IL206854A - Tricyclic compounds as modulators of a – tnf synthesis and 4pde inhibitors - Google Patents
Tricyclic compounds as modulators of a – tnf synthesis and 4pde inhibitorsInfo
- Publication number
- IL206854A IL206854A IL206854A IL20685410A IL206854A IL 206854 A IL206854 A IL 206854A IL 206854 A IL206854 A IL 206854A IL 20685410 A IL20685410 A IL 20685410A IL 206854 A IL206854 A IL 206854A
- Authority
- IL
- Israel
- Prior art keywords
- substituted
- fused
- alkyl
- methoxy
- aryl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims description 134
- 230000015572 biosynthetic process Effects 0.000 title description 9
- 238000003786 synthesis reaction Methods 0.000 title description 9
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 title description 4
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 title description 4
- 238000000034 method Methods 0.000 claims description 289
- 125000000217 alkyl group Chemical group 0.000 claims description 123
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- -1 alkoxyalkyi Chemical group 0.000 claims description 88
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- 125000000623 heterocyclic group Chemical group 0.000 claims description 75
- 229910052739 hydrogen Inorganic materials 0.000 claims description 69
- 229910052736 halogen Inorganic materials 0.000 claims description 64
- 150000002367 halogens Chemical group 0.000 claims description 64
- 239000001257 hydrogen Chemical group 0.000 claims description 61
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 48
- 229910052757 nitrogen Inorganic materials 0.000 claims description 42
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 42
- 125000003342 alkenyl group Chemical group 0.000 claims description 41
- 125000003545 alkoxy group Chemical group 0.000 claims description 39
- 125000000304 alkynyl group Chemical group 0.000 claims description 39
- 150000003839 salts Chemical class 0.000 claims description 36
- 239000008194 pharmaceutical composition Substances 0.000 claims description 32
- 125000001188 haloalkyl group Chemical group 0.000 claims description 30
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 28
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- 238000011282 treatment Methods 0.000 claims description 25
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- 125000004093 cyano group Chemical group *C#N 0.000 claims description 23
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 23
- 230000000694 effects Effects 0.000 claims description 20
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 20
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 18
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 16
- 125000004350 aryl cycloalkyl group Chemical group 0.000 claims description 15
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims description 15
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 8
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- 239000003112 inhibitor Substances 0.000 description 21
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| IL206854A0 IL206854A0 (en) | 2010-12-30 |
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| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| AR090100A1 (es) * | 2012-02-21 | 2014-10-22 | Celgene Corp | Procesos para la preparacion de la (s)-1-(3-etoxi-4-metoxifenil)-2-metanosulfoniletilamina |
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| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
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| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
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| WO2017089347A1 (en) | 2015-11-25 | 2017-06-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas |
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| CN109705037A (zh) * | 2019-01-24 | 2019-05-03 | 广西师范大学 | 4-氨基喹啉-3-甲酸酯衍生物及其制备方法和应用 |
| WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
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