CN101925301B - 作为TNF-α合成调节剂和作为PDE4抑制剂的三环化合物 - Google Patents

作为TNF-α合成调节剂和作为PDE4抑制剂的三环化合物 Download PDF

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CN101925301B
CN101925301B CN200980102961.0A CN200980102961A CN101925301B CN 101925301 B CN101925301 B CN 101925301B CN 200980102961 A CN200980102961 A CN 200980102961A CN 101925301 B CN101925301 B CN 101925301B
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quinoline
methoxy
phenyl
pyrimido
chloro
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CN101925301A (zh
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A·M·M·米贾里
B·加达穆
D·R·珀里斯蒂
M·考斯图拉
M·古泽尔
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Hengyi Biomedicine Shanghai Co ltd
vTv Therapeutics LLC
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High Point Pharnaceuticals LLC
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CN200980102961.0A 2008-01-25 2009-01-23 作为TNF-α合成调节剂和作为PDE4抑制剂的三环化合物 Active CN101925301B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2361708P 2008-01-25 2008-01-25
US61/023,617 2008-01-25
PCT/US2009/031819 WO2009094528A1 (en) 2008-01-25 2009-01-23 TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-α SYNTHESIS AND AS PDE4 INHIBITORS

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CN101925301A CN101925301A (zh) 2010-12-22
CN101925301B true CN101925301B (zh) 2014-09-17

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US (10) US7964608B2 (enExample)
EP (1) EP2244574B1 (enExample)
JP (1) JP5406215B2 (enExample)
KR (1) KR101709141B1 (enExample)
CN (1) CN101925301B (enExample)
AU (1) AU2009206368B2 (enExample)
BR (1) BRPI0906809A2 (enExample)
CA (1) CA2711576C (enExample)
EA (1) EA018462B1 (enExample)
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MX (1) MX2010007768A (enExample)
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US11607416B2 (en) 2019-10-14 2023-03-21 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
WO2021113462A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Derivatives of an fgfr inhibitor
US11897891B2 (en) 2019-12-04 2024-02-13 Incyte Corporation Tricyclic heterocycles as FGFR inhibitors
WO2021146424A1 (en) 2020-01-15 2021-07-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
CN113861189A (zh) 2020-06-29 2021-12-31 Vtv治疗有限责任公司 喹啉衍生物，其药学上可接受的盐及其使用方法
CA3186699A1 (en) * 2020-07-28 2022-02-03 Bapu Gaddam Crystalline form of hydrochloride salt of quinoline derivative
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