IL157615A0 - 4-(2-butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl) pyrazolo-[1,5-a]-1,3,5-triazine, its enantiomers and pharmaceutically acceptable salts as corticotropin releasing factor receptor ligands - Google Patents
4-(2-butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl) pyrazolo-[1,5-a]-1,3,5-triazine, its enantiomers and pharmaceutically acceptable salts as corticotropin releasing factor receptor ligandsInfo
- Publication number
- IL157615A0 IL157615A0 IL15761502A IL15761502A IL157615A0 IL 157615 A0 IL157615 A0 IL 157615A0 IL 15761502 A IL15761502 A IL 15761502A IL 15761502 A IL15761502 A IL 15761502A IL 157615 A0 IL157615 A0 IL 157615A0
- Authority
- IL
- Israel
- Prior art keywords
- methoxypyrid
- pyrazolo
- butylamino
- enantiomers
- triazine
- Prior art date
Links
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title 1
- 108010056643 Corticotropin-Releasing Hormone Receptors Proteins 0.000 title 1
- 102100038018 Corticotropin-releasing factor receptor 1 Human genes 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- LBWQSAZEYIZZCE-UHFFFAOYSA-N n-butan-2-yl-8-(6-methoxy-2-methylpyridin-3-yl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical compound CC1=NN2C(NC(C)CC)=NC(C)=NC2=C1C1=CC=C(OC)N=C1C LBWQSAZEYIZZCE-UHFFFAOYSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- Organic Chemistry (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
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- Rheumatology (AREA)
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- Addiction (AREA)
- Pulmonology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
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- Hematology (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
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- Oncology (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27540301P | 2001-03-13 | 2001-03-13 | |
| PCT/US2002/006837 WO2002072202A1 (en) | 2001-03-13 | 2002-03-06 | 4-(2-butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl) pyrazolo-[1,5-a]-1,3,5-triazine, its enantiomers and pharmaceutically acceptable salts as corticotropin releasing factor receptor ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL157615A0 true IL157615A0 (en) | 2004-03-28 |
Family
ID=23052141
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15761502A IL157615A0 (en) | 2001-03-13 | 2002-03-06 | 4-(2-butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl) pyrazolo-[1,5-a]-1,3,5-triazine, its enantiomers and pharmaceutically acceptable salts as corticotropin releasing factor receptor ligands |
| IL157615A IL157615A (en) | 2001-03-13 | 2003-08-27 | 4-(2-butylamino)-2,7-dimethyl-8- (2-methyl-6-methoxypyrid-3-yl) pyrazolo-[1,5-a] - 1,3,5 - triazine, its enantiomers and pharmaceutically acceptable salts as cortocotropin releasing factor receptor ligands |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL157615A IL157615A (en) | 2001-03-13 | 2003-08-27 | 4-(2-butylamino)-2,7-dimethyl-8- (2-methyl-6-methoxypyrid-3-yl) pyrazolo-[1,5-a] - 1,3,5 - triazine, its enantiomers and pharmaceutically acceptable salts as cortocotropin releasing factor receptor ligands |
Country Status (35)
| Country | Link |
|---|---|
| US (4) | US20030125330A1 (cs) |
| EP (1) | EP1368094B1 (cs) |
| JP (1) | JP4549630B2 (cs) |
| KR (1) | KR100875595B1 (cs) |
| CN (1) | CN100427093C (cs) |
| AR (1) | AR032986A1 (cs) |
| AT (1) | ATE355102T1 (cs) |
| AU (1) | AU2002245605B2 (cs) |
| BG (1) | BG66331B1 (cs) |
| BR (1) | BR0208357A (cs) |
| CA (1) | CA2440553C (cs) |
| CY (1) | CY1106607T1 (cs) |
| CZ (1) | CZ20032481A3 (cs) |
| DE (1) | DE60218434T2 (cs) |
| DK (1) | DK1368094T3 (cs) |
| EE (1) | EE05433B1 (cs) |
| ES (1) | ES2282401T3 (cs) |
| GE (1) | GEP20053608B (cs) |
| HR (1) | HRP20030822B1 (cs) |
| HU (1) | HU229317B1 (cs) |
| IL (2) | IL157615A0 (cs) |
| IS (1) | IS2839B (cs) |
| MX (1) | MXPA03008185A (cs) |
| MY (1) | MY146935A (cs) |
| NO (1) | NO328580B1 (cs) |
| NZ (1) | NZ528207A (cs) |
| PL (1) | PL208278B1 (cs) |
| PT (1) | PT1368094E (cs) |
| RS (1) | RS50863B (cs) |
| RU (1) | RU2292347C2 (cs) |
| SK (1) | SK287603B6 (cs) |
| TW (1) | TWI257388B (cs) |
| UA (1) | UA74634C2 (cs) |
| WO (1) | WO2002072202A1 (cs) |
| ZA (1) | ZA200306995B (cs) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7094782B1 (en) * | 1996-07-24 | 2006-08-22 | Bristol-Myers Squibb Company | Azolo triazines and pyrimidines |
| CZ20032481A3 (cs) * | 2001-03-13 | 2007-12-27 | Bristol-Myers Squibb Pharma Company | 4-(2-Butylamino)-2, 7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl)pyrazolo[1,5-A]-1, 3, 5-triazin, jeho enantiomery a farmaceuticky prijatelné soli jakoligandy receptoru faktoru uvolnujícího kortikotropin |
| FR2842809A1 (fr) * | 2002-07-26 | 2004-01-30 | Greenpharma Sas | NOUVELLES PYRAZOLO[1,5-a]-1,3,5-TRIAZINES SUBSTITUEES ET LEURS ANALOGUES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION |
| AR041470A1 (es) * | 2002-10-17 | 2005-05-18 | Upjohn Co | Compuestos de pirrolo (1,2 - b) piridazina y sus usos |
| US7329658B2 (en) * | 2003-02-06 | 2008-02-12 | Pfizer Inc | Cannabinoid receptor ligands and uses thereof |
| US7176210B2 (en) * | 2003-02-10 | 2007-02-13 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
| US7041671B2 (en) | 2003-04-02 | 2006-05-09 | Pfizer Inc | Pyrrolo[1,2-b]pyridazine compounds and their uses |
| US7056920B2 (en) | 2003-04-04 | 2006-06-06 | Pfizer Inc | Pyrrolo[1,2-B]pyridazine compounds and their uses |
| US7034023B2 (en) | 2003-04-04 | 2006-04-25 | Pfizer Inc | Pyrrolo[1,2-B]pyridazine compounds and their uses |
| JP2006523675A (ja) * | 2003-04-15 | 2006-10-19 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | ピロロ［１，２−ｂ］ピリダジン化合物及びそれらの使用 |
| US7153961B2 (en) | 2003-11-25 | 2006-12-26 | Bristol-Myers Squibb Pharma Co. | Salt and crystalline form thereof of a corticotropin releasing factor receptor antagonist |
| US7208596B2 (en) * | 2003-11-25 | 2007-04-24 | Bristol-Myers Squibb Pharma Company | Processes for the preparation of pyrazolo[1,5-a]-1,3,5-triazines and intermediates thereof |
| EP2094709B1 (en) * | 2006-09-20 | 2010-09-15 | Eli Lilly And Company | Thiazole pyrazolopyrimidines as crf1 receptor antagonists |
| WO2013160317A2 (en) * | 2012-04-23 | 2013-10-31 | Holsboermaschmeyer Neurochemie Gmbh | Crhr1 antagonists for use in the treatment of patients having crh overactivity |
| GB201210686D0 (en) | 2012-06-15 | 2012-08-01 | Holsboermaschmeyer Neurochemie Gmbh | V1B receptor antagonist for use in the treatment of patients having an elevated AVP level and/or an elevated copeptin level |
| JP6440625B2 (ja) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 精神分裂病を処置するための方法および組成物 |
| GB201310782D0 (en) | 2013-06-17 | 2013-07-31 | Max Planck Innovation Gmbh | Method for predicting a treatment response to a CRHR1 antagonist and/or V1B antagonist in a patient with depressive and/or anxiety symptoms |
| KR102079844B1 (ko) | 2016-09-20 | 2020-02-20 | 가톨릭대학교 산학협력단 | 담석 용해제를 포함하는 담낭 질환 치료용 약학 조성물 |
| CN110996943A (zh) | 2017-08-14 | 2020-04-10 | 云杉生物科学公司 | 促肾上腺皮质激素释放因子受体拮抗剂 |
| EP4175572A4 (en) | 2020-08-12 | 2024-03-27 | Spruce Biosciences, Inc. | METHODS AND COMPOSITIONS FOR TREATING POLYCYSTIC OVARIAN SYNDROME |
| US11708372B2 (en) | 2021-11-19 | 2023-07-25 | Spruce Biosciences, Inc. | Crystalline composition of tildacerfont and methods of use and preparation thereof |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW444018B (en) | 1992-12-17 | 2001-07-01 | Pfizer | Pyrazolopyrimidines |
| RU2153494C2 (ru) | 1993-10-12 | 2000-07-27 | Дзе Дюпон Мерк Фармасьютикал Компани | 1-n-алкил-n-арилпиримидинамины, способ лечения заболеваний, фармацевтическая композиция |
| TW530047B (en) | 1994-06-08 | 2003-05-01 | Pfizer | Corticotropin releasing factor antagonists |
| WO1997035846A1 (en) | 1996-03-26 | 1997-10-02 | Dupont Pharmaceuticals Company | Aryloxy- and arylthio-fused pyridines and pyrimidines and derivatives |
| US6107300A (en) | 1996-03-27 | 2000-08-22 | Dupont Pharmaceuticals | Arylamino fused pyrimidines |
| WO1997044308A1 (en) | 1996-05-24 | 1997-11-27 | The Dow Chemical Company | Process for preparing aliphatic ester compounds and alkanols |
| EP0915880B1 (en) | 1996-07-24 | 2007-10-10 | Bristol-Myers Squibb Pharma Company | Azolo triazines and pyrimidines |
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