IL161358A0 - Process for preparing insulin compounds - Google Patents

Process for preparing insulin compounds

Info

Publication number
IL161358A0
IL161358A0 IL16135802A IL16135802A IL161358A0 IL 161358 A0 IL161358 A0 IL 161358A0 IL 16135802 A IL16135802 A IL 16135802A IL 16135802 A IL16135802 A IL 16135802A IL 161358 A0 IL161358 A0 IL 161358A0
Authority
IL
Israel
Prior art keywords
insulin compounds
preparing insulin
compounds
insulin
ester
Prior art date
Application number
IL16135802A
Other languages
English (en)
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of IL161358A0 publication Critical patent/IL161358A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Emergency Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL16135802A 2001-11-19 2002-11-15 Process for preparing insulin compounds IL161358A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200101716 2001-11-19
PCT/DK2002/000765 WO2003044210A2 (fr) 2001-11-19 2002-11-15 Elaboration de composes insuliniques

Publications (1)

Publication Number Publication Date
IL161358A0 true IL161358A0 (en) 2004-09-27

Family

ID=8160841

Family Applications (2)

Application Number Title Priority Date Filing Date
IL16135802A IL161358A0 (en) 2001-11-19 2002-11-15 Process for preparing insulin compounds
IL161358A IL161358A (en) 2001-11-19 2004-04-14 Process for preparing insulin compounds

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL161358A IL161358A (en) 2001-11-19 2004-04-14 Process for preparing insulin compounds

Country Status (15)

Country Link
EP (1) EP1448786B1 (fr)
JP (1) JP4404631B2 (fr)
KR (1) KR100925381B1 (fr)
CN (1) CN100424179C (fr)
AT (1) ATE464390T1 (fr)
AU (1) AU2002342597A1 (fr)
BR (1) BR0213583A (fr)
CA (1) CA2464616C (fr)
DE (1) DE60236014D1 (fr)
ES (1) ES2344448T3 (fr)
HU (1) HU228934B1 (fr)
IL (2) IL161358A0 (fr)
PL (1) PL210437B1 (fr)
RU (1) RU2376379C2 (fr)
WO (1) WO2003044210A2 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006031955A1 (de) 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
DE102006031962A1 (de) 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Amidiertes Insulin Glargin
TW200902708A (en) * 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
HUE037449T2 (hu) 2008-10-17 2018-08-28 Sanofi Aventis Deutschland Egy inzulin és egy GLP-1 agonista kombinációja
KR20120055653A (ko) * 2009-08-11 2012-05-31 바이오콘 리미티드 크로마토그래피 방법 및 그의 정제된 화합물
EP3831402A1 (fr) 2009-11-13 2021-06-09 Sanofi-Aventis Deutschland GmbH Composition pharmaceutique comprenant un agoniste du glp-1, une insuline et de la méthionine
ES2965209T3 (es) 2009-11-13 2024-04-11 Sanofi Aventis Deutschland Composición farmacéutica que comprende desPro36exendina-4(1-39)-Lys6-NH2 y metionina
PT2611458T (pt) 2010-08-30 2016-12-16 Sanofi Aventis Deutschland Utilização de ave0010 para o fabrico de um medicamento para o tratamento da diabetes mellitus tipo 2
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
AR087693A1 (es) 2011-08-29 2014-04-09 Sanofi Aventis Deutschland Combinacion farmaceutica para uso en el control glucemico en pacientes con diabetes de tipo 2
AR087744A1 (es) 2011-09-01 2014-04-16 Sanofi Aventis Deutschland Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
CN102703552B (zh) * 2012-05-15 2014-10-29 山东阿华生物药业有限公司 重组人胰岛素的制备方法及其产品
CN102816819B (zh) * 2012-08-13 2014-10-29 山东阿华生物药业有限公司 提高人胰岛素前体融合蛋白酶切转换成b30缺苏氨酸人胰岛素产率的方法
CN103305581B (zh) * 2013-07-04 2015-05-27 珠海联邦制药股份有限公司 一种重组人胰岛素的制备方法
EP3087192B1 (fr) * 2013-12-23 2020-08-12 Biocon Biologics India Limited Procédé de production d'ester méthylique créant de l'insuline humaine
DK3229828T5 (da) 2014-12-12 2024-10-14 Sanofi Aventis Deutschland Formulering med fast forhold mellem insulin glargin og lixisenatid
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
CN108473548A (zh) * 2015-09-24 2018-08-31 韩美药品股份有限公司 胰岛素生产方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE50892B1 (en) 1980-02-11 1986-08-06 Novo Industri As Process for preparing insulin esters
WO1983000504A1 (fr) 1981-08-10 1983-02-17 Andresen, Finn, Hede Preparation enzymatique d'insuline humaine
CA1174623A (fr) 1981-09-15 1984-09-18 Finn H. Andresen Procede de preparation de l'insuline humaine ou de ses esters b-30
DK149824C (da) 1982-01-22 1987-03-16 Carlsberg Biotechnology Ltd Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyrer i insuliner
EP0087238A1 (fr) 1982-02-08 1983-08-31 Biogen N.V. Méthode de préparation d'insuline humaine à partir d'insuline non-humaine-
DK347086D0 (da) 1986-07-21 1986-07-21 Novo Industri As Novel peptides
PH25772A (en) 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
CA1339955C (fr) 1986-10-14 1998-07-14 Richard Eugene Heiney Methode pour transformer un pecurseur d'insuline humaine en insuline humaine
EP0280534B1 (fr) 1987-02-25 1993-04-21 Novo Nordisk A/S Nouveaux dérivés de l'insuline
US6011007A (en) 1993-09-17 2000-01-04 Novo Nordisk A/S Acylated insulin
UA45321C2 (uk) 1993-09-17 2002-04-15 Ново Нордіск А/С Похідне інсуліну, фармацевтична композиція для лікування діабету та спосіб лікування діабету
WO2001049870A1 (fr) 1999-12-29 2001-07-12 Novo Nordisk A/S Procede de fabrication de precurseurs d'insuline et analogues des precurseurs d'insuline presentant un meilleur rendement de fermentation dans la levure
ES2307544T3 (es) 1999-12-29 2008-12-01 Novo Nordisk A/S Metodo de produccion de precursores de insulina y analogos de precursores de insulina.
ATE381573T1 (de) 2000-04-14 2008-01-15 Univ Maryland Biotech Inst Verbesserte thermostabilität und temperaturresistenz von proteinen
US20040198960A1 (en) 2001-03-29 2004-10-07 Janoff Edward N Human monoclonal antibodies against capsular polysaccharides of streptococcus pneumoniae

Also Published As

Publication number Publication date
PL369447A1 (en) 2005-04-18
WO2003044210A3 (fr) 2004-03-25
IL161358A (en) 2011-05-31
HUP0500037A3 (en) 2010-01-28
DE60236014D1 (de) 2010-05-27
KR100925381B1 (ko) 2009-11-09
AU2002342597A1 (en) 2003-06-10
HU228934B1 (hu) 2013-06-28
KR20050044855A (ko) 2005-05-13
PL210437B1 (pl) 2012-01-31
CN100424179C (zh) 2008-10-08
CA2464616C (fr) 2012-07-24
EP1448786B1 (fr) 2010-04-14
JP4404631B2 (ja) 2010-01-27
CA2464616A1 (fr) 2003-05-30
CN1589328A (zh) 2005-03-02
AU2002342597A8 (en) 2003-06-10
ES2344448T3 (es) 2010-08-27
JP2005509687A (ja) 2005-04-14
EP1448786A2 (fr) 2004-08-25
RU2376379C2 (ru) 2009-12-20
RU2004118503A (ru) 2005-06-10
BR0213583A (pt) 2004-08-24
HUP0500037A2 (hu) 2005-03-29
WO2003044210A2 (fr) 2003-05-30
ATE464390T1 (de) 2010-04-15

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