BRPI0819780B1 - Polinucleotídeo e método para produzir um ou mais polipeptídeos de plasmina recombinante - Google Patents

Polinucleotídeo e método para produzir um ou mais polipeptídeos de plasmina recombinante Download PDF

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Publication number
BRPI0819780B1
BRPI0819780B1 BRPI0819780-6A BRPI0819780A BRPI0819780B1 BR PI0819780 B1 BRPI0819780 B1 BR PI0819780B1 BR PI0819780 A BRPI0819780 A BR PI0819780A BR PI0819780 B1 BRPI0819780 B1 BR PI0819780B1
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BR
Brazil
Prior art keywords
polypeptide
plasminogen
tal6003
amino acid
plasmin
Prior art date
Application number
BRPI0819780-6A
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English (en)
Portuguese (pt)
Inventor
Valery Novokhatny
Original Assignee
Grifols Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grifols Therapeutics Inc filed Critical Grifols Therapeutics Inc
Publication of BRPI0819780A2 publication Critical patent/BRPI0819780A2/pt
Publication of BRPI0819780B1 publication Critical patent/BRPI0819780B1/pt

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6435Plasmin (3.4.21.7), i.e. fibrinolysin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21007Plasmin (3.4.21.7), i.e. fibrinolysin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
BRPI0819780-6A 2007-11-29 2008-11-25 Polinucleotídeo e método para produzir um ou mais polipeptídeos de plasmina recombinante BRPI0819780B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99114807P 2007-11-29 2007-11-29
US60/991,148 2007-11-29
PCT/US2008/084645 WO2009073471A1 (en) 2007-11-29 2008-11-25 Recombinantly modified plasmin

Publications (2)

Publication Number Publication Date
BRPI0819780A2 BRPI0819780A2 (pt) 2015-08-11
BRPI0819780B1 true BRPI0819780B1 (pt) 2023-01-24

Family

ID=40379999

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0819780-6A BRPI0819780B1 (pt) 2007-11-29 2008-11-25 Polinucleotídeo e método para produzir um ou mais polipeptídeos de plasmina recombinante

Country Status (17)

Country Link
US (3) US8101394B2 (enExample)
EP (1) EP2220221B1 (enExample)
JP (1) JP5539896B2 (enExample)
KR (1) KR101529743B1 (enExample)
CN (1) CN101918548B (enExample)
AU (1) AU2008331545B2 (enExample)
BR (1) BRPI0819780B1 (enExample)
CA (1) CA2707266C (enExample)
ES (1) ES2534040T3 (enExample)
HU (1) HUE024916T2 (enExample)
IL (1) IL205936A (enExample)
MX (1) MX2010005947A (enExample)
NZ (2) NZ593837A (enExample)
PL (1) PL2220221T3 (enExample)
PT (1) PT2220221E (enExample)
WO (1) WO2009073471A1 (enExample)
ZA (1) ZA201003730B (enExample)

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WO2009073471A1 (en) 2007-11-29 2009-06-11 Talecris Biotherapeutics, Inc. Recombinantly modified plasmin
UA103771C2 (ru) 2008-06-04 2013-11-25 Грифолз Терапьютикс Инк. Стрептокиназа, активирующая плазмин, способ и набор для получения плазмина
HUE025670T2 (en) * 2009-03-03 2016-04-28 Grifols Therapeutics Inc A method for producing plasminogen
EP2451835A1 (en) 2009-07-10 2012-05-16 ThromboGenics N.V. Variants of plasminogen and plasmin
WO2011023805A1 (en) 2009-08-28 2011-03-03 Thrombogenics N.V. Use of plasmin for the treatment of filtration failure after trabeculectomy
CN102121023B (zh) * 2010-12-22 2012-07-04 中山大学 突变型人纤溶酶原kringle5及其制备方法及应用
ES2583082T3 (es) 2011-01-05 2016-09-19 Thrombogenics N.V. Variantes de plasminógeno y plasmina
WO2013024074A1 (en) 2011-08-12 2013-02-21 Thrombogenics N.V. Plasminogen and plasmin variants
CN103205410B (zh) * 2012-01-13 2018-03-06 蔺莹莹 重组微纤维蛋白溶酶及其制备方法和应用
JP2016519081A (ja) 2013-03-14 2016-06-30 バイエル・ヘルスケア・エルエルシーBayer HealthCare LLC ヘパリンと結合体化した抗トロンビンβに対するモノクローナル抗体
DE102014112212A1 (de) * 2014-08-26 2016-03-03 Akesion Gmbh Rekombinante Fusionsproteine zur Vorbeugung oder Behandlung von Adhäsionen bei Geweben oder Organen
FR3035120B1 (fr) * 2015-04-15 2020-02-07 Arcadophta Composition de plasminogenase immobilisee, procede de preparation, utilisation et dispositif comprenant une telle composition
US11400142B2 (en) 2015-12-18 2022-08-02 Talengen International Limited Treatment of diabetic nerve injury comprising administering plasminogen
DK3391902T5 (da) 2015-12-18 2024-09-23 Talengen Int Ltd Plasminogen til anvendelse i behandlingen af diabetisk angiokardiopati
JP2019500426A (ja) 2015-12-18 2019-01-10 タレンゲン インターナショナル リミティッドTalengen International Limited 糖尿病網膜症を予防または治療するための方法
CN108778307A (zh) 2015-12-18 2018-11-09 泰伦基国际有限公司 一种预防和治疗糖尿病肾病的方法
CN110114080A (zh) 2016-12-15 2019-08-09 泰伦基国际有限公司 一种预防和治疗皮肤纤维化的方法
WO2018108161A1 (zh) 2016-12-15 2018-06-21 深圳瑞健生命科学研究院有限公司 一种预防和治疗肥胖症的方法和药物
CN110366425A (zh) * 2016-12-15 2019-10-22 泰伦基国际有限公司 一种预防动脉粥样硬化及其并发症的方法
JP7171572B2 (ja) * 2016-12-15 2022-11-15 タレンゲン インターナショナル リミテッド 糖尿病を治療するための新しい方法
EP3556385A4 (en) 2016-12-15 2020-12-30 Talengen International Limited PROCESS FOR ALLEGING HEART DISEASE
CN108210910A (zh) * 2016-12-15 2018-06-29 深圳瑞健生命科学研究院有限公司 预防和治疗系统性硬化症的药物及其用途
TWI714862B (zh) 2017-06-19 2021-01-01 大陸商深圳瑞健生命科學硏究院有限公司 一種調控glp-1/glp-1r的方法和藥物
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EP4140498A4 (en) * 2020-05-11 2023-11-01 Talengen International Limited METHOD AND DRUGS FOR TREATING SPINAL MUSCLE ATROPHY
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WO2009073471A1 (en) 2007-11-29 2009-06-11 Talecris Biotherapeutics, Inc. Recombinantly modified plasmin

Also Published As

Publication number Publication date
BRPI0819780A2 (pt) 2015-08-11
US8101394B2 (en) 2012-01-24
AU2008331545B2 (en) 2014-01-16
CN101918548A (zh) 2010-12-15
CN101918548B (zh) 2013-10-16
KR101529743B1 (ko) 2015-06-17
US20120093799A1 (en) 2012-04-19
HK1146089A1 (en) 2011-05-13
EP2220221A1 (en) 2010-08-25
IL205936A (en) 2015-04-30
ZA201003730B (en) 2012-11-28
IL205936A0 (en) 2010-11-30
JP2011505140A (ja) 2011-02-24
US8182808B2 (en) 2012-05-22
EP2220221B1 (en) 2014-12-31
AU2008331545A1 (en) 2009-06-11
KR20100102135A (ko) 2010-09-20
JP5539896B2 (ja) 2014-07-02
CA2707266C (en) 2013-12-31
US20120276611A1 (en) 2012-11-01
HUE024916T2 (en) 2016-02-29
WO2009073471A1 (en) 2009-06-11
NZ593837A (en) 2013-01-25
MX2010005947A (es) 2010-09-10
ES2534040T3 (es) 2015-04-16
PT2220221E (pt) 2015-04-16
CA2707266A1 (en) 2009-06-11
NZ585715A (en) 2011-11-25
US8512980B2 (en) 2013-08-20
US20110003332A1 (en) 2011-01-06
PL2220221T3 (pl) 2015-07-31

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: GRIFOLS THERAPEUTICS INC. (US)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 25/11/2008, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 16A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2802 DE 17-09-2024 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.