DK2342227T3 - Behandling af akut lymfoblastær leukæmi - Google Patents
Behandling af akut lymfoblastær leukæmi Download PDFInfo
- Publication number
- DK2342227T3 DK2342227T3 DK09760483.9T DK09760483T DK2342227T3 DK 2342227 T3 DK2342227 T3 DK 2342227T3 DK 09760483 T DK09760483 T DK 09760483T DK 2342227 T3 DK2342227 T3 DK 2342227T3
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- DK
- Denmark
- Prior art keywords
- chain antibody
- bispecific single
- single chain
- cd19xcd3 bispecific
- patient
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Claims (17)
- BEHANDLING AF AKUT LYMFOBLASTÆR LEUKÆMI Patentkrav1. CD19xCD3-bispecifik enkeltkædet antistofkonstruktion til anvendelse i en fremgangsmåde til behandling, lindring eller eliminering af akut lymfoblastær leukæmi (ALL) hos en voksen patient.
- 2. CD19xCD3-bispecifik enkeltkædet antistofkonstruktion til anvendelse ifølge krav 1, hvor den akutte lymfoblastære leukæmi (ALL) er B-cellelinje akut lymfoblastær leukæmi, fortrinsvis B-forstadie akut lymfoblastær leukæmi.
- 3. CD19xCD3-bispecifik enkeltkædet antistofkonstruktion til anvendelse ifølge krav 1 eller 2, hvor den akutte lymfoblastære leukæmi (ALL) er refraktær over for kemoterapi, hos patienter, der er uegnet til allogen hæmatopoietisk stamcelletransplantation.
- 4. CD19xCD3-bispecifik enkeltkædet antistofkonstruktion til anvendelse ifølge krav 1 eller 2 efterfulgt af allogen hæmatopoietisk stamcelletransplantation, eller hvor fremgangsmåden erstatter allogen hæmatopoietisk stamcelletransplantation, hos patienter, der er egnet til allogen hæmatopoietisk stamcelletransplantation.
- 5. CD19xCD3-bispecifik enkeltkædet antistofkonstruktion til anvendelse ifølge et hvilket som helst af kravene 1 til 4, hvor fremgangsmåden er til behandling, lindring eller eliminering af minimal restsygdom (MRD) hos en patient med akut lymfoblastær leukæmi (ALL).
- 6. CD19xCD3-bispecifik enkeltkædet antistofkonstruktion til anvendelse ifølge krav 5, hvor patienten er MRD-positiv i komplet hæmatologisk remission.
- 7. CD19xCD3-bispecifik enkeltkædet antistofkonstruktion til anvendelse ifølge krav 5 eller 6, hvor administrationen af det farmaceutiske præparat resulterer i stabil disease eller ændring af MRD-positiv akut lymfoblastær leukæmi (ALL) til en MRD-negativ status.
- 8. CD19xCD3-bispecifik enkeltkædet antistofkonstruktion til anvendelse ifølge et hvilket som helst af kravene 5 til 7, hvor MRD måles ved hjælp af kvantitativ detektion af individuelle omlejringer af immunoglobulingener eller T-cellereceptor (TCR)-omlejringer eller ved hjælp af bcr/abl-fusionstranskripter eller ved hjælp af t(4;ll)-translokationer ved anvendelse af PCR- eller FACS-an alyse.
- 9. CD19xCD3-bispecifik enkeltkædet antistofkonstruktion til anvendelse ifølge et hvilket som helst af kravene 1 til 8, hvor de modsvarende variable regioner af tung kæde (VH) og let kæde (VL) i den CD19xCD3-bispecifikke enkeltkædede antistofkonstruktion er placeret fra N-terminus til C-terminus i rækkefølgen V.l.(CD19)-V.h.(CD19)-V.h.(CD3)-V.l.(CD3).
- 10. CD 19xCD3-bispecifik enkeltkædet antistofkonstruktion til anvendelse ifølge krav 9, hvor den CD19xCD3-bispecifikke enkeltkædede antistofkonstruktion omfatter en aminosyresekvens ifølge SEQ ID NO: 1 eller en aminosyresekvens, der er mindst 90 %, fortrinsvis 95 % identisk med SEQ ID NO: 1.
- 11. CD19xCD3-bispecifik enkeltkædet antistofkonstruktion til anvendelse ifølge et hvilket som helst af kravene 1 til 10, hvor én behandlingscyklus er en 4-ugers kontinuert infusion, efterfulgt af gentagne cyklusser efter et 2-ugers behandlingsfrit interval.
- 12. CD19xCD3-bispecifik enkeltkædet antistofkonstruktion til anvendelse ifølge krav 11, hvor behandlingscyklussen gentages mindst tre gange efter bestemmelse af en MRD-negativ status (konsolidering).
- 13. CD19xCD3-bispecifik enkeltkædet antistofkonstruktion til anvendelse ifølge et hvilket som helst af kravene 1 til 12, hvor den CD19xCD3-bispecifikke enkeltkædede antistofkonstruktion skal administreres i en daglig dosis på 10 pg o til 100 pg pr. m kropsoverfladeareal hos patienten.
- 14. CD19xCD3-bispecifik enkeltkædet antistofkonstruktion til anvendelse ifølge krav 13, hvor den CD19xCD3-bispecifikke enkeltkædede antistofkonstruktion skal administreres i en daglig dosis på 15 pg til 30 pg pr. m.2 kropsoverfladeareal hos patienten.
- 15. CD19xCD3-bispecifik enkeltkædet antistofkonstruktion til anvendelse ifølge et hvilket som helst af kravene 1 til 12, hvor den CD19xCD3-bispecifikke enkeltkædede antistofkonstruktion skal administreres i en daglig dosis på 15 pg, 30 pg, 60 pg eller 90 pg pr. m2 kropsoverfladeareal hos patienten.
- 16. CD19xCD3-bispecifik enkeltkædet antistofkonstruktion til anvendelse ifølge et hvilket som helst af kravene 1 til 12, hvor den CD19xCD3-bispecifikke enkeltkædede antistofkonstruktion skal administreres ved en dosis på 5 pg pr. m2 kropsoverfladeareal hos patienten de(n) første dag(e) af infusionsperioden, 2 efterfulgt af administration of 15 μg pr. m kropsoverfladeareal hos patienten de(n) følgende dag(e) af infusionsperioden, efterfulgt af administration of 45 pg pr. m kropsoverfladeareal hos patienten som daglig dosis i den resterende behandlingsperiode.
- 17. CD19xCD3-bispecifik enkeltkædet antistofkonstruktion til anvendelse ifølge krav 16, hvor den initiale dosis skal administreres i én, to eller flere dage eller i syv dage.
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| US18329109P | 2009-06-02 | 2009-06-02 | |
| PCT/EP2009/007970 WO2010052014A1 (en) | 2008-11-07 | 2009-11-06 | Treatment of acute lymphoblastic leukemia |
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