IL179162A0 - Cxcr1 and cxcr2 chemokine antagonists - Google Patents
Cxcr1 and cxcr2 chemokine antagonistsInfo
- Publication number
- IL179162A0 IL179162A0 IL179162A IL17916206A IL179162A0 IL 179162 A0 IL179162 A0 IL 179162A0 IL 179162 A IL179162 A IL 179162A IL 17916206 A IL17916206 A IL 17916206A IL 179162 A0 IL179162 A0 IL 179162A0
- Authority
- IL
- Israel
- Prior art keywords
- cxcr1
- chemokine antagonists
- cxcr2 chemokine
- cxcr2
- antagonists
- Prior art date
Links
- 101150013700 CXCR1 gene Proteins 0.000 title 1
- 102000019034 Chemokines Human genes 0.000 title 1
- 108010012236 Chemokines Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
Classifications
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- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
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- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57032604P | 2004-05-12 | 2004-05-12 | |
| PCT/US2005/016507 WO2005113534A2 (en) | 2004-05-12 | 2005-05-11 | Cxcr1 and cxcr2 chemokine antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL179162A0 true IL179162A0 (en) | 2007-03-08 |
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| IL179162A IL179162A0 (en) | 2004-05-12 | 2006-11-09 | Cxcr1 and cxcr2 chemokine antagonists |
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| EP (1) | EP1745032B1 (enExample) |
| JP (2) | JP2007537272A (enExample) |
| KR (1) | KR20070011475A (enExample) |
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| AU (1) | AU2005245399A1 (enExample) |
| CA (1) | CA2565519A1 (enExample) |
| IL (1) | IL179162A0 (enExample) |
| MX (1) | MXPA06013118A (enExample) |
| WO (1) | WO2005113534A2 (enExample) |
| ZA (1) | ZA200609237B (enExample) |
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| DE102005008183A1 (de) * | 2005-02-23 | 2006-08-31 | Bayer Healthcare Ag | Heterocyclylamid-substituierte Imidazole |
| EP2009992B1 (en) * | 2006-04-21 | 2012-06-27 | GlaxoSmithKline LLC | Il-8 receptor antagonists |
| UA95480C2 (uk) * | 2006-06-08 | 2011-08-10 | Елі Ліллі Енд Компані | Заміщені карбоксаміди |
| JP2010504996A (ja) * | 2006-09-26 | 2010-02-18 | ケース ウエスタン リザーブ ユニバーシティ | サイトカインシグナリング |
| ATE484505T1 (de) * | 2006-11-23 | 2010-10-15 | Novartis Ag | 5-sulfanylmethylä1,2,4ütriazolä1,5-aüpyrimidin- - olderivate als cxcr2-antagonisten |
| EP2094697A1 (en) * | 2006-11-23 | 2009-09-02 | Novartis AG | 5-sulfanylmethyl-pyrazolo [1,5-a]pyrimidin-7-ol derivatives as cxcr2 antagonists |
| PL2116530T3 (pl) | 2007-02-26 | 2013-03-29 | Santen Pharmaceutical Co Ltd | Nowa pochodna pirolu zawierająca jako podstawniki grupę ureidową i grupę aminokarbonylową |
| WO2009026248A2 (en) * | 2007-08-17 | 2009-02-26 | The Government Of The United States, As Represented By The Secretary Of Health And Human Services, National Institutes Of Health, Office Of Technology Transfer | Hydrazide, amide, phthalimide and phthalhydrazide analogs as inhibitors of retroviral integrase |
| KR101039235B1 (ko) * | 2007-08-29 | 2011-06-07 | 메디포스트(주) | 제대혈 유래 간엽줄기세포를 포함하는 인터루킨-8 또는지알오-알파 발현 세포가 관련된 질병의 진단, 예방 또는치료용 조성물 |
| GB2455539B (en) * | 2007-12-12 | 2012-01-18 | Cambridge Entpr Ltd | Anti-inflammatory compositions and combinations |
| SG176464A1 (en) | 2008-05-09 | 2011-12-29 | Agency Science Tech & Res | Diagnosis and treatment of kawasaki disease |
| JP5716180B2 (ja) | 2008-11-11 | 2015-05-13 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 抗cxcr1組成物および方法 |
| JP5881705B2 (ja) * | 2010-09-03 | 2016-03-09 | フォーマ ティーエム, エルエルシー. | Namptの阻害のための新規化合物及び組成物 |
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| US8865723B2 (en) | 2012-10-25 | 2014-10-21 | Tetra Discovery Partners Llc | Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury |
| WO2014205127A2 (en) | 2013-06-18 | 2014-12-24 | New York University | Cellular factors involved in the cytotoxicity of staphylococcus aureus leukocidins: novel therapeutic targets |
| WO2015054117A1 (en) * | 2013-10-08 | 2015-04-16 | Temple University-Of The Commonwealth System Of Higher Education | Functionalized furan-2-sulfonamides exhibiting endothelial lipase inhibition |
| US9763992B2 (en) | 2014-02-13 | 2017-09-19 | Father Flanagan's Boys' Home | Treatment of noise induced hearing loss |
| CA2961021C (en) | 2014-09-26 | 2022-08-02 | Shifa Biomedical Corporation | Anti-endothelial lipase compounds and methods of using the same in the treatment and/or prevention of cardiovascular diseases |
| WO2017040742A1 (en) * | 2015-09-04 | 2017-03-09 | Dow Agrosciences Llc | Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto |
| JP7092356B2 (ja) * | 2016-06-22 | 2022-06-28 | フーダン ユニヴァーシティ | ビアリール尿素誘導体またはそれらの塩、およびそれらの調製方法および使用 |
| US20190216790A1 (en) * | 2016-10-13 | 2019-07-18 | The Regents Of The University Of California | Methods for Treating Pruritis |
| EP3551034A1 (en) | 2016-12-07 | 2019-10-16 | Progenity, Inc. | Gastrointestinal tract detection methods, devices and systems |
| CA3045310A1 (en) | 2016-12-14 | 2018-06-21 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor |
| WO2020106704A2 (en) | 2018-11-19 | 2020-05-28 | Progenity, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
| CN121197633A (zh) | 2019-12-13 | 2025-12-26 | 比特比德科有限责任公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
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| DE3529247A1 (de) * | 1985-05-17 | 1986-11-20 | Bayer Ag, 5090 Leverkusen | Verwendung von thienylharnstoffen und -isoharnstoffen als leistungsfoerdernde mittel bei tieren, neue thienylharnstoffe und -isoharnstoffe und ihre herstellung |
| DE3785507T2 (de) * | 1986-07-31 | 1993-07-29 | Beecham Group Plc | Azabicyclische verbindungen, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung. |
| DE4412334A1 (de) * | 1994-04-11 | 1995-10-19 | Hoechst Ag | Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
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| WO1998006398A1 (en) | 1996-08-15 | 1998-02-19 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| JP2001527519A (ja) | 1996-08-15 | 2001-12-25 | スミスクライン・ビーチャム・コーポレイション | Il―8レセプターアンタゴニスト |
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| JP2001501918A (ja) | 1996-08-21 | 2001-02-13 | スミスクライン・ビーチャム・コーポレイション | Il―8レセプターアンタゴニスト |
| KR20000070368A (ko) | 1997-01-23 | 2000-11-25 | 스튜어트 알. 수터, 스티븐 베네티아너, 피터 존 기딩스 | 인터루킨-8 수용체 길항제 |
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| AR015426A1 (es) | 1997-09-05 | 2001-05-02 | Smithkline Beecham Corp | Compuestos de benzotiazol antagonistas del receptor de il-8, composicion farmaceutica que los contiene, su uso para la manufactura de un medicamento,procedimiento para su preparacion, compuestos intermediarios y procedimiento para su preparacion |
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| EP1274413A4 (en) | 2000-03-01 | 2005-08-10 | Smithkline Beecham Corp | IL-8 RECEPTOR ANTAGONISTS |
| AU2001243351A1 (en) | 2000-03-01 | 2001-09-12 | Smith Kline Beecham Corporation | Il-8 receptor antagonists |
| AR031098A1 (es) | 2000-03-16 | 2003-09-10 | Smithkline Beecham Corp | Compuestos de hidroxifenil urea sustituidos con sulfonamidas, composiciones farmaceuticas que los comprenden, y uso de los mismos en la fabricacion de medicamentos para tratar una enfermedad mediada por una quimioquina |
| UY26627A1 (es) | 2000-03-24 | 2001-09-28 | Smithkline Beecham Corp | Antagonistas de receptores de il-8 |
| CA2413421A1 (en) * | 2000-06-21 | 2001-12-27 | Bristol-Myers Squibb Pharma Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
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| US6878709B2 (en) * | 2002-01-04 | 2005-04-12 | Schering Corporation | 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists |
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| JP4939229B2 (ja) * | 2003-12-19 | 2012-05-23 | シェーリング コーポレイション | Cxc−ケモカインレセプターリガンドおよびcc−ケモカインレセプターリガンドとしてのチアジアゾール |
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| JP2009500328A (ja) * | 2005-06-29 | 2009-01-08 | シェーリング コーポレイション | Cxc−ケモカインレセプターリガンドとしての5,6−ジ−置換オキサジアゾロピラジンおよびチアジアゾロピラジン |
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-
2005
- 2005-05-11 CN CN2005800232328A patent/CN1984899B/zh not_active Expired - Fee Related
- 2005-05-11 JP JP2007513317A patent/JP2007537272A/ja not_active Ceased
- 2005-05-11 EP EP05779979.3A patent/EP1745032B1/en not_active Expired - Lifetime
- 2005-05-11 US US11/126,977 patent/US7326729B2/en not_active Expired - Fee Related
- 2005-05-11 WO PCT/US2005/016507 patent/WO2005113534A2/en not_active Ceased
- 2005-05-11 CA CA002565519A patent/CA2565519A1/en not_active Abandoned
- 2005-05-11 AU AU2005245399A patent/AU2005245399A1/en not_active Abandoned
- 2005-05-11 MX MXPA06013118A patent/MXPA06013118A/es active IP Right Grant
- 2005-05-11 KR KR1020067023571A patent/KR20070011475A/ko not_active Withdrawn
-
2006
- 2006-11-06 ZA ZA200609237A patent/ZA200609237B/xx unknown
- 2006-11-09 IL IL179162A patent/IL179162A0/en unknown
-
2007
- 2007-07-10 US US11/775,567 patent/US20070248594A1/en not_active Abandoned
-
2011
- 2011-10-11 JP JP2011224353A patent/JP2012006982A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CA2565519A1 (en) | 2005-12-01 |
| CN1984899B (zh) | 2011-07-27 |
| ZA200609237B (en) | 2008-08-27 |
| EP1745032B1 (en) | 2013-07-31 |
| US20070248594A1 (en) | 2007-10-25 |
| JP2012006982A (ja) | 2012-01-12 |
| WO2005113534A3 (en) | 2006-10-26 |
| WO2005113534A2 (en) | 2005-12-01 |
| MXPA06013118A (es) | 2007-02-28 |
| US20060014794A1 (en) | 2006-01-19 |
| CN1984899A (zh) | 2007-06-20 |
| US7326729B2 (en) | 2008-02-05 |
| EP1745032A2 (en) | 2007-01-24 |
| KR20070011475A (ko) | 2007-01-24 |
| JP2007537272A (ja) | 2007-12-20 |
| AU2005245399A1 (en) | 2005-12-01 |
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