IL207609A - Pyrimidine-2-amine compounds and their use as the inhibitors of jak kinases - Google Patents

Pyrimidine-2-amine compounds and their use as the inhibitors of jak kinases

Info

Publication number
IL207609A
IL207609A IL207609A IL20760910A IL207609A IL 207609 A IL207609 A IL 207609A IL 207609 A IL207609 A IL 207609A IL 20760910 A IL20760910 A IL 20760910A IL 207609 A IL207609 A IL 207609A
Authority
IL
Israel
Prior art keywords
pyrimidine
inhibitors
amine compounds
jak kinases
jak
Prior art date
Application number
IL207609A
Other languages
English (en)
Hebrew (he)
Other versions
IL207609A0 (en
Inventor
Somasekhar Bhamidipati
Jeffrey Clough
Ankush Argade
Rajinder Singh
Vadim Markovtosov
Pingyu Ding
Jiaxin Yu
Andy Atuegbu
Hui Hong
Ihab Darwish
Sambiah Thota
Original Assignee
Rigel Pharmaceuticals Inc
Somasekhar Bhamidipati
Jeffrey Clough
Ankush Argade
Rajinder Singh
Vadim Markovtosov
Pingyu Ding
Jiaxin Yu
Andy Atuegbu
Hui Hong
Ihab Darwish
Sambiah Thota
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rigel Pharmaceuticals Inc, Somasekhar Bhamidipati, Jeffrey Clough, Ankush Argade, Rajinder Singh, Vadim Markovtosov, Pingyu Ding, Jiaxin Yu, Andy Atuegbu, Hui Hong, Ihab Darwish, Sambiah Thota filed Critical Rigel Pharmaceuticals Inc
Publication of IL207609A0 publication Critical patent/IL207609A0/en
Publication of IL207609A publication Critical patent/IL207609A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL207609A 2008-02-15 2010-08-12 Pyrimidine-2-amine compounds and their use as the inhibitors of jak kinases IL207609A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2926508P 2008-02-15 2008-02-15
US3867208P 2008-03-21 2008-03-21
US11204608P 2008-11-06 2008-11-06
PCT/US2009/034159 WO2009103032A1 (en) 2008-02-15 2009-02-13 Pyrimidine-2-amine compounds and their use as inhibitors of jak kinases

Publications (2)

Publication Number Publication Date
IL207609A0 IL207609A0 (en) 2010-12-30
IL207609A true IL207609A (en) 2015-08-31

Family

ID=40591956

Family Applications (1)

Application Number Title Priority Date Filing Date
IL207609A IL207609A (en) 2008-02-15 2010-08-12 Pyrimidine-2-amine compounds and their use as the inhibitors of jak kinases

Country Status (20)

Country Link
US (3) US8309566B2 (enExample)
EP (1) EP2265607B1 (enExample)
JP (2) JP5711537B2 (enExample)
KR (1) KR101700454B1 (enExample)
CN (1) CN102007124B (enExample)
AU (1) AU2009214440B2 (enExample)
CA (1) CA2715658C (enExample)
CY (1) CY1118969T1 (enExample)
DK (1) DK2265607T3 (enExample)
ES (1) ES2617622T3 (enExample)
HR (1) HRP20170317T1 (enExample)
HU (1) HUE030912T2 (enExample)
IL (1) IL207609A (enExample)
LT (1) LT2265607T (enExample)
MX (1) MX2010008926A (enExample)
NZ (1) NZ587589A (enExample)
PL (1) PL2265607T3 (enExample)
PT (1) PT2265607T (enExample)
SI (1) SI2265607T1 (enExample)
WO (1) WO2009103032A1 (enExample)

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LT2265607T (lt) 2017-03-27
EP2265607B1 (en) 2016-12-14
US8735418B2 (en) 2014-05-27
AU2009214440B2 (en) 2014-09-25
IL207609A0 (en) 2010-12-30
MX2010008926A (es) 2011-02-23
HRP20170317T1 (hr) 2017-04-21
PL2265607T3 (pl) 2017-07-31
PT2265607T (pt) 2017-03-08
CN102007124A (zh) 2011-04-06
KR20100124292A (ko) 2010-11-26
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ES2617622T3 (es) 2017-06-19
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CA2715658A1 (en) 2009-08-20
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