JP5406215B2 - ＴＮＦ−α合成の調節因子及びＰＤＥ４阻害剤としての三環系化合物 - Google Patents
ＴＮＦ−α合成の調節因子及びＰＤＥ４阻害剤としての三環系化合物 Download PDFInfo
- Publication number
- JP5406215B2 JP5406215B2 JP2010544436A JP2010544436A JP5406215B2 JP 5406215 B2 JP5406215 B2 JP 5406215B2 JP 2010544436 A JP2010544436 A JP 2010544436A JP 2010544436 A JP2010544436 A JP 2010544436A JP 5406215 B2 JP5406215 B2 JP 5406215B2
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- JP
- Japan
- Prior art keywords
- methoxy
- quinoline
- pyrimido
- dione
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 *c(c(*)c1**N2C(N3*)=*)c(*)c(nc4)c1c2c4C3=* Chemical compound *c(c(*)c1**N2C(N3*)=*)c(*)c(nc4)c1c2c4C3=* 0.000 description 1
- GMEQCFSPZBKXJY-UHFFFAOYSA-N CC(C)OC(N(CC1)CCC1N(c(c(cccc1OC)c1nc1)c1C(N1c2cccc(Cl)c2)=O)C1=O)=O Chemical compound CC(C)OC(N(CC1)CCC1N(c(c(cccc1OC)c1nc1)c1C(N1c2cccc(Cl)c2)=O)C1=O)=O GMEQCFSPZBKXJY-UHFFFAOYSA-N 0.000 description 1
- DLVHYSMNJZZBJZ-UHFFFAOYSA-N CCN(C(c(cnc1c2cccc1OC)c2N1C2CCC(C)CC2)=O)C1=O Chemical compound CCN(C(c(cnc1c2cccc1OC)c2N1C2CCC(C)CC2)=O)C1=O DLVHYSMNJZZBJZ-UHFFFAOYSA-N 0.000 description 1
- UUWDCIKSKPEDMO-UHFFFAOYSA-N CCN(C(c(cnc1c2cccc1OC)c2N1C2CCCC2)=O)C1=S Chemical compound CCN(C(c(cnc1c2cccc1OC)c2N1C2CCCC2)=O)C1=S UUWDCIKSKPEDMO-UHFFFAOYSA-N 0.000 description 1
- GPMSLBNLZRLROA-UHFFFAOYSA-N CCN(C(c(cnc1c2cccc1OC)c2N1CC(C)(C)C)=O)C1=O Chemical compound CCN(C(c(cnc1c2cccc1OC)c2N1CC(C)(C)C)=O)C1=O GPMSLBNLZRLROA-UHFFFAOYSA-N 0.000 description 1
- SJGQNDBTUUOYSK-UHFFFAOYSA-N CCN(C(c(cnc1c2cccc1OC)c2N1Cc(cc2)ccc2OC)=O)C1=O Chemical compound CCN(C(c(cnc1c2cccc1OC)c2N1Cc(cc2)ccc2OC)=O)C1=O SJGQNDBTUUOYSK-UHFFFAOYSA-N 0.000 description 1
- SRZNJZKKXAHSLG-UHFFFAOYSA-N COc1cccc2c1ncc(C(N1C3CCCC3)=O)c2N(C2CCCC2)C1=O Chemical compound COc1cccc2c1ncc(C(N1C3CCCC3)=O)c2N(C2CCCC2)C1=O SRZNJZKKXAHSLG-UHFFFAOYSA-N 0.000 description 1
- DFTGKUJJDBYDBZ-UHFFFAOYSA-N COc1cccc2c1ncc(C(N1c3cc(Cl)ccc3)=O)c2N(C(CC2)CCN2C(c2ccccc2)=O)C1=O Chemical compound COc1cccc2c1ncc(C(N1c3cc(Cl)ccc3)=O)c2N(C(CC2)CCN2C(c2ccccc2)=O)C1=O DFTGKUJJDBYDBZ-UHFFFAOYSA-N 0.000 description 1
- VLSIAPYZDCCBPU-UHFFFAOYSA-N COc1cccc2c1ncc(C(N1c3cccc(Cl)c3)=O)c2N(C(CC2)CCC2C(O)=O)C1=O Chemical compound COc1cccc2c1ncc(C(N1c3cccc(Cl)c3)=O)c2N(C(CC2)CCC2C(O)=O)C1=O VLSIAPYZDCCBPU-UHFFFAOYSA-N 0.000 description 1
- PYZDPPRYPHIHCL-UHFFFAOYSA-N COc1cccc2c1ncc(C(N1c3cccc(Cl)c3)=O)c2N(CC(CC2)CCN2S(C)(=O)=O)C1=O Chemical compound COc1cccc2c1ncc(C(N1c3cccc(Cl)c3)=O)c2N(CC(CC2)CCN2S(C)(=O)=O)C1=O PYZDPPRYPHIHCL-UHFFFAOYSA-N 0.000 description 1
- UXQHERGWFNFMGT-UHFFFAOYSA-N Cc1c(C)c(N(C(c(cnc2c3cccc2OC)c3N2C3CCCC3)=O)C2=O)ccc1 Chemical compound Cc1c(C)c(N(C(c(cnc2c3cccc2OC)c3N2C3CCCC3)=O)C2=O)ccc1 UXQHERGWFNFMGT-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Dermatology (AREA)
- AIDS & HIV (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Transplantation (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2361708P | 2008-01-25 | 2008-01-25 | |
| US61/023,617 | 2008-01-25 | ||
| PCT/US2009/031819 WO2009094528A1 (en) | 2008-01-25 | 2009-01-23 | TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-α SYNTHESIS AND AS PDE4 INHIBITORS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011510929A JP2011510929A (ja) | 2011-04-07 |
| JP2011510929A5 JP2011510929A5 (enExample) | 2012-03-08 |
| JP5406215B2 true JP5406215B2 (ja) | 2014-02-05 |
Family
ID=40901439
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010544436A Active JP5406215B2 (ja) | 2008-01-25 | 2009-01-23 | ＴＮＦ−α合成の調節因子及びＰＤＥ４阻害剤としての三環系化合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (10) | US7964608B2 (enExample) |
| EP (1) | EP2244574B1 (enExample) |
| JP (1) | JP5406215B2 (enExample) |
| KR (1) | KR101709141B1 (enExample) |
| CN (1) | CN101925301B (enExample) |
| AU (1) | AU2009206368B2 (enExample) |
| BR (1) | BRPI0906809A2 (enExample) |
| CA (1) | CA2711576C (enExample) |
| EA (1) | EA018462B1 (enExample) |
| ES (1) | ES2523169T3 (enExample) |
| IL (1) | IL206854A (enExample) |
| MA (1) | MA32035B1 (enExample) |
| MX (1) | MX2010007768A (enExample) |
| NZ (1) | NZ586695A (enExample) |
| WO (1) | WO2009094528A1 (enExample) |
| ZA (1) | ZA201004818B (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5406215B2 (ja) | 2008-01-25 | 2014-02-05 | ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー | ＴＮＦ−α合成の調節因子及びＰＤＥ４阻害剤としての三環系化合物 |
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| AR090100A1 (es) * | 2012-02-21 | 2014-10-22 | Celgene Corp | Procesos para la preparacion de la (s)-1-(3-etoxi-4-metoxifenil)-2-metanosulfoniletilamina |
| HUE042374T2 (hu) | 2012-06-13 | 2019-06-28 | Incyte Holdings Corp | Szubsztituált triciklusos vegyületek mint FGFR inhibitorok |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| EP2950649B1 (en) | 2013-02-01 | 2020-03-04 | Wellstat Therapeutics Corporation | Amine compounds having anti-inflammatory, antifungal, antiparasitic and anticancer activity |
| KR102469849B1 (ko) | 2013-04-19 | 2022-11-23 | 인사이트 홀딩스 코포레이션 | Fgfr 저해제로서 이환식 헤테로사이클 |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| AU2016219822B2 (en) | 2015-02-20 | 2020-07-09 | Incyte Holdings Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| TN2017000485A1 (en) * | 2015-06-17 | 2019-04-12 | Pfizer | Tricyclic compounds and their use as phosphodiesterase inhibitors |
| WO2017089347A1 (en) | 2015-11-25 | 2017-06-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas |
| MA47106A (fr) | 2016-12-21 | 2019-10-30 | Amgen Inc | Formulations d'anticorps anti-tnf alpha |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| EP3788046B1 (en) | 2018-05-04 | 2025-12-10 | Incyte Corporation | Salts of an fgfr inhibitor |
| EP4309737A3 (en) | 2018-05-04 | 2024-03-27 | Incyte Corporation | Solid forms of an fgfr inhibitor and processes for preparing the same |
| CN109705037A (zh) * | 2019-01-24 | 2019-05-03 | 广西师范大学 | 4-氨基喹啉-3-甲酸酯衍生物及其制备方法和应用 |
| US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| KR102766496B1 (ko) | 2019-08-09 | 2025-02-10 | 주식회사 엘지에너지솔루션 | 연쇄발화 방지를 위한 에너지 드레인 저항체를 구비한 배터리 팩 |
| US12122767B2 (en) | 2019-10-01 | 2024-10-22 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2021076602A1 (en) | 2019-10-14 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
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| JPH0741479A (ja) * | 1993-07-28 | 1995-02-10 | Taisho Pharmaceut Co Ltd | ７−アザプテリジン類およびその製造方法 |
| JP2000510866A (ja) * | 1996-05-20 | 2000-08-22 | ダーウィン・ディスカバリー・リミテッド | Ｔｎｆとｐｄｅ―ｉｖのインヒビターとしてのキノリンスルホンアミド |
| US6930101B1 (en) * | 1999-05-17 | 2005-08-16 | The Regents Of The University Of California | Thiazolopyrimidines useful as TNFα inhibitors |
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| PL193012B1 (pl) * | 2003-06-09 | 2007-01-31 | Univ Medyczny | 3-podstawiony 1,2,3,4-tetrahydropirymido[5,4-c]cynnolin-2,4-dion i 3-podstawiony 1,2,3,4-tetrahydropirymido[5,4-c]chinolin-2,4-dion oraz sposób otrzymywania 3-podstawionego 1,2,3,4-tetrahydropirymido[5,4-c]cynnolin-2,4-dionu i 3-podstawionego 1,2,3,4-tetrahydropirymido[5,4-c]chinolin-2,4-dionu |
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| JP2012519159A (ja) | 2009-02-27 | 2012-08-23 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｐｄｅ４阻害剤及びｎｓａｉｄを含有する複合薬 |
| WO2010097334A1 (de) | 2009-02-27 | 2010-09-02 | Boehringer Ingelheim International Gmbh | Arzneimittelkombinationen enthaltend pde4-inhibitoren und nsaids |
| EP2555774B1 (de) | 2010-04-08 | 2015-10-21 | Boehringer Ingelheim International GmbH | Arnzeimittelkombinationen enthaltend pde4-inhibitoren und ep4-rezeptor-antagonisten |
| JP2013529184A (ja) | 2010-04-08 | 2013-07-18 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｐｄｅ４阻害剤及びｅｐ４受容体アンタゴニストを含有する医薬の組み合わせ |
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