DE60215338D1 - Abtrennung von plasmin(ogen) aus proteinlösungen - Google Patents

Abtrennung von plasmin(ogen) aus proteinlösungen

Info

Publication number
DE60215338D1
DE60215338D1 DE60215338T DE60215338T DE60215338D1 DE 60215338 D1 DE60215338 D1 DE 60215338D1 DE 60215338 T DE60215338 T DE 60215338T DE 60215338 T DE60215338 T DE 60215338T DE 60215338 D1 DE60215338 D1 DE 60215338D1
Authority
DE
Germany
Prior art keywords
amino acid
plasmin
plasmine
ogens
separation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60215338T
Other languages
English (en)
Other versions
DE60215338T2 (de
Inventor
Israel Nur
Liliana Bar
Malkit Azachi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Omrix Biopharmaceuticals SA
Original Assignee
Omrix Biopharmaceuticals SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omrix Biopharmaceuticals SA filed Critical Omrix Biopharmaceuticals SA
Application granted granted Critical
Publication of DE60215338D1 publication Critical patent/DE60215338D1/de
Publication of DE60215338T2 publication Critical patent/DE60215338T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
DE60215338T 2001-05-21 2002-05-17 Abtrennung von plasmin(ogen) aus proteinlösungen Expired - Lifetime DE60215338T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US29196801P 2001-05-21 2001-05-21
US291968P 2001-05-21
EP01115157 2001-06-21
EP01115157 2001-06-21
PCT/EP2002/005462 WO2002095019A1 (en) 2001-05-21 2002-05-17 Removal of plasmin(ogen) from protein solutions

Publications (2)

Publication Number Publication Date
DE60215338D1 true DE60215338D1 (de) 2006-11-23
DE60215338T2 DE60215338T2 (de) 2007-05-16

Family

ID=26076623

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60215338T Expired - Lifetime DE60215338T2 (de) 2001-05-21 2002-05-17 Abtrennung von plasmin(ogen) aus proteinlösungen

Country Status (20)

Country Link
US (4) US20040197891A1 (de)
EP (1) EP1390485B1 (de)
JP (1) JP4385097B2 (de)
KR (1) KR100871454B1 (de)
AT (1) ATE342353T1 (de)
AU (1) AU2002314081B2 (de)
CA (1) CA2447789C (de)
CZ (1) CZ20033097A3 (de)
DE (1) DE60215338T2 (de)
EE (1) EE05485B1 (de)
ES (1) ES2274044T3 (de)
HK (1) HK1060902A1 (de)
HU (1) HU228899B1 (de)
IL (2) IL158754A0 (de)
MX (1) MXPA03010616A (de)
PL (1) PL205685B1 (de)
RU (2) RU2458067C2 (de)
SK (1) SK288005B6 (de)
WO (1) WO2002095019A1 (de)
ZA (1) ZA200309030B (de)

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JP5836577B2 (ja) * 2010-09-14 2015-12-24 株式会社カネカ クリングル配列を有する蛋白質またはペプチドを精製または除去するアフィニティ担体の製造方法、その精製方法、除去方法
JP2013537215A (ja) * 2010-09-20 2013-09-30 オクタファルマ・アーゲー フィブリノーゲンの生産方法
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CA2896760A1 (en) 2012-12-30 2014-07-03 Omrix Biopharmaceuticals Ltd. Device and method for the application of a curable fluid composition to a portion of a bodily organ
USD754325S1 (en) 2013-06-06 2016-04-19 Omrix Biopharmaceuticals Ltd. Device of a curable fluid composition to a bodily organ
IL230151A0 (en) 2013-12-24 2014-09-30 Omrix Biopharmaceuticals Ltd One-component fibrin glue containing a polymerization inhibitor
IL230150A0 (en) 2013-12-24 2014-09-30 Omrix Biopharmaceuticals Ltd One-component fibrin glue containing zymogens
IL231230A0 (en) 2014-02-27 2014-08-31 Omrix Biopharmaceuticals Ltd Fibrinogen preparation
IL231792A0 (en) 2014-03-27 2014-08-31 Omrix Biopharmaceuticals Ltd Device and method for the preparation and administration of one-component fibrin glue
IL234246A0 (en) 2014-08-21 2014-11-30 Omrix Biopharmaceuticals Ltd Stabilized thrombin
IL235751A0 (en) 2014-11-18 2015-02-26 Omrix Biopharmaceuticals Ltd An addition to the spray dryer
WO2016079727A1 (en) 2014-11-18 2016-05-26 Omrix Biopharmaceuticals Ltd. Spray-drying apparatus and method of use
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
CN107427535A (zh) 2015-02-16 2017-12-01 纳雅康医疗有限公司 经修饰的血凝块
CN107406840B (zh) 2015-02-25 2021-05-28 奥姆里克斯生物药品有限公司 用于纯化和定量凝血酶及其降解多肽的方法
IL242984A0 (en) 2015-12-08 2016-02-29 Omrix Biopharmaceuticals Ltd Thrombin microcapsules, their preparation and how to use them
US10159720B2 (en) 2015-12-08 2018-12-25 Omrix Biopharmaceuticals Ltd Thrombin microcapsules, preparation and uses thereof
BR112018009459A8 (pt) 2015-11-11 2019-02-26 Ethicon Inc formulação de selante e usos da mesma
IL242924A0 (en) 2015-12-03 2016-04-21 Omrix Biopharmaceuticals Ltd Syringe system for storing and mixing two ingredients
CA3035650A1 (en) * 2016-09-01 2018-03-08 Plas-Free Ltd Human blood-derived products having decreased fibrinolytic activity and uses thereof in hemostatic disorders
IT201600091964A1 (it) * 2016-09-13 2018-03-13 Kedrion Spa Processo per la purificazione del plasminogeno a partire da plasma umano.
IL247821A0 (en) 2016-09-14 2017-01-31 Omrix Biopharmaceuticals Ltd Adhesive preparations and their use
CN110612350A (zh) 2017-03-09 2019-12-24 先觉药业咨询公司 源自血液的谷氨酸-纤溶酶原的制备和使用
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EP3746151B1 (de) * 2018-02-28 2024-04-24 Plas-Free Ltd. Extrakorporale und matrix zur entfernung von fibrinolytischen proteinen aus biologischen flüssigkeiten, verfahren und verwendungen davon
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IL263679A (en) 2018-12-12 2019-03-31 Omrix Biopharmaceuticals Ltd Kits, methods, and ingredients for preventing tissue adhesion
CN111760556B (zh) * 2020-07-09 2023-06-30 江苏尤里卡生物科技有限公司 一种尿激酶吸附剂及其制备方法和应用
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Also Published As

Publication number Publication date
HUP0600110A2 (en) 2006-05-29
US7641918B2 (en) 2010-01-05
JP4385097B2 (ja) 2009-12-16
CA2447789C (en) 2012-11-06
US20040197891A1 (en) 2004-10-07
SK14202003A3 (sk) 2004-08-03
ATE342353T1 (de) 2006-11-15
PL365808A1 (en) 2005-01-10
HU228899B1 (en) 2013-06-28
ZA200309030B (en) 2005-06-29
SK288005B6 (sk) 2012-10-02
EE05485B1 (et) 2011-10-17
AU2002314081B2 (en) 2007-04-05
US7125569B2 (en) 2006-10-24
US20090176293A1 (en) 2009-07-09
PL205685B1 (pl) 2010-05-31
CZ20033097A3 (cs) 2004-06-16
EP1390485A1 (de) 2004-02-25
DE60215338T2 (de) 2007-05-16
CA2447789A1 (en) 2002-11-28
JP2004528853A (ja) 2004-09-24
EP1390485B1 (de) 2006-10-11
RU2008130356A (ru) 2010-01-27
KR100871454B1 (ko) 2008-12-03
US20030124703A1 (en) 2003-07-03
WO2002095019A1 (en) 2002-11-28
RU2003136746A (ru) 2005-05-20
ES2274044T3 (es) 2007-05-16
IL158754A0 (en) 2004-05-12
US8563288B2 (en) 2013-10-22
IL158754A (en) 2009-05-04
MXPA03010616A (es) 2004-04-02
HK1060902A1 (en) 2004-08-27
KR20040011503A (ko) 2004-02-05
RU2344143C2 (ru) 2009-01-20
US20070092959A1 (en) 2007-04-26
EE200300578A (et) 2004-02-16
HUP0600110A3 (en) 2010-01-28
RU2458067C2 (ru) 2012-08-10

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