IL189021A0 - Solid dosage forms of valsartan and amlodipine and method of making the same - Google Patents

Solid dosage forms of valsartan and amlodipine and method of making the same

Info

Publication number
IL189021A0
IL189021A0 IL189021A IL18902108A IL189021A0 IL 189021 A0 IL189021 A0 IL 189021A0 IL 189021 A IL189021 A IL 189021A IL 18902108 A IL18902108 A IL 18902108A IL 189021 A0 IL189021 A0 IL 189021A0
Authority
IL
Israel
Prior art keywords
valsartan
amlodipine
making
same
dosage forms
Prior art date
Application number
IL189021A
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37758280&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL189021(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IL189021A0 publication Critical patent/IL189021A0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
IL189021A 2005-08-17 2008-01-24 Solid dosage forms of valsartan and amlodipine and method of making the same IL189021A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70908305P 2005-08-17 2005-08-17
PCT/US2006/031699 WO2007022113A2 (en) 2005-08-17 2006-08-15 Solid dosage forms of valsartan and amlodipine and method of making the same

Publications (1)

Publication Number Publication Date
IL189021A0 true IL189021A0 (en) 2008-08-07

Family

ID=37758280

Family Applications (1)

Application Number Title Priority Date Filing Date
IL189021A IL189021A0 (en) 2005-08-17 2008-01-24 Solid dosage forms of valsartan and amlodipine and method of making the same

Country Status (22)

Country Link
US (3) US20080171086A1 (enExample)
EP (1) EP1917002A2 (enExample)
JP (2) JP2009504744A (enExample)
KR (3) KR20120135356A (enExample)
CN (1) CN101237859A (enExample)
AR (1) AR055120A1 (enExample)
AU (2) AU2006279670A1 (enExample)
BR (1) BRPI0614790A2 (enExample)
CA (1) CA2617367A1 (enExample)
EC (1) ECSP088188A (enExample)
GT (1) GT200600371A (enExample)
IL (1) IL189021A0 (enExample)
MA (1) MA29734B1 (enExample)
MX (1) MX2008002267A (enExample)
NO (1) NO20081310L (enExample)
NZ (1) NZ565020A (enExample)
PE (1) PE20070420A1 (enExample)
RU (2) RU2008109913A (enExample)
TN (1) TNSN08071A1 (enExample)
TW (1) TW200740432A (enExample)
WO (1) WO2007022113A2 (enExample)
ZA (1) ZA200800397B (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EG24716A (en) 2002-05-17 2010-06-07 Novartis Ag Combination of organic compounds
US8951562B2 (en) * 2006-11-10 2015-02-10 Atacama Labs Oy Method and apparatus or dry granulation
FI20070521A7 (fi) 2006-11-10 2008-05-11 Atacama Labs Oy Rakeita, tabletteja ja rakeistusmenetelmä
TR200703568A1 (tr) * 2007-05-24 2008-07-21 Sanovel �La� Sanay� Ve T�Caret Anon�M ��Rket� Valsartan formülasyonları
WO2009061713A1 (en) 2007-11-06 2009-05-14 Novartis Ag Dual-acting pharmaceutical compositions based on superstructures of angiotensin receptor antagonist/blocker (arb) and neutral endopeptidase (nep) inhibitor
MX2010007281A (es) * 2007-12-31 2010-10-05 Lupin Ltd Composiciones farmaceuticas de amlodipina y valsartan.
EP2291233B1 (en) 2008-05-09 2019-09-04 Atacama Labs Oy Method for dry granulation
JO3239B1 (ar) 2008-09-22 2018-03-08 Novartis Ag تركيبات جالينية من مركبات عضوية
DE102008051783A1 (de) * 2008-10-17 2010-04-22 Tiefenbacher Pharmachemikalien Alfred E. Tiefenbacher Gmbh & Co. Kg Valsartan enthaltende Tablette
WO2010104485A2 (en) * 2009-03-11 2010-09-16 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Valsartan formulations
CN101926798B (zh) * 2009-06-26 2013-09-18 北京德众万全药物技术开发有限公司 一种含有氨氯地平和缬沙坦的分散片
US20120107397A1 (en) * 2009-07-03 2012-05-03 Hetero Research Foundation Pharmaceutical compositions of valsartan
CN101647797B (zh) * 2009-09-18 2011-06-08 海南锦瑞制药股份有限公司 一种含有苯磺酸氨氯地平和缬沙坦的药物组合物及其制备方法
CN102091069A (zh) * 2009-12-11 2011-06-15 浙江华海药业股份有限公司 缬沙坦和氨氯地平的复方制剂及其制备方法
CN101897675B (zh) * 2010-02-10 2012-11-21 温士顿医药股份有限公司 含有凡尔沙坦或其药学上可接受的盐的固体剂型口服医药组成物
CN101843615A (zh) * 2010-06-25 2010-09-29 包丽昕 含有缬沙坦和苯磺酸氨氯地平的分散片及其制备方法
TR201102067A1 (tr) 2011-03-03 2012-09-21 Sanovel İlaç Sanayi̇ Ve Ti̇caret Anoni̇m Şi̇rketi̇ Valsartan ve amlodipin kombinasyonları.
CN102283837A (zh) * 2011-07-29 2011-12-21 江苏省药物研究所有限公司 缬沙坦和氨氯地平复方的固体制剂的制备方法
CN102697778B (zh) * 2012-06-21 2014-04-30 上海医药集团股份有限公司 缬沙坦氨氯地平复方固体制剂及其制备方法
WO2013191668A1 (en) 2012-06-22 2013-12-27 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Compositions preventing hypertension comprising soluplus
WO2014058047A1 (ja) * 2012-10-12 2014-04-17 味の素株式会社 カルシウム拮抗薬／アンジオテンシンｉｉ受容体拮抗薬含有医薬製剤の製造方法
CN103006649B (zh) * 2012-12-27 2014-06-25 石家庄市华新药业有限责任公司 一种复方制剂缬沙坦氨氯地平片（ⅰ）及其制备方法
CZ2013783A3 (cs) 2013-10-08 2015-04-15 Zentiva, K. S Stabilní farmaceutická kompozice obsahující amlodipin a valsartan
MX380070B (es) * 2015-07-08 2025-03-11 Cj Healthcare Corp Una composición farmacéutica que comprende amlodipino, valsartán y rosuvastatina.
CN105232551A (zh) * 2015-11-19 2016-01-13 哈尔滨圣吉药业股份有限公司 一种缬沙坦/苯磺酸氨氯地平复方制剂及其制备方法
CN106176744A (zh) * 2016-07-13 2016-12-07 精华制药集团股份有限公司 缬沙坦氨氯地平胶囊在制备治疗脑中风的药物中的应用
ES3035030T3 (en) 2016-10-07 2025-08-28 Silvergate Pharmaceuticals Inc Amlodipine formulations
EP3522888A4 (en) * 2016-10-10 2020-06-10 Alembic Pharmaceuticals Limited STABLE PHARMACEUTICAL COMPOSITION WITH TELMISARTAN AND AMLODIPINE BESYLATE
CN109498626A (zh) * 2017-09-14 2019-03-22 北京万全德众医药生物技术有限公司 一种稳定的复方制剂缬沙坦氨氯地平处方及其制备方法
US10799453B2 (en) 2018-04-11 2020-10-13 Silvergate Pharmaceuticals, Inc. Amlodipine formulations
CN109260160A (zh) * 2018-08-30 2019-01-25 天津仁生医药科技有限公司 一种缬沙坦氨氯地平片剂及其制备方法
CN109010338B (zh) * 2018-09-13 2021-09-21 合肥合源药业有限公司 一种缬沙坦氨氯地平片的制备方法及缬沙坦氨氯地平片
CN109157526A (zh) * 2018-09-13 2019-01-08 合肥合源药业有限公司 一种缬沙坦氨氯地平复方制剂及其制备工艺
CN109394712B (zh) * 2018-11-23 2019-11-12 海南妙音春制药有限公司 一种缬沙坦氨氯地平复方片剂及其制备方法
WO2025162195A1 (zh) * 2024-01-30 2025-08-07 上海汇伦医药股份有限公司 包衣复方片剂
CN120392682A (zh) * 2024-01-30 2025-08-01 上海汇伦医药股份有限公司 速释组合物
CN119925284B (zh) * 2025-04-09 2025-07-11 杭州沐源生物医药科技有限公司 一种含有厄贝沙坦和氨氯地平的药物组合物及制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3152978B2 (ja) * 1991-12-17 2001-04-03 塩野義製薬株式会社 二層錠およびその製造方法
DE19539361A1 (de) * 1995-10-23 1997-04-24 Basf Ag Verfahren zur Herstellung von mehrschichtigen, festen Arzneiformen zur oralen oder rektalen Verabreichung
DK1096932T3 (da) 1998-07-10 2007-10-15 Novartis Pharma Ag Antihypertensiv kombination af valsartan og calciumkanalblokker
US6204281B1 (en) * 1998-07-10 2001-03-20 Novartis Ag Method of treatment and pharmaceutical composition
DK1588706T3 (da) 1998-12-23 2012-01-16 Novartis Ag Valsartantablet
JP3796562B2 (ja) * 1999-05-26 2006-07-12 ライオン株式会社 多層錠、多層錠の製造方法及び多層錠の剥離抑制方法
US6395728B2 (en) * 1999-07-08 2002-05-28 Novartis Ag Method of treatment and pharmaceutical composition
AU2002226365A1 (en) * 2000-12-01 2002-06-11 Novartis Ag Combinations of an angiotensin receptor antagonist and an anti-hypertensive drug or a statin, for the treatment of sexual dysfunction
AR037565A1 (es) * 2001-11-21 2004-11-17 Synthon Bv Formas de sales de amlodipina y procedimientos para prepararlas.
ES2445041T3 (es) * 2002-01-16 2014-02-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Método para la preparación de telmisartán amorfo
EG24716A (en) * 2002-05-17 2010-06-07 Novartis Ag Combination of organic compounds
WO2005070463A2 (en) * 2004-01-12 2005-08-04 Sepracor, Inc. Compositions comprising (s)-amlodipine malate and an angiotensin receptor blocker and methods of their use
EP1559419A1 (en) * 2004-01-23 2005-08-03 Fournier Laboratories Ireland Limited Pharmaceutical formulations comprising metformin and a fibrate, and processes for their obtention
AU2006206738A1 (en) * 2005-01-19 2006-07-27 Merck Sharp & Dohme Corp. Mitotic kinesin inhibitors
WO2007001067A2 (en) * 2005-06-27 2007-01-04 Daiichi Sankyo Company, Limited Solid dosage form comprising an angiotensin ii receptor antagonist and a calcium channel blocker

Also Published As

Publication number Publication date
CN101237859A (zh) 2008-08-06
GT200600371A (es) 2007-03-21
US20080171086A1 (en) 2008-07-17
KR20120078751A (ko) 2012-07-10
AR055120A1 (es) 2007-08-08
TNSN08071A1 (en) 2009-07-14
PE20070420A1 (es) 2007-05-21
AU2006279670A1 (en) 2007-02-22
EP1917002A2 (en) 2008-05-07
ECSP088188A (es) 2008-03-26
KR20120135356A (ko) 2012-12-12
JP2009504744A (ja) 2009-02-05
RU2008109913A (ru) 2009-09-27
NO20081310L (no) 2008-05-16
ZA200800397B (en) 2009-03-25
KR20080034159A (ko) 2008-04-18
WO2007022113A2 (en) 2007-02-22
MX2008002267A (es) 2008-03-27
JP2013091660A (ja) 2013-05-16
US20120177733A1 (en) 2012-07-12
CA2617367A1 (en) 2007-02-22
US20100303906A1 (en) 2010-12-02
WO2007022113A3 (en) 2007-05-10
TW200740432A (en) 2007-11-01
MA29734B1 (fr) 2008-09-01
NZ565020A (en) 2011-07-29
AU2010227062A1 (en) 2010-11-04
BRPI0614790A2 (pt) 2011-04-12
RU2012131668A (ru) 2014-01-27

Similar Documents

Publication Publication Date Title
IL189021A0 (en) Solid dosage forms of valsartan and amlodipine and method of making the same
IL195797A0 (en) Solid dosage forms of valsartan, amlodipine and hydrochlorothiazide and method of making the same
TWI320360B (en) Composite materials and methods of making the same
GB0718972D0 (en) Compounds and methods of making the compounds
IL191554A0 (en) Lactam compounds and methods of using the same
IL186915A0 (en) Rapid deployment barrier and method of using the same
IL181303A (en) METHOD FOR CREATING DIHYDROPROTRIDINONS AND NUMBER OF THESE COMPOUNDS
EP2008628A4 (en) PACKING WITH AN ARTICLE AND METHOD OF MANUFACTURING THEREOF
IL184297A0 (en) Indexable insert and method of manufacturing the same
TWI367969B (en) Corner fitting and method of forming the same
ZA200806922B (en) Delay elements, detonators containing the same and methods of making
ZA200705131B (en) Solid pharmaceutical composition comprising valsartan
PT2033629E (pt) Composição farmacêutica sólida que compreende valsartan
EP1603800A4 (en) MULTILAYER STRUCTURES, PACKAGING AND METHODS OF MANUFACTURING MULTILAYER STRUCTURES
EP1900970A4 (en) SCREW DEVICE AND METHOD FOR MANUFACTURING SAME
GB0505568D0 (en) Method of manufacture and associated component
ZA200708259B (en) Extremely insensitive detonating substance and method for is manufacture
ZA200707731B (en) End mills and method of making the same
ZA200804872B (en) Lactam compounds and methods of using the same
GB0515702D0 (en) Building material and method
EP1872169A4 (en) LENTICULAR CONTAINER AND METHOD OF MANUFACTURE
IL186277A0 (en) Dnt-maleate and methods of preparation thereof
HK1117393A (en) Solid dosage forms of valsartan and amlodipine and method of making the same
HK1128001A (en) Solid dosage forms of valsartan, amlodipine and hydrochlorothiazide and method of making the same
GB0408156D0 (en) Process and compounds