A (ja) | 1990-10-19 | 1992-05-28 | Konica Corp | 新規な写真用カプラー |
| JPH04156453A (ja) | 1990-10-19 | 1992-05-28 | Konica Corp | 新規な写真用カプラー |
| US6060478A (en) | 1996-07-24 | 2000-05-09 | Dupont Pharmaceuticals | Azolo triazines and pyrimidines |
| US6191131B1 (en) | 1997-07-23 | 2001-02-20 | Dupont Pharmaceuticals Company | Azolo triazines and pyrimidines |
| US6313124B1 (en) | 1997-07-23 | 2001-11-06 | Dupont Pharmaceuticals Company | Tetrazine bicyclic compounds |
| US6124289A (en) | 1996-07-24 | 2000-09-26 | Dupont Pharmaceuticals Co. | Azolo triazines and pyrimidines |
| WO2000059907A2 (en) | 1999-04-06 | 2000-10-12 | Du Pont Pharmaceuticals Company | Pyrazolotriazines as crf antagonists |
| PL354675A1 (en) | 1999-09-30 | 2004-02-09 | Neurogen Corporation | Certain alkylene diamine-substituted pyrazolo[1,5,-a]-1,5-pyrimidines and pyrazolo[1,5-a]-1,3,5-triazines |
| CZ20021089A3 (cs) | 1999-09-30 | 2002-11-13 | Neurogen Corporation | Aminosustituované pyrazolo[1,5-a]-1,5-pyrimidiny a pyrazolo[1,5-a]-1,3,5-triaziny |
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| MXPA04010441A (es) | 2002-04-23 | 2005-02-14 | Shionogi & Co | Derivado de pirazolo[1,5-a]pirimidina e inhibidor de nad(p)h oxidasa que contiene el mismo. |
| FR2842809A1 (fr) | 2002-07-26 | 2004-01-30 | Greenpharma Sas | NOUVELLES PYRAZOLO[1,5-a]-1,3,5-TRIAZINES SUBSTITUEES ET LEURS ANALOGUES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION |
| AU2003265585B2 (en) | 2002-08-26 | 2008-07-03 | Takeda Pharmaceutical Company Limited | Calcium receptor modulating compound and use thereof |
| ATE364608T1 (de) | 2002-09-04 | 2007-07-15 | Schering Corp | Pyrazolopyrimidine als hemmstoffe cyclin- abhängiger kinasen |
| US7605155B2 (en) | 2002-09-04 | 2009-10-20 | Schering Corporation | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
| DK1537116T3 (da) | 2002-09-04 | 2010-09-27 | Schering Corp | Pyrazolopyrimidiner egnede til behandling af cancersygdomme |
| US7119200B2 (en) | 2002-09-04 | 2006-10-10 | Schering Corporation | Pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| AU2003299651A1 (en) | 2002-12-11 | 2004-06-30 | Merck And Co., Inc. | Tyrosine kinase inhibitors |
| EP1608628A2 (en) | 2003-03-17 | 2005-12-28 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
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| ATE418555T1 (de) | 2003-04-09 | 2009-01-15 | Biogen Idec Inc | A2a-adenosinrezeptorantagonisten |
| EP1615930A2 (en) | 2003-04-09 | 2006-01-18 | Biogen Idec MA, Inc. | Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagonists |
| WO2005063766A2 (en) | 2003-12-23 | 2005-07-14 | Novartis Ag | Bicyclic heterocyclic p-38 kinase inhibitors |
| PE20051128A1 (es) | 2004-02-25 | 2006-01-16 | Schering Corp | Pirazolotriazinas como inhibidores de quinasa |
| US7306631B2 (en) | 2004-03-30 | 2007-12-11 | The Procter & Gamble Company | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof |
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| CN101600718B (zh) | 2006-11-06 | 2013-07-03 | 特雷罗药物股份有限公司 | 咪唑并[1,2-b]哒嗪和吡唑并[1,5-a]嘧啶衍生物及其作为蛋白激酶抑制剂的用途 |
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| US20100029657A1 (en) | 2008-02-29 | 2010-02-04 | Wyeth | Bridged, Bicyclic Heterocyclic or Spiro Bicyclic Heterocyclic Derivatives of Pyrazolo[1, 5-A]Pyrimidines, Methods for Preparation and Uses Thereof |
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| EP2525659B1 (en) | 2010-01-19 | 2019-02-27 | Merck Sharp & Dohme Corp. | PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS |
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| JP5951750B2 (ja) | 2011-04-06 | 2016-07-13 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 置換イミダゾピリジン類およびその中間体 |
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| AU2013344716B2 (en) | 2012-11-16 | 2018-03-01 | University Health Network | Pyrazolopyrimidine compounds |
-
2013
- 2013-11-15 AU AU2013344716A patent/AU2013344716B2/en active Active
- 2013-11-15 EP EP13855919.0A patent/EP2920181B1/en active Active
- 2013-11-15 NZ NZ707432A patent/NZ707432A/en unknown
- 2013-11-15 JP JP2015542121A patent/JP6377068B2/ja active Active
- 2013-11-15 US US14/443,072 patent/US9573954B2/en active Active
- 2013-11-15 CA CA2889919A patent/CA2889919C/en active Active
- 2013-11-15 WO PCT/CA2013/000957 patent/WO2014075168A1/en not_active Ceased
-
2014
- 2014-11-14 HU HUE14861448A patent/HUE039351T2/hu unknown
- 2014-11-14 WO PCT/CA2014/051091 patent/WO2015070349A1/en not_active Ceased
- 2014-11-14 PT PT148614480T patent/PT3068786T/pt unknown
- 2014-11-14 SG SG11201603102TA patent/SG11201603102TA/en unknown
- 2014-11-14 PL PL14861448T patent/PL3068786T3/pl unknown
- 2014-11-14 ME MEP-2018-171A patent/ME03093B/me unknown
- 2014-11-14 SI SI201430815T patent/SI3068786T1/sl unknown
- 2014-11-14 DK DK14861448.0T patent/DK3068786T3/en active
- 2014-11-14 ES ES14861448.0T patent/ES2686097T3/es active Active
- 2014-11-14 EP EP14861448.0A patent/EP3068786B1/en active Active
- 2014-11-14 CN CN201480062623.XA patent/CN105793261B/zh active Active
- 2014-11-14 LT LTEP14861448.0T patent/LT3068786T/lt unknown
- 2014-11-14 MX MX2016006336A patent/MX373713B/es active IP Right Grant
- 2014-11-14 HR HRP20181041TT patent/HRP20181041T1/hr unknown
- 2014-11-14 TW TW103139540A patent/TWI679201B/zh active
- 2014-11-14 BR BR112016010080-8A patent/BR112016010080B1/pt active IP Right Grant
- 2014-11-14 RS RS20180775A patent/RS57481B1/sr unknown
-
2015
- 2015-10-29 US US14/926,977 patent/US9657025B2/en active Active
-
2016
- 2016-04-18 IL IL245187A patent/IL245187B/en active IP Right Grant
-
2017
- 2017-02-16 US US15/434,275 patent/US10106545B2/en active Active
- 2017-05-18 US US15/598,402 patent/US10167289B2/en active Active
-
2018
- 2018-07-30 CY CY20181100786T patent/CY1120480T1/el unknown
- 2018-10-09 US US16/155,846 patent/US10570143B2/en active Active
- 2018-12-19 US US16/225,970 patent/US20190322669A1/en not_active Abandoned
-
2020
- 2020-05-21 US US16/880,192 patent/US20210009595A1/en not_active Abandoned
-
2021
- 2021-11-08 US US17/521,255 patent/US20220204511A1/en not_active Abandoned
-
2023
- 2023-12-20 US US18/391,047 patent/US20240287077A1/en not_active Abandoned
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