CN105793261B - 吡唑并嘧啶化合物 - Google Patents

吡唑并嘧啶化合物 Download PDF

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Publication number
CN105793261B
CN105793261B CN201480062623.XA CN201480062623A CN105793261B CN 105793261 B CN105793261 B CN 105793261B CN 201480062623 A CN201480062623 A CN 201480062623A CN 105793261 B CN105793261 B CN 105793261B
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cancer
compound
mmol
pharmaceutically acceptable
compounds
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CN105793261A (zh
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R·劳弗
吴碧玲
李诗韵
H·W·保尔斯
刘勇
N·K·B·帕特尔
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University Health Network
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201480062623.XA 2012-11-16 2014-11-14 吡唑并嘧啶化合物 Active CN105793261B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261727581P 2012-11-16 2012-11-16
US201361808152P 2013-04-03 2013-04-03
PCT/CA2013/000957 WO2014075168A1 (en) 2012-11-16 2013-11-15 Pyrazolopyrimidine compounds
CAPCT/CA2013/000957 2013-11-15
PCT/CA2014/051091 WO2015070349A1 (en) 2012-11-16 2014-11-14 Pyrazolopyrimidine compounds

Publications (2)

Publication Number Publication Date
CN105793261A CN105793261A (zh) 2016-07-20
CN105793261B true CN105793261B (zh) 2018-11-30

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CN201480062623.XA Active CN105793261B (zh) 2012-11-16 2014-11-14 吡唑并嘧啶化合物

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JP (1) JP6377068B2 (enExample)
CN (1) CN105793261B (enExample)
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RS (1) RS57481B1 (enExample)
SG (1) SG11201603102TA (enExample)
SI (1) SI3068786T1 (enExample)
TW (1) TWI679201B (enExample)
WO (2) WO2014075168A1 (enExample)

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JP7034935B2 (ja) 2016-04-06 2022-03-14 リソソーマル・セラピューティクス・インコーポレイテッド ピロロ［１，２－ａ］ピリミジニルカルボキサミド化合物および医学的障害の処置におけるその使用
US11345698B2 (en) 2016-05-05 2022-05-31 Bial—R&D Investments, S.A. Substituted imidazo[1,2-a]pyridines, substituted imidazo[1,2-a]pyrazines, related compounds, and their use in the treatment of medical disorders
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JP6961675B2 (ja) * 2016-07-18 2021-11-05 ユニバーシティー ヘルス ネットワーク Ｔｔｋ阻害剤の固体形態
MY205416A (en) 2017-07-28 2024-10-21 Takeda Pharmaceuticals Co Tyk2 inhibitors and uses thereof
WO2019023786A1 (en) * 2017-08-01 2019-02-07 University Health Network COMBINED THERAPIES FOR THE INHIBITION OF TTK PROTEIN KINASE
CN112334135A (zh) * 2018-05-23 2021-02-05 大学健康网络 治疗特征在于纺锤体和着丝粒相关复合物亚基3(ska3)基因的高表达水平的癌症的方法
SG11202104229WA (en) 2018-10-30 2021-05-28 Kronos Bio Inc Compounds, compositions, and methods for modulating cdk9 activity
CN111377925B (zh) * 2018-12-28 2024-03-12 四川科伦博泰生物医药股份有限公司 嘌呤类衍生物、其制备方法及其在医药上的应用
CN112142744A (zh) * 2019-06-28 2020-12-29 上海瑛派药业有限公司 取代的稠合杂芳双环化合物作为激酶抑制剂及其应用
TW202146416A (zh) * 2019-12-11 2021-12-16 德商拜耳廠股份有限公司 吡唑并三𠯤
CN113773324B (zh) * 2021-09-07 2022-07-26 武汉九州钰民医药科技有限公司 抗肿瘤药cfi-402257的合成制备工艺
CN116396298A (zh) * 2023-06-06 2023-07-07 四川维亚本苑生物科技有限公司 CDK Ligand-1的中间体XII及CDK Ligand-1的制备方法

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AU2013344716B2 (en) 2018-03-01
US20190322669A1 (en) 2019-10-24
US20170320881A1 (en) 2017-11-09
WO2015070349A1 (en) 2015-05-21
US20160137651A1 (en) 2016-05-19
NZ707432A (en) 2020-01-31
CA2889919A1 (en) 2014-05-22
JP6377068B2 (ja) 2018-08-22
SI3068786T1 (sl) 2018-09-28
EP3068786A1 (en) 2016-09-21
US10167289B2 (en) 2019-01-01
SG11201603102TA (en) 2016-05-30
EP2920181A4 (en) 2016-07-27
EP2920181A1 (en) 2015-09-23
US10570143B2 (en) 2020-02-25
WO2014075168A1 (en) 2014-05-22
US20240287077A1 (en) 2024-08-29
TWI679201B (zh) 2019-12-11
RS57481B1 (sr) 2018-10-31
ES2686097T3 (es) 2018-10-16
US9657025B2 (en) 2017-05-23
BR112016010080A8 (pt) 2020-04-14
CY1120480T1 (el) 2019-07-10
US9573954B2 (en) 2017-02-21
DK3068786T3 (en) 2018-07-16
CA2889919C (en) 2021-08-17
PT3068786T (pt) 2018-07-26
IL245187A0 (en) 2016-06-30
CN105793261A (zh) 2016-07-20
HRP20181041T1 (hr) 2018-09-21
AU2013344716A1 (en) 2015-05-14
HUE039351T2 (hu) 2018-12-28
EP2920181B1 (en) 2019-01-09
PL3068786T3 (pl) 2018-10-31
US20170217966A1 (en) 2017-08-03
ME03093B (me) 2019-01-20
IL245187B (en) 2019-12-31
MX373713B (es) 2020-05-08
US20150299203A1 (en) 2015-10-22
TW201605860A (zh) 2016-02-16
EP3068786B1 (en) 2018-06-06
EP3068786A4 (en) 2017-04-12
JP2015537008A (ja) 2015-12-24
US10106545B2 (en) 2018-10-23
BR112016010080B1 (pt) 2020-12-29
LT3068786T (lt) 2018-08-27
US20210009595A1 (en) 2021-01-14
MX2016006336A (es) 2016-09-06
US20190040074A1 (en) 2019-02-07
US20220204511A1 (en) 2022-06-30

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