IL155771A0 - Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents - Google Patents

Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents

Info

Publication number
IL155771A0
IL155771A0 IL15577101A IL15577101A IL155771A0 IL 155771 A0 IL155771 A0 IL 155771A0 IL 15577101 A IL15577101 A IL 15577101A IL 15577101 A IL15577101 A IL 15577101A IL 155771 A0 IL155771 A0 IL 155771A0
Authority
IL
Israel
Prior art keywords
sugar
substituted
hypocholesterolemic agents
azetidinones useful
azetidinones
Prior art date
Application number
IL15577101A
Other languages
English (en)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22973953&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL155771(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of IL155771A0 publication Critical patent/IL155771A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL15577101A 2000-12-20 2001-12-17 Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents IL155771A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25687500P 2000-12-20 2000-12-20
PCT/US2001/049127 WO2002050090A1 (en) 2000-12-20 2001-12-17 Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents

Publications (1)

Publication Number Publication Date
IL155771A0 true IL155771A0 (en) 2003-12-23

Family

ID=22973953

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15577101A IL155771A0 (en) 2000-12-20 2001-12-17 Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents

Country Status (34)

Country Link
US (1) US20020137690A1 (es)
EP (1) EP1347987B1 (es)
JP (2) JP4351842B2 (es)
KR (1) KR100883461B1 (es)
CN (1) CN100475829C (es)
AR (1) AR035611A1 (es)
AT (2) ATE369334T1 (es)
AU (2) AU3104902A (es)
BR (1) BR0116212A (es)
CA (1) CA2432798C (es)
CY (1) CY1106912T1 (es)
CZ (1) CZ302193B6 (es)
DE (2) DE60106489T2 (es)
DK (2) DK1347987T3 (es)
EC (1) ECSP034659A (es)
ES (2) ES2287826T3 (es)
GE (1) GEP20053548B (es)
HU (1) HUP0302269A3 (es)
IL (1) IL155771A0 (es)
MA (1) MA26975A1 (es)
MX (1) MXPA03005671A (es)
MY (1) MY129148A (es)
NO (2) NO326981B1 (es)
NZ (1) NZ525722A (es)
PE (1) PE20020718A1 (es)
PL (1) PL208242B1 (es)
PT (2) PT1347987E (es)
RU (1) RU2297422C2 (es)
SI (2) SI1347987T1 (es)
SK (1) SK286703B6 (es)
TR (1) TR200402758T4 (es)
TW (1) TWI316942B (es)
WO (1) WO2002050090A1 (es)
ZA (1) ZA200303694B (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6982251B2 (en) 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
IL156445A0 (en) 2001-01-26 2004-01-04 Schering Corp Combinations of peroxisome proliferator-activated receptor (ppar) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications
ME00145B (me) 2001-01-26 2010-10-10 Merck Sharp & Dohme Upotreba supstituisanih jedinjenja azetidinona za lečenje sitosterolemije
US7071181B2 (en) 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
WO2002079174A2 (en) 2001-03-28 2002-10-10 Schering Corporation Enantioselective synthesis of azetidinone intermediate compounds
US7056906B2 (en) 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
US7053080B2 (en) 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
ES2272776T3 (es) 2001-09-21 2007-05-01 Schering Corporation Tratamiento de xantomas con derivados de azetidinona como inhibidores de la absorcion de esterol.
GB0215579D0 (en) * 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
AR040588A1 (es) 2002-07-26 2005-04-13 Schering Corp Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
WO2004043457A1 (en) 2002-11-06 2004-05-27 Schering Corporation Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
US7192944B2 (en) 2003-03-07 2007-03-20 Schering Corp. Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
DE602004018617D1 (de) 2003-03-07 2009-02-05 Schering Corp Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia
DE602004016123D1 (de) 2003-03-07 2008-10-09 Schering Corp Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia
JP2005015434A (ja) * 2003-06-27 2005-01-20 Kotobuki Seiyaku Kk 血清コレステロール低下剤或はアテローム性硬化症の予防又は治療剤
EP1522541A1 (en) * 2003-10-07 2005-04-13 Lipideon Biotechnology AG Novel hypocholesterolemic compounds
EP1918000A2 (en) 2003-11-05 2008-05-07 Schering Corporation Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions
GB0329778D0 (en) * 2003-12-23 2004-01-28 Astrazeneca Ab Chemical compounds
WO2005062824A2 (en) 2003-12-23 2005-07-14 Merck & Co., Inc. Anti-hypercholesterolemic compounds
BRPI0418004A (pt) 2003-12-23 2007-04-17 Astrazeneca Ab composto ou um sal, solvato, solvato de um tal sal ou uma pró-droga deste farmaceuticamente aceitáveis, métodos para tratar ou prevenir condições hiperlipidêmicas, aterosclerose, mal de alzheimer, e tumores associados com colesterol, formulação farmacêutica, combinação, e, processo para preparar um composto ou um sal, solvato, solvato de um tal sal ou uma pró-droga deste farmaceuticamente aceitáveis
CA2581596A1 (en) * 2004-09-29 2006-04-13 Schering Corporation Combinations of substituted azetidonones and cb1 antagonists
US7737155B2 (en) 2005-05-17 2010-06-15 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
AR054482A1 (es) * 2005-06-22 2007-06-27 Astrazeneca Ab Derivados de azetidinona para el tratamiento de hiperlipidemias
SA06270191B1 (ar) 2005-06-22 2010-03-29 استرازينيكا ايه بي مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
CA2644905A1 (en) * 2006-03-06 2007-09-13 Teva Pharmaceutical Industries Ltd. Ezetimibe compositions
TW200811098A (en) 2006-04-27 2008-03-01 Astrazeneca Ab Chemical compounds
EP2064222B1 (en) * 2007-04-02 2014-05-07 Theracos, Inc. Benzylic glycoside derivatives and methods of use
US20110245209A1 (en) 2008-12-16 2011-10-06 Schering Corporation Pyridopyrimidine derivatives and methods of use thereof
EP2379562A1 (en) 2008-12-16 2011-10-26 Schering Corporation Bicyclic pyranone derivatives as nicotinic acid receptor agonists
AU2010213749B2 (en) * 2009-02-11 2015-01-22 Dow Agrosciences Llc Pesticidal compositions
EP2403848A1 (en) 2009-03-06 2012-01-11 Lipideon Biotechnology AG Pharmaceutical hypocholesterolemic compositions
EP2414529A2 (en) 2009-04-01 2012-02-08 Matrix Laboratories Ltd Enzymatic process for the preparation of (s)-5-(4-fluoro-phenyl)-5-hydroxy- 1morpholin-4-yl-pentan-1-one, an intermediate of ezetimibe and further conversion to ezetimibe
CN101993403B (zh) 2009-08-11 2012-07-11 浙江海正药业股份有限公司 氮杂环丁酮类化合物及医药应用
KR101102749B1 (ko) * 2009-11-30 2012-01-05 최길용 곱셈 학습기
KR20150079373A (ko) 2013-12-30 2015-07-08 한미약품 주식회사 에제티미브 및 로수바스타틴을 포함하는 경구용 복합제제
CN105055404B (zh) * 2015-08-19 2017-07-18 四川大学 Hmgcs2抑制剂在制备治疗可卡因成瘾的药物中的用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3595B (en) * 1993-01-21 1995-12-27 Schering Corp Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents
US5631365A (en) * 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
US5627176A (en) * 1994-03-25 1997-05-06 Schering Corporation Substituted azetidinone compounds useful as hypocholesterolemic agents
US5633246A (en) * 1994-11-18 1997-05-27 Schering Corporation Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
CA2235943C (en) * 1995-10-31 2002-10-01 Schering Corporation Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
US5756470A (en) * 1996-10-29 1998-05-26 Schering Corporation Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
AUPQ342599A0 (en) * 1999-10-14 1999-11-04 University Of Melbourne, The Conjugates and uses thereof

Also Published As

Publication number Publication date
DK1347987T3 (da) 2005-01-31
HK1084945A1 (en) 2006-08-11
CN1483039A (zh) 2004-03-17
NZ525722A (en) 2004-11-26
PT1593670E (pt) 2007-11-08
ATE279425T1 (de) 2004-10-15
KR100883461B1 (ko) 2009-02-16
JP4351842B2 (ja) 2009-10-28
AU2002231049B2 (en) 2006-07-20
CZ20031674A3 (cs) 2003-10-15
PT1347987E (pt) 2005-01-31
SI1347987T1 (en) 2005-02-28
WO2002050090A8 (en) 2004-04-15
KR20030063414A (ko) 2003-07-28
PL208242B1 (pl) 2011-04-29
SI1593670T1 (sl) 2007-12-31
NO20083737L (no) 2003-08-19
ZA200303694B (en) 2004-08-13
EP1347987B1 (en) 2004-10-13
JP2009132745A (ja) 2009-06-18
AU3104902A (en) 2002-07-01
RU2003122520A (ru) 2005-02-27
CA2432798A1 (en) 2002-06-27
HUP0302269A3 (en) 2009-08-28
GEP20053548B (en) 2005-06-27
MY129148A (en) 2007-03-30
NO326981B1 (no) 2009-03-30
PL363237A1 (en) 2004-11-15
TR200402758T4 (tr) 2004-11-22
MA26975A1 (fr) 2004-12-20
RU2297422C2 (ru) 2007-04-20
NO20032806D0 (no) 2003-06-19
DE60129863T2 (de) 2008-04-30
SK7702003A3 (en) 2003-10-07
EP1347987A1 (en) 2003-10-01
CN100475829C (zh) 2009-04-08
AR035611A1 (es) 2004-06-16
TWI316942B (en) 2009-11-11
DE60106489T2 (de) 2005-10-13
BR0116212A (pt) 2003-12-30
ECSP034659A (es) 2003-07-25
MXPA03005671A (es) 2003-10-06
WO2002050090A1 (en) 2002-06-27
CY1106912T1 (el) 2012-09-26
PE20020718A1 (es) 2002-08-09
CZ302193B6 (cs) 2010-12-08
ATE369334T1 (de) 2007-08-15
NO20032806L (no) 2003-08-19
US20020137690A1 (en) 2002-09-26
CA2432798C (en) 2007-02-27
HK1056735A1 (en) 2004-02-27
DE60129863D1 (de) 2007-09-20
DE60106489D1 (de) 2004-11-18
DK1593670T3 (da) 2007-11-05
ES2287826T3 (es) 2007-12-16
HUP0302269A2 (hu) 2003-10-28
JP2004516299A (ja) 2004-06-03
ES2230385T3 (es) 2005-05-01
SK286703B6 (sk) 2009-03-05

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Legal Events

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MM9K Patent not in force due to non-payment of renewal fees