DK2342227T3 - TREATMENT OF ACUTE Lymphoblastic Tissue Leukemia - Google Patents

TREATMENT OF ACUTE Lymphoblastic Tissue Leukemia Download PDF

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Publication number
DK2342227T3
DK2342227T3 DK09760483.9T DK09760483T DK2342227T3 DK 2342227 T3 DK2342227 T3 DK 2342227T3 DK 09760483 T DK09760483 T DK 09760483T DK 2342227 T3 DK2342227 T3 DK 2342227T3
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DK
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Prior art keywords
chain antibody
bispecific single
single chain
cd19xcd3 bispecific
patient
Prior art date
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DK09760483.9T
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Danish (da)
English (en)
Inventor
Gerhard Zugmaier
Evelyn Degenhard
Original Assignee
Amgen Res Munich Gmbh
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41692882&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2342227(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Res Munich Gmbh filed Critical Amgen Res Munich Gmbh
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Publication of DK2342227T3 publication Critical patent/DK2342227T3/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • C07K16/468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK09760483.9T 2008-11-07 2009-11-06 TREATMENT OF ACUTE Lymphoblastic Tissue Leukemia DK2342227T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11232308P 2008-11-07 2008-11-07
US18329109P 2009-06-02 2009-06-02
PCT/EP2009/007970 WO2010052014A1 (en) 2008-11-07 2009-11-06 Treatment of acute lymphoblastic leukemia

Publications (1)

Publication Number Publication Date
DK2342227T3 true DK2342227T3 (en) 2016-02-15

Family

ID=41692882

Family Applications (2)

Application Number Title Priority Date Filing Date
DK15185767.9T DK2982696T3 (da) 2008-11-07 2009-11-06 Behandling af akut lymfoblastær leukæmi
DK09760483.9T DK2342227T3 (en) 2008-11-07 2009-11-06 TREATMENT OF ACUTE Lymphoblastic Tissue Leukemia

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK15185767.9T DK2982696T3 (da) 2008-11-07 2009-11-06 Behandling af akut lymfoblastær leukæmi

Country Status (26)

Country Link
US (3) US20130323247A1 (enExample)
EP (2) EP2342227B1 (enExample)
JP (2) JP5647132B2 (enExample)
KR (1) KR101695327B1 (enExample)
CN (2) CN107184977A (enExample)
AU (4) AU2009313040B2 (enExample)
BR (1) BRPI0921482B1 (enExample)
CA (1) CA2742249C (enExample)
CY (2) CY1117033T1 (enExample)
DK (2) DK2982696T3 (enExample)
ES (2) ES2727585T3 (enExample)
HR (2) HRP20151168T1 (enExample)
HU (2) HUE043326T2 (enExample)
IL (1) IL212652A (enExample)
LT (1) LT2982696T (enExample)
ME (2) ME03480B (enExample)
MX (1) MX2011002927A (enExample)
NZ (1) NZ591311A (enExample)
PL (2) PL2982696T3 (enExample)
PT (2) PT2342227E (enExample)
RS (2) RS54456B1 (enExample)
RU (1) RU2536940C2 (enExample)
SI (2) SI2342227T1 (enExample)
SM (2) SMT201900278T1 (enExample)
WO (1) WO2010052014A1 (enExample)
ZA (1) ZA201103255B (enExample)

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LT3412687T (lt) * 2010-10-27 2020-07-27 Amgen Research (Munich) Gmbh Didžiųjų b ląstelių difuzinės limfomos gydymo būdai
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ES2806142T3 (es) * 2011-04-28 2021-02-16 Amgen Res Munich Gmbh Pauta posológica para administrar un anticuerpo biespecífico CD19xCD3 a pacientes en riesgo de posibles efectos adversos
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RU2651776C2 (ru) * 2015-12-01 2018-04-23 Общество с ограниченной ответственностью "Международный биотехнологический центр "Генериум" ("МБЦ "Генериум") Биспецифические антитела против cd3*cd19
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EP3430058A4 (en) 2016-03-15 2019-10-23 Generon (Shanghai) Corporation Ltd. MULTISPECIFIC FAB FUSION PROTEINS AND USES THEREOF
CN109715668A (zh) 2016-08-02 2019-05-03 T细胞受体治疗公司 用于使用融合蛋白进行tcr重编程的组合物和方法
IL292551B2 (en) 2016-10-07 2023-10-01 Tcr2 Therapeutics Inc Preparations and methods for reprogramming T-cell receptors using fusion proteins
AU2017363311A1 (en) 2016-11-22 2019-06-13 TCR2 Therapeutics Inc. Compositions and methods for TCR reprogramming using fusion proteins
CN111565751A (zh) 2017-10-31 2020-08-21 詹森生物科技公司 治疗高危多发性骨髓瘤的方法
CN111315780A (zh) * 2017-12-11 2020-06-19 安进公司 双特异性抗体产品的连续制造工艺
KR102083481B1 (ko) 2018-03-22 2020-03-02 강원대학교산학협력단 아연-키토산 나노 입자를 포함한 급성 림프구성 백혈병 치료용 약학조성물
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Also Published As

Publication number Publication date
KR20110091668A (ko) 2011-08-12
EP2982696A3 (en) 2016-02-17
ME02363B (me) 2016-06-20
SI2982696T1 (sl) 2019-06-28
EP2342227B1 (en) 2015-10-07
RU2011122819A (ru) 2012-12-20
SMT201500328B (it) 2016-02-25
HUE028175T2 (en) 2016-12-28
HK1158668A1 (en) 2012-07-20
EP2982696B1 (en) 2019-03-27
HUE043326T2 (hu) 2019-08-28
RS58827B1 (sr) 2019-07-31
HRP20151168T1 (hr) 2015-12-04
ES2558434T3 (es) 2016-02-04
NZ591311A (en) 2012-10-26
JP5647132B2 (ja) 2014-12-24
CY1122366T1 (el) 2021-01-27
US20190300609A1 (en) 2019-10-03
AU2018260815A1 (en) 2018-11-22
HRP20190912T1 (hr) 2019-07-26
WO2010052014A1 (en) 2010-05-14
BRPI0921482A2 (pt) 2016-01-12
AU2009313040A1 (en) 2010-05-14
JP2015057417A (ja) 2015-03-26
AU2009313040B2 (en) 2015-07-09
RS54456B1 (sr) 2016-06-30
BRPI0921482B1 (pt) 2022-09-20
US11597766B2 (en) 2023-03-07
MX2011002927A (es) 2011-04-11
IL212652A0 (en) 2011-07-31
CA2742249A1 (en) 2010-05-14
SI2342227T1 (sl) 2015-12-31
CN102209728A (zh) 2011-10-05
US20240109964A1 (en) 2024-04-04
LT2982696T (lt) 2019-06-10
BRPI0921482A8 (pt) 2017-07-11
CY1117033T1 (el) 2017-04-05
US20130323247A1 (en) 2013-12-05
DK2982696T3 (da) 2019-05-27
EP2982696A2 (en) 2016-02-10
CN107184977A (zh) 2017-09-22
JP2012508164A (ja) 2012-04-05
ES2727585T3 (es) 2019-10-17
IL212652A (en) 2015-05-31
SMT201900278T1 (it) 2019-07-11
AU2017219083A1 (en) 2017-09-14
PT2342227E (pt) 2015-11-13
AU2015238784A1 (en) 2015-10-29
CA2742249C (en) 2020-07-21
KR101695327B1 (ko) 2017-01-11
HK1220705A1 (en) 2017-05-12
AU2017219083B2 (en) 2018-08-09
ME03480B (me) 2020-01-20
PT2982696T (pt) 2019-06-04
RU2536940C2 (ru) 2014-12-27
PL2342227T3 (pl) 2016-04-29
EP2342227A1 (en) 2011-07-13
AU2018260815B2 (en) 2020-03-05
JP5955921B2 (ja) 2016-07-20
PL2982696T3 (pl) 2019-08-30
ZA201103255B (en) 2013-12-23

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