IL205936A - Polynucleotide encoding a polypeptide having a single curling site at the homologous n-terminus to a human plasminogen ringing site, an activation site and a serine protease site at the homologous c-terminal end to parallel regions in human plasminogen, the polypeptide and cod encoding the polypeptide - Google Patents

Polynucleotide encoding a polypeptide having a single curling site at the homologous n-terminus to a human plasminogen ringing site, an activation site and a serine protease site at the homologous c-terminal end to parallel regions in human plasminogen, the polypeptide and cod encoding the polypeptide

Info

Publication number
IL205936A
IL205936A IL205936A IL20593610A IL205936A IL 205936 A IL205936 A IL 205936A IL 205936 A IL205936 A IL 205936A IL 20593610 A IL20593610 A IL 20593610A IL 205936 A IL205936 A IL 205936A
Authority
IL
Israel
Prior art keywords
polypeptide
domain
terminal
human plasminogen
homologous
Prior art date
Application number
IL205936A
Other languages
English (en)
Hebrew (he)
Other versions
IL205936A0 (en
Original Assignee
Grifols Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grifols Therapeutics Inc filed Critical Grifols Therapeutics Inc
Publication of IL205936A0 publication Critical patent/IL205936A0/en
Publication of IL205936A publication Critical patent/IL205936A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
IL205936A 2007-11-29 2010-05-24 Polynucleotide encoding a polypeptide having a single curling site at the homologous n-terminus to a human plasminogen ringing site, an activation site and a serine protease site at the homologous c-terminal end to parallel regions in human plasminogen, the polypeptide and cod encoding the polypeptide IL205936A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99114807P 2007-11-29 2007-11-29
PCT/US2008/084645 WO2009073471A1 (en) 2007-11-29 2008-11-25 Recombinantly modified plasmin

Publications (2)

Publication Number Publication Date
IL205936A0 IL205936A0 (en) 2010-11-30
IL205936A true IL205936A (en) 2015-04-30

Family

ID=40379999

Family Applications (1)

Application Number Title Priority Date Filing Date
IL205936A IL205936A (en) 2007-11-29 2010-05-24 Polynucleotide encoding a polypeptide having a single curling site at the homologous n-terminus to a human plasminogen ringing site, an activation site and a serine protease site at the homologous c-terminal end to parallel regions in human plasminogen, the polypeptide and cod encoding the polypeptide

Country Status (17)

Country Link
US (3) US8101394B2 (enExample)
EP (1) EP2220221B1 (enExample)
JP (1) JP5539896B2 (enExample)
KR (1) KR101529743B1 (enExample)
CN (1) CN101918548B (enExample)
AU (1) AU2008331545B2 (enExample)
BR (1) BRPI0819780B1 (enExample)
CA (1) CA2707266C (enExample)
ES (1) ES2534040T3 (enExample)
HU (1) HUE024916T2 (enExample)
IL (1) IL205936A (enExample)
MX (1) MX2010005947A (enExample)
NZ (2) NZ593837A (enExample)
PL (1) PL2220221T3 (enExample)
PT (1) PT2220221E (enExample)
WO (1) WO2009073471A1 (enExample)
ZA (1) ZA201003730B (enExample)

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JP5026254B2 (ja) 2004-04-22 2012-09-12 グリフオルス・セラピユーテイクス・インコーポレーテツド 組換え的に改変されたプラスミン
WO2009073471A1 (en) 2007-11-29 2009-06-11 Talecris Biotherapeutics, Inc. Recombinantly modified plasmin
UA103771C2 (ru) 2008-06-04 2013-11-25 Грифолз Терапьютикс Инк. Стрептокиназа, активирующая плазмин, способ и набор для получения плазмина
HUE025670T2 (en) * 2009-03-03 2016-04-28 Grifols Therapeutics Inc A method for producing plasminogen
EP2451835A1 (en) 2009-07-10 2012-05-16 ThromboGenics N.V. Variants of plasminogen and plasmin
WO2011023805A1 (en) 2009-08-28 2011-03-03 Thrombogenics N.V. Use of plasmin for the treatment of filtration failure after trabeculectomy
CN102121023B (zh) * 2010-12-22 2012-07-04 中山大学 突变型人纤溶酶原kringle5及其制备方法及应用
ES2583082T3 (es) 2011-01-05 2016-09-19 Thrombogenics N.V. Variantes de plasminógeno y plasmina
WO2013024074A1 (en) 2011-08-12 2013-02-21 Thrombogenics N.V. Plasminogen and plasmin variants
CN103205410B (zh) * 2012-01-13 2018-03-06 蔺莹莹 重组微纤维蛋白溶酶及其制备方法和应用
JP2016519081A (ja) 2013-03-14 2016-06-30 バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅ ＬＬＣ ヘパリンと結合体化した抗トロンビンβに対するモノクローナル抗体
DE102014112212A1 (de) * 2014-08-26 2016-03-03 Akesion Gmbh Rekombinante Fusionsproteine zur Vorbeugung oder Behandlung von Adhäsionen bei Geweben oder Organen
FR3035120B1 (fr) * 2015-04-15 2020-02-07 Arcadophta Composition de plasminogenase immobilisee, procede de preparation, utilisation et dispositif comprenant une telle composition
US11400142B2 (en) 2015-12-18 2022-08-02 Talengen International Limited Treatment of diabetic nerve injury comprising administering plasminogen
DK3391902T5 (da) 2015-12-18 2024-09-23 Talengen Int Ltd Plasminogen til anvendelse i behandlingen af diabetisk angiokardiopati
JP2019500426A (ja) 2015-12-18 2019-01-10 タレンゲン インターナショナル リミティッドＴａｌｅｎｇｅｎ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｌｉｍｉｔｅｄ 糖尿病網膜症を予防または治療するための方法
CN108778307A (zh) 2015-12-18 2018-11-09 泰伦基国际有限公司 一种预防和治疗糖尿病肾病的方法
CN110114080A (zh) 2016-12-15 2019-08-09 泰伦基国际有限公司 一种预防和治疗皮肤纤维化的方法
WO2018108161A1 (zh) 2016-12-15 2018-06-21 深圳瑞健生命科学研究院有限公司 一种预防和治疗肥胖症的方法和药物
CN110366425A (zh) * 2016-12-15 2019-10-22 泰伦基国际有限公司 一种预防动脉粥样硬化及其并发症的方法
JP7171572B2 (ja) * 2016-12-15 2022-11-15 タレンゲン インターナショナル リミテッド 糖尿病を治療するための新しい方法
EP3556385A4 (en) 2016-12-15 2020-12-30 Talengen International Limited PROCESS FOR ALLEGING HEART DISEASE
CN108210910A (zh) * 2016-12-15 2018-06-29 深圳瑞健生命科学研究院有限公司 预防和治疗系统性硬化症的药物及其用途
TWI714862B (zh) 2017-06-19 2021-01-01 大陸商深圳瑞健生命科學硏究院有限公司 一種調控glp-1/glp-1r的方法和藥物
US11140020B1 (en) 2018-03-01 2021-10-05 Amazon Technologies, Inc. Availability-enhancing gateways for network traffic in virtualized computing environments
US12226462B2 (en) 2019-01-25 2025-02-18 Council Of Scientific & Industrial Research Fibrinolytic composition and method of its preparation
EP4140498A4 (en) * 2020-05-11 2023-11-01 Talengen International Limited METHOD AND DRUGS FOR TREATING SPINAL MUSCLE ATROPHY
CN118308334B (zh) * 2024-06-06 2024-10-08 深圳市卫光生物制品股份有限公司 一种重组人纤溶酶原及其制备方法和应用

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WO2007047874A2 (en) * 2005-10-20 2007-04-26 Talecris Biotherapeutics, Inc. Recombinantly modified plasmin
WO2009073471A1 (en) 2007-11-29 2009-06-11 Talecris Biotherapeutics, Inc. Recombinantly modified plasmin

Also Published As

Publication number Publication date
BRPI0819780A2 (pt) 2015-08-11
US8101394B2 (en) 2012-01-24
AU2008331545B2 (en) 2014-01-16
CN101918548A (zh) 2010-12-15
BRPI0819780B1 (pt) 2023-01-24
CN101918548B (zh) 2013-10-16
KR101529743B1 (ko) 2015-06-17
US20120093799A1 (en) 2012-04-19
HK1146089A1 (en) 2011-05-13
EP2220221A1 (en) 2010-08-25
ZA201003730B (en) 2012-11-28
IL205936A0 (en) 2010-11-30
JP2011505140A (ja) 2011-02-24
US8182808B2 (en) 2012-05-22
EP2220221B1 (en) 2014-12-31
AU2008331545A1 (en) 2009-06-11
KR20100102135A (ko) 2010-09-20
JP5539896B2 (ja) 2014-07-02
CA2707266C (en) 2013-12-31
US20120276611A1 (en) 2012-11-01
HUE024916T2 (en) 2016-02-29
WO2009073471A1 (en) 2009-06-11
NZ593837A (en) 2013-01-25
MX2010005947A (es) 2010-09-10
ES2534040T3 (es) 2015-04-16
PT2220221E (pt) 2015-04-16
CA2707266A1 (en) 2009-06-11
NZ585715A (en) 2011-11-25
US8512980B2 (en) 2013-08-20
US20110003332A1 (en) 2011-01-06
PL2220221T3 (pl) 2015-07-31

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