IL210081A - 2-Fluoro-11-Fiprazine-1-Yl-Dibenzo [4,1] [f, b] Thiazepine and its uses in the preparation of drugs for the treatment of psychiatric disorders - Google Patents
2-Fluoro-11-Fiprazine-1-Yl-Dibenzo [4,1] [f, b] Thiazepine and its uses in the preparation of drugs for the treatment of psychiatric disordersInfo
- Publication number
- IL210081A IL210081A IL210081A IL21008110A IL210081A IL 210081 A IL210081 A IL 210081A IL 210081 A IL210081 A IL 210081A IL 21008110 A IL21008110 A IL 21008110A IL 210081 A IL210081 A IL 210081A
- Authority
- IL
- Israel
- Prior art keywords
- disorder
- compound
- pharmaceutically acceptable
- fluoro
- dibenzo
- Prior art date
Links
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- 229950004526 uldazepam Drugs 0.000 description 1
- LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 description 1
- 229960002004 valdecoxib Drugs 0.000 description 1
- 229960004688 venlafaxine Drugs 0.000 description 1
- PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 description 1
- 229960001722 verapamil Drugs 0.000 description 1
- 239000011345 viscous material Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- 150000003738 xylenes Chemical class 0.000 description 1
- HUNXMJYCHXQEGX-UHFFFAOYSA-N zaleplon Chemical compound CCN(C(C)=O)C1=CC=CC(C=2N3N=CC(=C3N=CC=2)C#N)=C1 HUNXMJYCHXQEGX-UHFFFAOYSA-N 0.000 description 1
- 229960004010 zaleplon Drugs 0.000 description 1
- MVWVFYHBGMAFLY-UHFFFAOYSA-N ziprasidone Chemical compound C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 MVWVFYHBGMAFLY-UHFFFAOYSA-N 0.000 description 1
- 229960000607 ziprasidone Drugs 0.000 description 1
- 229960001366 zolazepam Drugs 0.000 description 1
- 229960001360 zolmitriptan Drugs 0.000 description 1
- ULSDMUVEXKOYBU-ZDUSSCGKSA-N zolmitriptan Chemical compound C1=C2C(CCN(C)C)=CNC2=CC=C1C[C@H]1COC(=O)N1 ULSDMUVEXKOYBU-ZDUSSCGKSA-N 0.000 description 1
- ZAFYATHCZYHLPB-UHFFFAOYSA-N zolpidem Chemical compound N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1 ZAFYATHCZYHLPB-UHFFFAOYSA-N 0.000 description 1
- 229960001475 zolpidem Drugs 0.000 description 1
- 229960000820 zopiclone Drugs 0.000 description 1
- HDOZVRUNCMBHFH-UHFFFAOYSA-N zotepine Chemical compound CN(C)CCOC1=CC2=CC=CC=C2SC2=CC=C(Cl)C=C12 HDOZVRUNCMBHFH-UHFFFAOYSA-N 0.000 description 1
- 229960004496 zotepine Drugs 0.000 description 1
- XOFLBQFBSOEHOG-UUOKFMHZSA-N γS-GTP Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=S)[C@@H](O)[C@H]1O XOFLBQFBSOEHOG-UUOKFMHZSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D281/16—[b, f]-condensed
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7441708P | 2008-06-20 | 2008-06-20 | |
| PCT/SE2009/050763 WO2009154563A1 (en) | 2008-06-20 | 2009-06-18 | Dibenzothiazepine derivatives and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL210081A0 IL210081A0 (en) | 2011-02-28 |
| IL210081A true IL210081A (en) | 2013-12-31 |
Family
ID=41431860
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL210081A IL210081A (en) | 2008-06-20 | 2010-12-16 | 2-Fluoro-11-Fiprazine-1-Yl-Dibenzo [4,1] [f, b] Thiazepine and its uses in the preparation of drugs for the treatment of psychiatric disorders |
| IL229560A IL229560A (en) | 2008-06-20 | 2013-11-21 | Method for Preparation of 2-Fluoro-11- (Piperazine-1-Yl) Dibenzo [b, f] Thiazepine |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL229560A IL229560A (en) | 2008-06-20 | 2013-11-21 | Method for Preparation of 2-Fluoro-11- (Piperazine-1-Yl) Dibenzo [b, f] Thiazepine |
Country Status (37)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI488854B (zh) * | 2008-06-20 | 2015-06-21 | Astrazeneca Ab | 二苯并噻氮呯衍生物及其用途 |
| CN105981027A (zh) * | 2013-08-12 | 2016-09-28 | 哥莱菲特软件公司 | 安全认证并切换至加密域 |
| CN103524455A (zh) * | 2013-10-30 | 2014-01-22 | 苏州敬业医药化工有限公司 | 一种制备2-氯-二苯并[b,f][1,4]硫氮杂卓-11-[10H]酮的方法 |
| CN106134230A (zh) | 2013-11-21 | 2016-11-16 | 哥莱菲特软件公司 | 用于移动信息设备上的远程内容和配置控制的管理域 |
| CN104447615A (zh) * | 2014-02-28 | 2015-03-25 | 广东东阳光药业有限公司 | 喹硫平中间体的制备方法 |
| CN120981447A (zh) * | 2023-03-08 | 2025-11-18 | 法兰克福大学 | Slack激活化合物及其医学用途 |
| EP4428132A1 (en) * | 2023-03-08 | 2024-09-11 | Johann-Wolfgang-Goethe-Universität Frankfurt am Main | Slack-activating compounds and their medical use |
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| CH422793A (de) | 1961-07-20 | 1966-10-31 | Wander Ag Dr A | Verfahren zur Herstellung 11-basisch substituierter Dibenzo(b,f) (1,4)thiazepine |
| DE1620713A1 (de) * | 1962-05-25 | 1970-07-02 | Wander Ag Dr A | Verfahren zur Herstellung von 11-basisch substituierter Dibenzo[b,f][1,4]thiazepine |
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| NL140242B (nl) | 1963-03-01 | 1973-11-15 | Wander Ag Dr A | Werkwijze voor het bereiden van op de 11-plaats door een basische groep gesubstitueerde dibenz (b.f.)(1.4) oxazepinen. |
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-
2009
- 2009-06-18 TW TW098120494A patent/TWI488854B/zh not_active IP Right Cessation
- 2009-06-18 ME MEP-2013-27A patent/ME01516B/me unknown
- 2009-06-18 PT PT97669535T patent/PT2307389E/pt unknown
- 2009-06-18 KR KR1020117001427A patent/KR20110019781A/ko not_active Ceased
- 2009-06-18 AU AU2009260905A patent/AU2009260905B2/en not_active Ceased
- 2009-06-18 UY UY0001031919A patent/UY31919A/es not_active Application Discontinuation
- 2009-06-18 PL PL09766953T patent/PL2307389T3/pl unknown
- 2009-06-18 CA CA2728675A patent/CA2728675A1/en not_active Abandoned
- 2009-06-18 CN CN200980132601.5A patent/CN102131791B/zh not_active Expired - Fee Related
- 2009-06-18 SI SI200930544T patent/SI2307389T1/sl unknown
- 2009-06-18 JP JP2011514540A patent/JP5468068B2/ja not_active Expired - Fee Related
- 2009-06-18 WO PCT/SE2009/050763 patent/WO2009154563A1/en not_active Ceased
- 2009-06-18 EA EA201001889A patent/EA201001889A1/ru unknown
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- 2009-06-18 NZ NZ590616A patent/NZ590616A/xx not_active IP Right Cessation
- 2009-06-18 BR BRPI0914231A patent/BRPI0914231A2/pt not_active IP Right Cessation
- 2009-06-18 HR HRP20130234AT patent/HRP20130234T1/hr unknown
- 2009-06-18 US US12/999,808 patent/US20110160184A1/en not_active Abandoned
- 2009-06-18 ES ES09766953T patent/ES2402084T3/es active Active
- 2009-06-18 MY MYPI2010006035A patent/MY157518A/en unknown
- 2009-06-18 EP EP09766953A patent/EP2307389B1/en active Active
- 2009-06-18 DK DK09766953.5T patent/DK2307389T3/da active
- 2009-06-18 PE PE2010001170A patent/PE20110029A1/es not_active Application Discontinuation
- 2009-06-18 MX MX2010014203A patent/MX2010014203A/es active IP Right Grant
- 2009-06-18 UA UAA201015001A patent/UA105903C2/uk unknown
- 2009-06-19 AR ARP090102240A patent/AR072200A1/es unknown
- 2009-06-19 US US12/487,725 patent/US8158618B2/en not_active Expired - Fee Related
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2010
- 2010-12-16 IL IL210081A patent/IL210081A/en not_active IP Right Cessation
- 2010-12-17 CL CL2010001471A patent/CL2010001471A1/es unknown
- 2010-12-20 HN HN2010002683A patent/HN2010002683A/es unknown
- 2010-12-20 SV SV2010003769A patent/SV2010003769A/es not_active Application Discontinuation
- 2010-12-20 CU CU20100252A patent/CU23884B1/es not_active IP Right Cessation
- 2010-12-20 EC EC2010010698A patent/ECSP10010698A/es unknown
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2011
- 2011-01-19 ZA ZA2011/00488A patent/ZA201100488B/en unknown
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2012
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2013
- 2013-03-22 CY CY20131100246T patent/CY1113845T1/el unknown
- 2013-11-21 IL IL229560A patent/IL229560A/en not_active IP Right Cessation
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2014
- 2014-01-27 JP JP2014011979A patent/JP2014098006A/ja active Pending
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