AU2009251291B2 - Purine PI3K inhibitor compounds and methods of use - Google Patents

Purine PI3K inhibitor compounds and methods of use Download PDF

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Publication number
AU2009251291B2
AU2009251291B2 AU2009251291A AU2009251291A AU2009251291B2 AU 2009251291 B2 AU2009251291 B2 AU 2009251291B2 AU 2009251291 A AU2009251291 A AU 2009251291A AU 2009251291 A AU2009251291 A AU 2009251291A AU 2009251291 B2 AU2009251291 B2 AU 2009251291B2
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AU
Australia
Prior art keywords
purin
morpholino
methyl
carcinoma
aminopyrimidin
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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AU2009251291A
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English (en)
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AU2009251291A1 (en
Inventor
Georgette Castanedo
Irina Chuckowree
Adrian Folkes
Daniel P. Sutherlin
Nan Chi Wan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Genentech Inc
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F Hoffmann La Roche AG
Genentech Inc
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Publication of AU2009251291A1 publication Critical patent/AU2009251291A1/en
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Publication of AU2009251291B2 publication Critical patent/AU2009251291B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2009251291A 2008-05-30 2009-05-29 Purine PI3K inhibitor compounds and methods of use Ceased AU2009251291B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5755908P 2008-05-30 2008-05-30
US61/057,559 2008-05-30
PCT/US2009/045603 WO2009146406A1 (en) 2008-05-30 2009-05-29 Purine pi3k inhibitor compounds and methods of use

Publications (2)

Publication Number Publication Date
AU2009251291A1 AU2009251291A1 (en) 2009-12-03
AU2009251291B2 true AU2009251291B2 (en) 2013-05-02

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009251291A Ceased AU2009251291B2 (en) 2008-05-30 2009-05-29 Purine PI3K inhibitor compounds and methods of use

Country Status (14)

Country Link
US (2) US8158624B2 (OSRAM)
EP (1) EP2279188B1 (OSRAM)
JP (1) JP2011521968A (OSRAM)
KR (1) KR20110042153A (OSRAM)
CN (1) CN102105474B (OSRAM)
AU (1) AU2009251291B2 (OSRAM)
BR (1) BRPI0909614A2 (OSRAM)
CA (1) CA2721851A1 (OSRAM)
ES (1) ES2533788T3 (OSRAM)
IL (1) IL208838A0 (OSRAM)
MX (1) MX2010012583A (OSRAM)
RU (1) RU2509081C2 (OSRAM)
WO (1) WO2009146406A1 (OSRAM)
ZA (1) ZA201007524B (OSRAM)

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CN103936742B (zh) * 2013-01-17 2017-05-03 程鹏 含嘌呤基的新型pi3k抑制剂及其制备方法和应用
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JP6871919B2 (ja) 2015-06-16 2021-05-19 ナノファギックス エルエルシー 薬物送達及びイメージング化学コンジュゲート、製剤及びその使用方法
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Also Published As

Publication number Publication date
CN102105474B (zh) 2014-01-08
AU2009251291A1 (en) 2009-12-03
EP2279188A1 (en) 2011-02-02
US20090318411A1 (en) 2009-12-24
IL208838A0 (en) 2011-01-31
CA2721851A1 (en) 2009-12-03
BRPI0909614A2 (pt) 2015-09-22
ZA201007524B (en) 2012-01-25
RU2509081C2 (ru) 2014-03-10
EP2279188B1 (en) 2015-01-28
ES2533788T3 (es) 2015-04-14
JP2011521968A (ja) 2011-07-28
KR20110042153A (ko) 2011-04-25
CN102105474A (zh) 2011-06-22
RU2010154428A (ru) 2012-07-10
WO2009146406A1 (en) 2009-12-03
US20120135988A1 (en) 2012-05-31
US8158624B2 (en) 2012-04-17
US8445487B2 (en) 2013-05-21
MX2010012583A (es) 2011-02-24

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