IL212652A - Antibodies for the treatment of acute lymphoblastic leukemia in adults - Google Patents

Antibodies for the treatment of acute lymphoblastic leukemia in adults

Info

Publication number
IL212652A
IL212652A IL212652A IL21265211A IL212652A IL 212652 A IL212652 A IL 212652A IL 212652 A IL212652 A IL 212652A IL 21265211 A IL21265211 A IL 21265211A IL 212652 A IL212652 A IL 212652A
Authority
IL
Israel
Prior art keywords
antibodies
treatment
lymphoblastic leukemia
acute lymphoblastic
adult patient
Prior art date
Application number
IL212652A
Other languages
English (en)
Hebrew (he)
Other versions
IL212652A0 (en
Original Assignee
Amgen Res Munich Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41692882&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL212652(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Res Munich Gmbh filed Critical Amgen Res Munich Gmbh
Publication of IL212652A0 publication Critical patent/IL212652A0/en
Publication of IL212652A publication Critical patent/IL212652A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • C07K16/468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL212652A 2008-11-07 2011-05-03 Antibodies for the treatment of acute lymphoblastic leukemia in adults IL212652A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11232308P 2008-11-07 2008-11-07
US18329109P 2009-06-02 2009-06-02
PCT/EP2009/007970 WO2010052014A1 (en) 2008-11-07 2009-11-06 Treatment of acute lymphoblastic leukemia

Publications (2)

Publication Number Publication Date
IL212652A0 IL212652A0 (en) 2011-07-31
IL212652A true IL212652A (en) 2015-05-31

Family

ID=41692882

Family Applications (1)

Application Number Title Priority Date Filing Date
IL212652A IL212652A (en) 2008-11-07 2011-05-03 Antibodies for the treatment of acute lymphoblastic leukemia in adults

Country Status (26)

Country Link
US (3) US20130323247A1 (enExample)
EP (2) EP2982696B1 (enExample)
JP (2) JP5647132B2 (enExample)
KR (1) KR101695327B1 (enExample)
CN (2) CN102209728A (enExample)
AU (4) AU2009313040B2 (enExample)
BR (1) BRPI0921482B1 (enExample)
CA (1) CA2742249C (enExample)
CY (2) CY1117033T1 (enExample)
DK (2) DK2342227T3 (enExample)
ES (2) ES2727585T3 (enExample)
HR (2) HRP20151168T1 (enExample)
HU (2) HUE043326T2 (enExample)
IL (1) IL212652A (enExample)
LT (1) LT2982696T (enExample)
ME (2) ME03480B (enExample)
MX (1) MX2011002927A (enExample)
NZ (1) NZ591311A (enExample)
PL (2) PL2982696T3 (enExample)
PT (2) PT2982696T (enExample)
RS (2) RS58827B1 (enExample)
RU (1) RU2536940C2 (enExample)
SI (2) SI2342227T1 (enExample)
SM (2) SMT201900278T1 (enExample)
WO (1) WO2010052014A1 (enExample)
ZA (1) ZA201103255B (enExample)

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CA2742249C (en) * 2008-11-07 2020-07-21 Micromet Ag Treatment of acute lymphoblastic leukemia with a cd19xcd3 bispecific single chain antibody
AU2010311559B2 (en) 2009-10-27 2016-07-07 Amgen Research (Munich) Gmbh Dosage regimen for administering a CD19xCD3 bispecific antibody
LT3018145T (lt) * 2010-10-27 2018-05-10 Amgen Research (Munich) Gmbh Priemonės ir būdai dlbcl gydymui
EP3831386A1 (en) * 2010-11-10 2021-06-09 Amgen Research (Munich) GmbH Prevention of adverse effects caused by cd3 specific binding domains
AU2012247762B2 (en) * 2011-04-28 2017-07-06 Amgen Research (Munich) Gmbh Dosage regimen for administering a CD19xCD3 bispecific antibody to patients at risk for potential adverse effects
JP6400470B2 (ja) 2011-05-16 2018-10-03 ジェネロン(シャンハイ)コーポレイション リミテッド 多重特異性Fab融合タンパク質および使用法
EP3105252B1 (en) * 2014-02-12 2019-07-24 Michael Uhlin Bispecific antibodies for use in stem cell transplantation
US9603927B2 (en) 2014-02-28 2017-03-28 Janssen Biotech, Inc. Combination therapies with anti-CD38 antibodies
US9732154B2 (en) * 2014-02-28 2017-08-15 Janssen Biotech, Inc. Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia
PL3531133T3 (pl) 2014-05-30 2024-01-29 Amgen Research (Munich) Gmbh Stratyfikacja ryzyka u pacjentów z ostrą białaczką limfoblastyczną z prekursorów b
PH12017500442B1 (en) 2014-09-09 2023-05-24 Janssen Biotech Inc Combination therapies with anti-cd38 antibodies
IL307913A (en) 2014-12-04 2023-12-01 Janssen Biotech Inc Anti-CD38 antibodies for the treatment of acute myeloid leukemia
WO2016109549A1 (en) 2014-12-30 2016-07-07 University Of Utah Research Foundation Hdac1,2 inhibitors and methods of using the same
JP7025214B2 (ja) 2015-02-24 2022-02-24 バイオアトラ、エルエルシー 条件的活性型生物学的タンパク質
CN114634943A (zh) * 2015-05-18 2022-06-17 T细胞受体治疗公司 使用融合蛋白对tcr重编程的组合物和方法
CN108136218B (zh) 2015-05-20 2022-12-13 詹森生物科技公司 用于治疗轻链淀粉样变性及其它cd38阳性血液恶性肿瘤的抗cd38抗体
LT3298042T (lt) 2015-05-20 2025-02-10 Amgen Research (Munich) Gmbh B-ląstelių naikinimas kaip diagnostinis žymuo
PE20181323A1 (es) 2015-06-22 2018-08-14 Janssen Biotech Inc Terapias de combinacion para enfermedades malignas hematologicas con anticuerpos anti-cd38 e inhibidores de survivina
US20170044265A1 (en) 2015-06-24 2017-02-16 Janssen Biotech, Inc. Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38
CN105154440B (zh) * 2015-08-14 2016-11-30 深圳市瀚海基因生物科技有限公司 一种基于高通量测序构建白血病微小残留病灶tcr文库的多重pcr引物和方法
US10781261B2 (en) 2015-11-03 2020-09-22 Janssen Biotech, Inc. Subcutaneous formulations of anti-CD38 antibodies and their uses
HUE053366T2 (hu) 2015-11-03 2021-06-28 Janssen Biotech Inc Szubkután anti-CD38-ellenanyag-készítmények és alkalmazásuk
RU2651776C2 (ru) * 2015-12-01 2018-04-23 Общество с ограниченной ответственностью "Международный биотехнологический центр "Генериум" ("МБЦ "Генериум") Биспецифические антитела против cd3*cd19
GB201602974D0 (en) * 2016-02-19 2016-04-06 Clube Jasper R Engineered cells & methods (1)
AU2017233121B2 (en) 2016-03-15 2023-12-21 Itabmed (Hk) Limited Multispecific Fab fusion proteins and use thereof
EP3494138A1 (en) 2016-08-02 2019-06-12 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
GB2564823B8 (en) 2016-10-07 2022-06-29 Tcr2 Therapeutics Inc Compositions and methods for TCR reprogramming using fusion proteins
CA3044593A1 (en) * 2016-11-22 2018-05-31 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
CN111565751A (zh) 2017-10-31 2020-08-21 詹森生物科技公司 治疗高危多发性骨髓瘤的方法
KR20250111232A (ko) 2017-12-11 2025-07-22 암젠 인크 이중특이적 항체 생성물의 연속 제조 공정
KR102083481B1 (ko) 2018-03-22 2020-03-02 강원대학교산학협력단 아연-키토산 나노 입자를 포함한 급성 림프구성 백혈병 치료용 약학조성물
EP3847196A4 (en) 2018-09-07 2023-01-04 ITabMed (HK) Limited BISPECIFIC ANTIGEN BINDING PROTEINS AND USES THEREOF
WO2020132810A1 (en) * 2018-12-24 2020-07-02 Generon (Shanghai) Corporation Ltd. Multispecific antigen binding proteins capable of binding cd19 and cd3, and use thereof
KR20210122268A (ko) * 2019-01-30 2021-10-08 더 위스타 인스티튜트 오브 아나토미 앤드 바이올로지 암 항원을 표적화하는 dna-인코딩된 이중특이적 t-세포 인게이저 및 암 치료에서 사용 방법
JOP20210298A1 (ar) 2019-05-14 2023-01-30 Provention Bio Inc طرق وتركيبات للوقاية من مرض السكري من النوع الأول
JP2022537650A (ja) * 2019-06-13 2022-08-29 アムジエン・インコーポレーテツド 生物製剤の製造における自動化された生物量に基づく灌流制御
EP4118113A1 (en) 2020-03-12 2023-01-18 Amgen Inc. Method for treatment and prophylaxis of crs in patients comprising a combination of bispecifc antibodies binding to cds x cancer cell and tnfalpha or il-6 inhibitor
KR20230092863A (ko) 2020-06-11 2023-06-26 프로벤션 바이오, 인코포레이티드 제1형 당뇨병을 예방하기 위한 방법 및 조성물
EP4214233A1 (en) 2020-09-16 2023-07-26 Amgen Inc. Methods for administering therapeutic doses of bispecific t-cell engaging molecules for the treatment of cancer
IL311714A (en) 2021-10-15 2024-05-01 Amgen Res Munich Gmbh Subcutaneous administration of antibodies that engage CD19-binding T cells
US12319747B2 (en) 2023-07-03 2025-06-03 Medicovestor, Inc. Methods of using anti-SP17 immunotherapeutics
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WO2025137344A1 (en) 2023-12-20 2025-06-26 Bristol-Myers Squibb Company Antibodies targeting il-18 receptor beta (il-18rβ) and related methods
US12116410B1 (en) 2023-12-26 2024-10-15 Medicovestor, Inc. Methods of manufacturing dimeric antibodies
US12240900B1 (en) 2024-02-02 2025-03-04 Medicovestor, Inc. Nucleic acids, vectors, and cells that encode antibodies and other proteins that bind folate receptor alpha
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Also Published As

Publication number Publication date
DK2342227T3 (en) 2016-02-15
RU2011122819A (ru) 2012-12-20
SMT201900278T1 (it) 2019-07-11
AU2015238784A1 (en) 2015-10-29
HRP20151168T1 (hr) 2015-12-04
PL2342227T3 (pl) 2016-04-29
CY1122366T1 (el) 2021-01-27
US20130323247A1 (en) 2013-12-05
JP2015057417A (ja) 2015-03-26
CN107184977A (zh) 2017-09-22
HK1158668A1 (en) 2012-07-20
HRP20190912T1 (hr) 2019-07-26
KR20110091668A (ko) 2011-08-12
AU2017219083A1 (en) 2017-09-14
JP2012508164A (ja) 2012-04-05
EP2982696B1 (en) 2019-03-27
US20190300609A1 (en) 2019-10-03
PT2982696T (pt) 2019-06-04
ME03480B (me) 2020-01-20
US11597766B2 (en) 2023-03-07
PL2982696T3 (pl) 2019-08-30
MX2011002927A (es) 2011-04-11
RU2536940C2 (ru) 2014-12-27
SMT201500328B (it) 2016-02-25
RS58827B1 (sr) 2019-07-31
NZ591311A (en) 2012-10-26
AU2018260815A1 (en) 2018-11-22
WO2010052014A1 (en) 2010-05-14
HK1220705A1 (en) 2017-05-12
ME02363B (me) 2016-06-20
US20240109964A1 (en) 2024-04-04
HUE043326T2 (hu) 2019-08-28
CN102209728A (zh) 2011-10-05
BRPI0921482A8 (pt) 2017-07-11
CA2742249A1 (en) 2010-05-14
HUE028175T2 (en) 2016-12-28
AU2017219083B2 (en) 2018-08-09
AU2009313040A1 (en) 2010-05-14
JP5647132B2 (ja) 2014-12-24
SI2982696T1 (sl) 2019-06-28
ZA201103255B (en) 2013-12-23
EP2342227B1 (en) 2015-10-07
KR101695327B1 (ko) 2017-01-11
AU2018260815B2 (en) 2020-03-05
BRPI0921482A2 (pt) 2016-01-12
EP2342227A1 (en) 2011-07-13
RS54456B1 (sr) 2016-06-30
EP2982696A3 (en) 2016-02-17
IL212652A0 (en) 2011-07-31
PT2342227E (pt) 2015-11-13
BRPI0921482B1 (pt) 2022-09-20
ES2727585T3 (es) 2019-10-17
CA2742249C (en) 2020-07-21
LT2982696T (lt) 2019-06-10
CY1117033T1 (el) 2017-04-05
AU2009313040B2 (en) 2015-07-09
EP2982696A2 (en) 2016-02-10
DK2982696T3 (da) 2019-05-27
JP5955921B2 (ja) 2016-07-20
ES2558434T3 (es) 2016-02-04
SI2342227T1 (sl) 2015-12-31

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