IL158754A0 - Removal of plasmin(ogen) from protein solutions - Google Patents
Removal of plasmin(ogen) from protein solutionsInfo
- Publication number
- IL158754A0 IL158754A0 IL15875402A IL15875402A IL158754A0 IL 158754 A0 IL158754 A0 IL 158754A0 IL 15875402 A IL15875402 A IL 15875402A IL 15875402 A IL15875402 A IL 15875402A IL 158754 A0 IL158754 A0 IL 158754A0
- Authority
- IL
- Israel
- Prior art keywords
- plasmin
- ogen
- amino acid
- removal
- protein solutions
- Prior art date
Links
- 229940012957 plasmin Drugs 0.000 title abstract 5
- 229940099990 ogen Drugs 0.000 title abstract 3
- 239000012460 protein solution Substances 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 5
- 125000003277 amino group Chemical group 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 102000008946 Fibrinogen Human genes 0.000 abstract 1
- 108010049003 Fibrinogen Proteins 0.000 abstract 1
- 229940012952 fibrinogen Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29196801P | 2001-05-21 | 2001-05-21 | |
| EP01115157 | 2001-06-21 | ||
| PCT/EP2002/005462 WO2002095019A1 (en) | 2001-05-21 | 2002-05-17 | Removal of plasmin(ogen) from protein solutions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL158754A0 true IL158754A0 (en) | 2004-05-12 |
Family
ID=26076623
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15875402A IL158754A0 (en) | 2001-05-21 | 2002-05-17 | Removal of plasmin(ogen) from protein solutions |
| IL158754A IL158754A (en) | 2001-05-21 | 2003-11-05 | Removal of plasmin (flange) from protein solutions |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL158754A IL158754A (en) | 2001-05-21 | 2003-11-05 | Removal of plasmin (flange) from protein solutions |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US20040197891A1 (pl) |
| EP (1) | EP1390485B1 (pl) |
| JP (1) | JP4385097B2 (pl) |
| KR (1) | KR100871454B1 (pl) |
| AT (1) | ATE342353T1 (pl) |
| AU (1) | AU2002314081B2 (pl) |
| CA (1) | CA2447789C (pl) |
| CZ (1) | CZ20033097A3 (pl) |
| DE (1) | DE60215338T2 (pl) |
| EE (1) | EE05485B1 (pl) |
| ES (1) | ES2274044T3 (pl) |
| HU (1) | HU228899B1 (pl) |
| IL (2) | IL158754A0 (pl) |
| MX (1) | MXPA03010616A (pl) |
| PL (1) | PL205685B1 (pl) |
| RU (2) | RU2458067C2 (pl) |
| SK (1) | SK288005B6 (pl) |
| WO (1) | WO2002095019A1 (pl) |
| ZA (1) | ZA200309030B (pl) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE342353T1 (de) | 2001-05-21 | 2006-11-15 | Omrix Biopharm Sa | Abtrennung von plasmin(ogen) aus proteinlösungen |
| SE526038C2 (sv) * | 2002-07-08 | 2005-06-21 | Gambro Lundia Ab | Polymeraffinitetsmatris, förfarande för framställning därav och anvädning därav |
| CA2514474C (en) | 2003-01-30 | 2014-05-06 | Avner Yayon | Freeze-dried fibrin matrices and methods for preparation thereof |
| US7067123B2 (en) | 2003-04-29 | 2006-06-27 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
| US7901457B2 (en) | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
| DE102004009400A1 (de) | 2004-02-24 | 2005-09-08 | Zlb Behring Gmbh | Fibrinogen Reinigung |
| US7335508B2 (en) | 2004-07-22 | 2008-02-26 | Prochon Biotech Ltd. | Porous plasma protein matrices and methods for preparation thereof |
| US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
| DK1809343T3 (da) | 2004-10-20 | 2012-11-26 | Ethicon Inc | Forstærket absorberbar hæmostatisk flerlagssårforbinding samt fremstillingsfremgangsmåde |
| US9358318B2 (en) | 2004-10-20 | 2016-06-07 | Ethicon, Inc. | Method of making a reinforced absorbable multilayered hemostatic wound dressing |
| US7815926B2 (en) | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
| JP2007068497A (ja) * | 2005-09-09 | 2007-03-22 | Nihon Pharmaceutical Co Ltd | プラスミンの精製法 |
| EP1926459B1 (en) | 2005-09-19 | 2015-01-07 | Histogenics Corporation | Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof |
| US20070134231A1 (en) * | 2005-12-13 | 2007-06-14 | Jani Dharmendra M | Method for prolonging activity of autodegradable enzymes and compositions thereof |
| JP5373618B2 (ja) | 2006-11-02 | 2013-12-18 | オムリクス バイオファーマシューティカルズ リミテッド | 微粒化方法 |
| US8435551B2 (en) | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
| US8409499B2 (en) | 2007-06-07 | 2013-04-02 | Ethicon, Inc. | Method for establishing a sterilizing dose for radiation sensitive products |
| US7704453B2 (en) | 2007-06-07 | 2010-04-27 | Ethicon, Inc. | Method for establishing a sterilizing dose for radiation sensitive products |
| EP2011524A1 (en) * | 2007-07-02 | 2009-01-07 | Omrix Biopharmaceuticals Ltd. | Fibrin glue with a visualization agent |
| EP2034010A1 (en) | 2007-08-30 | 2009-03-11 | Omrix Biopharmaceuticals Ltd. | Compositions suitable for repair and/or treatment of injured spinal tissue |
| WO2009111069A1 (en) | 2008-03-05 | 2009-09-11 | Musculoskeletal Transplant Foundation | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
| US10039865B2 (en) | 2008-09-22 | 2018-08-07 | Omrix Biopharmaceuticals Ltd. | Implantable device comprising a substrate pre-coated with stabilized fibrin |
| WO2010095128A2 (en) | 2009-02-20 | 2010-08-26 | Omrix Biopharmaceuticals Ltd. | Device for administering an at least two-component substance |
| KR101786786B1 (ko) | 2010-01-28 | 2017-10-18 | 옴릭스 바이오파머슈티컬스 리미티드 | 개선된 피브린 밀봉 방법 |
| NZ603616A (en) * | 2010-05-18 | 2015-02-27 | Abbvie Inc | Apparatus and process of purification of proteins |
| IL207586A0 (en) * | 2010-08-12 | 2010-12-30 | Omrix Biopharmaceuticals Ltd | A fibrin based therapeutic preparation and use thereof |
| JP5836577B2 (ja) * | 2010-09-14 | 2015-12-24 | 株式会社カネカ | クリングル配列を有する蛋白質またはペプチドを精製または除去するアフィニティ担体の製造方法、その精製方法、除去方法 |
| JPWO2012036140A1 (ja) * | 2010-09-14 | 2014-02-03 | 株式会社カネカ | クリングル配列を有する蛋白質またはペプチドを精製または除去するアフィニティ担体、及びそれを用いた精製方法、除去方法 |
| EP2619225B1 (en) * | 2010-09-20 | 2016-06-15 | Octapharma AG | Process for production of fibrinogen |
| IL210162A0 (en) | 2010-12-21 | 2011-03-31 | Omrix Biopharmaceuticals | Viral inactivated platelet extract, use and preparation thereof |
| IL213375A0 (en) | 2011-06-05 | 2011-07-31 | Omrix Biopharmaceuticals | Device for spraying fluids in proximity to a surface |
| AU2012275562B2 (en) | 2011-06-27 | 2016-10-20 | Children's Healthcare Of Atlanta, Inc. | Compositions, uses, and preparation of platelet lysates |
| IL213864A0 (en) | 2011-06-30 | 2011-08-31 | Omrix Biopharmaceuticals Ltd | Method for removing a lytic enzyme from a heterogeneous mixture |
| IN2014DN05901A (pl) | 2011-12-29 | 2015-06-05 | Omrix Biopharmaceuticals Ltd | |
| US10130346B2 (en) | 2012-07-24 | 2018-11-20 | Omrix Biopharmaceuticals Ltd. | Device and method for the application of a curable fluid composition to a bodily organ |
| US20140154233A1 (en) * | 2012-12-05 | 2014-06-05 | Csl Limited | Method of purifying therapeutic proteins |
| EP3848058A1 (en) | 2012-12-20 | 2021-07-14 | Omrix Biopharmaceuticals Ltd. | Viral inactivated biological mixture |
| WO2014102763A1 (en) | 2012-12-30 | 2014-07-03 | Omrix Biopharmaceuticals Ltd. | Device and method for the application of a curable fluid composition to a portion of a bodily organ |
| USD754325S1 (en) | 2013-06-06 | 2016-04-19 | Omrix Biopharmaceuticals Ltd. | Device of a curable fluid composition to a bodily organ |
| IL230150A0 (en) | 2013-12-24 | 2014-09-30 | Omrix Biopharmaceuticals Ltd | One-component fibrin glue containing zymogens |
| IL230151A0 (en) | 2013-12-24 | 2014-09-30 | Omrix Biopharmaceuticals Ltd | One-component fibrin glue containing a polymerization inhibitor |
| IL231230A0 (en) | 2014-02-27 | 2014-08-31 | Omrix Biopharmaceuticals Ltd | Fibrinogen preparation |
| IL231792A0 (en) | 2014-03-27 | 2014-08-31 | Omrix Biopharmaceuticals Ltd | Device and method for the preparation and administration of one-component fibrin glue |
| IL234246A0 (en) | 2014-08-21 | 2014-11-30 | Omrix Biopharmaceuticals Ltd | Stabilized thrombin |
| IL235751A0 (en) | 2014-11-18 | 2015-02-26 | Omrix Biopharmaceuticals Ltd | An addition to the spray dryer |
| WO2016079727A1 (en) | 2014-11-18 | 2016-05-26 | Omrix Biopharmaceuticals Ltd. | Spray-drying apparatus and method of use |
| US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
| EP3258945B1 (en) | 2015-02-16 | 2020-10-07 | Nayacure Therapeutics Ltd. | Modified blood clots |
| JP6713479B2 (ja) | 2015-02-25 | 2020-06-24 | オムリックス・バイオファーマシューティカルズ・リミテッドＯｍｒｉｘ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ． | トロンビン及びその分解ポリペプチドの精製及び定量化方法 |
| US10159720B2 (en) | 2015-12-08 | 2018-12-25 | Omrix Biopharmaceuticals Ltd | Thrombin microcapsules, preparation and uses thereof |
| IL242984A0 (en) | 2015-12-08 | 2016-02-29 | Omrix Biopharmaceuticals Ltd | Thrombin microcapsules, their preparation and how to use them |
| CN108463254A (zh) | 2015-11-11 | 2018-08-28 | 伊西康公司 | 密封剂制剂及其用途 |
| IL242924A0 (en) | 2015-12-03 | 2016-04-21 | Omrix Biopharmaceuticals Ltd | Syringe system for storing and mixing two ingredients |
| IL265102B2 (en) * | 2016-09-01 | 2023-11-01 | Plas Free Ltd | Human Blood-Derived Products Having Decreased Fibrinolytic Activity And Uses Thereof In Hemostatic Disorders |
| IT201600091964A1 (it) * | 2016-09-13 | 2018-03-13 | Kedrion Spa | Processo per la purificazione del plasminogeno a partire da plasma umano. |
| IL247821A0 (en) | 2016-09-14 | 2017-01-31 | Omrix Biopharmaceuticals Ltd | Adhesive preparations and their use |
| AU2018231623B2 (en) | 2017-03-09 | 2024-07-18 | Previpharma Consulting Gmbh | Preparing and use of Glu-plasminogen from blood fractions |
| IL256405A (en) | 2017-12-19 | 2018-01-31 | Omrix Biopharmaceuticals Ltd | Wound bandage and method for its production |
| CN111770767B (zh) * | 2018-02-28 | 2024-03-05 | 普拉斯富瑞有限公司 | 用于从生物流体中去除纤溶蛋白的体外设备和基质、其方法和用途 |
| WO2020121289A1 (en) | 2018-12-12 | 2020-06-18 | Omrix Biopharmaceuticals Ltd. | Low concentrated protein compositions for preventing tissue adhesion |
| IL263679A (en) | 2018-12-12 | 2019-03-31 | Omrix Biopharmaceuticals Ltd | Kits, methods, and compositions for preventing tissue adhesion |
| CN111760556B (zh) * | 2020-07-09 | 2023-06-30 | 江苏尤里卡生物科技有限公司 | 一种尿激酶吸附剂及其制备方法和应用 |
| EP4240757A2 (en) | 2020-11-09 | 2023-09-13 | Takeda Pharmaceutical Company Limited | Purification of fviii from plasma using silicon oxide adsorption |
| US20240262861A1 (en) | 2021-06-08 | 2024-08-08 | Previpharma Consulting Gmbh | Process for isolating plasminogen from a blood plasma fraction |
| CN113533594A (zh) * | 2021-06-30 | 2021-10-22 | 长沙都正生物科技股份有限公司 | 用于测定氨甲环酸含量的方法及试剂盒 |
| WO2023042146A1 (en) | 2021-09-16 | 2023-03-23 | Ethicon, Inc. | Kit for composition for tissue tract sealing |
| EP4452233B1 (en) | 2021-12-21 | 2025-12-24 | Omrix Biopharmaceuticals Ltd. | Highly soluble fibrinogen compositions |
| US20250108142A1 (en) | 2023-09-28 | 2025-04-03 | Ethicon, Inc. | Methods for treating leakage from a gastrointestinal site |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3943245A (en) * | 1974-02-14 | 1976-03-09 | Armour Pharmaceutical Company | Purification of plasminogen |
| SU979508A1 (ru) * | 1980-07-23 | 1982-12-07 | Ордена Трудового Красного Знамени Институт Биохимии Им.А.В.Палладина | Способ получени иммобилизованного плазминогена |
| US4639513A (en) * | 1984-02-02 | 1987-01-27 | Cuno Inc. | Intravenously injectable immunoglobulin G (IGG) and method for producing same |
| US4639543A (en) | 1985-02-04 | 1987-01-27 | Richard J. Birch | Semiconductor devices having a metallic glass substrate |
| JPS6391080A (ja) | 1986-10-03 | 1988-04-21 | Kanegafuchi Chem Ind Co Ltd | ヒト組織プラスミノゲン活性化因子の精製法 |
| GB8902771D0 (en) * | 1989-02-08 | 1989-03-30 | Bioprocessing Ltd | Improvements in or relating to affinity chromatography |
| DE69033653T2 (de) | 1989-04-07 | 2001-06-07 | Cancerforskningsfonden Af 1989 (Fonden Til Fremme Af Eksperimental Cancerforskning), Kopenhagen | Plasminogen-aktivator-rezeptor vom urokinasetyp |
| SU1727839A1 (ru) | 1990-05-30 | 1992-04-23 | МГУ им.М.В.Ломоносова | Способ получени фибриногена |
| US5792835A (en) * | 1991-09-05 | 1998-08-11 | Baxter International Inc. | Method of preparing a topical fibrinogen complex |
| DK82592D0 (da) * | 1992-06-23 | 1992-06-23 | Novo Nordisk As | Fremstilling af proteiner |
| US5362859A (en) | 1992-07-27 | 1994-11-08 | Sepracor, Inc. | High-capacity affinity supports and methods for the preparation and use of same |
| JPH08225461A (ja) | 1995-02-21 | 1996-09-03 | Green Cross Corp:The | プラスミノーゲンの精製方法およびプラスミノーゲン製剤 |
| JP3763598B2 (ja) | 1995-09-11 | 2006-04-05 | 旭電化工業株式会社 | トラネキサム酸の製造方法 |
| US6451978B2 (en) * | 2000-01-21 | 2002-09-17 | Biovitrum Ab | Purification of antithrombin-III-α and β |
| ATE342353T1 (de) | 2001-05-21 | 2006-11-15 | Omrix Biopharm Sa | Abtrennung von plasmin(ogen) aus proteinlösungen |
-
2002
- 2002-05-17 AT AT02740615T patent/ATE342353T1/de active
- 2002-05-17 EP EP02740615A patent/EP1390485B1/en not_active Expired - Lifetime
- 2002-05-17 DE DE60215338T patent/DE60215338T2/de not_active Expired - Lifetime
- 2002-05-17 JP JP2002592482A patent/JP4385097B2/ja not_active Expired - Lifetime
- 2002-05-17 SK SK1420-2003A patent/SK288005B6/sk not_active IP Right Cessation
- 2002-05-17 RU RU2008130356/10A patent/RU2458067C2/ru active
- 2002-05-17 WO PCT/EP2002/005462 patent/WO2002095019A1/en not_active Ceased
- 2002-05-17 ES ES02740615T patent/ES2274044T3/es not_active Expired - Lifetime
- 2002-05-17 US US10/477,519 patent/US20040197891A1/en not_active Abandoned
- 2002-05-17 CA CA2447789A patent/CA2447789C/en not_active Expired - Lifetime
- 2002-05-17 HU HU0600110A patent/HU228899B1/hu not_active IP Right Cessation
- 2002-05-17 CZ CZ20033097A patent/CZ20033097A3/cs unknown
- 2002-05-17 RU RU2003136746/13A patent/RU2344143C2/ru active
- 2002-05-17 KR KR1020037015108A patent/KR100871454B1/ko not_active Expired - Lifetime
- 2002-05-17 AU AU2002314081A patent/AU2002314081B2/en not_active Expired
- 2002-05-17 MX MXPA03010616A patent/MXPA03010616A/es active IP Right Grant
- 2002-05-17 EE EEP200300578A patent/EE05485B1/xx not_active IP Right Cessation
- 2002-05-17 IL IL15875402A patent/IL158754A0/xx unknown
- 2002-05-17 PL PL365808A patent/PL205685B1/pl unknown
- 2002-05-20 US US10/150,490 patent/US7125569B2/en not_active Expired - Lifetime
-
2003
- 2003-11-05 IL IL158754A patent/IL158754A/en unknown
- 2003-11-20 ZA ZA2003/09030A patent/ZA200309030B/en unknown
-
2006
- 2006-10-17 US US11/581,753 patent/US7641918B2/en not_active Expired - Lifetime
-
2008
- 2008-10-29 US US12/289,499 patent/US8563288B2/en not_active Expired - Fee Related
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