IL162884A0 - Deazapurines and uses thereof - Google Patents

Deazapurines and uses thereof

Info

Publication number
IL162884A0
IL162884A0 IL16288403A IL16288403A IL162884A0 IL 162884 A0 IL162884 A0 IL 162884A0 IL 16288403 A IL16288403 A IL 16288403A IL 16288403 A IL16288403 A IL 16288403A IL 162884 A0 IL162884 A0 IL 162884A0
Authority
IL
Israel
Prior art keywords
inflammatory
generally
deazapurines
subclasses
autoimmune
Prior art date
Application number
IL16288403A
Other languages
English (en)
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of IL162884A0 publication Critical patent/IL162884A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL16288403A 2002-01-07 2003-01-07 Deazapurines and uses thereof IL162884A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34659802P 2002-01-07 2002-01-07
PCT/US2003/000366 WO2003057696A1 (fr) 2002-01-07 2003-01-07 Deazapurines et leurs utilisations

Publications (1)

Publication Number Publication Date
IL162884A0 true IL162884A0 (en) 2005-11-20

Family

ID=23360154

Family Applications (3)

Application Number Title Priority Date Filing Date
IL16288403A IL162884A0 (en) 2002-01-07 2003-01-07 Deazapurines and uses thereof
IL191543A IL191543A0 (en) 2002-01-07 2008-05-19 Deazapurines derivatives
IL197484A IL197484A0 (en) 2002-01-07 2009-03-09 5-AMINO-7-(1H-INDOL-2-YL)-1,3-DIHYDRO-IMIDAZOL[4,5-b]PYRIDIN-2-ONE AND ITS N- BOC PROTECTED-7-(1H-INDOL-2-YL)-2-METHYL-3H-IMIDAZO[4,5-b]PYRIDIN-5-YLAMINE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL191543A IL191543A0 (en) 2002-01-07 2008-05-19 Deazapurines derivatives
IL197484A IL197484A0 (en) 2002-01-07 2009-03-09 5-AMINO-7-(1H-INDOL-2-YL)-1,3-DIHYDRO-IMIDAZOL[4,5-b]PYRIDIN-2-ONE AND ITS N- BOC PROTECTED-7-(1H-INDOL-2-YL)-2-METHYL-3H-IMIDAZO[4,5-b]PYRIDIN-5-YLAMINE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM

Country Status (22)

Country Link
US (4) US7314936B2 (fr)
EP (2) EP1707566A1 (fr)
JP (1) JP4411455B2 (fr)
KR (2) KR101108722B1 (fr)
CN (1) CN100503608C (fr)
AT (1) ATE327236T1 (fr)
AU (2) AU2003235741B8 (fr)
BR (1) BR0306785A (fr)
CA (1) CA2472479C (fr)
CY (1) CY1106138T1 (fr)
DE (2) DE60305446D1 (fr)
DK (1) DK1474425T3 (fr)
ES (1) ES2262996T3 (fr)
IL (3) IL162884A0 (fr)
MX (1) MXPA04006614A (fr)
NO (1) NO329994B1 (fr)
NZ (2) NZ555911A (fr)
PT (1) PT1474425E (fr)
RU (1) RU2380368C2 (fr)
SI (1) SI1474425T1 (fr)
WO (1) WO2003057696A1 (fr)
ZA (1) ZA200406272B (fr)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6589954B1 (en) * 1998-05-22 2003-07-08 Scios, Inc. Compounds and methods to treat cardiac failure and other disorders
DK1474425T3 (da) * 2002-01-07 2006-09-25 Eisai Co Ltd Deazapuriner og anvendelser deraf
MY179032A (en) 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
UY29177A1 (es) 2004-10-25 2006-05-31 Astex Therapeutics Ltd Derivados sustituidos de purina, purinona y deazapurina, composiciones que los contienen métodos para su preparación y sus usos
KR20060087386A (ko) 2005-01-28 2006-08-02 주식회사 대웅제약 신규 벤조이미다졸 유도체 및 이를 함유하는 약제학적조성물
KR101285050B1 (ko) 2005-02-02 2013-07-15 에자이 알앤드디 매니지먼트 가부시키가이샤 결정형 1Ｈ-이미다조[4,5-ｂ]피리딘-5-아민,7-[5-[(시클로헥실메틸아미노)-메틸]-1Ｈ-인돌-2-일]-2-메틸, 설페이트 (1:1), 삼수화물 및 이의 약학적 용도
AR055669A1 (es) * 2005-10-03 2007-08-29 Astrazeneca Ab Derivados de 3h - imidazo[4, 5 -b]piridina como inhibidores selectivos de gsk3, metodos e internediarios para su preparacion, composiciones farmaceuticas que los contienen y su uso para la elaboracion de un medicamento para el tratamiento de enfermedades neurodegenerativas y mentales.
WO2007125321A2 (fr) 2006-04-25 2007-11-08 Astex Therapeutics Limited Composés pharmaceutiques
WO2007125315A2 (fr) * 2006-04-25 2007-11-08 Astex Therapeutics Limited Composés pharmaceutiques
RS53552B1 (en) 2007-10-11 2015-02-27 Astrazeneca Ab DERIVATI PIROLO [2,3-D] PIRIMIDINA KAO INHIBITORI PROTEIN KINAZE B
US8507473B2 (en) * 2008-09-11 2013-08-13 Arena Pharmaceuticals, Inc. 3H-imidazo[4,5-b]pyridin-5-ol derivatives useful in the treatment of GPR81 receptor disorders
WO2011021678A1 (fr) * 2009-08-21 2011-02-24 武田薬品工業株式会社 Composé à hétérocycles fusionnés
US8299070B2 (en) * 2009-11-25 2012-10-30 Japan Tobacco Inc. Indole compounds and pharmaceutical use thereof
WO2012033149A1 (fr) * 2010-09-10 2012-03-15 塩野義製薬株式会社 Dérivé d'imidazole à hétérocycle fusionné ayant un effet d'activation de l'ampk
EP2677869B1 (fr) * 2011-02-25 2017-11-08 Merck Sharp & Dohme Corp. Nouveaux dérivés d'azabenzimidazole cyclique utiles en tant qu'agents antidiabétiques
AU2012235902B2 (en) 2011-04-01 2015-08-27 Astrazeneca Ab Therapeutic treatment
GB201106814D0 (en) * 2011-04-21 2011-06-01 Astex Therapeutics Ltd New compounds
MX2014000452A (es) * 2011-07-15 2014-03-21 Shionogi & Co Derivados de azabencimiazol que tiene actividad activadora de la proteina cinasa activada monofosfato de denosina (ampk).
JP6309454B2 (ja) 2011-11-30 2018-04-11 アストラゼネカ アクチボラグ 癌の併用処置
AU2013204533B2 (en) 2012-04-17 2017-02-02 Astrazeneca Ab Crystalline forms
GB201401198D0 (en) * 2014-01-24 2014-03-12 Bial Portela & Ca Sa Process for the syntheis of substituted urea compounds
EP2913330A1 (fr) 2014-02-27 2015-09-02 Laboratoire Biodim Dérivés condensés d'imidazole utiles comme produits pharmaceutiques
CN104974187A (zh) * 2014-04-10 2015-10-14 吉林省博创药业有限公司 菲罗啉类衍生物及其制备方法和应用
AU2015328285B2 (en) * 2014-10-06 2019-07-18 Merck Patent Gmbh Heteroaryl compounds as BTK inhibitors and uses thereof
WO2018125799A2 (fr) 2016-12-29 2018-07-05 Viamet Pharmaceuticals (Bermuda), Ltd. Composés inhibiteurs des métalloenzymes
WO2018125800A2 (fr) * 2016-12-29 2018-07-05 Viamet Pharmaceuticals (Bermuda), Ltd. Composés inhibiteurs des métalloenzymes
JOP20180094A1 (ar) * 2017-10-18 2019-04-18 Hk Inno N Corp مركب حلقي غير متجانس كمثبط بروتين كيناز
JP7265554B2 (ja) 2017-11-14 2023-04-26 ブリストル－マイヤーズ スクイブ カンパニー 置換インドール化合物
ES2927960T3 (es) 2017-12-15 2022-11-14 Bristol Myers Squibb Co Compuestos de indol éter sustituidos
EP3728253B1 (fr) 2017-12-19 2024-03-27 Bristol-Myers Squibb Company Composés de 6-azaindole
KR20200101398A (ko) 2017-12-19 2020-08-27 브리스톨-마이어스 스큅 컴퍼니 Tlr 억제제로서 유용한 아미드 치환된 인돌 화합물
US11878975B2 (en) * 2017-12-19 2024-01-23 Bristol-Myers Squibb Company Substituted indole compounds useful as TLR inhibitors
ES2904676T3 (es) * 2017-12-20 2022-04-05 Bristol Myers Squibb Co Compuestos de amino indol útiles como inhibidores de TLR
EP3728264B1 (fr) 2017-12-20 2021-12-01 Bristol-Myers Squibb Company Composés de diazaindole
KR20200101400A (ko) 2017-12-20 2020-08-27 브리스톨-마이어스 스큅 컴퍼니 아릴 및 헤테로아릴 치환된 인돌 화합물
WO2020086505A1 (fr) 2018-10-24 2020-04-30 Bristol-Myers Squibb Company Composés dimères d'indole substitués

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3891660A (en) * 1974-02-07 1975-06-24 Squibb & Sons Inc Derivatives of 1H-imidazo{8 4,5-c{9 pyridine-7-carboxylic acids and esters
US6410516B1 (en) * 1986-01-09 2002-06-25 President & Fellows Of Harvard College Nuclear factors associated with transcriptional regulation
US4939146A (en) * 1987-01-29 1990-07-03 Kramer Richard S Method for alleviating ischemic-reperfusion injury
DE3702757A1 (de) 1987-01-30 1988-08-11 Hoechst Ag Neue imidazo- und triazolo-thiadiazine, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung, sowie einige bei der herstellung der genannten verbindungen gebildete zwischenprodukte
US4999365A (en) * 1987-03-20 1991-03-12 Merrell Dow Pharmaceuticals Inc. Method of reducing reperfusion injury with imidazol-2-thiones
US4877810A (en) * 1988-02-05 1989-10-31 Eastman Kodak Company Protection of heart tissue from reperfusion injury
US5632991A (en) 1988-11-14 1997-05-27 Brigham & Women's Hospital Antibodies specific for E-selectin and the uses thereof
US5002965A (en) * 1989-05-09 1991-03-26 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Use of ginkgolides to prevent reperfusion injury in organ transplantation
IE64514B1 (en) 1989-05-23 1995-08-09 Zeneca Ltd Azaindenes
US5298518A (en) * 1989-09-29 1994-03-29 Eisai Co., Ltd. Biphenylmethane derivative and pharmacological use
US5081253A (en) 1989-12-21 1992-01-14 American Home Products Corporation Imidazo(4,5-c)pyridines as antiosteoporotic agents
SE8904355D0 (sv) 1989-12-21 1989-12-21 Perstorp Ab Medicament
FR2665159B1 (fr) 1990-07-24 1992-11-13 Rhone Poulenc Sante Nouveaux derives de la pyridine et de la quinoleine, leur preparation et les compositions pharmaceutiques qui les contiennent.
JP3468520B2 (ja) 1992-06-22 2003-11-17 ベーリンガー インゲルハイム コマンディトゲゼルシャフト ９−アミノ−ピリダジノ〔４′，５′：３，４〕ピローロ〔２，１−ａ〕イソキノリンと該化合物の医薬製剤製造への使用
US5591835A (en) * 1992-06-29 1997-01-07 Glycomed Incorporated Substituted lactose derivatives
US5360794A (en) 1992-08-03 1994-11-01 Medicarb Inc. Disubstituted and deoxy disubstituted derivatives of α-D-mannofuranosides and β-L-gulofuranosides having anti-inflammatory and anti-proliferative activity
GB9313638D0 (en) 1993-07-01 1993-08-18 Erba Carlo Spa Arylidene and heteroarylidene oxindole derivatives and process for their preparation
WO1995014787A1 (fr) * 1993-11-22 1995-06-01 Centocor, Inc. Peptides inhibiteurs de liaison a la selectine
US5486525A (en) * 1993-12-16 1996-01-23 Abbott Laboratories Platelet activating factor antagonists: imidazopyridine indoles
US5567711A (en) * 1995-04-19 1996-10-22 Abbott Laboratories Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists
US5880141A (en) 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
ES2172690T3 (es) * 1995-11-22 2002-10-01 Darwin Discovery Ltd Compuestos de mercaptoalquilpeptidil con un sustituyente de imidazol y su utilizacion como inhibidores de metaloproteinasas de matriz (mmp) y/o del factor de necrosis tumoral (tnf).
US5981536A (en) 1996-07-31 1999-11-09 Hoechst Aktiengesellschaft Use of xanthine derivatives for the modulation of apoptosis
JPH10139709A (ja) 1996-11-13 1998-05-26 Chisso Corp フェニルポリハロアルキルエーテル誘導体、これを含む液晶組成物および液晶表示素子
DE69814800T2 (de) * 1997-04-18 2003-12-18 Taiho Pharmaceutical Co. Ltd., Tokio/Tokyo Epoxysuccinamid-derivate oder ihre salze
BR9810508A (pt) 1997-07-03 2000-09-05 Du Pont Pharm Co Composto, composição farmacêutica e método de tratamento de uma desordem
DE19751251A1 (de) 1997-11-19 1999-05-20 Hoechst Marion Roussel De Gmbh Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
KR100699514B1 (ko) 1998-03-27 2007-03-26 얀센 파마슈티카 엔.브이. Ｈｉｖ를 억제하는 피리미딘 유도체
PA8474101A1 (es) 1998-06-19 2000-09-29 Pfizer Prod Inc Compuestos de pirrolo [2,3-d] pirimidina
US6867294B1 (en) 1998-07-14 2005-03-15 Isis Pharmaceuticals, Inc. Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
US6451810B1 (en) * 1999-06-10 2002-09-17 3M Innovative Properties Company Amide substituted imidazoquinolines
EP1194425B1 (fr) * 1999-06-23 2005-08-10 Aventis Pharma Deutschland GmbH Benzimidazoles substitues
CN1222520C (zh) * 1999-08-12 2005-10-12 沃泰克斯药物股份有限公司 c－JUN N－末端激酶(JNK)和其它蛋白激酶的抑制剂
US6599741B1 (en) 1999-09-14 2003-07-29 Avontec Gmbh Modulating transcription of genes in vascular cells
US6864355B1 (en) 2000-05-02 2005-03-08 Yale University Inhibition of NF-κB activation by blockade of IKKβ-NEMO interactions at the NEMO binding domain
DE19951360A1 (de) 1999-10-26 2001-05-03 Aventis Pharma Gmbh Substituierte Indole
ES2254238T3 (es) * 1999-10-27 2006-06-16 Novartis Ag Compuestos de tiazol e imidazo(4,5-b)piridina y su uso farmaceutico.
AU2001230584A1 (en) * 2000-02-09 2001-08-20 Hokuriku Seiyaku Co., Ltd. 1h-imidazopyridine derivatives
US7186683B2 (en) * 2000-09-18 2007-03-06 Sanos Bioscience A/S Use of GLP for the treatment, prevention, diagnosis, and prognosis of bone-related and nutrition-related disorders
CA2446864C (fr) * 2001-05-16 2011-02-15 Vertex Pharmaceuticals Incorporated Inhibiteurs de src et autres proteine kinases
JP2005517640A (ja) * 2001-12-04 2005-06-16 エフ．ホフマン−ラ　ロシュ　アーゲー 置換２−アミノ−シクロアルカンカルボキサアミドならびにシステインプロテアーゼインヒビターとしてのその使用
DK1474425T3 (da) * 2002-01-07 2006-09-25 Eisai Co Ltd Deazapuriner og anvendelser deraf
US6861278B2 (en) * 2002-04-11 2005-03-01 Nordson Corporation Method and apparatus for underfilling semiconductor devices
KR101285050B1 (ko) * 2005-02-02 2013-07-15 에자이 알앤드디 매니지먼트 가부시키가이샤 결정형 1Ｈ-이미다조[4,5-ｂ]피리딘-5-아민,7-[5-[(시클로헥실메틸아미노)-메틸]-1Ｈ-인돌-2-일]-2-메틸, 설페이트 (1:1), 삼수화물 및 이의 약학적 용도

Also Published As

Publication number Publication date
KR100980163B1 (ko) 2010-09-03
KR20040077707A (ko) 2004-09-06
US20040186127A1 (en) 2004-09-23
SI1474425T1 (sl) 2006-10-31
DE60305446T4 (de) 2009-07-09
BR0306785A (pt) 2004-11-09
RU2004124054A (ru) 2005-04-10
EP1474425B9 (fr) 2008-07-02
RU2380368C2 (ru) 2010-01-27
DK1474425T3 (da) 2006-09-25
ATE327236T1 (de) 2006-06-15
EP1707566A1 (fr) 2006-10-04
JP4411455B2 (ja) 2010-02-10
WO2003057696A1 (fr) 2003-07-17
MXPA04006614A (es) 2004-10-04
EP1474425A1 (fr) 2004-11-10
US8691814B2 (en) 2014-04-08
CN1630657A (zh) 2005-06-22
IL191543A0 (en) 2008-11-03
US20050124649A1 (en) 2005-06-09
CN100503608C (zh) 2009-06-24
EP1474425B1 (fr) 2006-05-24
AU2003235741A1 (en) 2003-07-24
NZ555911A (en) 2008-07-31
PT1474425E (pt) 2006-09-29
IL197484A0 (en) 2009-12-24
NO329994B1 (no) 2011-02-07
CA2472479A1 (fr) 2003-07-17
NZ533958A (en) 2007-09-28
NO20043290D0 (no) 2004-08-06
US7314936B2 (en) 2008-01-01
US7868002B2 (en) 2011-01-11
AU2003235741B2 (en) 2008-12-04
KR101108722B1 (ko) 2012-02-17
ES2262996T3 (es) 2006-12-01
ZA200406272B (en) 2006-01-25
CA2472479C (fr) 2011-10-11
DE60305446D1 (de) 2006-06-29
JP2005524621A (ja) 2005-08-18
US20110105427A1 (en) 2011-05-05
AU2003235741B8 (en) 2009-01-15
US20080103137A1 (en) 2008-05-01
DE60305446T2 (de) 2007-03-08
AU2009200689A1 (en) 2009-03-12
CY1106138T1 (el) 2011-06-08
NO20043290L (no) 2004-09-22
KR20100066593A (ko) 2010-06-17

Similar Documents

Publication Publication Date Title
IL162884A0 (en) Deazapurines and uses thereof
SG146624A1 (en) Cytokine inhibitors
IS6950A (is) Samsetning epóþílonhliðstæðna og efnameðferðarlyfja til meðhöndlunar frumufjölgunarsjúkdóma
MY136800A (en) Inhibitors of the interaction between mdm2 and p53
GEP20074148B (en) Pyrrolo-triazine aniline compounds useful as kinase inhibitors
DE60313004D1 (de) Alpha-7-nikotinsäure-rezeptoragonisten und statine in kombination
TW200508214A (en) Novel compounds
DE602004001857D1 (de) Thienopyrimidindione und deren verwendung bei der modulierung von autoimmunerkrankungen
BR0307833A (pt) Sìntese controlada de ziprasidona e suas composições
PL366198A1 (en) Novel compounds
IL181271A0 (en) Triazolophthalazine derivatives and pharmaceutical compositions containing the same
AU2003228770A8 (en) Substituted pyrazolopyrimidines
MXPA05002440A (es) Composiciones y kits para la eliminacion de compuestos irritantes de superficies corporales.
ECSP045378A (es) Derivados novedosos de diazabiciclononeno
TW200514772A (en) Novel tetrahydropyridine derivatives
SE0302139D0 (sv) Novel compounds
TW200604197A (en) New compounds
IL173809A0 (en) Imidazopyridine derivatives and pharmaceutical compositions containing the same
WO2002068476A3 (fr) Composition et procede de traitement de troubles inflammatoires
GB0120461D0 (en) Novel compounds
IL172538A0 (en) Depsipeptide compounds, pharmaceutical compositions containing the same and processes for the preparation thereof
SE0303280D0 (sv) Novel compounds
IL173629A0 (en) Imidazo(4,5-b) pyridine derivatives and pharmaceutical compositions containing the same
SE0302755D0 (sv) Novel compounds
MXPA03010259A (es) Nuevos derivados de 5-tio-ss-d-xilopiranosida, procedimiento de preparacion, composiciones farmaceuticas que los contienen y el uso terapeutico de los mismos.

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees