IL152315A - Soluble mutant ALTC4 molecules and pharmaceutical preparations containing them - Google Patents

Soluble mutant ALTC4 molecules and pharmaceutical preparations containing them

Info

Publication number
IL152315A
IL152315A IL152315A IL15231501A IL152315A IL 152315 A IL152315 A IL 152315A IL 152315 A IL152315 A IL 152315A IL 15231501 A IL15231501 A IL 15231501A IL 152315 A IL152315 A IL 152315A
Authority
IL
Israel
Prior art keywords
ctla4 mutant
mutant molecule
molecule
ctla4
cell
Prior art date
Application number
IL152315A
Other languages
English (en)
Hebrew (he)
Other versions
IL152315A0 (en
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of IL152315A0 publication Critical patent/IL152315A0/xx
Publication of IL152315A publication Critical patent/IL152315A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL152315A 2000-05-26 2001-05-23 Soluble mutant ALTC4 molecules and pharmaceutical preparations containing them IL152315A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57992700A 2000-05-26 2000-05-26
US21406500P 2000-06-26 2000-06-26
PCT/US2001/017139 WO2001092337A2 (en) 2000-05-26 2001-05-23 Soluble ctla4 mutant molecules and uses thereof

Publications (2)

Publication Number Publication Date
IL152315A0 IL152315A0 (en) 2003-05-29
IL152315A true IL152315A (en) 2010-04-15

Family

ID=26908652

Family Applications (1)

Application Number Title Priority Date Filing Date
IL152315A IL152315A (en) 2000-05-26 2001-05-23 Soluble mutant ALTC4 molecules and pharmaceutical preparations containing them

Country Status (41)

Country Link
EP (3) EP1248802B9 (en:Method)
JP (1) JP4328525B2 (en:Method)
KR (2) KR100889887B1 (en:Method)
CN (2) CN1309735C (en:Method)
AR (1) AR031699A1 (en:Method)
AT (1) ATE271066T1 (en:Method)
AU (2) AU2001263466C1 (en:Method)
BE (1) BE2011C041I2 (en:Method)
BR (1) BRPI0111191B8 (en:Method)
CA (1) CA2409748C (en:Method)
CY (2) CY2011019I2 (en:Method)
CZ (1) CZ304451B6 (en:Method)
DE (2) DE60104282T2 (en:Method)
DK (1) DK1248802T3 (en:Method)
EC (1) ECSP024365A (en:Method)
EE (2) EE05458B1 (en:Method)
EG (1) EG24459A (en:Method)
ES (2) ES2571852T3 (en:Method)
FR (1) FR11C0053I2 (en:Method)
GE (1) GEP20053658B (en:Method)
HK (1) HK1048126B (en:Method)
HU (2) HU228137B1 (en:Method)
IL (1) IL152315A (en:Method)
LT (1) LT5133B (en:Method)
LU (1) LU91902I2 (en:Method)
LV (1) LV12994B (en:Method)
MX (1) MXPA02011534A (en:Method)
MY (1) MY136113A (en:Method)
NO (2) NO330797B1 (en:Method)
PE (1) PE20011338A1 (en:Method)
PL (1) PL206267B1 (en:Method)
PT (1) PT1248802E (en:Method)
RU (1) RU2283847C2 (en:Method)
SI (1) SI1248802T1 (en:Method)
SK (1) SK288131B6 (en:Method)
TR (1) TR200402703T4 (en:Method)
TW (2) TWI319405B (en:Method)
UA (1) UA87432C2 (en:Method)
UY (1) UY26723A1 (en:Method)
WO (1) WO2001092337A2 (en:Method)
ZA (1) ZA200208944B (en:Method)

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US7094874B2 (en) 2000-05-26 2006-08-22 Bristol-Myers Squibb Co. Soluble CTLA4 mutant molecules
US20040022787A1 (en) 2000-07-03 2004-02-05 Robert Cohen Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID
UY26815A1 (es) 2000-07-03 2002-01-31 Bristol Myers Squibb Co Métodos para tratar enfermedades reumáticas al usar una molécula ctla4 soluble
CZ305380B6 (cs) 2001-05-23 2015-08-26 Bristol-Myers Squibb Company Léčivo pro inhibici rejekce transplantovaných buněk ostrůvků slinivky břišní
EP1496931A4 (en) * 2002-04-19 2009-07-01 Bristol Myers Squibb Co METHODS OF TREATING AUTOIMMUNE DISEASE USING SOLUBLE CTLA4 MOLECULE AND ARMM OR NSAID
DE10232697A1 (de) * 2002-07-15 2004-02-05 Universitätsklinikum Charité, Medizinische Fakultät der Humboldt-Universität zu Berlin Verwendung von CD152 zur Behandlung von Autoimmunkrankheiten und Entzündungen
TWI328614B (en) 2002-12-23 2010-08-11 Bristol Myers Squibb Co Product quality enhancement in mammalian cell culture processes for protein production
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US8735359B2 (en) 2012-05-24 2014-05-27 Orban Biotech Llc Combinations of modalities for the treatment of diabetes
KR20150033703A (ko) 2012-06-27 2015-04-01 오르반 바이오테크 엘엘씨 당뇨병 치료를 위한 ctla4 융합 단백질
US20140112958A1 (en) 2012-10-24 2014-04-24 Mwm Biomodels Gmbh Pancreatic islets of transgenic LEA29Y animals for treating diabetes
CN104740608A (zh) * 2013-12-30 2015-07-01 上海中信国健药业股份有限公司 可溶性ctla4分子用于制备治疗类风湿性关节炎药物的用途
CN106029896B (zh) 2014-01-13 2020-10-27 美国安进公司 调控鸟氨酸代谢以操控重组蛋白的高甘露糖糖型含量
GB2523399B (en) 2014-02-25 2019-03-13 Orban Tihamer A composition comprising ten overlapping peptide fragments of the entire preproinsulin sequence
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AU2016321298A1 (en) 2015-09-09 2018-03-29 The Trustees Of Columbia University In The City Of New York Reduction of ER-MAM localized APP-C99 and methods of treating Alzheimer's Disease
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CN107987153A (zh) * 2016-10-27 2018-05-04 广东香雪精准医疗技术有限公司 高亲和力的可溶性pd-1分子
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AU2020396490C1 (en) 2019-12-06 2023-04-27 Regeneron Pharmaceuticals, Inc. Anti-VEGF protein compositions and methods for producing the same
CN115803009A (zh) 2020-05-08 2023-03-14 瑞泽恩制药公司 用于治疗眼病和癌症的vegf阱和微阱及方法
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Also Published As

Publication number Publication date
AU6346601A (en) 2001-12-11
EE05458B1 (et) 2011-08-15
DE122011100063I1 (de) 2012-06-14
ECSP024365A (es) 2003-03-31
CZ20023892A3 (cs) 2003-09-17
CY2011019I1 (el) 2016-12-14
KR100889887B1 (ko) 2009-03-24
PL206267B1 (pl) 2010-07-30
EP3029062A1 (en) 2016-06-08
EE05557B1 (et) 2012-08-15
NO2011027I2 (en:Method) 2011-12-15
BE2011C041I2 (en:Method) 2020-08-20
CN1441810A (zh) 2003-09-10
WO2001092337A3 (en) 2002-05-10
RU2283847C2 (ru) 2006-09-20
EP1536234A3 (en) 2009-06-03
BR0111191A (pt) 2004-07-06
LV12994B (en) 2003-08-20
AU2001263466B2 (en) 2006-04-27
CZ304451B6 (cs) 2014-05-14
HUS1300012I1 (hu) 2016-08-29
EE201100050A (et) 2011-10-17
TR200402703T4 (tr) 2004-11-22
JP4328525B2 (ja) 2009-09-09
SK288131B6 (sk) 2013-10-02
IL152315A0 (en) 2003-05-29
NO330797B1 (no) 2011-07-18
EG24459A (en) 2009-07-16
UY26723A1 (es) 2001-12-28
PE20011338A1 (es) 2002-01-13
AR031699A1 (es) 2003-10-01
HK1048126B (en) 2005-03-04
TWI314933B (en) 2009-09-21
AU2001263466C1 (en) 2006-10-26
HUP0302201A3 (en) 2010-01-28
HU228137B1 (en) 2012-12-28
GEP20053658B (en) 2005-11-10
EE200200659A (et) 2004-06-15
TWI319405B (en) 2010-01-11
HK1048126A1 (en) 2003-03-21
WO2001092337A2 (en) 2001-12-06
EP1248802B9 (en) 2005-05-11
SK15702002A3 (sk) 2004-01-08
EP1536234B1 (en) 2016-03-16
SI1248802T1 (en) 2005-02-28
DE60104282T2 (de) 2005-10-13
CN101255192A (zh) 2008-09-03
CY2011019I2 (el) 2016-12-14
EP1248802A2 (en) 2002-10-16
BRPI0111191B1 (pt) 2019-12-31
LT5133B (lt) 2004-05-25
EP1536234A2 (en) 2005-06-01
KR20070094019A (ko) 2007-09-19
LU91902I2 (fr) 2012-01-16
CN1309735C (zh) 2007-04-11
NO20025656D0 (no) 2002-11-25
BRPI0111191B8 (pt) 2021-05-25
CA2409748A1 (en) 2001-12-06
ES2571852T3 (es) 2016-05-27
KR20030009502A (ko) 2003-01-29
PT1248802E (pt) 2004-11-30
PL366231A1 (en) 2005-01-24
MY136113A (en) 2008-08-29
EP1248802B1 (en) 2004-07-14
FR11C0053I1 (en:Method) 2012-01-13
NO20025656L (no) 2002-11-25
DE60104282D1 (de) 2004-08-19
UA87432C2 (uk) 2009-07-27
HUP0302201A2 (hu) 2003-10-28
TW200906857A (en) 2009-02-16
MXPA02011534A (es) 2004-08-12
KR100895134B1 (ko) 2009-05-04
DK1248802T3 (da) 2004-11-15
FR11C0053I2 (fr) 2013-01-11
JP2004511213A (ja) 2004-04-15
ES2225549T3 (es) 2005-03-16
LT2002114A (en) 2003-12-29
NO2011027I1 (no) 2012-01-09
HK1071931A1 (en) 2005-08-05
CY1117625T1 (el) 2017-04-26
CA2409748C (en) 2008-09-16
ZA200208944B (en) 2004-02-13
ATE271066T1 (de) 2004-07-15

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