IL208838A0 - Purine pi3k inhibitor compounds and methods of use - Google Patents
Purine pi3k inhibitor compounds and methods of useInfo
- Publication number
- IL208838A0 IL208838A0 IL208838A IL20883810A IL208838A0 IL 208838 A0 IL208838 A0 IL 208838A0 IL 208838 A IL208838 A IL 208838A IL 20883810 A IL20883810 A IL 20883810A IL 208838 A0 IL208838 A0 IL 208838A0
- Authority
- IL
- Israel
- Prior art keywords
- purine
- methods
- inhibitor compounds
- pi3k inhibitor
- pi3k
- Prior art date
Links
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 title 2
- 239000012828 PI3K inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 229940043441 phosphoinositide 3-kinase inhibitor Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5755908P | 2008-05-30 | 2008-05-30 | |
| PCT/US2009/045603 WO2009146406A1 (en) | 2008-05-30 | 2009-05-29 | Purine pi3k inhibitor compounds and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL208838A0 true IL208838A0 (en) | 2011-01-31 |
Family
ID=41017038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL208838A IL208838A0 (en) | 2008-05-30 | 2010-10-20 | Purine pi3k inhibitor compounds and methods of use |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8158624B2 (OSRAM) |
| EP (1) | EP2279188B1 (OSRAM) |
| JP (1) | JP2011521968A (OSRAM) |
| KR (1) | KR20110042153A (OSRAM) |
| CN (1) | CN102105474B (OSRAM) |
| AU (1) | AU2009251291B2 (OSRAM) |
| BR (1) | BRPI0909614A2 (OSRAM) |
| CA (1) | CA2721851A1 (OSRAM) |
| ES (1) | ES2533788T3 (OSRAM) |
| IL (1) | IL208838A0 (OSRAM) |
| MX (1) | MX2010012583A (OSRAM) |
| RU (1) | RU2509081C2 (OSRAM) |
| WO (1) | WO2009146406A1 (OSRAM) |
| ZA (1) | ZA201007524B (OSRAM) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8247410B2 (en) | 2007-10-05 | 2012-08-21 | Verastem | Pyrimidine substituted purine derivatives |
| JP5348725B2 (ja) * | 2007-10-25 | 2013-11-20 | ジェネンテック, インコーポレイテッド | チエノピリミジン化合物の製造方法 |
| EP2215090B1 (en) * | 2007-10-26 | 2015-03-04 | F. Hoffmann-La Roche AG | Purine derivatives useful as pi3 kinase inhibitors |
| GB0721095D0 (en) * | 2007-10-26 | 2007-12-05 | Piramed Ltd | Pharmaceutical compounds |
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| EP2240451B1 (en) | 2008-01-04 | 2017-08-09 | Intellikine, LLC | Isoquinolinone derivatives substituted with a purine useful as PI3K inhibitors |
| CA2738429C (en) | 2008-09-26 | 2016-10-25 | Intellikine, Inc. | Heterocyclic kinase inhibitors |
| US20100233733A1 (en) * | 2009-02-10 | 2010-09-16 | Nodality, Inc., A Delaware Corporation | Multiple mechanisms for modulation of the pi3 kinase pathway |
| DK2414362T3 (da) | 2009-04-03 | 2014-09-22 | Verastem Inc | Pyrimidinsubstituerede purinforbindelser som kinaseinhibitorer |
| JP5789252B2 (ja) | 2009-05-07 | 2015-10-07 | インテリカイン, エルエルシー | 複素環式化合物およびその使用 |
| EP2451811A1 (en) * | 2009-05-27 | 2012-05-16 | F. Hoffmann-La Roche AG | Bicyclic indole-pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use |
| CN102459272B (zh) * | 2009-05-27 | 2014-08-06 | 健泰科生物技术公司 | 对P110δ具有选择性的为PI3K抑制剂的二环嘧啶化合物和使用方法 |
| CA2778686C (en) * | 2009-11-12 | 2015-07-21 | F. Hoffmann-La Roche Ag | N-9-substituted purine compounds, compositions and methods of use |
| WO2011058025A1 (en) * | 2009-11-12 | 2011-05-19 | F. Hoffmann-La Roche Ag | N-7 substituted purine and pyrazolopyrimidine compounds, compositions and methods of use |
| AU2011255218B2 (en) | 2010-05-21 | 2015-03-12 | Infinity Pharmaceuticals, Inc. | Chemical compounds, compositions and methods for kinase modulation |
| WO2012007493A1 (en) * | 2010-07-14 | 2012-01-19 | F. Hoffmann-La Roche Ag | Purine compounds selective for ρi3κ p110 delta, and methods of use |
| US9346807B2 (en) | 2010-09-14 | 2016-05-24 | Exelixis, Inc. | Inhibitors of PI3K-delta and methods of their use and manufacture |
| AU2011326427B2 (en) | 2010-11-10 | 2016-01-07 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
| KR20140099556A (ko) | 2010-12-16 | 2014-08-12 | 에프. 호프만-라 로슈 아게 | 트라이사이클릭 pi3k 억제제 화합물 및 이의 사용 방법 |
| AR084824A1 (es) | 2011-01-10 | 2013-06-26 | Intellikine Inc | Procesos para preparar isoquinolinonas y formas solidas de isoquinolinonas |
| WO2012156379A1 (en) | 2011-05-13 | 2012-11-22 | Universität Zürich | PIK3/P110α INHIBITORS FOR PREVENTION OF RESTENOSIS BY APPLICATION AS AN IMPLANT COATING |
| HK1198443A1 (en) | 2011-07-19 | 2015-04-24 | 无限药品股份有限公司 | Heterocyclic compounds and uses thereof |
| WO2013012918A1 (en) | 2011-07-19 | 2013-01-24 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
| KR20140050689A (ko) * | 2011-07-28 | 2014-04-29 | 제넨테크, 인크. | Pik3ca h1047r 녹-인 비인간 동물 유방암 모델 |
| WO2013032591A1 (en) | 2011-08-29 | 2013-03-07 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
| PH12014500912A1 (en) * | 2011-10-28 | 2014-06-09 | Novartis Ag | Novel purine derivatives and their use in the treatment of disease |
| US20150011569A1 (en) * | 2011-12-15 | 2015-01-08 | Philadelphia Health & Education Corporation D/B/A Drexel University College Of Medicine | NOVEL P13K p110 INHIBITORS AND METHODS OF USE THEREOF |
| US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| KR20160027217A (ko) | 2012-05-23 | 2016-03-09 | 에프. 호프만-라 로슈 아게 | 내배엽 및 간세포를 수득하고 사용하는 조성물 및 방법 |
| US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
| EP2914260A1 (en) | 2012-10-31 | 2015-09-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for preventing antiphospholipid syndrome (aps) |
| RU2702908C2 (ru) | 2012-11-01 | 2019-10-14 | Инфинити Фармасьютикалз, Инк. | Лечение злокачественных опухолей с использованием модуляторов изоформ pi3-киназы |
| CN103936742B (zh) * | 2013-01-17 | 2017-05-03 | 程鹏 | 含嘌呤基的新型pi3k抑制剂及其制备方法和应用 |
| US9481667B2 (en) | 2013-03-15 | 2016-11-01 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
| MX376599B (es) * | 2013-05-02 | 2025-03-07 | Hoffmann La Roche | Derivados de purina como agonistas del receptor de cannabinoides 2 (cb2). |
| WO2014185367A1 (ja) * | 2013-05-13 | 2014-11-20 | 第一三共株式会社 | モルホリノプリン誘導体の製造方法 |
| WO2015051241A1 (en) | 2013-10-04 | 2015-04-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| EA201690713A1 (ru) | 2013-10-04 | 2016-08-31 | Инфинити Фармасьютикалз, Инк. | Гетероциклические соединения и их применения |
| JP6139789B2 (ja) * | 2013-10-16 | 2017-05-31 | シャンハイ インリ ファーマシューティカル カンパニー リミティド | 縮合複素環化合物、その調製方法、医薬組成物及びその使用 |
| CN103804380B (zh) * | 2014-01-24 | 2016-05-18 | 温州医科大学 | 以IKK-β为靶点的2-氨基-8-取代鸟嘌呤衍生物、应用及其制备方法 |
| SG11201607705XA (en) | 2014-03-19 | 2016-10-28 | Infinity Pharmaceuticals Inc | Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders |
| US20150320755A1 (en) | 2014-04-16 | 2015-11-12 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| WO2015188369A1 (en) * | 2014-06-13 | 2015-12-17 | Merck Sharp & Dohme Corp. | Purine inhibitors of human phosphatidylinositol 3-kinase delta |
| US9708348B2 (en) | 2014-10-03 | 2017-07-18 | Infinity Pharmaceuticals, Inc. | Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof |
| RU2672875C1 (ru) * | 2014-12-17 | 2018-11-20 | Пфайзер Инк. | Композиции PI3K/MTOR-ингибитора для внутривенного введения |
| CA2980517C (en) | 2015-03-30 | 2020-02-25 | Daiichi Sankyo Company, Limited | 6-morpholinyl-2-pyrazolyl-9h-purine derivatives and their use as pi3k inhibitors |
| PL236355B1 (pl) * | 2015-04-02 | 2021-01-11 | Celon Pharma Spolka Akcyjna | Pochodne 7-(morfolin-4-ylo)pirazolo[1,5-α]pirymidyny jako inhibitory kinazy PI3 |
| WO2016169417A1 (zh) * | 2015-04-21 | 2016-10-27 | 成都金瑞长青生物科技有限公司 | 嘌呤基-n-羟基嘧啶甲酰胺衍生物及其制备方法和用途 |
| AU2016278040B2 (en) | 2015-06-16 | 2019-07-04 | Nanophagix LLC | Drug delivery and imaging chemical conjugate, formulations and methods of use thereof |
| CN114230571B (zh) | 2015-09-14 | 2025-07-08 | 无限药品股份有限公司 | 异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法 |
| WO2017161116A1 (en) | 2016-03-17 | 2017-09-21 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors |
| US10919914B2 (en) | 2016-06-08 | 2021-02-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| CN109640999A (zh) | 2016-06-24 | 2019-04-16 | 无限药品股份有限公司 | 组合疗法 |
| TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| WO2018062382A1 (ja) * | 2016-09-29 | 2018-04-05 | 第一三共株式会社 | [2-(1-メチル-1h-ピラゾール-4-イル)-6-(モルホリン-4-イル)-9h-プリン-8-イル][4-(モルホリン-4-イル)ピペリジン-1-イル]メタノン及びその製薬上許容される塩の結晶 |
| CN110036109A (zh) | 2016-12-02 | 2019-07-19 | 第一三共株式会社 | 新颖的内-β-N-乙酰基氨基葡糖苷酶 |
| SG11202103118PA (en) * | 2018-09-27 | 2021-04-29 | Shanghai Yingli Pharmaceutical Co Ltd | Crystal form of morpholino quinazoline compound, preparation method therefor and use thereof |
| UY38912A (es) * | 2019-10-09 | 2021-05-31 | Biocryst Pharm Inc | Inhibidores del factor d del complemento para administración oral |
| CN111875606B (zh) * | 2020-07-20 | 2023-04-07 | 武汉工程大学 | 一种基于虚拟对接获得的嘌呤类化合物及其制备方法和应用 |
| US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
| CN116425751B (zh) * | 2022-12-19 | 2024-01-23 | 艾立康药业股份有限公司 | 作为mat2a抑制剂的多环类化合物 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3016378A (en) | 1959-07-01 | 1962-01-09 | Thomae Gmbh Dr K | Amino-substituted purine derivatives |
| JPS60260579A (ja) | 1984-01-13 | 1985-12-23 | Yoshitomi Pharmaceut Ind Ltd | プリン誘導体 |
| DE3406533A1 (de) | 1984-02-23 | 1985-08-29 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verwendung von adenosin-derivaten als antiallergica und arzneimittel, die diese enthalten |
| US5332744A (en) | 1989-05-30 | 1994-07-26 | Merck & Co., Inc. | Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists |
| US6790958B2 (en) * | 1996-08-02 | 2004-09-14 | Robert T. Lum | Purine inhibitors of cyclin dependent kinase 2 & IKBA |
| US5866702A (en) | 1996-08-02 | 1999-02-02 | Cv Therapeutics, Incorporation | Purine inhibitors of cyclin dependent kinase 2 |
| GB9817623D0 (en) * | 1998-08-13 | 1998-10-07 | Glaxo Group Ltd | Pharmaceutical compounds |
| JP2003146987A (ja) * | 1999-05-31 | 2003-05-21 | Dainippon Pharmaceut Co Ltd | 2−アリールプリン−9−アセトアミド誘導体 |
| KR100774855B1 (ko) * | 2000-04-27 | 2007-11-08 | 아스텔라스세이야쿠 가부시키가이샤 | 축합 헤테로아릴 유도체 |
| WO2003022274A2 (en) | 2001-09-13 | 2003-03-20 | Synta Pharmaceuticals Corp. | 2-aroylimidazole compounds for treating cancer |
| US6949644B2 (en) | 2001-10-12 | 2005-09-27 | Irm Llc | Methods for the synthesis of substituted purines |
| EP1578722A4 (en) * | 2001-10-12 | 2006-09-06 | Irm Llc | KINASEINHIBITOR SCAFFOLD AND METHOD FOR THE PRODUCTION THEREOF |
| DE60218525T2 (de) * | 2001-12-18 | 2007-11-22 | CV Therapeutics, Inc., Palo Alto | A2a adenosinrezeptorantagonisten |
| US20030139427A1 (en) | 2002-08-23 | 2003-07-24 | Osi Pharmaceuticals Inc. | Bicyclic pyrimidinyl derivatives and methods of use thereof |
| AU2003265636A1 (en) * | 2002-09-06 | 2004-03-29 | Smithkline Beecham Corporation | Pyrrolo(2, 3-d)pyrimidine-4-yl and purin-6-yl urea compounds |
| AU2003284142A1 (en) | 2002-10-15 | 2004-05-04 | Synta Pharmaceuticals Corp | Aromatic bicyclic heterocyles to modulate 1L-12 production |
| CA2527079A1 (en) | 2003-05-29 | 2005-01-06 | Synta Pharmaceuticals, Corp. | Heterocyclic compounds for preventing and treating disorders associated with excessive bone loss |
| GB0423653D0 (en) | 2004-10-25 | 2004-11-24 | Piramed Ltd | Pharmaceutical compounds |
| GB2431156A (en) * | 2005-10-11 | 2007-04-18 | Piramed Ltd | 1-cyclyl-3-substituted- -benzenes and -azines as inhibitors of phosphatidylinositol 3-kinase |
| TW200801012A (en) | 2006-04-26 | 2008-01-01 | Piramed Ltd | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
| US7919490B2 (en) | 2006-10-04 | 2011-04-05 | Wyeth Llc | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
| US20080233127A1 (en) * | 2007-03-21 | 2008-09-25 | Wyeth | Imidazolopyrimidine analogs and their use as pi3 kinase and mtor inhibitors |
| US20100152210A1 (en) * | 2007-03-28 | 2010-06-17 | Neuro Search A/S/ | Purinyl derivatives and their use as potassium channel modulators |
| JP2010522720A (ja) * | 2007-03-28 | 2010-07-08 | ノイロサーチ アクティーゼルスカブ | プリニル誘導体及びカリウムチャネルモジュレーターとしてのそれらの使用 |
| EP2215090B1 (en) * | 2007-10-26 | 2015-03-04 | F. Hoffmann-La Roche AG | Purine derivatives useful as pi3 kinase inhibitors |
| TWI378933B (en) * | 2008-10-14 | 2012-12-11 | Daiichi Sankyo Co Ltd | Morpholinopurine derivatives |
| PE20100362A1 (es) * | 2008-10-30 | 2010-05-27 | Irm Llc | Derivados de purina que expanden las celulas madre hematopoyeticas |
| DK2414362T3 (da) * | 2009-04-03 | 2014-09-22 | Verastem Inc | Pyrimidinsubstituerede purinforbindelser som kinaseinhibitorer |
| CN102459272B (zh) * | 2009-05-27 | 2014-08-06 | 健泰科生物技术公司 | 对P110δ具有选择性的为PI3K抑制剂的二环嘧啶化合物和使用方法 |
| EP2451811A1 (en) * | 2009-05-27 | 2012-05-16 | F. Hoffmann-La Roche AG | Bicyclic indole-pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use |
| CA2778686C (en) * | 2009-11-12 | 2015-07-21 | F. Hoffmann-La Roche Ag | N-9-substituted purine compounds, compositions and methods of use |
| WO2012007493A1 (en) * | 2010-07-14 | 2012-01-19 | F. Hoffmann-La Roche Ag | Purine compounds selective for ρi3κ p110 delta, and methods of use |
-
2009
- 2009-05-29 MX MX2010012583A patent/MX2010012583A/es active IP Right Grant
- 2009-05-29 CN CN200980129148.2A patent/CN102105474B/zh active Active
- 2009-05-29 JP JP2011511842A patent/JP2011521968A/ja active Pending
- 2009-05-29 WO PCT/US2009/045603 patent/WO2009146406A1/en not_active Ceased
- 2009-05-29 AU AU2009251291A patent/AU2009251291B2/en not_active Ceased
- 2009-05-29 BR BRPI0909614A patent/BRPI0909614A2/pt not_active Application Discontinuation
- 2009-05-29 RU RU2010154428/04A patent/RU2509081C2/ru not_active IP Right Cessation
- 2009-05-29 KR KR1020107026673A patent/KR20110042153A/ko not_active Ceased
- 2009-05-29 CA CA2721851A patent/CA2721851A1/en not_active Abandoned
- 2009-05-29 ES ES09755767.2T patent/ES2533788T3/es active Active
- 2009-05-29 EP EP09755767.2A patent/EP2279188B1/en active Active
- 2009-05-29 US US12/474,613 patent/US8158624B2/en active Active
-
2010
- 2010-10-20 IL IL208838A patent/IL208838A0/en unknown
- 2010-10-21 ZA ZA2010/07524A patent/ZA201007524B/en unknown
-
2012
- 2012-02-09 US US13/369,941 patent/US8445487B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201007524B (en) | 2012-01-25 |
| ES2533788T3 (es) | 2015-04-14 |
| CN102105474A (zh) | 2011-06-22 |
| BRPI0909614A2 (pt) | 2015-09-22 |
| US20120135988A1 (en) | 2012-05-31 |
| US8445487B2 (en) | 2013-05-21 |
| CN102105474B (zh) | 2014-01-08 |
| AU2009251291B2 (en) | 2013-05-02 |
| AU2009251291A1 (en) | 2009-12-03 |
| WO2009146406A1 (en) | 2009-12-03 |
| RU2010154428A (ru) | 2012-07-10 |
| CA2721851A1 (en) | 2009-12-03 |
| KR20110042153A (ko) | 2011-04-25 |
| EP2279188A1 (en) | 2011-02-02 |
| MX2010012583A (es) | 2011-02-24 |
| RU2509081C2 (ru) | 2014-03-10 |
| US8158624B2 (en) | 2012-04-17 |
| JP2011521968A (ja) | 2011-07-28 |
| US20090318411A1 (en) | 2009-12-24 |
| EP2279188B1 (en) | 2015-01-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA201007524B (en) | Purine pi3k inhibitor compounds and methods of use | |
| IL275881B (en) | Methods for using alpha1–il antibodies | |
| IL239081A0 (en) | Benzoxazepine pi3k inhibitor compounds and methods of use | |
| IL218800A0 (en) | Benzoxepin pi3k inhibitor compounds and methods of use | |
| ZA201100211B (en) | Kinase inhibitors and methods of use | |
| EP2252293A4 (en) | KINASEHEMMER AND USE PROCESS | |
| IL207865A0 (en) | Pim kinase inhibitors and methods of their use | |
| IL240771A0 (en) | Benzoxazole kinase inhibitors and methods of use | |
| IL208359A0 (en) | Benzopyran and benzoxepin pi3k inhibitor compounds and methods of use | |
| IL213547A0 (en) | Compounds and methods of use | |
| EP2340244A4 (en) | COMPOUNDS AND APPLICATION PROCEDURES | |
| IL201284A0 (en) | Methods of treating caner using pyridopyrimidinone inhibitors of pi3k alpha | |
| ZA201304128B (en) | Tricyclic pi3k inhibitor compounds and methods of use | |
| IL216473A0 (en) | BENZOXAZEPINES AS INHIBITORS OF PI3K/mTOR AND METHODS OF THEIR USE AND MANUFACTURE | |
| IL207843A0 (en) | Raf inhibitor compounds and methods of use thereof | |
| IL220154A0 (en) | Novel pyrimidine compounds as mtor and pi3k inhibitors | |
| IL193693A0 (en) | Purine compounds and methods of use thereof | |
| PL2050749T3 (pl) | Pochodna pirymidyny jako inhibitor pi3k i jej zastosowanie | |
| SI2379096T1 (sl) | Zaviralci TFPI in postopki uporabe | |
| ZA200807956B (en) | Purine compounds and methods of use thereof | |
| GB0805693D0 (en) | Combinations of P13-delta and P13-gamma kinase inhibitor compounds | |
| HK1160469A (en) | Pyridopyrimidinone inhibitors of pi3k and mtor |