HRP20181041T1 - Pirazolopirimidinski spojevi - Google Patents

Pirazolopirimidinski spojevi

Info

Publication number
HRP20181041T1
HRP20181041T1 HRP20181041TT HRP20181041T HRP20181041T1 HR P20181041 T1 HRP20181041 T1 HR P20181041T1 HR P20181041T T HRP20181041T T HR P20181041TT HR P20181041 T HRP20181041 T HR P20181041T HR P20181041 T1 HRP20181041 T1 HR P20181041T1
Authority
HR
Croatia
Prior art keywords
pyrazolopyrimidine compounds
pyrazolopyrimidine
compounds
Prior art date
Application number
HRP20181041TT
Other languages
English (en)
Inventor
Radoslaw Laufer
Grace Ng
Sze-Wan Li
Heinz W. Pauls
Yong Liu
Narendra Kumar B. Patel
Original Assignee
University Health Network
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Health Network filed Critical University Health Network
Publication of HRP20181041T1 publication Critical patent/HRP20181041T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
HRP20181041TT 2012-11-16 2018-07-05 Pirazolopirimidinski spojevi HRP20181041T1 (hr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261727581P 2012-11-16 2012-11-16
US201361808152P 2013-04-03 2013-04-03
PCT/CA2013/000957 WO2014075168A1 (en) 2012-11-16 2013-11-15 Pyrazolopyrimidine compounds
EP14861448.0A EP3068786B1 (en) 2012-11-16 2014-11-14 Pyrazolopyrimidine compounds
PCT/CA2014/051091 WO2015070349A1 (en) 2012-11-16 2014-11-14 Pyrazolopyrimidine compounds

Publications (1)

Publication Number Publication Date
HRP20181041T1 true HRP20181041T1 (hr) 2018-09-21

Family

ID=50730425

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20181041TT HRP20181041T1 (hr) 2012-11-16 2018-07-05 Pirazolopirimidinski spojevi

Country Status (24)

Country Link
US (8) US9573954B2 (hr)
EP (2) EP2920181B1 (hr)
JP (1) JP6377068B2 (hr)
CN (1) CN105793261B (hr)
AU (1) AU2013344716B2 (hr)
BR (1) BR112016010080B1 (hr)
CA (1) CA2889919C (hr)
CY (1) CY1120480T1 (hr)
DK (1) DK3068786T3 (hr)
ES (1) ES2686097T3 (hr)
HR (1) HRP20181041T1 (hr)
HU (1) HUE039351T2 (hr)
IL (1) IL245187B (hr)
LT (1) LT3068786T (hr)
ME (1) ME03093B (hr)
MX (1) MX2016006336A (hr)
NZ (1) NZ707432A (hr)
PL (1) PL3068786T3 (hr)
PT (1) PT3068786T (hr)
RS (1) RS57481B1 (hr)
SG (1) SG11201603102TA (hr)
SI (1) SI3068786T1 (hr)
TW (1) TWI679201B (hr)
WO (2) WO2014075168A1 (hr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2889919C (en) 2012-11-16 2021-08-17 University Health Network Pyrazolopyrimidine compounds
EA029372B1 (ru) * 2013-11-15 2018-03-30 Юниверсити Хелс Нетуорк Пиразолопиримидиновые соединения
EP3191095A2 (en) * 2014-09-08 2017-07-19 Dana Farber Cancer Institute, Inc. Methods of treating cancer comprising administering a ppar-gamma agonist
MX2017005940A (es) 2014-11-06 2018-01-11 Lysosomal Therapeutics Inc Pyrazolo [1, 5-a] pirimidinas sustituidas y su uso en el tratamiento de trastornos médicos.
WO2016073891A1 (en) 2014-11-06 2016-05-12 Lysosomal Therapeutics Inc. Substituted pyrrolo[1,2-a]pyrimidines and their use in the treatment of medical disorders
ES2958391T3 (es) 2014-11-06 2024-02-08 Bial R&D Invest S A Imidazo[1,5-a]pirimidinas sustituidas y su uso en el tratamiento de trastornos médicos
EP3313842B1 (en) * 2015-06-24 2020-04-15 Curovir Ab Pyrazolo[1,5-a]triazin-4-amine derivatives useful in therapy
JP7046827B2 (ja) 2016-04-06 2022-04-04 リソソーマル・セラピューティクス・インコーポレイテッド イミダゾ［１，５－ａ］ピリミジニルカルボキサミド化合物および医学的障害の処置におけるその使用
JP7038063B2 (ja) 2016-04-06 2022-03-17 リソソーマル・セラピューティクス・インコーポレイテッド ピラゾロ［１，５－ａ］ピリミジニルカルボキサミド化合物および医学的障害の処置におけるその使用
CA3020310A1 (en) 2016-04-06 2017-10-12 Lysosomal Therapeutics Inc. Pyrrolo[1,2-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
WO2017192931A1 (en) 2016-05-05 2017-11-09 Lysosomal Therapeutics Inc. SUBSTITUTED IMDAZO[1,2-α]PYRIDINES, SUBSTITUTED IMIDAZO[1,2-α]PYRAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
SG11201809693SA (en) 2016-05-05 2018-11-29 Lysosomal Therapeutics Inc SUBSTITUTED IMIDAZO[1,2-b]PYRIDAZINES, SUBSTITUTED IMIDAZO[1,5-b]PYRIDAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
HRP20230481T1 (hr) 2016-07-18 2023-07-21 University Health Network Čvrsti oblici inhibitora ttk
EP3658557A4 (en) 2017-07-28 2020-12-09 Nimbus Lakshmi, Inc. TYK2 INHIBITORS AND USES THEREOF
WO2019023786A1 (en) * 2017-08-01 2019-02-07 University Health Network COMBINED THERAPIES FOR THE INHIBITION OF TTK PROTEIN KINASE
JP7473483B2 (ja) * 2018-05-23 2024-04-23 ユニバーシティー ヘルス ネットワーク 紡錘体および動原体関連複合体サブユニット３（ｓｋａ３）遺伝子の高発現レベルを特徴とする癌を治療する方法
EP3873911A4 (en) 2018-10-30 2022-06-22 Kronos Bio, Inc. COMPOUNDS, COMPOSITIONS AND METHODS FOR MODULATING CDK9 ACTIVITY
CN111377925B (zh) * 2018-12-28 2024-03-12 四川科伦博泰生物医药股份有限公司 嘌呤类衍生物、其制备方法及其在医药上的应用
CN112142744A (zh) * 2019-06-28 2020-12-29 上海瑛派药业有限公司 取代的稠合杂芳双环化合物作为激酶抑制剂及其应用
TW202146416A (zh) * 2019-12-11 2021-12-16 德商拜耳廠股份有限公司 吡唑并三𠯤
CN113773324B (zh) * 2021-09-07 2022-07-26 武汉九州钰民医药科技有限公司 抗肿瘤药cfi-402257的合成制备工艺
CN116396298A (zh) * 2023-06-06 2023-07-07 四川维亚本苑生物科技有限公司 CDK Ligand-1的中间体XII及CDK Ligand-1的制备方法

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021556A (en) * 1972-06-08 1977-05-03 Icn Pharmaceuticals, Inc. Xanthine oxidase inhibitors
JPH04156452A (ja) 1990-10-19 1992-05-28 Konica Corp 新規な写真用カプラー
JPH04156453A (ja) 1990-10-19 1992-05-28 Konica Corp 新規な写真用カプラー
US6060478A (en) 1996-07-24 2000-05-09 Dupont Pharmaceuticals Azolo triazines and pyrimidines
US6124289A (en) 1996-07-24 2000-09-26 Dupont Pharmaceuticals Co. Azolo triazines and pyrimidines
US6191131B1 (en) 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
US6313124B1 (en) 1997-07-23 2001-11-06 Dupont Pharmaceuticals Company Tetrazine bicyclic compounds
WO2000059907A2 (en) 1999-04-06 2000-10-12 Du Pont Pharmaceuticals Company Pyrazolotriazines as crf antagonists
ATE347553T1 (de) 1999-09-30 2006-12-15 Neurogen Corp Amino-substituierte pyrazolo 1,5-aö-1,5- pyrimidine und pyrazolo 1,5-aö-1,3,5-triazine
CZ20021067A3 (cs) 1999-09-30 2002-11-13 Neurogen Corporation Určité alkylendiaminové substituované pyrazolo[1,5-a]- 1,5-pyrimidiny a pyrazolo[1,5-a]-1,3,5-triaziny
US7067520B2 (en) 2000-11-17 2006-06-27 Ishihara Sangyo Kaisha, Ltd. Preventive or therapeutic medicines for diabetes containing fused-heterocyclic compounds or their salts
JP2005525382A (ja) 2002-03-07 2005-08-25 スミスクライン ビーチャム コーポレーション ピラゾロピリミジンおよびピラゾロトリアジン誘導体ならびにそれを含む医薬組成物
AU2003227437A1 (en) 2002-04-23 2003-11-10 Shionogi And Co., Ltd. PYRAZOLO(1,5-a)PYRIMIDINE DERIVATIVE AND NAD(P)H OXIDASE INHIBITOR CONTAINING THE SAME
FR2842809A1 (fr) 2002-07-26 2004-01-30 Greenpharma Sas NOUVELLES PYRAZOLO[1,5-a]-1,3,5-TRIAZINES SUBSTITUEES ET LEURS ANALOGUES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION
KR101050700B1 (ko) 2002-08-26 2011-07-20 다케다 야쿠힌 고교 가부시키가이샤 칼슘 수용체 조절 화합물 및 이의 용도
ATE469903T1 (de) 2002-09-04 2010-06-15 Schering Corp Zur behandlung von krebserkrankungen geeignete pyrazolopyrimidine
NZ539162A (en) 2002-09-04 2006-07-28 Schering Corp Pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7605155B2 (en) * 2002-09-04 2009-10-20 Schering Corporation Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
US7119200B2 (en) 2002-09-04 2006-10-10 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
AU2003299651A1 (en) * 2002-12-11 2004-06-30 Merck And Co., Inc. Tyrosine kinase inhibitors
WO2004082638A2 (en) 2003-03-17 2004-09-30 Syrrx, Inc. Histone deacetylase inhibitors
EP1608652A1 (en) * 2003-03-31 2005-12-28 Vernalis (Cambridge) Limited Pyrazolopyrimidine compounds and their use in medicine
EP1615930A2 (en) 2003-04-09 2006-01-18 Biogen Idec MA, Inc. Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagonists
US7834014B2 (en) 2003-04-09 2010-11-16 Biogen Idec Ma Inc. A2a adenosine receptor antagonists
AU2004309420B2 (en) 2003-12-23 2008-10-30 Novartis Ag Bicyclic heterocyclic p-38 kinase inhibitors
TW200536536A (en) 2004-02-25 2005-11-16 Schering Corp Pyrazolotriazines as kinase inhibitors
US7306631B2 (en) 2004-03-30 2007-12-11 The Procter & Gamble Company Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof
US20100216798A1 (en) 2005-07-29 2010-08-26 Astellas Pharma Inc Fused heterocycles as lck inhibitors
US20070078136A1 (en) 2005-09-22 2007-04-05 Bristol-Myers Squibb Company Fused heterocyclic compounds useful as kinase modulators
US7723336B2 (en) 2005-09-22 2010-05-25 Bristol-Myers Squibb Company Fused heterocyclic compounds useful as kinase modulators
NZ567151A (en) * 2005-10-06 2012-03-30 Schering Corp Pyrazolo [1,5 -A] pyrimidine derivatives and their use for inhibiting Checkpoint kinases
EP1873157A1 (en) * 2006-06-21 2008-01-02 Bayer Schering Pharma Aktiengesellschaft Pyrazolopyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
EP1900739A1 (en) 2006-08-30 2008-03-19 Cellzome Ag Diazolodiazine derivatives as kinase inhibitors
MX2009004700A (es) 2006-11-06 2009-05-15 Supergen Inc Derivados de imidazo[1,2-b]piridazin y pirazolo[1,5-a] pirimidina y su uso como inhibidores de proteina cinasa.
WO2008056176A1 (en) 2006-11-10 2008-05-15 Scottish Biomedical Limited Pyrazolopyrimidines as phosphodiesterase inhibitors
CA2693915A1 (en) * 2007-07-20 2009-01-29 Merck & Co., Inc. Pyrazolo[1,5-a]pyrimidine derivatives
US20100029657A1 (en) 2008-02-29 2010-02-04 Wyeth Bridged, Bicyclic Heterocyclic or Spiro Bicyclic Heterocyclic Derivatives of Pyrazolo[1, 5-A]Pyrimidines, Methods for Preparation and Uses Thereof
US8703778B2 (en) 2008-09-26 2014-04-22 Intellikine Llc Heterocyclic kinase inhibitors
WO2010086040A1 (en) 2009-01-29 2010-08-05 Biomarin Iga, Ltd. Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy
GB0908957D0 (en) 2009-05-22 2009-07-01 Ucb Pharma Sa Therapeutic agents
TW201107329A (en) 2009-07-30 2011-03-01 Oncotherapy Science Inc Fused imidazole derivative having ttk inhibitory action
WO2011075643A1 (en) 2009-12-18 2011-06-23 Incyte Corporation Substituted heteroaryl fused derivatives as pi3k inhibitors
US9227971B2 (en) 2010-01-19 2016-01-05 Merck Sharp & Dohme Corp. Pyrazolo[1,5-a]pyrimidine compounds as mTOR inhibitors
WO2011151259A1 (en) 2010-06-01 2011-12-08 Bayer Pharma Aktiengesellschaft Substituted imidazopyrazines
US20120149708A1 (en) 2010-06-17 2012-06-14 George Mason University Modulators of viral transcription, and methods and compositions therewith
US20120083498A1 (en) 2010-06-17 2012-04-05 Fatah Kashanchi Modulators of Viral Transcription, and Methods and Compositions Therewith
MX2012015292A (es) 2010-06-24 2013-05-30 Gilead Sciences Inc Pirazolo[1, 5]pirimidinas en la forma de agentes antivirales.
EP2402337A1 (en) 2010-06-29 2012-01-04 Basf Se Pyrazolopyridine compounds
TWI541243B (zh) * 2010-09-10 2016-07-11 拜耳知識產權公司 經取代咪唑并嗒
US20120077814A1 (en) 2010-09-10 2012-03-29 Zhong Wang Sulfonamide, sulfamate, and sulfamothioate derivatives
US20140187548A1 (en) * 2010-12-17 2014-07-03 Bayer Intellectual Property Gmbh 6 substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders
WO2012080236A1 (en) * 2010-12-17 2012-06-21 Bayer Pharma Aktiengesellschaft 6-substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders
JP2014503521A (ja) 2010-12-17 2014-02-13 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 過増殖性障害の処置におけるｍｐｓ−１およびｔｋｋ阻害剤としての使用のための、イミダゾピラジン類
JP2014504604A (ja) 2011-01-21 2014-02-24 ザ ジェネラル ホスピタル コーポレイション 心血管疾患のための組成物および方法
WO2012136531A1 (en) 2011-04-06 2012-10-11 Bayer Pharma Aktiengesellschaft Substituted imidazopyridines and intermediates thereof
WO2013013188A1 (en) 2011-07-21 2013-01-24 Tolero Pharmaceuticals, Inc. Heterocyclic protein kinase inhibitors
US20140249147A1 (en) 2011-10-20 2014-09-04 GlaxoSmithKline, LLC Substituted Bicyclic Aza-Heterocycles and Analogues as Sirtuin Modulators
CA2889919C (en) 2012-11-16 2021-08-17 University Health Network Pyrazolopyrimidine compounds

Also Published As

Publication number Publication date
EP3068786A1 (en) 2016-09-21
US20210009595A1 (en) 2021-01-14
US9657025B2 (en) 2017-05-23
US10570143B2 (en) 2020-02-25
CN105793261B (zh) 2018-11-30
US20160137651A1 (en) 2016-05-19
HUE039351T2 (hu) 2018-12-28
RS57481B1 (sr) 2018-10-31
AU2013344716A1 (en) 2015-05-14
US20190322669A1 (en) 2019-10-24
LT3068786T (lt) 2018-08-27
JP6377068B2 (ja) 2018-08-22
US9573954B2 (en) 2017-02-21
US20170320881A1 (en) 2017-11-09
EP3068786A4 (en) 2017-04-12
NZ707432A (en) 2020-01-31
WO2015070349A1 (en) 2015-05-21
TW201605860A (zh) 2016-02-16
IL245187B (en) 2019-12-31
ME03093B (me) 2019-01-20
EP3068786B1 (en) 2018-06-06
US10167289B2 (en) 2019-01-01
IL245187A0 (en) 2016-06-30
PT3068786T (pt) 2018-07-26
EP2920181A4 (en) 2016-07-27
US20150299203A1 (en) 2015-10-22
PL3068786T3 (pl) 2018-10-31
DK3068786T3 (en) 2018-07-16
EP2920181B1 (en) 2019-01-09
WO2014075168A1 (en) 2014-05-22
JP2015537008A (ja) 2015-12-24
SI3068786T1 (sl) 2018-09-28
US10106545B2 (en) 2018-10-23
TWI679201B (zh) 2019-12-11
AU2013344716B2 (en) 2018-03-01
CA2889919C (en) 2021-08-17
US20190040074A1 (en) 2019-02-07
US20220204511A1 (en) 2022-06-30
ES2686097T3 (es) 2018-10-16
CN105793261A (zh) 2016-07-20
BR112016010080A8 (pt) 2020-04-14
EP2920181A1 (en) 2015-09-23
US20170217966A1 (en) 2017-08-03
CY1120480T1 (el) 2019-07-10
CA2889919A1 (en) 2014-05-22
BR112016010080B1 (pt) 2020-12-29
MX2016006336A (es) 2016-09-06
SG11201603102TA (en) 2016-05-30

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